Peter L Strick

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Stimulating research on motor cortex
    Peter L Strick
    Nat Neurosci 5:714-5. 2002
  2. ncbi request reprint Supplementary motor area and presupplementary motor area: targets of basal ganglia and cerebellar output
    Dalila Akkal
    Center for the Neural Basis of Cognition and Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:10659-73. 2007
  3. pmc The cerebellum and basal ganglia are interconnected
    Andreea C Bostan
    Center for the Neural Basis of Cognition, Systems Neuroscience Institute, and Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neuropsychol Rev 20:261-70. 2010
  4. pmc Posterior parietal cortex contains a command apparatus for hand movements.
    Jean Alban Rathelot
    Proc Natl Acad Sci U S A 114:4255-4260. 2017
  5. doi request reprint Cerebellum and nonmotor function
    Peter L Strick
    Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Annu Rev Neurosci 32:413-34. 2009
  6. pmc Extended practice of a motor skill is associated with reduced metabolic activity in M1
    Nathalie Picard
    Center for the Neural Basis of Cognition and Systems Neuroscience Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nat Neurosci 16:1340-7. 2013
  7. pmc Cerebellar vermis is a target of projections from the motor areas in the cerebral cortex
    Keith A Coffman
    Center for the Neural Basis of Cognition, Systems Neuroscience Institute, and Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 108:16068-73. 2011
  8. ncbi request reprint Frontal lobe inputs to the digit representations of the motor areas on the lateral surface of the hemisphere
    Richard P Dum
    Center for the Neural Basis of Cognition and Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 25:1375-86. 2005
  9. pmc The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys
    Richard P Dum
    Center for the Neural Basis of Cognition, Systems Neuroscience Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:14223-35. 2009
  10. ncbi request reprint Skill representation in the primary motor cortex after long-term practice
    Yoshiya Matsuzaka
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    J Neurophysiol 97:1819-32. 2007

Research Grants

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Stimulating research on motor cortex
    Peter L Strick
    Nat Neurosci 5:714-5. 2002
  2. ncbi request reprint Supplementary motor area and presupplementary motor area: targets of basal ganglia and cerebellar output
    Dalila Akkal
    Center for the Neural Basis of Cognition and Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:10659-73. 2007
    ..Although both systems are the target of outputs from the basal ganglia and the cerebellum, these two cortical areas seem to be dominated by basal ganglia input...
  3. pmc The cerebellum and basal ganglia are interconnected
    Andreea C Bostan
    Center for the Neural Basis of Cognition, Systems Neuroscience Institute, and Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neuropsychol Rev 20:261-70. 2010
    ..Furthermore, we discuss how these pathways may provide a useful framework for understanding cerebellar contributions to the manifestation of two prototypical basal ganglia disorders, Parkinson's disease and dystonia...
  4. pmc Posterior parietal cortex contains a command apparatus for hand movements.
    Jean Alban Rathelot
    Proc Natl Acad Sci U S A 114:4255-4260. 2017
    ..Thus, our results establish that a region within area 5 contains a motor area with corticospinal neurons that could function as a command apparatus for operation of the hand...
  5. doi request reprint Cerebellum and nonmotor function
    Peter L Strick
    Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Annu Rev Neurosci 32:413-34. 2009
    ..These data, along with the revelations about cerebro-cerebellar circuitry, provide a new framework for exploring the contribution of the cerebellum to diverse aspects of behavior...
  6. pmc Extended practice of a motor skill is associated with reduced metabolic activity in M1
    Nathalie Picard
    Center for the Neural Basis of Cognition and Systems Neuroscience Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nat Neurosci 16:1340-7. 2013
    ..Thus, practice leading to skilled performance results in more efficient generation of neuronal activity in M1...
  7. pmc Cerebellar vermis is a target of projections from the motor areas in the cerebral cortex
    Keith A Coffman
    Center for the Neural Basis of Cognition, Systems Neuroscience Institute, and Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 108:16068-73. 2011
    ..We argue that the projection from the cerebral cortex to the vermis is part of the neural substrate for anticipatory postural adjustments and speculate that dysfunction of this system may underlie some forms of dystonia...
  8. ncbi request reprint Frontal lobe inputs to the digit representations of the motor areas on the lateral surface of the hemisphere
    Richard P Dum
    Center for the Neural Basis of Cognition and Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 25:1375-86. 2005
    ..Overall, the laminar origins of neurons that interconnect the three cortical areas are typical of "lateral" interactions. Thus, from an anatomical perspective, this cortical network lacks a clear hierarchical organization...
  9. pmc The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys
    Richard P Dum
    Center for the Neural Basis of Cognition, Systems Neuroscience Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:14223-35. 2009
    ..The cingulate motor areas in the monkey project directly to the primary motor cortex and to the spinal cord. Thus, the substrate exists for the ST system to have an important influence on the cortical control of movement...
  10. ncbi request reprint Skill representation in the primary motor cortex after long-term practice
    Yoshiya Matsuzaka
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    J Neurophysiol 97:1819-32. 2007
    ..Our results suggest that practice sculpts the response properties of M1 neurons. M1 may be a site of storage for the internal representation of skilled sequential movements...
  11. pmc Cerebellar networks with the cerebral cortex and basal ganglia
    Andreea C Bostan
    Center for the Neural Basis of Cognition, Systems Neuroscience Institute and Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Trends Cogn Sci 17:241-54. 2013
    ....
  12. pmc Subdivisions of primary motor cortex based on cortico-motoneuronal cells
    Jean Alban Rathelot
    Research Service, Veterans Affairs Medical Center, Pittsburgh, PA 15240, USA
    Proc Natl Acad Sci U S A 106:918-23. 2009
    ..The direct access to motoneurons afforded by CM cells enables the newly recognized M1 to bypass spinal cord mechanisms and sculpt novel patterns of motor output that are essential for highly skilled movements...
  13. ncbi request reprint Motor and nonmotor domains in the monkey dentate
    Richard P Dum
    Pittsburgh Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, USA
    Ann N Y Acad Sci 978:289-301. 2002
    ..This organization provides the dentate nucleus with the anatomical substrate to influence not only the control of movement, but also cognitive, higher-order executive and visuospatial functions...
  14. pmc The basal ganglia communicate with the cerebellum
    Andreea C Bostan
    Department of Neurobiology, University of Pittsburgh School of Medicine, Center for the Neural Basis of Cognition, Systems Neuroscience Institute, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 107:8452-6. 2010
    ..Thus, the two subcortical structures may be linked together to form an integrated functional network...
  15. pmc The motor cortex communicates with the kidney
    David J Levinthal
    Pittsburgh Veterans Affairs Medical Center and Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Neurosci 32:6726-31. 2012
    ..Thus, a map of visceromotor representation appears to be embedded within the classic somatotopic map of skeletomotor representation...
  16. ncbi request reprint Basal ganglia and cerebellar inputs to 'AIP'
    Dottie M Clower
    Pittsburgh Veterans Affairs Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cereb Cortex 15:913-20. 2005
    ..In addition, our findings provide further support for the concept that posterior parietal cortex is a target of cerebellar output...
  17. pmc Muscle representation in the macaque motor cortex: an anatomical perspective
    Jean Alban Rathelot
    Research Service, Veterans Affairs Medical Center, Department of Neurobiology, University of Pittsburgh School of Medicine, W1640 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 103:8257-62. 2006
    ..Second, the size range of CM cells includes both "fast" and "slow" pyramidal tract neurons. These observations are likely to lead to dramatic changes in views about the function of the CM system...
  18. ncbi request reprint Rapid and long-lasting plasticity of input-output mapping
    Kenji Yamamoto
    Department of Neurobiology, University of Pittsburgh School of Medicine, 4074 Biomedical Science Tower 3, 3501 Fifth Ave, Pittsburgh, PA 15261, USA
    J Neurophysiol 96:2797-801. 2006
    ..Our results show that sensorimotor performance remains flexible despite considerable practice on a specific task, and even relatively short-term exposure to a new input-output mapping leads to a long-lasting change in motor performance...
  19. pmc Transneuronal tracing with neurotropic viruses reveals network macroarchitecture
    Richard P Dum
    Department of Neurobiology, Center for Neural Basis of Cognition, and Systems Neuroscience Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, United States
    Curr Opin Neurobiol 23:245-9. 2013
    ..These examples demonstrate the power of transneuronal tracing with rabies virus to identify the macroarchitecture of complex neural circuits...
  20. ncbi request reprint The cerebellum communicates with the basal ganglia
    Eiji Hoshi
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 8:1491-3. 2005
    ..Using transneuronal transport of rabies virus in macaques, we found that a disynaptic pathway links an output stage of cerebellar processing, the dentate nucleus, with an input stage of basal ganglia processing, the striatum...
  21. ncbi request reprint An unfolded map of the cerebellar dentate nucleus and its projections to the cerebral cortex
    Richard P Dum
    Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania 15261, USA
    J Neurophysiol 89:634-9. 2003
    ..In contrast, projections to prefrontal and posterior parietal areas of cortex originated from ventral portions of the dentate. Thus the dentate contains anatomically separate and functionally distinct motor and nonmotor domains...
  22. pmc Targeted single-neuron infection with rabies virus for transneuronal multisynaptic tracing
    Tuan D Nguyen
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Neurosci Methods 209:367-70. 2012
    ..Here we report on a method that can initially infect a single neuron-of-choice, allowing for greater precision and specificity of labeled circuits...
  23. pmc Motor, cognitive, and affective areas of the cerebral cortex influence the adrenal medulla
    Richard P Dum
    University of Pittsburgh Brain Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 Systems Neuroscience Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 Center for the Neural Basis of Cognition, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261
    Proc Natl Acad Sci U S A 113:9922-7. 2016
    ..This circuitry may mediate the effects of internal states like chronic stress and depression on organ function and, thus, provide a concrete neural substrate for some psychosomatic illness. ..
  24. ncbi request reprint Activation of the supplementary motor area (SMA) during performance of visually guided movements
    Nathalie Picard
    Center for the Neural Basis of Cognition, Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cereb Cortex 13:977-86. 2003
    ..Furthermore, our observations suggest that during externally guided reaching, SMA activation is tightly coupled to that of M1, but dissociated from that of the cingulate motor areas...
  25. pmc Inactivation of the Dorsal Premotor Area Disrupts Internally Generated, But Not Visually Guided, Sequential Movements
    Machiko Ohbayashi
    Center for the Neural Basis of Cognition, Systems Neuroscience Institute, University of Pittsburgh Brain Institute, and Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
    J Neurosci 36:1971-6. 2016
    ..These results emphasize the importance of the PMd in the internal generation of sequential movements, perhaps through maintaining arbitrary motor-motor associations...
  26. pmc Corticomotoneuronal cells are "functionally tuned"
    Darcy M Griffin
    University of Pittsburgh Brain Institute, Center for the Neural Basis of Cognition and Systems Neuroscience Institute, Pittsburgh, PA, USA Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Science 350:667-70. 2015
    ..These observations suggest that the different functional uses of a muscle are generated by separate populations of CM cells. We propose that muscle function is one of the dimensions represented in the output of M1. ..
  27. ncbi request reprint Motor areas in the frontal lobe of the primate
    Richard P Dum
    Center for the Neural Basis of Cognition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Physiol Behav 77:677-82. 2002
    ..We propose that each premotor area is a functionally distinct efferent system that differentially generates and/or controls specific aspects of motor behavior...
  28. ncbi request reprint Basal-ganglia 'projections' to the prefrontal cortex of the primate
    Frank A Middleton
    Department of Neurobiology, Center for the Neural Basis of Cognition, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cereb Cortex 12:926-35. 2002
    ..Thus, basal-ganglia outputs to prefrontal cortex are both extensive and topographically organized, forming a rich anatomical substrate for basal-ganglia influences on the cognitive operations of the frontal lobe...
  29. ncbi request reprint Sensorimotor transformations in cortical motor areas
    Shinji Kakei
    Systems Neuroscience, Graduate School of Life Science, Tohoku University, 2 1 1 Katahira, Aoba ku, Sendai 980 8577, Japan
    Neurosci Res 46:1-10. 2003
    ..Recent modeling studies have demonstrated the computational plausibility of such a process...
  30. ncbi request reprint Motor systems. Editorial Overview
    Eve Marder
    Curr Opin Neurobiol 16:601-3. 2006
  31. ncbi request reprint Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate
    Roberta M Kelly
    Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:8432-44. 2003
    ..Thus, our observations suggest that multiple closed-loop circuits represent a fundamental architectural feature of cerebrocerebellar interactions...
  32. ncbi request reprint Deficits in movements of the wrist ipsilateral to a stroke in hemiparetic subjects
    Cherylon A Yarosh
    Department of Neurosurgery, State University of New York Upstate Medical University, Syrause 13210, USA
    J Neurophysiol 92:3276-85. 2004
    ..These observations indicate that unilateral lesions can have significant bilateral effects on the generation and control of distal limb movements...
  33. ncbi request reprint Macro-architecture of basal ganglia loops with the cerebral cortex: use of rabies virus to reveal multisynaptic circuits
    Roberta M Kelly
    Johnson and Johnson Pharmaceutical Research and Development, San Diego, CA 92121, USA
    Prog Brain Res 143:449-59. 2004
    ..Overall, our results indicate that basal ganglia circuits with the cerebral cortex can be characterized by both open- and closed-loop macro-architectures...

Research Grants1

  1. Cortical contributions to basal ganglia disorders
    PETER STRICK; Fiscal Year: 2006
    ..abstract_text> ..