Genomes and Genes
Affiliation: University of Maryland
- Variation in the lamin A/C gene: associations with metabolic syndromeNanette I Steinle
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
Arterioscler Thromb Vasc Biol 24:1708-13. 2004..To determine whether polymorphisms in LMNA influence susceptibility to metabolic syndrome and its constituent components...
- Variants in the ghrelin gene are associated with metabolic syndrome in the Old Order AmishNanette I Steinle
Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
J Clin Endocrinol Metab 90:6672-7. 2005..Its gene, GHRL, is located on chromosome 3 in a region where we have shown linkage to eating behavior, percentage body fat, and total and low-density lipoprotein cholesterol levels in subjects of the Amish Family Diabetes Study...
- Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart StudyPatrick F McArdle
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
BMC Med Genet 9:67. 2008..We assessed the role of genetic variation in three subunits of the neuromuscular nicotinic acetylcholine receptor positioned on chromosome 2q, a region showing replicated evidence of linkage to blood pressure...
- Bitter taste receptors influence glucose homeostasisCedrick D Dotson
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA
PLoS ONE 3:e3974. 2008..Together, these findings suggest that a functionally compromised TAS2R receptor negatively impacts glucose homeostasis, providing an important link between alimentary chemosensation and metabolic disease...
- Patient understanding of diabetes self-management: participatory decision-making in diabetes careCharlene C Quinn
Department of Epidemiology and Public Health, Division of Gerontology, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Diabetes Sci Technol 5:723-30. 2011..We also identified issues that would impact messaging for use in mobile diabetes communication...
- A genome-wide scan of serum lipid levels in the Old Order AmishToni I Pollin
Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA
Atherosclerosis 173:89-96. 2004....
- From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility geneYing Wang
Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 106:226-31. 2009..Thus, variants in STK39 may influence BP by increasing STK39 expression and consequently altering renal Na(+) excretion, thus unifying rare and common BP-regulating alleles in the same physiological pathway...
- Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish womenCedrick D Dotson
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Appetite 54:93-9. 2010..Therefore, our results indicate that a polymorphism in TAS2R38 is associated with differences in ingestive behavior...
- Analysis of the gut microbiota in the old order Amish and its relation to the metabolic syndromeMargaret L Zupancic
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 7:e43052. 2012....
- Eating behavior in the Old Order Amish: heritability analysis and a genome-wide linkage analysisNanette I Steinle
University of Maryland School of Medicine, Baltimore 21201, USA
Am J Clin Nutr 75:1098-106. 2002..Eating behavior and thus dietary intake affect the development of obesity-related diseases such as diabetes, hypertension, and hyperlipidemia...
- T1R and T2R receptors: the modulation of incretin hormones and potential targets for the treatment of type 2 diabetes mellitusCedrick D Dotson
University of Maryland School of Medicine, Department of Anatomy and Neurobiology, Baltimore, MD 21201, USA
Curr Opin Investig Drugs 11:447-54. 2010..This review focuses on the intriguing finding that taste receptors may be involved in modulating the incretin response, and considers T1Rs and T2Rs as potential targets for new hypoglycemic drugs...
- Cloning a Blood Pressure Gene on Human Chromosome 2q32.3Nanette Steinle; Fiscal Year: 2008..These advances will impact substantially on the quality of life of millions of Americans. ..