B Steffensen

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Fragmentation of fibronectin by inherent autolytic and matrix metalloproteinase activities
    Bjorn Steffensen
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Matrix Biol 30:34-42. 2011
  2. ncbi Proteolytic events of wound-healing--coordinated interactions among matrix metalloproteinases (MMPs), integrins, and extracellular matrix molecules
    B Steffensen
    Department of Periodontics, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Crit Rev Oral Biol Med 12:373-98. 2001
  3. ncbi Human fibronectin and MMP-2 collagen binding domains compete for collagen binding sites and modify cellular activation of MMP-2
    Bjorn Steffensen
    Department of Periodontics MC 7894, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Matrix Biol 21:399-414. 2002
  4. pmc Co-purified gelatinases alter the stability and biological activities of human plasma fibronectin preparations
    S Pal
    Department of Periodontics and Biochemistry, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    J Periodontal Res 45:292-5. 2010
  5. ncbi Clinical validation of a new subtraction radiography technique for periodontal bone loss detection
    P V Nummikoski
    Department of Dental Diagnostic Science, University of Texas Health Science Center at San Antonio, 78284, USA
    J Periodontol 71:598-605. 2000
  6. ncbi Human gingival fibroblast integrin subunit expression on titanium implant surfaces
    Thomas W Oates
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Periodontol 76:1743-50. 2005
  7. pmc Functional basis for the overlap in ligand interactions and substrate specificities of matrix metalloproteinases-9 and -2
    Xiaoping Xu
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7894, San Antonio, TX 78229 3900, USA
    Biochem J 392:127-34. 2005
  8. pmc Nuclear magnetic resonance mapping and functional confirmation of the collagen binding sites of matrix metalloproteinase-2
    Xiaoping Xu
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7894, San Antonio, Texas 78229 3900, USA
    Biochemistry 48:5822-31. 2009
  9. pmc Advanced glycation of type I collagen and fibronectin modifies periodontal cell behavior
    Jesse Murillo
    Department of Periodontics, University of Texas Health Science Center, San Antonio, TX, USA
    J Periodontol 79:2190-9. 2008
  10. ncbi Amelogenin is a cell adhesion protein
    A M Hoang
    Department of Periodontics, University of Texas Health Science Center, San Antonio 78229, USA
    J Dent Res 81:497-500. 2002

Research Grants

Collaborators

Detail Information

Publications16

  1. pmc Fragmentation of fibronectin by inherent autolytic and matrix metalloproteinase activities
    Bjorn Steffensen
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Matrix Biol 30:34-42. 2011
    ....
  2. ncbi Proteolytic events of wound-healing--coordinated interactions among matrix metalloproteinases (MMPs), integrins, and extracellular matrix molecules
    B Steffensen
    Department of Periodontics, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Crit Rev Oral Biol Med 12:373-98. 2001
    ..This review will focus on those aspects of the extensive knowledge of fibroblast and keratinocyte MMPs and integrins in biological processes that relate to wound-healing...
  3. ncbi Human fibronectin and MMP-2 collagen binding domains compete for collagen binding sites and modify cellular activation of MMP-2
    Bjorn Steffensen
    Department of Periodontics MC 7894, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Matrix Biol 21:399-414. 2002
    ....
  4. pmc Co-purified gelatinases alter the stability and biological activities of human plasma fibronectin preparations
    S Pal
    Department of Periodontics and Biochemistry, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    J Periodontal Res 45:292-5. 2010
    ..Available methods for separating gelatinases from FN are resource demanding. Therefore, our objective was to devise a time- and cost-efficient protocol for purification of gelatinase-free FN...
  5. ncbi Clinical validation of a new subtraction radiography technique for periodontal bone loss detection
    P V Nummikoski
    Department of Dental Diagnostic Science, University of Texas Health Science Center at San Antonio, 78284, USA
    J Periodontol 71:598-605. 2000
    ....
  6. ncbi Human gingival fibroblast integrin subunit expression on titanium implant surfaces
    Thomas W Oates
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Periodontol 76:1743-50. 2005
    ..Therefore, the aim of this study was to examine integrin expression for gingival fibroblasts on titanium surfaces and the influence of titanium surface roughness on integrin expression and cell morphology...
  7. pmc Functional basis for the overlap in ligand interactions and substrate specificities of matrix metalloproteinases-9 and -2
    Xiaoping Xu
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7894, San Antonio, TX 78229 3900, USA
    Biochem J 392:127-34. 2005
    ..Collectively, these results emphasize the essential contribution of CBD-9 to MMP-9 substrate binding and gelatinolysis, and demonstrate that the CBDs of MMP-9 and MMP-2 bind the same or closely positioned sites on type I collagen...
  8. pmc Nuclear magnetic resonance mapping and functional confirmation of the collagen binding sites of matrix metalloproteinase-2
    Xiaoping Xu
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7894, San Antonio, Texas 78229 3900, USA
    Biochemistry 48:5822-31. 2009
    ..These results have localized and confirmed the key collagen binding site residues in the three fibronectin type II-like modules of MMP-2...
  9. pmc Advanced glycation of type I collagen and fibronectin modifies periodontal cell behavior
    Jesse Murillo
    Department of Periodontics, University of Texas Health Science Center, San Antonio, TX, USA
    J Periodontol 79:2190-9. 2008
    ..Therefore, this study investigated whether glycation of type I collagen (COLI) and fibronectin (FN) modified the behavior of human gingival fibroblasts (hGFs) and periodontal ligament fibroblasts (hPDLs)...
  10. ncbi Amelogenin is a cell adhesion protein
    A M Hoang
    Department of Periodontics, University of Texas Health Science Center, San Antonio 78229, USA
    J Dent Res 81:497-500. 2002
    ..The cell-adhesive activity of amelogenin may play a role in development and may provide a partial explanation for the therapeutic effects of Emdogain in periodontal regeneration...
  11. pmc Fibronectin fragmentation is a feature of periodontal disease sites and diabetic foot and leg wounds and modifies cell behavior
    Corey M Stanley
    Department of Periodontics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Periodontol 79:861-75. 2008
    ..The biologic effects of FN fragments on wound healing remain unresolved. This study characterized the pattern of FN fragmentation and its effects on cellular behavior compared to intact FN...
  12. ncbi Matrix metalloproteinase-2 contributes to cancer cell migration on collagen
    Xiaoping Xu
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Cancer Res 65:130-6. 2005
    ..Together, our results provide evidence that MMP-2 is an important determinant of cancer cell behavior but is not inhibited by the collagen binding segment of fibronectin...
  13. pmc Inhibition of MMP-2 gelatinolysis by targeting exodomain-substrate interactions
    Xiaoping Xu
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7894, San Antonio, TX 78229 3900, USA
    Biochem J 406:147-55. 2007
    ..These experiments identified a CBD-binding site on type I collagen and demonstrated that a corresponding synthetic peptide can inhibit hydrolysis of type I and IV collagens by competing CBD-mediated gelatin binding to MMP-2...
  14. ncbi Contributions of the MMP-2 collagen binding domain to gelatin cleavage. Substrate binding via the collagen binding domain is required for hydrolysis of gelatin but not short peptides
    Xiaoping Xu
    Departments of Periodontics and Biochemistry MC 7894, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Matrix Biol 23:171-81. 2004
    ..Together, these results demonstrate that the CBD is absolutely required for MMP-2 cleavage of full-length collagen alpha-chains, but not for short protein fragments such as those generated by hydrolysis of gelatin...
  15. ncbi Tetracycline at subcytotoxic levels inhibits matrix metalloproteinase-2 and -9 but does not remove the smear layer
    Yao Wang
    Departments of Periodontics and Biochemistry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Periodontol 76:1129-39. 2005
    ..However, recent reports pointing to cytotoxic effects of several acids prompted this study to define TCN concentrations that are anticollagenolytic and remove the smear layer, but have low cytotoxicity...
  16. ncbi IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation
    Dolores M Cortez
    Department of Veterans Affairs South Texas Veterans Health Care System, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Heart Circ Physiol 293:H3356-65. 2007
    ..Our data indicate that IL-17 induces MMP-1 in human cardiac fibroblasts directly via p38 MAPK- and ERK-dependent AP-1, NF-kappaB, and C/EBP-beta activation and suggest that IL-17 may play a critical role in myocardial remodeling...

Research Grants3

  1. MMP-2 in Periodontal Disease and Oral Cancer
    Bjorn Steffensen; Fiscal Year: 2005
    ....
  2. MMP-2 in Periodontal Disease and Oral Cancer
    Bjorn Steffensen; Fiscal Year: 2008
    ..The proposed studies should define the specific binding sites of MMP-2 and collagen and explore a new strategy to inhibit MMP-2 in periodontal disease and oral cancer. ..
  3. MMP-2 and Fibronectin Fragmentation in Periodontal Diseases and Oral Cancer
    Bjorn Steffensen; Fiscal Year: 2010
    ..Successful inhibition of fibronectin fragmentation could be of significant benefit for the management of both periodontal disease and oral cancer. ..