John Stanley

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi Mechanisms of Disease: Pemphigus and Bullous Pemphigoid
    Christoph M Hammers
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 email
    Annu Rev Pathol 11:175-97. 2016
  2. pmc Targeted delivery of tumor necrosis factor-related apoptosis-inducing ligand to keratinocytes with a pemphigus mAb
    Michiyoshi Kouno
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Invest Dermatol 133:2212-20. 2013
  3. pmc Desmoglein as a target in skin disease and beyond
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 132:776-84. 2012
  4. pmc Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris
    P J Koch
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 137:1091-102. 1997
  5. pmc Synergy of understanding dermatologic disease and epidermal biology
    John R Stanley
    Department of Dermatology, University of Pennsylvania, 415 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 122:436-9. 2012
  6. pmc Desmoglein isoform distribution affects stratum corneum structure and function
    P M Elias
    Department of Dermatology, University of California San Francisco, San Francisco, California 94143, USA
    J Cell Biol 153:243-9. 2001
  7. pmc Update on the cloning of monoclonal anti-desmoglein antibodies from human pemphigus patients: implications for targeted therapy
    John R Stanley
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Vet Dermatol 20:327-30. 2009
  8. pmc Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies
    Ken Ishii
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 128:939-48. 2008
  9. ncbi Enzymatic and molecular characteristics of the efficiency and specificity of exfoliative toxin cleavage of desmoglein 1
    Yasushi Hanakawa
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:5268-77. 2004
  10. ncbi Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI)
    Norman M Schechter
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biol Chem 386:1173-84. 2005

Research Grants

  1. PATHOGENESIS OF PEMPHIGUS
    John Stanley; Fiscal Year: 2001
  2. Mechanisms of Blister Formation by Staphylococcal Toxins
    John Stanley; Fiscal Year: 2006

Collaborators

Detail Information

Publications23

  1. doi Mechanisms of Disease: Pemphigus and Bullous Pemphigoid
    Christoph M Hammers
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 email
    Annu Rev Pathol 11:175-97. 2016
    ..Understanding these mechanisms of disease has led to rational targeted therapeutic strategies. ..
  2. pmc Targeted delivery of tumor necrosis factor-related apoptosis-inducing ligand to keratinocytes with a pemphigus mAb
    Michiyoshi Kouno
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Invest Dermatol 133:2212-20. 2013
    ..These data suggest that such targeted therapy is feasible and may be useful for hyperproliferative and inflamed skin diseases. ..
  3. pmc Desmoglein as a target in skin disease and beyond
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 132:776-84. 2012
    ....
  4. pmc Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris
    P J Koch
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 137:1091-102. 1997
    ..These results demonstrate the critical importance of Dsg3 for adhesion in deep stratified squamous epithelia and suggest that pemphigus autoantibodies might interfere directly with such a function...
  5. pmc Synergy of understanding dermatologic disease and epidermal biology
    John R Stanley
    Department of Dermatology, University of Pennsylvania, 415 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 122:436-9. 2012
    ..This type of synergy is a profound strength of clinical research of the type that the JCI is dedicated to publishing...
  6. pmc Desmoglein isoform distribution affects stratum corneum structure and function
    P M Elias
    Department of Dermatology, University of California San Francisco, San Francisco, California 94143, USA
    J Cell Biol 153:243-9. 2001
    ..These data demonstrate that differential expression of desmoglein isoforms affects the major function of epidermis, the permeability barrier, by altering the structure of the stratum corneum...
  7. pmc Update on the cloning of monoclonal anti-desmoglein antibodies from human pemphigus patients: implications for targeted therapy
    John R Stanley
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Vet Dermatol 20:327-30. 2009
    ..In summary, the antibody response is restricted and, therefore, it may be feasible to target the specific pathogenic antibodies for therapy...
  8. pmc Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies
    Ken Ishii
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 128:939-48. 2008
    ..These mAbs will be useful for studying Dsg1 function and mechanisms of blister formation in PF and for developing targeted therapies and tools to monitor disease activity...
  9. ncbi Enzymatic and molecular characteristics of the efficiency and specificity of exfoliative toxin cleavage of desmoglein 1
    Yasushi Hanakawa
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:5268-77. 2004
    ..These data suggest that the exquisite specificity and efficiency of ETA may depend on the enzyme's binding upstream of the cleavage site with a very specific fit, like a key in a lock...
  10. ncbi Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI)
    Norman M Schechter
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biol Chem 386:1173-84. 2005
    ..0 in a reaction that was rapidly reversible. These results show that LEKTI, at least in fragment form, is a potent inhibitor of rhK5 and that this protease may be a target of LEKTI in human skin...
  11. pmc Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display
    Aimee S Payne
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 115:888-99. 2005
    ..Detailed characterization of these pemphigus mAbs should lead to a better understanding of the immunopathogenesis of disease and to more specifically targeted therapeutic approaches...
  12. ncbi Targeting pemphigus autoantibodies through their heavy-chain variable region genes
    Aimee S Payne
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 127:1681-91. 2007
    ..Together, these data suggest novel V(H) gene-targeted approaches toward PV treatment...
  13. pmc Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus
    Jun Yamagami
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 183:5615-21. 2009
    ..However, presentation of peptides from Dsg1 by preDsg1-specific B cells may be one step in developing autoimmunity in PF...
  14. ncbi Calcium-dependent conformation of desmoglein 1 is required for its cleavage by exfoliative toxin
    Yasushi Hanakawa
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Invest Dermatol 121:383-9. 2003
    ..These data suggest that the specificity of exfoliative toxin cleavage of desmoglein 1 resides not only in simple amino acid sequences but also in its calcium-dependent conformation...
  15. pmc Homologous regions of autoantibody heavy chain complementarity-determining region 3 (H-CDR3) in patients with pemphigus cause pathogenicity
    Jun Yamagami
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 120:4111-7. 2010
    ..These studies indicate that H-CDR3 is critical for pathogenicity of a human autoantibody, that a small region (even 1 amino acid) can mediate pathogenicity, and that pathogenicity can be uncoupled from binding in these antibodies...
  16. ncbi Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome
    John R Stanley
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    N Engl J Med 355:1800-10. 2006
  17. pmc Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome
    Yasushi Hanakawa
    Department of Dermatology, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    J Clin Invest 110:53-60. 2002
    ..aureus to spread under the stratum corneum, the main barrier of the skin, explaining how, although they circulate through the entire body in SSSS, they cause pathology only in the superficial epidermis...
  18. ncbi Desmogleins 1 and 3 in the companion layer anchor mouse anagen hair to the follicle
    Yasushi Hanakawa
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 123:817-22. 2004
    ..These findings demonstrate the importance of the companion layer, and particularly the Dsg1 and Dsg3 in this layer, in anchoring the anagen hair to the follicle...
  19. ncbi Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation
    Hong Wu
    Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 120:1052-7. 2003
    ..We conclude that desmoglein expression patterns define compartments of cells in similar states of differentiation within the cutaneous epithelium, and reveal a hierarchy of differentiation among these compartments...
  20. ncbi Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1
    Masayuki Amagai
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 118:845-50. 2002
    ..These findings demonstrate that exfoliative toxin A and exfoliative toxin B cause blister formation in staphylococcal scalded skin syndrome and bullous impetigo by identical molecular pathophysiologic mechanisms...
  21. ncbi Expression of desmoglein 1 compensates for genetic loss of desmoglein 3 in keratinocyte adhesion
    Yasushi Hanakawa
    Department of Dermatology, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, U S A
    J Invest Dermatol 119:27-31. 2002
    ..These studies show that desmoglein-1 can compensate for loss of desmoglein-3-mediated adhesion, and provide genetic evidence confirming the desmoglein compensation hypothesis...
  22. ncbi Production of low titers of anti-desmoglein 1 IgG autoantibodies in some patients with staphylococcal scalded skin syndrome
    Hidemi Anzai
    J Invest Dermatol 126:2139-41. 2006
  23. ncbi Desmosomes and disease: pemphigus and bullous impetigo
    Aimee S Payne
    Department of Dermatology, University of Pennsylvania, Philadelphia, 415 Curie Boulevard, 211 Clinical Research Building, Pennsylvania, 19104 USA
    Curr Opin Cell Biol 16:536-43. 2004
    ..These studies offer new insight into the potential mechanisms of acantholysis in pemphigus and staphylococcal-associated blistering disease, with implications for the role of desmogleins in desmosomal structure and function...

Research Grants2

  1. PATHOGENESIS OF PEMPHIGUS
    John Stanley; Fiscal Year: 2001
    ..Finally, it will be determined if glucocorticoids can stabilize adhesion and rescue the PV phenotype in these knockout mice. ..
  2. Mechanisms of Blister Formation by Staphylococcal Toxins
    John Stanley; Fiscal Year: 2006
    ..abstract_text> ..