Affiliation: University of Kansas Medical Center
- Selective atonal gene delivery improves balance function in a mouse model of vestibular diseaseC Schlecker
Department of Otolaryngology, Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS, USA
Gene Ther 18:884-90. 2011..Delivery of this vector to IDPN-damaged vestibular organs resulted in a significant recovery of vestibular hair cells and restoration of balance, as measured by time on rotarod compared with untreated controls...
- Developments in delivery of medications for inner ear diseaseHinrich Staecker
University of Kansas School of Medicine, Department of Otolaryngology Head and Neck Surgery, MS 3010, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Expert Opin Drug Deliv 10:639-50. 2013..Despite the high incidence of inner ear disease in the general population, there are currently no dedicated pharmacologic interventions available to treat these problems...
- Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transferHinrich Staecker
Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
Otol Neurotol 28:223-31. 2007..Delivery of math1 using an adenovector (Admath1.11D) results in vestibular hair cell regeneration and recovery of balance function in ototoxin-treated adult mice...
- Vector-mediated delivery of bcl-2 prevents degeneration of auditory hair cells and neurons after injuryHinrich Staecker
Department of Otolaryngology, University of Kansas, Kansas City, Kans 66160, USA
ORL J Otorhinolaryngol Relat Spec 69:43-50. 2007..To test the hypothesis that bcl-2 prevents oxidative stress-induced apoptosis of auditory sensory cells in explants of the organ of Corti and dissociated cell cultures of the spiral ganglion...
- Neurotrophin therapy and cochlear implantation: translating animal models to human therapyHinrich Staecker
Department of Otolaryngology Head and Neck Surgery, University of Kansas, Kansas City, KS 66160, USA
Exp Neurol 226:1-5. 2010....
- Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational researchHinrich Staecker
Dept Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, MS 3010, 3901 Rainbow Blvd, Kansas City, KS 66209, USA
Hear Res 276:44-51. 2011..This approach is particularly suited for the development of molecular therapies targeted at the vestibular system given that no device based therapeutic such a cochlear implant available for vestibular loss...
- Bcl-2 gene therapy prevents aminoglycoside-induced degeneration of auditory and vestibular hair cellsSusanna C Pfannenstiel
Department of Otolaryngology Head and Neck Surgery, University of Kansas, School of Medicine, Kansas City, Kans 66160, USA
Audiol Neurootol 14:254-66. 2009..Pretreatment with Ad.11D.bcl-2 resulted in morphologic protection of hair cells and preservation of hearing thresholds measured by ABR...
- Arrest of apoptosis in auditory neurons: implications for sensorineural preservation in cochlear implantationUlysses Scarpidis
Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, New York, USA
Otol Neurotol 24:409-17. 2003..The JNK/c-Jun cell death pathway is a major pathway responsible for the loss of oxidative stress-damaged auditory neurons...
- Transsynaptic delivery of nanoparticles to the central auditory nervous systemMark Praetorius
Department of Otolaryngology, Head and Neck Surgery, University of Heidelberg Medical Center, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
Acta Otolaryngol 127:486-90. 2007..Silica nanoparticles may serve as a nonviral delivery system to the sensory hair cells, spiral ganglion cells within the cochlea, and the vestibular organ, as well as the cochlear nucleus...
- Cochlear implantation: an opportunity for drug developmentHinrich Staecker
Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS 66160, USA
Drug Discov Today 15:314-21. 2010..The evolution of cochlear implantation thus presents us with an opportunity to develop a range of local pharmacologic interventions to prevent hearing degeneration...
- Canalostomy as a surgical approach for cochlear gene therapy in the ratDavina Gassner
Department of Otolaryngology, Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas, USA
Anat Rec (Hoboken) 295:1830-6. 2012..Immunohistochemical assessment after delivery of a green fluorescent protein expressing vector showed significant GFP expression in the cochlea...
- Optimizing atoh1-induced vestibular hair cell regenerationHinrich Staecker
Department of Otolaryngology, Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas
Laryngoscope 124:S1-S12. 2014..Determine the optimal design characteristics of an adenoviral (Ad) vector to deliver atoh1 and induce regeneration of vestibular hair cells...
- A review of gene delivery and stem cell based therapies for regenerating inner ear hair cellsKeerthana Devarajan
Bioengineering Program, University of Kansas, Lawrence, KS 66045, USA
J Funct Biomater 2:249-70. 2011..Understanding the role of genes, vectors and stem cells in therapeutic strategies led us to explore potential solutions to overcome the limitations associated with their use in hair cell regeneration. ..
- Adenovector-mediated gene delivery to human umbilical cord mesenchymal stromal cells induces inner ear cell phenotypeKeerthana Devarajan
Bioengineering Program, University of Kansas, Lawrence, 66045, USA
Cell Reprogram 15:43-54. 2013..The results demonstrated for the first time that hUCMSCs can differentiate into hair cell-like cells, thus introducing a new potential tissue engineering and cell transplantation approach for the treatment of hearing loss...
- Atoh1 induces auditory hair cell recovery in mice after ototoxic injuryShannon Kraft
Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
Laryngoscope 123:992-9. 2013..To evaluate the ability of the Ad28.gfap.atoh1 to promote hair cell regeneration and hearing recovery in cochlea injured with kanamycin and furosemide...
- Low dose oxidative stress induces mitochondrial damage in hair cellsKim Baker
Department of Otolaryngology, Children s Mercy Medical Center, Kansas City, Missouri, USA
Anat Rec (Hoboken) 295:1868-76. 2012....
- Advances in inner ear gene therapy: exploring cochlear protection and regenerationCarrie R Maiorana
Department of Otolaryngology, University of Kansas, Kansas City, KS 66160, USA
Curr Opin Otolaryngol Head Neck Surg 13:308-12. 2005..To review the application of gene therapy in the inner ear. Gene delivery to the inner ear was first reported in 1996. Since then the field has progressed on multiple fronts...
- Partial deafness cochlear implantation at the University of Kansas: techniques and outcomesSandra Prentiss
Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, USA
J Am Acad Audiol 21:197-203. 2010..Initial studies have demonstrated that a combination of residual acoustic hearing in the low frequencies with electrical stimulation in the mid- to high frequencies resulted in superior hearing performance in background noise...
- The Use of Human Wharton's Jelly Cells for Cochlear Tissue EngineeringAdam J Mellott
Department of Plastic Surgery, University of Kansas Medical Center, MS 3015, 3901 Rainbow Blvd, Kansas City, KS, 66160, USA
Methods Mol Biol 1427:319-45. 2016..Here, we report the methods for isolating hWJCs from human umbilical cords and non-virally transfected for use in cochlear tissue engineering studies. ..
- Hair cell counts in a rat model of sound damage: Effects of tissue preparation & identification of regions of hair cell lossChristopher Neal
Neuroscience Graduate Program, University of Kansas Medical Center, Kansas City, KS 66160, USA Department of Otolaryngology and Head and Neck Surgery, University of Kansas Medical Center, Kansas City, KS 66160, USA Electronic address
Hear Res 328:120-32. 2015..Inner HC loss was either equal to or greater than outer HC loss. Increasing the duration of sound exposures resulted in more severe HC loss, which included all HC lesions observed in an analogous shorter duration exposure. ..
- The effect of diabetes on sensorineural hearing lossVenkata Kakarlapudi
Department of Otolaryngology, Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
Otol Neurotol 24:382-6. 2003..To identify whether patients with diabetes have a higher incidence of sensorineural hearing loss than the general population and examine whether control of diabetes is related to severity of hearing loss...
- Pharmacodynamics of adenovector distribution within the inner ear tissues of the mouseMark Praetorius
Department of Otolaryngology, University of Heidelberg Medical Center, Heidelberg, Germany
Hear Res 227:53-8. 2007..Understanding these basic distribution patterns and parameters for delivery are important for the design of gene delivery vectors and vital for modeling dose responses to achieve safe efficacious delivery of a therapeutic agent...
- Hearing preservation after inner ear gene therapy: the effect of vector and surgical approachMark Praetorius
Department of Otolaryngology, University Hospital of the Saarland, Homburg Saar, Germany
ORL J Otorhinolaryngol Relat Spec 65:211-4. 2003..Injection of comparable doses of vector into a basal turn cochleostomy resulted in high-frequency hearing loss. Addition of a pancaspase inhibitor protected hearing when larger volumes of fluid were administered to the inner ear...
- Drug delivery to the inner ear using gene therapyHinrich Staecker
Division of Otolaryngology, University of Maryland School of Medicine, 16 S Eutaw Street, Suite 500, Baltimore, MD 21201, USA
Otolaryngol Clin North Am 37:1091-108. 2004..As the understanding of gene therapy improves, investigators will be able to move toward targeted single-gene replacement to treat disorders such as connexin mutations and applying gene therapy to sensory cell replacement...
- Mechanisms of cell death in the injured auditory system: otoprotective strategiesPhilippe P Lefebvre
Department of Otolaryngology, University of Liege, Belgium
Audiol Neurootol 7:165-70. 2002..These mechanisms have several different points at which inhibitors could be targeted to protect cells from programmed cell death, including the prevention of oxidative stress-induced apoptosis and the activation of caspases and calpains...
- Vertigo and abacavirLori E Fantry
University of Maryland Medical School Institute of Human Virology, Baltimore, Maryland, USA
AIDS Patient Care STDS 16:5-7. 2002..The mechanism by which abacavir appeared to be associated with vertigo in this patient is unknown...