Matthew E Spector

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Nasopharyngeal airway to prevent tension pneumocephalus after open resection of anterior skull base tumors
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, 1904 Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    Ear Nose Throat J 95:E32-E35. 2016
  2. ncbi request reprint E6 and E7 antibody levels are potential biomarkers of recurrence in patients with advanced stage human papillomavirus positive oropharyngeal squamous cell carcinoma
    Matthew E Spector
    Otolaryngology Head and Neck Surgery, University of Michigan
    Clin Cancer Res . 2016
  3. pmc Diagnostic modalities for distant metastasis in head and neck squamous cell carcinoma: are we changing life expectancy?
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Laryngoscope 122:1507-11. 2012
  4. pmc Correlation of radiographic and pathologic findings of dermal lymphatic invasion in head and neck squamous cell carcinoma
    M E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    AJNR Am J Neuroradiol 33:462-4. 2012
  5. pmc Clinical and pathologic predictors of recurrence and survival in spindle cell squamous cell carcinoma
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 145:242-7. 2011
  6. pmc Matted nodes as a predictor of distant metastasis in advanced-stage III/IV oropharyngeal squamous cell carcinoma
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan
    Head Neck 38:184-90. 2016
  7. pmc Efficacy of induction selection chemotherapy vs primary surgery for patients with advanced oral cavity carcinoma
    Steven B Chinn
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor
    JAMA Otolaryngol Head Neck Surg 140:134-42. 2014
  8. pmc Matted nodes: High distant-metastasis risk and a potential indication for intensification of systemic therapy in human papillomavirus-related oropharyngeal cancer
    Jeffrey M Vainshtein
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan
    Head Neck 38:E805-14. 2016
  9. pmc High-risk human papillomavirus detection in oropharyngeal, nasopharyngeal, and oral cavity cancers: comparison of multiple methods
    Heather M Walline
    Cancer Biology Program, Program in the Biomedical Sciences, Rackham Graduate School, University of Michigan, Ann Arbor
    JAMA Otolaryngol Head Neck Surg 139:1320-7. 2013
  10. pmc Prevalence and Outcomes of Head and Neck versus Non-Head and Neck Second Primary Malignancies in Head and Neck Squamous Cell Carcinoma: An Analysis of the Surveillance, Epidemiology, and End Results Database
    Andrew C Birkeland
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Mich, USA
    ORL J Otorhinolaryngol Relat Spec 78:61-9. 2016

Collaborators

  • Carol R Bradford
  • Jonathan B McHugh
  • Gregory T Wolf
  • Francis P Worden
  • Jeffrey S Moyer
  • Matthew H Stenmark
  • Mark E P Prince
  • Andrew G Shuman
  • Jeffrey Vainshtein
  • Soheil Soliman
  • Jessica H Maxwell
  • Garrett R Griffin
  • Trachette L Jackson
  • Gordon H Sun
  • Laura S Rozek
  • Vasu Divi
  • S K Mukherji
  • Andrew C Birkeland
  • Thomas E Carey
  • Douglas B Chepeha
  • Avraham Eisbruch
  • Steven B Chinn
  • Andrew J Rosko
  • J Chad Brenner
  • Emily Bellile
  • Megan L Ludwig
  • Brittny N Tillman
  • Heather M Walline
  • Serena A Byrd
  • Kevin F Wilson
  • Joshua Smith
  • Scott A McLean
  • Jae Y Lee
  • Shaomeng Wang
  • Alexander T Pearson
  • Kristy A Warner
  • Megan Yanik
  • Paul L Swiecicki
  • Jacques E Nor
  • Irina Y Dobrosotskaya
  • Randall T Butler
  • Kelly K Gallagher
  • Cedric V Pritchett
  • Hussam K El-Kashlan
  • Emily L Bellile
  • Amy Anne D Lassig
  • Lawrence J Marentette
  • P Daniel Ward
  • Rogerio M Castilho
  • Erin McKean
  • Scott McLean
  • Assuntina G Sacco
  • Daniel G Muenz
  • Susan K Foltin
  • Eli Sapir
  • Kelly Malloy
  • Christine M Komarck
  • George S Arnould
  • Daniel H Hovelson
  • Krithika Suresh
  • Jacqueline E Mann
  • Scott A Tomlins
  • Mohamad R Issa
  • Kelly M Malloy
  • Christopher A Moskaluk
  • Morgan M Sandelski
  • Gerson A Acasigua
  • Keith Casper
  • Chia Jen Liu
  • Andi K Cani
  • Ammar Sukari
  • Nallasivam Palanisamy
  • Jeremy M G Taylor
  • Megan V Scott
  • Jae Lee
  • Joseph Helman
  • Nicole L Michmerhuizen
  • Paul Swiecicki
  • Zhaocheng Zhang
  • Rebecca Hoesli
  • Rebecca Nguyen
  • Michael J Wick
  • Shannon Carskadon
  • Manoela D Martins
  • Matthew J Schipper
  • Felipe Nör
  • Janell S Dow
  • Owen A Darr
  • John H Owen
  • Silvana M Papagerakis

Detail Information

Publications38

  1. ncbi request reprint Nasopharyngeal airway to prevent tension pneumocephalus after open resection of anterior skull base tumors
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, 1904 Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    Ear Nose Throat J 95:E32-E35. 2016
    ..Lumbar drainage, the development of a CSF leak, or both may increase the risk of tension pneumocephalus...
  2. ncbi request reprint E6 and E7 antibody levels are potential biomarkers of recurrence in patients with advanced stage human papillomavirus positive oropharyngeal squamous cell carcinoma
    Matthew E Spector
    Otolaryngology Head and Neck Surgery, University of Michigan
    Clin Cancer Res . 2016
    ..The ratio of E7 antibody at disease recurrence compared to baseline is potentially a clinically significant measurement of disease status in HPV+OPSCC...
  3. pmc Diagnostic modalities for distant metastasis in head and neck squamous cell carcinoma: are we changing life expectancy?
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Laryngoscope 122:1507-11. 2012
    ..To determine if the various imaging modalities for distant metastasis (DM) diagnosis alters life expectancy in head and neck squamous cell carcinoma (HNSCC)...
  4. pmc Correlation of radiographic and pathologic findings of dermal lymphatic invasion in head and neck squamous cell carcinoma
    M E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    AJNR Am J Neuroradiol 33:462-4. 2012
    ..This study demonstrates that the linear areas of reticulation are most commonly caused by peritumoral inflammation and are not due to dermal lymphatic invasion...
  5. pmc Clinical and pathologic predictors of recurrence and survival in spindle cell squamous cell carcinoma
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 145:242-7. 2011
    ..To determine clinicopathologic predictors of recurrence and survival in patients with spindle cell squamous cell carcinoma (SpSCC)...
  6. pmc Matted nodes as a predictor of distant metastasis in advanced-stage III/IV oropharyngeal squamous cell carcinoma
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan
    Head Neck 38:184-90. 2016
    ..The purpose of this study was to determine if matted nodes are a predictive marker for distant metastasis...
  7. pmc Efficacy of induction selection chemotherapy vs primary surgery for patients with advanced oral cavity carcinoma
    Steven B Chinn
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor
    JAMA Otolaryngol Head Neck Surg 140:134-42. 2014
    ..The IS approach was extended to oral cavity squamous cell carcinoma (OCSCC) to help understand whether organ preservation or survival benefit resulted...
  8. pmc Matted nodes: High distant-metastasis risk and a potential indication for intensification of systemic therapy in human papillomavirus-related oropharyngeal cancer
    Jeffrey M Vainshtein
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan
    Head Neck 38:E805-14. 2016
    ....
  9. pmc High-risk human papillomavirus detection in oropharyngeal, nasopharyngeal, and oral cavity cancers: comparison of multiple methods
    Heather M Walline
    Cancer Biology Program, Program in the Biomedical Sciences, Rackham Graduate School, University of Michigan, Ann Arbor
    JAMA Otolaryngol Head Neck Surg 139:1320-7. 2013
    ....
  10. pmc Prevalence and Outcomes of Head and Neck versus Non-Head and Neck Second Primary Malignancies in Head and Neck Squamous Cell Carcinoma: An Analysis of the Surveillance, Epidemiology, and End Results Database
    Andrew C Birkeland
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Mich, USA
    ORL J Otorhinolaryngol Relat Spec 78:61-9. 2016
    ..The prevalence, distribution, and patient survival in head and neck versus non-head and neck SPMs are not fully elucidated. The objective of this study was to quantify the rate of SPMs in patients with HNSCC...
  11. pmc Exploration for an Algorithm for Deintensification to Exclude the Retropharyngeal Site From Advanced Oropharyngeal Squamous Cell Carcinoma Treatment
    Matthew E Spector
    Department of Otolaryngology, University of Michigan, Ann Arbor
    JAMA Otolaryngol Head Neck Surg 142:313-8. 2016
    ..Prediction of these drainage patterns could not only help minimize treatment morbidity but also prevent failures in at-risk patients as deintensification trials are under way for this disease...
  12. pmc Human papillomavirus-related oropharyngeal cancer: HPV and p16 status in the recurrent versus parent tumor
    Jeffrey Vainshtein
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan
    Head Neck 37:8-11. 2015
    ..We postulated that a minor HPV-negative tumor subfraction may be responsible for recurrences of HPV+ oropharyngeal cancer...
  13. pmc Patterns of nodal metastasis and prognosis in human papillomavirus-positive oropharyngeal squamous cell carcinoma
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan
    Head Neck 36:1233-40. 2014
    ..The purpose of this study was to develop a system that more precisely predicts survival...
  14. pmc Refining risk stratification for locoregional failure after chemoradiotherapy in human papillomavirus-associated oropharyngeal cancer
    Jeffrey M Vainshtein
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States
    Oral Oncol 50:513-9. 2014
    ....
  15. pmc Impact of perineural invasion in the pathologically N0 neck in oral cavity squamous cell carcinoma
    Steven B Chinn
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 149:893-9. 2013
    ..In the absence of these high-risk features, our objective was to determine if perineural invasion (PNI) is an independent risk factor and if adjuvant radiation (XRT) improves disease control rates...
  16. pmc Neurologic late effects associated with radiologic evidence of vertebral osteoradionecrosis after salvage laryngectomy: A syndrome associated with survivors of laryngeal and hypopharyngeal cancer
    Andrew J Rosko
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan
    Head Neck 38:1187-93. 2016
    ..Delayed nonspecific posterior neck pain after pharyngeal instrumentation can be associated with a syndrome of rapidly progressive neurologic embarrassment. We present this cohort to help define the syndrome and aid in early detection...
  17. pmc Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy
    Andrew C Birkeland
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 154:473-9. 2016
    ..Our goals were to determine the prevalence of occult nodal disease, analyze nodal disease distribution patterns, and identify predictors of occult nodal disease in a salvage laryngectomy cohort...
  18. pmc Tumor Biomarkers in Spindle Cell Variant Squamous Cell Carcinoma of the Head and Neck
    Andrew J Rosko
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 155:106-12. 2016
    ..To determine biomarkers of recurrence and survival in patients with spindle cell variant squamous cell carcinoma (SpSCC) of the head and neck...
  19. pmc Cancer stem cells: mediators of tumorigenesis and metastasis in head and neck squamous cell carcinoma
    Steven B Chinn
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan
    Head Neck 37:317-26. 2015
    ..Cancer stem cells (CSCs) represent a subpopulation of cells responsible for tumor growth. Their role in head and neck squamous cell carcinoma (HNSCC) tumorigenesis and metastasis remains uncertain...
  20. pmc Reliability of post-chemoradiotherapy F-18-FDG PET/CT for prediction of locoregional failure in human papillomavirus-associated oropharyngeal cancer
    Jeffrey M Vainshtein
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States Electronic address
    Oral Oncol 50:234-9. 2014
    ..We assessed the predictive value of 3-month PET/CT response for LRF in this population...
  21. pmc Weekly chemotherapy with radiation versus high-dose cisplatin with radiation as organ preservation for patients with HPV-positive and HPV-negative locally advanced squamous cell carcinoma of the oropharynx
    Irina Y Dobrosotskaya
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI
    Head Neck 36:617-23. 2014
    ..Optimal treatment for locally advanced squamous cell carcinoma of the oropharynx (SCCOP) is not well defined. Here we retrospectively compare survival and toxicities from 2 different organ preservation protocols...
  22. pmc Predictors of recurrence and survival for head and neck mucoepidermoid carcinoma
    Serena A Byrd
    Departments of Otolaryngology Head and Neck Surgery, Pathology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 149:402-8. 2013
    ..To describe the epidemiology and determine the clinicopathologic predictors of recurrence and survival in patients with head and neck mucoepidermoid carcinoma (MEC)...
  23. pmc Matted nodes: poor prognostic marker in oropharyngeal squamous cell carcinoma independent of HPV and EGFR status
    Matthew E Spector
    Departments of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Head Neck 34:1727-33. 2012
    ..Despite better prognosis, there is a group of oropharyngeal squamous cell carcinoma (SCC) human papillomavirus (HPV)+ patients who experience treatment failure and succumb to distant metastasis...
  24. pmc Fibroblast growth factor family aberrations as a putative driver of head and neck squamous cell carcinoma in an epidemiologically low-risk patient as defined by targeted sequencing
    Brittny N Tillman
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan
    Head Neck 38:E1646-52. 2016
    ..Targeted sequencing of patients with epidemiologically low-risk (ELR) head and neck squamous cell carcinoma (HNSCC) could help identify novel drivers or lost suppressors leading to precision medicine protocols and improved survival rates...
  25. doi request reprint Predictors of severe long-term toxicity after re-irradiation for head and neck cancer
    Jae Y Lee
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States
    Oral Oncol 60:32-40. 2016
    ..To identify predictive factors of severe long-term toxicity after re-irradiation of recurrent/persistent or second-primary head and neck cancer...
  26. doi request reprint Esthesioneuroblastoma: updating histologic grading as it relates to prognosis
    Kelly K Gallagher
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Ann Otol Rhinol Laryngol 123:353-8. 2014
    ....
  27. pmc A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer
    Paul L Swiecicki
    University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Invest New Drugs 34:481-9. 2016
    ..Given the evidence of activity in xenograft models, treatment with AT-101 in combination with docetaxel is a therapeutic doublet of interest in metastatic head and neck squamous cell carcinoma...
  28. pmc Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma
    Megan L Ludwig
    Department of Otolaryngology, Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Biol Med 13:87-100. 2016
    ....
  29. pmc Chemoselection: a paradigm for optimization of organ preservation in locally advanced larynx cancer
    Jeffrey M Vainshtein
    Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, MI, USA
    Expert Rev Anticancer Ther 13:1053-64. 2013
    ..The rationale, treatment results and future directions of this approach are discussed. ..
  30. pmc Tracheobronchial amyloidosis: A case report and review of the literature
    Andrew C Birkeland
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan
    J Case Rep Med 3:. 2014
    ..This is a case report on tracheobronchial amyloidosis. This disease may provide a diagnostic challenge for otolaryngologists due to its rarity and relative lack of literature. Our case highlights presentation and workup of this disease...
  31. pmc Identification of Targetable ERBB2 Aberrations in Head and Neck Squamous Cell Carcinoma
    Andrew C Birkeland
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor
    JAMA Otolaryngol Head Neck Surg 142:559-67. 2016
    ..ERBB2 status in head and neck squamous cell carcinoma (HNSCC) has not been well studied. Identification of ERBB2-positive tumors and characterization of response to ERBB2 therapy could lead to targeted treatment options in HNSCC...
  32. pmc Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma
    Kristy A Warner
    Department of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan
    Clin Cancer Res 22:3550-9. 2016
    ..There are no effective treatment options for patients with advanced adenoid cystic carcinoma (ACC). Here, we evaluated the effect of a new small molecule inhibitor of the MDM2-p53 interaction (MI-773) in preclinical models of ACC...
  33. pmc The potential for tumor suppressor gene therapy in head and neck cancer
    Andrew C Birkeland
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Discov Med 21:41-7. 2016
    ..This review will summarize new techniques, challenges to implementation, future directions, and ethical ramifications of gene therapy in head and neck cancer. ..
  34. pmc Maxilla Osteonecrosis: a differential diagnosis in patients with metastatic cancer on bisphosphonates
    Joshua Smith
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Case Rep Med 5:. 2016
    ..As bisphosphonates are often prescribed for patients with metastatic disease, it is important to recognize that bisphosphonate-induced osteonecrosis may present similarly to bony metastases...
  35. doi request reprint Squamous cell carcinoma involving the temporal bone: lateral temporal bone resection as primary intervention
    Amy Anne D Lassig
    Department of Otolaryngology Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Otol Neurotol 34:141-50. 2013
    ..To provide an up-to-date review of treatment and outcomes of patients with squamous cell carcinoma (SCCA) involving the temporal bone...
  36. doi request reprint Surgical treatment of hearing loss when otosclerosis coexists with superior semicircular canal dehiscence syndrome
    Cedric V Pritchett
    Divisions of Otology Neurotology, and Head and Neck Surgery, Department of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, U S A
    Otol Neurotol 35:1163-7. 2014
    ..Document a case of bilateral otosclerosis with coexisting bilateral superior semicircular canal dehiscence syndrome and the treatment of hearing loss in this setting...
  37. pmc An immunohistochemical panel for reliable differentiation of salivary duct carcinoma and mucoepidermoid carcinoma
    Randall T Butler
    Department of Pathology, University of Michigan, 1500 E Medical Center Drive, Room 2G332 UH, Ann Arbor, MI, 48109, USA
    Head Neck Pathol 8:133-40. 2014
    ..Utilization of this set of immunohistochemical markers allows reliable differentiation of salivary duct and mucoepidermoid carcinoma, a distinction with important prognostic and therapeutic implications. ..
  38. ncbi request reprint Orbitocranial approach for treatment of adenoid cystic carcinoma of the lacrimal gland
    Kevin F Wilson
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Ann Otol Rhinol Laryngol 120:397-400. 2011
    ..Our objective was to perform an analysis of outcomes in a cohort of patients with adenoid cystic carcinoma of the lacrimal gland treated identically with an orbitocranial approach...