J R Smythies

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Philosophy, perception, and neuroscience
    John Smythies
    Center for Brain and Cognition, University of California San Diego, La Jolla, CA 92093, USA
    Perception 38:638-51. 2009
  2. ncbi request reprint The biochemical basis of Parkinson's disease: the role of catecholamine o-quinones: a review-discussion
    John Smythies
    Center for Brain and Cognition, Department of Psychology, University of California, San Diego, La Jolla, CA, USA
    Neurotox Res 4:77-81. 2002
  3. ncbi request reprint The adrenochrome hypothesis of schizophrenia revisited
    John Smythies
    Department of Psychology, Center for Brain and Cognition, University of California at San Diego, La Jolla, CA 92093 0109, USA and Department of Neuropsychiatry, Institute of Neurology, Queen Square, London, UK
    Neurotox Res 4:147-50. 2002
  4. ncbi request reprint The neurotoxicity of glutamate, dopamine, iron and reactive oxygen species: functional interrelationships in health and disease: a review-discussion
    J Smythies
    Center for Brain and Cognition, Department of Psychology, UCSD, La Jolla, CA 92093 0109, USA
    Neurotox Res 1:27-39. 1999
  5. pmc How the brain decides what we see
    John Smythies
    Center for Brain and Cognition, UCSD, La Jolla, CA 92037 0109, USA
    J R Soc Med 98:18-20. 2005
  6. pmc Nerve gas antidotes
    John Smythies
    Center for Brain and Cognition, UCSD, La Jolla, CA 92093 0109, USA
    J R Soc Med 97:32. 2004
  7. ncbi request reprint Oxidative reactions and schizophrenia: a review-discussion
    J R Smythies
    Department of Neuropsychiatry, Institute of Neurology, London, UK
    Schizophr Res 24:357-64. 1997
  8. ncbi request reprint Redox aspects of signaling by catecholamines and their metabolites
    J Smythies
    Center for Brain and Cognition, Department of Psychology, University of California San Diego, La Jolla 92093 0109, USA
    Antioxid Redox Signal 2:575-83. 2000
  9. pmc What is the function of receptor and membrane endocytosis at the postsynaptic neuron?
    J Smythies
    Center for Brain and Cognition, Department of Psychology, University of California, San Diego, La Jolla 92093 0109, USA
    Proc Biol Sci 267:1363-7. 2000
  10. ncbi request reprint The neurochemical basis of learning and neurocomputation: the redox theory
    J Smythies
    Department of Neuropsychiatry, Institute of Neurology, London, UK
    Behav Brain Res 99:1-6. 1999

Detail Information

Publications14

  1. ncbi request reprint Philosophy, perception, and neuroscience
    John Smythies
    Center for Brain and Cognition, University of California San Diego, La Jolla, CA 92093, USA
    Perception 38:638-51. 2009
    ..It is directly relevant to criticisms by certain analytical philosophers of aspects of neuroscience relating to these matters. Particular attention is paid to their support for Naive Realism...
  2. ncbi request reprint The biochemical basis of Parkinson's disease: the role of catecholamine o-quinones: a review-discussion
    John Smythies
    Center for Brain and Cognition, Department of Psychology, University of California, San Diego, La Jolla, CA, USA
    Neurotox Res 4:77-81. 2002
    ..The hypothesis is put forward that an important factor in the genesis of PD may be the overload by environmental toxins of enzymes such as glutathione S-transferase that also detoxify catecholamine oQs...
  3. ncbi request reprint The adrenochrome hypothesis of schizophrenia revisited
    John Smythies
    Department of Psychology, Center for Brain and Cognition, University of California at San Diego, La Jolla, CA 92093 0109, USA and Department of Neuropsychiatry, Institute of Neurology, Queen Square, London, UK
    Neurotox Res 4:147-50. 2002
    ..Lastly the recent evidence is reviewed that the gene for the enzyme glutathione S-transferase is defective in schizophrenia. This enzyme detoxifies adrenochrome...
  4. ncbi request reprint The neurotoxicity of glutamate, dopamine, iron and reactive oxygen species: functional interrelationships in health and disease: a review-discussion
    J Smythies
    Center for Brain and Cognition, Department of Psychology, UCSD, La Jolla, CA 92093 0109, USA
    Neurotox Res 1:27-39. 1999
    ..In the former two the neurotoxicity of catecholaminergic o-quinones is important. In the later excessive oxidation of neuronal membranes and excessive endocytosis and receptor recycling may be an important factor...
  5. pmc How the brain decides what we see
    John Smythies
    Center for Brain and Cognition, UCSD, La Jolla, CA 92037 0109, USA
    J R Soc Med 98:18-20. 2005
  6. pmc Nerve gas antidotes
    John Smythies
    Center for Brain and Cognition, UCSD, La Jolla, CA 92093 0109, USA
    J R Soc Med 97:32. 2004
  7. ncbi request reprint Oxidative reactions and schizophrenia: a review-discussion
    J R Smythies
    Department of Neuropsychiatry, Institute of Neurology, London, UK
    Schizophr Res 24:357-64. 1997
    ....
  8. ncbi request reprint Redox aspects of signaling by catecholamines and their metabolites
    J Smythies
    Center for Brain and Cognition, Department of Psychology, University of California San Diego, La Jolla 92093 0109, USA
    Antioxid Redox Signal 2:575-83. 2000
    ..This might contribute under certain circumstances to synaptic deletion. Evidence is presented that abnormalities in this system may contribute to the pathogenesis of Parkinson's disease and schizophrenia...
  9. pmc What is the function of receptor and membrane endocytosis at the postsynaptic neuron?
    J Smythies
    Center for Brain and Cognition, Department of Psychology, University of California, San Diego, La Jolla 92093 0109, USA
    Proc Biol Sci 267:1363-7. 2000
    ..The possible involvement of this system in Alzheimer's disease is discussed...
  10. ncbi request reprint The neurochemical basis of learning and neurocomputation: the redox theory
    J Smythies
    Department of Neuropsychiatry, Institute of Neurology, London, UK
    Behav Brain Res 99:1-6. 1999
    ..Mediation of signals of reinforcing stimuli by the catecholamines may be mediated in part by their antioxidant effect on glutamate synapses. Some experiments to test the theory are suggested...
  11. ncbi request reprint Redox mechanisms at the glutamate synapse and their significance: a review
    J Smythies
    Institute of Neurology, London, UK
    Eur J Pharmacol 370:1-7. 1999
    ..Additional agents participating in spine pruning may be neurotoxic catecholamine o-quinones present in the brain. This system may be at fault in schizophrenia and Parkinson's disease. Experiments to test the hypothesis are suggested...
  12. ncbi request reprint The functional neuroanatomy of awareness: with a focus on the role of various anatomical systems in the control of intermodal attention
    J Smythies
    Department of Neuropsychiatry, Institute of Neurology, London, England
    Conscious Cogn 6:455-81. 1997
    ..Clinical loss of consciousness results from damage to these nuclei but not from damage to the cholinergic nucleus basalis of the basal forebrain...
  13. doi request reprint Does the O'Brien cycle occur in vivo as a key component in H(2)O(2) production and redox signalling?
    John Smythies
    Center for Brain and Cognition, UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0109, USA
    Med Hypotheses 76:299-301. 2011
    ..Three different microanatomical loci are evaluated to explain how the coma might result from these redox reactions...
  14. ncbi request reprint The oxidative metabolism of catecholamines in the brain: a review
    J Smythies
    Institute of Neurology, Queen Square, London WC1 3BG, UK
    Biochim Biophys Acta 1380:159-62. 1998
    ..Supportive evidence is presented from a number of sources including enzymology. A suggestion as to the possible normal function of this system is made...