Alan G Smulian

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006, USA
    Mol Microbiol 44:989-99. 2002
  2. doi request reprint Invasive models of histoplasmosis
    A George Smulian
    Infectious Disease Division, Cincinnati VA Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Methods Mol Biol 845:519-25. 2012
  3. pmc Insertional mutagenesis enables cleistothecial formation in a non-mating strain of Histoplasma capsulatum
    Meggan C Laskowski
    Infectious Disease Division, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0560, USA
    BMC Microbiol 10:49. 2010
  4. pmc Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum
    A George Smulian
    Infectious Disease Division, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Eukaryot Cell 6:2066-71. 2007
  5. pmc The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis
    Jeremy Hilty
    Department of Internal Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Mol Microbiol 70:127-39. 2008
  6. pmc Gene arrays at Pneumocystis carinii telomeres
    Scott P Keely
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Genetics 170:1589-600. 2005
  7. ncbi request reprint Evidence for cholesterol scavenging by Pneumocystis and potential modifications of host-synthesized sterols by the P. carinii SAM:SMT
    D Nicole Worsham
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH, USA
    J Eukaryot Microbiol 50:678-9. 2003
  8. pmc Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs
    George S Deepe
    Veterans Affairs Hospital, Cincinnati, OH, USA
    J Leukoc Biol 84:669-78. 2008
  9. doi request reprint Sequence and structure of the linear mitochondrial genome of Pneumocystis carinii
    Thomas M Sesterhenn
    Department of Internal Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45220 0560, USA
    Mol Genet Genomics 283:63-72. 2010
  10. pmc Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite
    Melanie T Cushion
    University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Infectious Diseases, Cincinnati, Ohio, United States of America
    PLoS ONE 2:e423. 2007

Collaborators

Detail Information

Publications22

  1. ncbi request reprint The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006, USA
    Mol Microbiol 44:989-99. 2002
    ..These observations, together with the absence of SAM:SMT among mammals, further support the identification of sterol C-24 alkylation reactions as excellent targets for the development of drugs specifically directed against this pathogen...
  2. doi request reprint Invasive models of histoplasmosis
    A George Smulian
    Infectious Disease Division, Cincinnati VA Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Methods Mol Biol 845:519-25. 2012
    ..This chapter describes these models and explores variability introduced with the use of mice of varied genetic backgrounds and different H. capsulatum strains...
  3. pmc Insertional mutagenesis enables cleistothecial formation in a non-mating strain of Histoplasma capsulatum
    Meggan C Laskowski
    Infectious Disease Division, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0560, USA
    BMC Microbiol 10:49. 2010
    ..We also present initial studies demonstrating that UC1 can be used as a tool to determine molecular correlates of mating in H. capsulatum...
  4. pmc Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum
    A George Smulian
    Infectious Disease Division, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Eukaryot Cell 6:2066-71. 2007
    ..The lethality was dependent on the kinase activity of hygromycin phosphotransferase. These results should raise awareness of the potential detrimental effects of the hph gene...
  5. pmc The Histoplasma capsulatum vacuolar ATPase is required for iron homeostasis, intracellular replication in macrophages and virulence in a murine model of histoplasmosis
    Jeremy Hilty
    Department of Internal Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Mol Microbiol 70:127-39. 2008
    ..These studies demonstrate the importance of V-ATPase function in the pathogenicity of H. capsulatum, in iron homeostasis and in fungal dimorphism...
  6. pmc Gene arrays at Pneumocystis carinii telomeres
    Scott P Keely
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Genetics 170:1589-600. 2005
    ..Long mononucleotide tracts were present in some MSR genes. These unstable sequences can be expected to suffer frequent frameshift mutations, providing P. carinii with another mechanism to generate antigen variation...
  7. ncbi request reprint Evidence for cholesterol scavenging by Pneumocystis and potential modifications of host-synthesized sterols by the P. carinii SAM:SMT
    D Nicole Worsham
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH, USA
    J Eukaryot Microbiol 50:678-9. 2003
  8. pmc Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs
    George S Deepe
    Veterans Affairs Hospital, Cincinnati, OH, USA
    J Leukoc Biol 84:669-78. 2008
    ..These results reveal the complex nature of intracellular residence of this fungus. Moreover, the findings demonstrate that there is a skewing in the subpopulations of cells that are infected, especially DC...
  9. doi request reprint Sequence and structure of the linear mitochondrial genome of Pneumocystis carinii
    Thomas M Sesterhenn
    Department of Internal Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45220 0560, USA
    Mol Genet Genomics 283:63-72. 2010
    ..Together with the identification of terminal repeats similar to those found in other linear fungal mt genomes and the inability to join the ends by PCR, these data provide strong evidence that the mt genome of P. carinii is linear...
  10. pmc Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite
    Melanie T Cushion
    University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Infectious Diseases, Cincinnati, Ohio, United States of America
    PLoS ONE 2:e423. 2007
    ..This study represents the first characterization of the expressed genes of a non-culturable fungal pathogen of mammals during the infective process...
  11. ncbi request reprint Draft assembly and annotation of the Pneumocystis carinii genome
    Bradley E Slaven
    University of Cincinnati College of Medicine, Cincinnati, Ohio 46267 0560, USA
    J Eukaryot Microbiol 53:S89-91. 2006
  12. ncbi request reprint Protein oxidation and heme oxygenase-1 induction in porcine white matter following intracerebral infusions of whole blood or plasma
    Kenneth R Wagner
    Department of Neurology, University of Cincinnati College of Medicine, Department of Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
    Dev Neurosci 24:154-60. 2002
    ..This rapid response, possibly in microglial cells, may contribute to white matter damage not only following ICH, but also in pathophysiological states in which blood-brain-barrier permeability to plasma proteins is increased...
  13. ncbi request reprint Pathogen-specific induction of CD154 is impaired in CD4+ T cells from human immunodeficiency virus-infected patients
    Carlos S Subauste
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Infect Dis 189:61-70. 2004
    ..gondii in cells from HIV-infected patients. Together, defective induction of CD154 is likely to contribute to impaired cell-mediated immunity against opportunistic pathogens in HIV-infected patients...
  14. ncbi request reprint Plasma infusions into porcine cerebral white matter induce early edema, oxidative stress, pro-inflammatory cytokine gene expression and DNA fragmentation: implications for white matter injury with increased blood-brain-barrier permeability
    Kenneth R Wagner
    Department of Neurology, University of Cincinnati College of Medicine, Ohio 45267, USA
    Curr Neurovasc Res 2:149-55. 2005
    ..These results suggest that in diseases with increased blood-brain barrier (BBB) permeability or following intracerebral hemorrhage or traumatic brain injury, interstitial plasma can rapidly damage white matter...
  15. ncbi request reprint Large-scale characterization of introns in the Pneumocystis carinii genome
    Bradley E Slaven
    University of Cincinnati College of Medicine, Cincinnati, Ohio 46267 0560, USA
    J Eukaryot Microbiol 53:S151-3. 2006
  16. ncbi request reprint Serologic responses to epitopes of the major surface glycoprotein of Pneumocystis jiroveci differ in human immunodeficiency virus-infected and uninfected persons
    Kieran R Daly
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    J Infect Dis 186:644-51. 2002
    ..None of the serum samples drawn from 9 patients before they had developed PcP recognized MsgC. These data suggest that these novel recombinant proteins are useful for the analysis of antibody responses to Msg...
  17. doi request reprint Dendritic cells restrict the transformation of Histoplasma capsulatum conidia into yeasts
    Simon L Newman
    Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, PO Box 670560, Cincinnati, OH 45267 0560, USA
    Med Mycol 49:356-64. 2011
    ..These data suggest that in vivo, conidia may transform into yeast-like cells efficiently whether or not they are phagocytosed by MΦ, but not when ingested by DC...
  18. pmc TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function
    Reena Rani
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Eur J Immunol 41:2000-9. 2011
    ....
  19. pmc The MAT1 locus of Histoplasma capsulatum is responsive in a mating type-specific manner
    Meggan Bubnick
    Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    Eukaryot Cell 6:616-21. 2007
    ..These studies support a role for the identified MAT1 locus in determining mating type in H. capsulatum...
  20. ncbi request reprint Sequence of the mitochondrial genome of Pneumocystis carinii: implications for biological function and identification of potential drug targets
    Thomas M Sesterhenn
    University of Cincinnati, Cincinnati, Ohio, USA
    J Eukaryot Microbiol 53:S154-5. 2006
  21. ncbi request reprint Generation of sequencing libraries for the Pneumocystis Genome project
    Thomas M Sesterhenn
    University of Cincinnati, Cincinnati, OH, USA
    J Eukaryot Microbiol 50:663-5. 2003
  22. ncbi request reprint Pneumocystis 2006: summary of the research presented at the ninth International Workshop on Opportunistic Protists
    Melanie T Cushion
    University of Cincinnati College of Medicine, and the Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
    J Eukaryot Microbiol 53:S80-4. 2006