Marilyn Smith

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. ncbi request reprint Lasting effects of transient postinoculation tenofovir [9-R-(2-Phosphonomethoxypropyl)adenine] treatment on SHIV(KU2) infection of rhesus macaques
    M S Smith
    Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Virology 277:306-15. 2000
  2. ncbi request reprint Systemic infection and limited replication of SHIV vaccine virus in brains of macaques inoculated intracerebrally with infectious viral DNA
    Marilyn S Smith
    Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Virology 301:130-5. 2002
  3. ncbi request reprint Active simian immunodeficiency virus (strain smmPGm) infection in macaque central nervous system correlates with neurologic disease
    Marilyn S Smith
    Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Acquir Immune Defic Syndr 38:518-30. 2005
  4. pmc Quantification of tetracycline resistance genes in feedlot lagoons by real-time PCR
    Marilyn S Smith
    Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Appl Environ Microbiol 70:7372-7. 2004
  5. pmc Antigen expression kinetics and immune responses of mice immunized with noninfectious simian-human immunodeficiency virus DNA
    Ramakrishna Hegde
    Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City 66160, USA
    J Virol 79:14688-97. 2005
  6. pmc Protection of macaques against AIDS with a live attenuated SHIV vaccine is of finite duration
    Anil Kumar
    Division of Pharmacology, School of Pharmacy, University of Missouri, Kansas City, MO 64108, USA
    Virology 371:238-45. 2008
  7. pmc A noninfectious simian/human immunodeficiency virus DNA vaccine that protects macaques against AIDS
    Dinesh K Singh
    Marion Merrell Dow Laboratory of Viral Pathogenesis, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Virol 79:3419-28. 2005
  8. ncbi request reprint Protection against late-onset AIDS in macaques prophylactically immunized with a live simian HIV vaccine was dependent on persistence of the vaccine virus
    Glenn A Mackay
    Marion Merrell Dow Laboratory of Viral Pathogenesis, Division of Infectious Diseases, Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Immunol 173:4100-7. 2004
  9. ncbi request reprint Presence of Intact vpu and nef genes in nonpathogenic SHIV is essential for acquisition of pathogenicity of this virus by serial passage in macaques
    Glenn A Mackay
    Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA
    Virology 295:133-46. 2002
  10. ncbi request reprint Immunoprophylaxis against AIDS in macaques with a lentiviral DNA vaccine
    Zhenqian Liu
    Marion Merrell Dow Laboratory of Viral Pathogenesis, Department of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Virology 351:444-54. 2006

Research Grants

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Lasting effects of transient postinoculation tenofovir [9-R-(2-Phosphonomethoxypropyl)adenine] treatment on SHIV(KU2) infection of rhesus macaques
    M S Smith
    Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Virology 277:306-15. 2000
    ....
  2. ncbi request reprint Systemic infection and limited replication of SHIV vaccine virus in brains of macaques inoculated intracerebrally with infectious viral DNA
    Marilyn S Smith
    Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Virology 301:130-5. 2002
    ..Histopathological analyses of all the sampled brain and spinal cord regions did not reveal any abnormalities. Despite intracerebral inoculation of the viral DNA, the brain was not targeted for high levels of virus replication...
  3. ncbi request reprint Active simian immunodeficiency virus (strain smmPGm) infection in macaque central nervous system correlates with neurologic disease
    Marilyn S Smith
    Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Acquir Immune Defic Syndr 38:518-30. 2005
    ..Our results are consistent with the hypothesis that active virus expression in the CNS is strongly correlated with neurologic disease and that the event occurs at variable periods after infection...
  4. pmc Quantification of tetracycline resistance genes in feedlot lagoons by real-time PCR
    Marilyn S Smith
    Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Appl Environ Microbiol 70:7372-7. 2004
    ..Successful development of this real-time PCR assay will permit other studies quantifying Tcr gene numbers in environmental and other samples...
  5. pmc Antigen expression kinetics and immune responses of mice immunized with noninfectious simian-human immunodeficiency virus DNA
    Ramakrishna Hegde
    Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City 66160, USA
    J Virol 79:14688-97. 2005
    ..Since new waves of viral antigen production could be induced with each boosting injection of the vaccine DNA, this DNA could be a safe and efficient agent to induce long-term protection against HIV...
  6. pmc Protection of macaques against AIDS with a live attenuated SHIV vaccine is of finite duration
    Anil Kumar
    Division of Pharmacology, School of Pharmacy, University of Missouri, Kansas City, MO 64108, USA
    Virology 371:238-45. 2008
    ..All 8 animals succumbed to disease when challenged with pathogenic viruses...
  7. pmc A noninfectious simian/human immunodeficiency virus DNA vaccine that protects macaques against AIDS
    Dinesh K Singh
    Marion Merrell Dow Laboratory of Viral Pathogenesis, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Virol 79:3419-28. 2005
    ....
  8. ncbi request reprint Protection against late-onset AIDS in macaques prophylactically immunized with a live simian HIV vaccine was dependent on persistence of the vaccine virus
    Glenn A Mackay
    Marion Merrell Dow Laboratory of Viral Pathogenesis, Division of Infectious Diseases, Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Immunol 173:4100-7. 2004
    ..The two others harboring SHIV(KU-1) remain at risk for developing late-onset disease. The primary correlate against AIDS was persistence of the vaccine virus...
  9. ncbi request reprint Presence of Intact vpu and nef genes in nonpathogenic SHIV is essential for acquisition of pathogenicity of this virus by serial passage in macaques
    Glenn A Mackay
    Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA
    Virology 295:133-46. 2002
    ..The nef, LTR, and env of the SHIV(PPC) viruses underwent numerous mutations, compared to DeltavpuDeltanefSHIV(PPC). This study confirms the seminal role that nef, LTR, and vpu could play in regulation of pathogenesis of HIV infection...
  10. ncbi request reprint Immunoprophylaxis against AIDS in macaques with a lentiviral DNA vaccine
    Zhenqian Liu
    Marion Merrell Dow Laboratory of Viral Pathogenesis, Department of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Virology 351:444-54. 2006
    ..The DNA vaccine induced broad-based protection without using viral proteins to boost the immunity...
  11. pmc Kaposi's sarcoma-associated herpesvirus modulates microtubule dynamics via RhoA-GTP-diaphanous 2 signaling and utilizes the dynein motors to deliver its DNA to the nucleus
    Pramod P Naranatt
    Department of Microbiology, Molecular Genetics and Immunology, Mail Stop 3029, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Virol 79:1191-206. 2005
    ..These results further support our hypothesis that HHV-8 manipulates the host cell signaling pathway to create an appropriate intracellular environment that is conducive to the establishment of a successful infection...
  12. pmc Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of l
    Harinivas H Krishnan
    Department of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, Kansas City, Kansas, USA
    J Virol 78:3601-20. 2004
    ..These are unique observations among in vitro herpesvirus infections and may have important implications in KSHV biology and pathogenesis...
  13. ncbi request reprint Abundance of six tetracycline resistance genes in wastewater lagoons at cattle feedlots with different antibiotic use strategies
    Nicholas Peak
    Department of Civil, Environmental, and Architectural Engineering, University of Kansas, Lawrence, KS 66045, USA
    Environ Microbiol 9:143-51. 2007
    ..Results show that antibiotic use strategy strongly affects both the abundance and seasonal distribution of resistance genes in associated lagoons, which has implications on water quality and feedlot management practices...

Research Grants1

  1. WITHIN-HOST POPULATION DYNAMICS OF RETROVIRUS VACCINE
    Marilyn Smith; Fiscal Year: 2005
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