A Gordon Smith
Affiliation: University of Utah
- Epidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathyA G Smith
Department of Neurology, University of Utah, Salt Lake City, UT 84132, USA
Neurology 57:1701-4. 2001..Skin biopsy was abnormal in all neuropathy subjects and correlated poorly with NCS. Neuropathy associated with IGT primarily affects small fibers and is similar to early diabetes-associated neuropathy...
- The diagnostic utility of Sudoscan for distal symmetric peripheral neuropathyA Gordon Smith
University of Utah Department of Neurology Electronic address
J Diabetes Complications 28:511-6. 2014..This study evaluated Sudoscan's diagnostic utility for DSP...
- Obesity and hyperlipidemia are risk factors for early diabetic neuropathyA Gordon Smith
Department of Neurology, University of Utah, Salt Lake City, UT, USA Electronic address
J Diabetes Complications 27:436-42. 2013..Obesity/hypertriglyceridemia and hyperglycemia may have differential effects on small versus large fibers...
- Corneal confocal microscopy is efficient, well-tolerated, and reproducibleAlbert Gordon Smith
Department of Neurology, University of Utah, Salt Lake City, UT 84132, USA
J Peripher Nerv Syst 18:54-8. 2013..TC was less reproducible. CCM is a rapid, well-tolerated, and reproducible method for assessing corneal innervation...
- Diabetic neuropathyA Gordon Smith
University of Utah, Department of Neurology, 30 North 1900 East SOM 3R242, Salt Lake City, UT 84132, USA
Continuum (Minneap Minn) 18:60-84. 2012..Diabetic neuropathy is a major cause of disability and health care expense. This article reviews the various forms of diabetic neuropathy with a focus on diagnosis and treatment...
- Impaired glucose tolerance and metabolic syndrome in idiopathic neuropathyA Gordon Smith
Division of Neuromuscular Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
J Peripher Nerv Syst 17:15-21. 2012..Further research is needed to better define the epidemiological relation between IGT, metabolic syndrome, and neuropathy, its underlying pathophysiology, and to develop appropriate surrogate measures and clinical trials strategies...
- Idiopathic neuropathy patients are at high risk for metabolic syndromeA Gordon Smith
Department of Neurology, University of Utah, United States
J Neurol Sci 273:25-8. 2008..The primary objective was to determine if metabolic syndrome features other than hyperglycemia increase neuropathy risk...
- Impaired glucose tolerance and neuropathyA Gordon Smith
Department of Neurology, University of Utah, Salt Lake City, Utah 84132, USA
Neurologist 14:23-9. 2008..Among this population, impaired glucose tolerance (IGT or "prediabetes") is observed in approximately 40%. The exact nature of the relationship between IGT and neuropathy is debated...
- Lifestyle intervention for pre-diabetic neuropathyA Gordon Smith
Department of Neurology, University of Utah School of Medicine, 50 N Medical Drive, SOM 3R152, Salt Lake City, UT 84132, USA
Diabetes Care 29:1294-9. 2006....
- Idiopathic neuropathy, prediabetes and the metabolic syndromeA Gordon Smith
Neurology and Pathology, University of Utah School of Medicine, 30 North 1900 East, SOM 3R152, Salt Lake City, UT 84132, USA
J Neurol Sci 242:9-14. 2006..Thus, a multifactorial treatment approach to individual components of Metabolic Syndrome may slow prediabetic neuropathy progression or result in improvement...
- The diagnostic yield of a standardized approach to idiopathic sensory-predominant neuropathyA Gordon Smith
Department of Neurology, University of Utah School of Medicine, Salt Lake City 84132, USA
Arch Intern Med 164:1021-5. 2004..This study focuses on patients with sensory-predominant neuropathy. The goal was to develop a focused diagnostic algorithm that can be easily applied in a general medical setting...
- Reliability of quantitative sudomotor axon reflex testing and quantitative sensory testing in neuropathy of impaired glucose regulationAmanda Peltier
Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA
Muscle Nerve 39:529-35. 2009..QSART reproducibility was significantly lower than QST. In this group of patients, the reproducibility of QSART was unacceptable for use as a secondary endpoint measure in clinical research trials...
- The Utah Early Neuropathy Scale: a sensitive clinical scale for early sensory predominant neuropathyJ Robinson Singleton
Department of Neurology, University of Utah School of Medicine, SOM 3R 152, Salt Lake City, UT 84132, USA
J Peripher Nerv Syst 13:218-27. 2008..UENS is a sensitive and reproducible clinical measure of sensory and small-fiber nerve injury and may be useful in trials of early neuropathy...
- Increased axonal regeneration and swellings in intraepidermal nerve fibers characterize painful phenotypes of diabetic neuropathyHsinlin T Cheng
Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 2200, USA
J Pain 14:941-7. 2013..These axonal swellings were positive for tropomyosin-receptor-kinase A and substance P, suggesting that they are associated with nociception...
- Assessing the Reproducibility of Quantitative In Vivo Confocal Microscopy of Corneal Nerves in Different Corneal LocationsGene Kim
John A Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah Health Care, Salt Lake City, UT Ruiz Department of Ophthalmology and Visual Science, The University of Texas Medical School at Houston, Houston, TX Robert Cizik Eye Clinic, Houston, TX and Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT
Cornea 32:1331-8. 2013..To evaluate the reproducibility of in vivo confocal microscopy for quantitative corneal nerve analysis in different corneal locations...
- The diabetic neuropathies: practical and rational therapyJ Robinson Singleton
University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
Semin Neurol 32:196-203. 2012..The approach to the most common acute diabetic neuropathies is also reviewed...
- The reliability of skin biopsy with measurement of intraepidermal nerve fiber densityA Gordon Smith
University of Utah, Department of Neurology, Salt Lake City, UT 84132, USA
J Neurol Sci 228:65-9. 2005..IENFD measurement is highly reproducible. At least four sections should be analyzed. Reliability does not vary with severity of disease. These findings suggest IENFD may be a useful endpoint measure in future neuropathy treatment trials...
- Microvascular complications of impaired glucose toleranceJ Robinson Singleton
Department of Neurology, University of Utah, Salt Lake City, Utah, USA
Diabetes 52:2867-73. 2003..To what degree intervention will limit recognized complications is not known...
- Pulsed electromagnetic fields to reduce diabetic neuropathic pain and stimulate neuronal repair: a randomized controlled trialMichael I Weintraub
Department of Neurology, New York Medical College, Valhalla, NY, USA
Arch Phys Med Rehabil 90:1102-9. 2009....
- Neuropathy associated with prediabetes: what is new in 2007?J Rob Singleton
Department of Neurology, University of Utah, 1900 East, 30 North, Salt Lake City, UT 84132, USA
Curr Diab Rep 7:420-4. 2007....
- Polyneuropathy with Impaired Glucose Tolerance: Implications for Diagnosis and TherapyJ Robinson Singleton
University of Utah, Department of Neurology, SOM 3R 152, 1900 E 30 North, Salt Lake City, UT 84132, USA
Curr Treat Options Neurol 7:33-42. 2005..Adjunctive therapy with opioids, nonsteroidal anti-inflammatory drugs often are necessary. Diet and exercise seem to reduce neuropathic pain in patients with NAP...
- Therapy insight: neurological complications of prediabetesJ Robinson Singleton
Neurology, University of Utah, Salt Lake City, UT 84132, USA
Nat Clin Pract Neurol 2:276-82. 2006..Goal-driven diet and exercise regimens, together with pharmacological treatment of hyperlipidemia and hypertension, reduce stroke risk, but the effect of these interventions on neuropathy has not been fully explored...
- Exercise as Therapy for Diabetic and Prediabetic NeuropathyJ Robinson Singleton
Department of Neurology, University of Utah, Salt Lake City, UT, USA
Curr Diab Rep 15:120. 2015..Behavioral reduction in periods of seated, awake inactivity produces multimodal metabolic benefits similar to exercise, and the two strategies when combined may offer sustained benefit to peripheral nerve function. ..
- Chronic migraine is associated with reduced corneal nerve fiber density and symptoms of dry eyeKrista I Kinard
Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA
Headache 55:543-9. 2015..Noninvasive imaging of the corneal sub-basal nerve plexus is possible with in vivo corneal confocal microscopy...
- Clinical and diagnostic features of delayed hypoxic leukoencephalopathyDavid R Shprecher
University of Rochester, Department of Neurology, 1351 Mt Hope Ave, Suite 100, Rochester, NY 14620 3917, USA
J Neuropsychiatry Clin Neurosci 20:473-7. 2008..The authors describe clinical and diagnostic features of three such cases, review the pathophysiology of delayed hypoxic leukoencephalopathy, and discuss features which may help distinguish it from toxic leukoencephalopathy...
- The Association of Chemotherapy-Induced Peripheral Neuropathy Symptoms and the Risk of FallingNoah A Kolb
Department of Neurology, University of Utah School of Medicine, Salt Lake City
JAMA Neurol 73:860-6. 2016..Few studies have prospectively examined the relationship between sensory neuropathy symptoms, falls, and fall-related injuries for patients receiving neurotoxic chemotherapy...
- Glucose intolerance, metabolic syndrome, and neuropathyMelissa Cortez
Imaging and Neurosciences Center, University of Utah, Salt Lake City, UT, USA
Handb Clin Neurol 126:109-22. 2014..Further research is required to fully elucidate the complex pathophysiology, as well as identify optimal diagnostic and treatment approaches. ..
- Supervised exercise improves cutaneous reinnervation capacity in metabolic syndrome patientsJ Robinson Singleton
Departments of Neurology, University of Utah, Salt Lake City, UT
Ann Neurol 77:146-53. 2015..We used this capsaicin axotomy technique to examine the effects of exercise on cutaneous regenerative capacity in the setting of metabolic syndrome...
- 2007 International Peripheral Nerve Society Meeting at Snowbird, UtahA Smith; Fiscal Year: 2007..The meeting directly impacts public health and patient care by disseminating important new ideas (both research and therapeutic) and by developing consensus guidelines. [unreadable] [unreadable] [unreadable]..