Mark S Slaughter

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Increase in circadian variation after continuous-flow ventricular assist device implantation
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Louisville, Louisville, KY 40202, USA
    J Heart Lung Transplant 29:695-7. 2010
  2. doi request reprint Transcutaneous energy transmission for mechanical circulatory support systems: history, current status, and future prospects
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    J Card Surg 25:484-9. 2010
  3. ncbi request reprint Percutaneous closure of a patent foramen ovale to prevent paradoxical thromboembolism in a patient with a continuous-flow LVAD
    Carlo R Bartoli
    MD PhD Program, University of Louisville, 201 Abraham Flexner Way, Suite 1200, Louisville, KY 40202 USA
    J Invasive Cardiol 25:154-6. 2013
  4. doi request reprint HeartWare ventricular assist system for bridge to transplant: combined results of the bridge to transplant and continued access protocol trial
    Mark S Slaughter
    Division of Cardiothoracic Surgery and Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    J Heart Lung Transplant 32:675-83. 2013
  5. doi request reprint Hematologic effects of continuous flow left ventricular assist devices
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, 201 Abraham Flexner Way, Louisville, KY 40202, USA
    J Cardiovasc Transl Res 3:618-24. 2010
  6. doi request reprint Advanced heart failure treated with continuous-flow left ventricular assist device
    Mark S Slaughter
    Advocate Christ Medical Center, Oak Lawn, IL, USA
    N Engl J Med 361:2241-51. 2009
  7. doi request reprint Intraoperative evaluation of the HeartMate II flow estimator
    Mark S Slaughter
    Division of Cardiothoracic Surgery, Cardiovascular Innovation Institute, University of Louisville, Kentucky, USA
    J Heart Lung Transplant 28:39-43. 2009
  8. doi request reprint Post-operative heparin may not be required for transitioning patients with a HeartMate II left ventricular assist system to long-term warfarin therapy
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    J Heart Lung Transplant 29:616-24. 2010
  9. doi request reprint Reducing emboli in cardiac surgery: does it make a difference?
    Mark S Slaughter
    Division of Cardiac Surgery, Advocate Christ Medical Center, Oak Lawn, IL, USA
    Artif Organs 32:880-4. 2008
  10. doi request reprint Long-term continuous flow left ventricular assist device support and end-organ function: prospects for destination therapy
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    J Card Surg 25:490-4. 2010

Detail Information

Publications87

  1. pmc Increase in circadian variation after continuous-flow ventricular assist device implantation
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Louisville, Louisville, KY 40202, USA
    J Heart Lung Transplant 29:695-7. 2010
    ..The return of the circadian rhythm has implications for cardiac recovery, and the observation indicates that the continuous-flow LVAD has an intrinsic automatic response to physiologic demands...
  2. doi request reprint Transcutaneous energy transmission for mechanical circulatory support systems: history, current status, and future prospects
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    J Card Surg 25:484-9. 2010
    ..A totally implantable LVAD with an incorporated TETS for destination therapy could become an important advance in the treatment of end-stage heart failure...
  3. ncbi request reprint Percutaneous closure of a patent foramen ovale to prevent paradoxical thromboembolism in a patient with a continuous-flow LVAD
    Carlo R Bartoli
    MD PhD Program, University of Louisville, 201 Abraham Flexner Way, Suite 1200, Louisville, KY 40202 USA
    J Invasive Cardiol 25:154-6. 2013
    ..Strategies to diagnose PFO at the time of LVAD implantation and physiological implications of a right-to-left atrial shunt during mechanical unloading of the failing left ventricle are reviewed...
  4. doi request reprint HeartWare ventricular assist system for bridge to transplant: combined results of the bridge to transplant and continued access protocol trial
    Mark S Slaughter
    Division of Cardiothoracic Surgery and Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    J Heart Lung Transplant 32:675-83. 2013
    ..The pivotal bridge to transplant and continued access protocols trials have enrolled patients with advanced heart failure in a bridge-to-transplant indication...
  5. doi request reprint Hematologic effects of continuous flow left ventricular assist devices
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, 201 Abraham Flexner Way, Louisville, KY 40202, USA
    J Cardiovasc Transl Res 3:618-24. 2010
    ..Because bleeding causes significant morbidity for this population, more effective treatment strategies need to be developed...
  6. doi request reprint Advanced heart failure treated with continuous-flow left ventricular assist device
    Mark S Slaughter
    Advocate Christ Medical Center, Oak Lawn, IL, USA
    N Engl J Med 361:2241-51. 2009
    ..New continuous-flow devices are smaller and may be more durable than the pulsatile-flow devices...
  7. doi request reprint Intraoperative evaluation of the HeartMate II flow estimator
    Mark S Slaughter
    Division of Cardiothoracic Surgery, Cardiovascular Innovation Institute, University of Louisville, Kentucky, USA
    J Heart Lung Transplant 28:39-43. 2009
    ..This study evaluated the accuracy of HeartMate II flow estimation at the time of implantation...
  8. doi request reprint Post-operative heparin may not be required for transitioning patients with a HeartMate II left ventricular assist system to long-term warfarin therapy
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    J Heart Lung Transplant 29:616-24. 2010
    ..We retrospectively evaluated the effects of heparin use on thromboembolic and bleeding complications after implantation of the HeartMate II left ventricular assist device (LVAD)...
  9. doi request reprint Reducing emboli in cardiac surgery: does it make a difference?
    Mark S Slaughter
    Division of Cardiac Surgery, Advocate Christ Medical Center, Oak Lawn, IL, USA
    Artif Organs 32:880-4. 2008
    ....
  10. doi request reprint Long-term continuous flow left ventricular assist device support and end-organ function: prospects for destination therapy
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    J Card Surg 25:490-4. 2010
    ..Current clinical evidence indicates that end-organ perfusion and function can be well maintained for extended durations of support with a CF-LVAD...
  11. pmc Transapical miniaturized ventricular assist device: design and initial testing
    Mark S Slaughter
    Department of Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY 40202, USA
    J Thorac Cardiovasc Surg 142:668-74. 2011
    ..We evaluated a new miniaturized left ventricular assist device that requires minimal surgery for implantation, potentially allowing implantation in earlier stage heart failure...
  12. doi request reprint Evaluation of new Forcefield technology: reducing platelet adhesion and cell coverage of pyrolytic carbon surfaces
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Louisville, Louisville, KY, USA
    J Thorac Cardiovasc Surg 142:921-5. 2011
    ..A modulated low-voltage current is directly applied to pyrolytic carbon surfaces to stimulate adherence of a layer of charged proteins from circulating blood components that is resistive to platelet deposition...
  13. doi request reprint Destination therapy with left ventricular assist devices: patient selection and outcomes
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, 201 Abraham Flexner Way, Louisville, KY 40202, USA
    Curr Opin Cardiol 26:232-6. 2011
    ..With the advent of continuous-flow LVADs, safe and effective long-term circulatory support is available for properly identified candidates...
  14. doi request reprint Platelet activation in heart failure patients supported by the HeartMate II ventricular assist device
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Louisville, Louisville, KY 40202, USA
    Int J Artif Organs 34:461-8. 2011
    ..In this study, markers of platelet activation were investigated in HF patients supported by a HeartMate II left ventricular assist device (LVAD)...
  15. ncbi request reprint The total artificial heart
    A Meyer
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, KY, USA
    Panminerva Med 53:141-54. 2011
    ..In this review article, a brief history on the evolution of TAH devices, their current use and emerging use of evolving continuous flow VAD technology as chronic biventricular and TAH device systems are presented...
  16. doi request reprint Temporal changes in hospital costs for left ventricular assist device implantation
    Mark S Slaughter
    Division of Cardiothoracic Surgery, University of Louisville, KY 40202, USA
    J Card Surg 26:535-41. 2011
    ..The current study examines the hospitalization costs associated with treatment of New York Heart Failure Class IV patients when implanted with a CF LVAD and compares them to previously reported costs of a PF LVAD in the same population...
  17. doi request reprint Implantation of the HeartWare left ventricular assist device
    Mark S Slaughter
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky, USA
    Semin Thorac Cardiovasc Surg 23:245-7. 2011
    ..The HeartWare HVAD is a new continuous flow LVAD, currently in trials, that is designed to be implanted and contained completely within the pericardial space...
  18. doi request reprint Bovine model of chronic ischemic cardiomyopathy: implications for ventricular assist device research
    Carlo R Bartoli
    MD PhD Program, School of Medicine, University of Louisville, Louisville, KY, USA Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA
    Artif Organs 37:E202-14. 2013
    ..This model is an appropriate physiological substrate in which to test VAD and adjunctive biological therapies...
  19. doi request reprint Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States
    Michael A Acker
    Division of Cardiothoracic Surgery, University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 94:2147-58. 2012
    ....
  20. pmc Low incidence of neurologic events during long-term support with the HeartMate XVE left ventricular assist device
    Mark S Slaughter
    Cardiac Surgery Research and Mechanical Assist Device Program, Advocate Christ Medical Center, Oak Lawn, Illinois 60453, USA
    Tex Heart Inst J 35:245-9. 2008
    ..They also suggest that modifications made to the HeartMate LVAD since the REMATCH trial have resulted in fewer complications, and that better patient selection and supportive care have improved outcomes...
  21. doi request reprint Heart transplant vs left ventricular assist device in heart transplant-eligible patients
    Matthew L Williams
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, and Jewish Hospital Transplant Center, Louisville, Kentucky 40202, USA
    Ann Thorac Surg 91:1330-3; discussion 1333-4. 2011
    ..We evaluated 1-year outcome and effectiveness of LVAD vs heart transplantation...
  22. doi request reprint Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States
    Michael A Acker
    Division of Cardiothoracic Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Circ Heart Fail 6:e1-e11. 2013
    ....
  23. doi request reprint Early and midterm outcomes following surgery for acute type A aortic dissection
    Sebastian Pagni
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky
    J Card Surg 28:543-9. 2013
    ..Surgical repair of acute Type A aortic dissection (AADA) is still associated with high in-hospital mortality. We evaluated the impact of perioperative risk factors on early and midterm survival...
  24. doi request reprint Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States
    Michael A Acker
    Division of Cardiothoracic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Heart Lung Transplant 31:1241-52. 2012
    ....
  25. doi request reprint Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States: executive summary
    Michael A Acker
    Division of Cardiothoracic Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Circ Heart Fail 6:145-50. 2013
    ....
  26. pmc Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance
    Atul R Chugh
    Division of Cardiovascular Medicine, University of Louisville, Louisville, KY, USA
    Circulation 126:S54-64. 2012
    ..In the present study, we report the surgical aspects and interim cardiac magnetic resonance (CMR) results...
  27. doi request reprint Human, bovine and porcine systematic vascular input impedances are not equivalent: implications for device testing and xenotransplantation in heart failure
    Steven C Koenig
    Cardiovascular Innovation Institute, Department of Bioengineering and Surgery, University of Louisville, Louisville, Kentucky 502 852 1795, USA
    J Heart Lung Transplant 27:1340-7. 2008
    ..Systemic aortic input impedance (Z(ART)) is an important physiologic determinant of left ventricular (LV) performance. We tested the hypothesis that Z(ART) is lower in bovine and porcine than in humans with normal or failing hearts...
  28. pmc HeartWare miniature axial-flow ventricular assist device: design and initial feasibility test
    Mark S Slaughter
    Mechanical Assist Device Program, Advocate Christ Medical Center, Oak Lawn, IL 60453, USA
    Tex Heart Inst J 36:12-6. 2009
    ..Further in vivo testing is planned. Herein, we discuss the unique design of the HeartWare miniature ventricular assist device, our feasibility study of its performance, and the possibilities for its use in human beings...
  29. ncbi request reprint Vascular pulsatility in patients with a pulsatile- or continuous-flow ventricular assist device
    Adam R Travis
    Cardiovascular Innovation Institute, University of Louisville, Louisville, KY 40202, USA
    J Thorac Cardiovasc Surg 133:517-24. 2007
    ....
  30. pmc Acute hemodynamic efficacy of a 32-ml subcutaneous counterpulsation device in a calf model of diminished cardiac function
    Steven C Koenig
    Department of Bioengineering, Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky 40202, USA
    ASAIO J 54:578-84. 2008
    ..The CPD provides hemodynamic efficacy equivalent to an IABP and may become a therapeutic option for patients who may benefit from prolonged counterpulsation...
  31. pmc Paradoxical Effect of Nonphysiological Shear Stress on Platelets and von Willebrand Factor
    Zengsheng Chen
    Department of Cardiovascular and Thoracic Surgery, University of Louisville School of Medicine, Louisville, KY, USA
    Artif Organs 40:659-68. 2016
    ..The finding might provide a new perspective to understand thrombosis and acquired bleeding disorder in patients supported with blood contacting medical devices. ..
  32. doi request reprint Blood trauma testing of CentriMag and RotaFlow centrifugal flow devices: a pilot study
    Michael A Sobieski
    Departments of Bioengineering and Surgery, Cardiovascular Innovation Institute, University of Louisville, 302 East Muhammad Ali Blvd, Louisville, KY 40202, USA
    Artif Organs 36:677-82. 2012
    ..The RotaFlow device may be a more cost-effective alternative to the CentriMag...
  33. doi request reprint Control strategies for afterload reduction with an artificial vasculature device
    Guruprasad A Giridharan
    Department of Bioengineering, University of Louisville, Kentucky 40202, USA
    ASAIO J 58:353-62. 2012
    ..The developed AVD impedance control algorithms may be implemented with current VADs to promote myocardial recovery and facilitate weaning...
  34. doi request reprint Left ventricular volume unloading with axial and centrifugal rotary blood pumps
    Guruprasad A Giridharan
    From the Department of Bioengineering, Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky 40292 Department of Cardiovascular and Thoracic Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky 40202 Eidgenössische Technische Hochschule Hönggerberg, Zurich, Switzerland and Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104
    ASAIO J 61:292-300. 2015
    ..These findings suggest no pronounced acute differences in LV volume unloading between AX and CFG LVAD...
  35. doi request reprint Outcomes in advanced heart failure patients with left ventricular assist devices for destination therapy
    Soon J Park
    Division of Cardiac Surgery, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Circ Heart Fail 5:241-8. 2012
    ..The primary hypothesis of the current study is that trial patients enrolled after the initial data cohort would have better clinical outcomes...
  36. doi request reprint Hemodynamic responses to continuous versus pulsatile mechanical unloading of the failing left ventricle
    Carlo R Bartoli
    University of Louisville School of Medicine, Kentucky, USA
    ASAIO J 56:410-6. 2010
    ..These findings may have important implications for chronic LVAD therapy...
  37. ncbi request reprint Managing mechanical valves with reduced anticoagulation
    Mark S Slaughter
    Advocate Christ Medical Center, 4440 West 95th Street, Oak Lawn, IL 60453, USA
    Expert Rev Cardiovasc Ther 5:1073-85. 2007
    ..The current trend is more frequent use of bioprosthetic valves; however, this trend may again reverse as therapy for mechanical valves is refined...
  38. doi request reprint Hemodynamic changes and retrograde flow in LVAD failure
    Guruprasad A Giridharan
    From the Department of Bioengineering, Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky 40292 Department of Cardiovascular and Thoracic Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky 40202 Eidgenössische Technische Hochschule Hönggerberg, Zurich, Switzerland and Division of Cardiovascular Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104
    ASAIO J 61:282-91. 2015
    ..Retrograde flow increased ventricular end-systolic and end-diastolic volumes and workload, and decreased myocardial and end-organ perfusion during LVAD failure compared with baseline, LVAD support, and pulsatile LVAD failure...
  39. doi request reprint Rotary pump speed modulation for generating pulsatile flow and phasic left ventricular volume unloading in a bovine model of chronic ischemic heart failure
    Kevin G Soucy
    Departments of a gt Cardiovascular and Thoracic Surgery Bioengineering, University of Louisville, Louisville, Kentucky
    J Heart Lung Transplant 34:122-31. 2015
    ....
  40. doi request reprint Benefits of aggressive medical management in a bovine model of chronic ischemic heart failure
    Leslie C Sherwood
    Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky, USA
    ASAIO J 59:221-9. 2013
    ..These findings support the hypothesis that a single coronary microembolization procedure and aggressive medical therapy produces a clinically relevant chronic IHF model with a significantly higher SR than conservative medical therapy...
  41. doi request reprint A novel subcutaneous counterpulsation device: acute hemodynamic efficacy during pharmacologically induced hypertension, hypotension, and heart failure
    Carlo R Bartoli
    MD PhD Program, University of Louisville School of Medicine, Louisville, KY, USA
    Artif Organs 34:537-45. 2010
    ..A novel 32-mL CPD connected to a peripheral artery produced equivalent or greater hemodynamic benefits than a standard 40-mL IABP during pharmacologically induced hypertension, hypotension, and heart failure conditions...
  42. doi request reprint Destination therapy: safety and feasibility of national and international travel
    Laura A Coyle
    Mechanical Assist Device Program, Advocate Christ Medical Center, Oak Lawn, Illinois, USA
    ASAIO J 54:172-6. 2008
    ..All patients returned home safely for routine follow-up. Long-distance travel is possible for DT patients. Anticipating potential problems and careful planning is necessary for safe national and international travel...
  43. ncbi request reprint Left ventricular assist device weaning: hemodynamic response and relationship to stroke volume and rate reduction protocols
    Mark S Slaughter
    Mechanical Assist Device Program, Advocate Christ Medical Center, Oak Lawn, IL 60453, USA
    ASAIO J 52:228-33. 2006
    ..The long-term effects of steady-state and transient LV mechanical reloading on myocardial structure and function toward achieving sustained myocardial recovery warrant further investigation...
  44. doi request reprint Flow modulation algorithms for intra-aortic rotary blood pumps to minimize coronary steal
    Mickey S Ising
    School of Medicine, University of Louisville, Louisville, Kentucky, USA
    ASAIO J 59:261-8. 2013
    ..However, even with flow modulation, IARBP support provides a smaller improvement in myocardial supply demand ratio compared to ventricular assist devices and intra-aortic balloon pumps...
  45. pmc Miniaturization of mechanical circulatory support systems
    Guruprasad A Giridharan
    Departments of Bioengineering and Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA
    Artif Organs 36:731-9. 2012
    ....
  46. ncbi request reprint Peripheral cardiopulmonary bypass with modified assisted venous drainage and transthoracic aortic crossclamp: optimal management for robotic mitral valve repair
    Michael A Sobieski
    Division of Cardiac Surgery, Christ Hospital and Medical Center, Oak Lawn, IL, USA
    Perfusion 18:307-11. 2003
    ..This approach may be applied to other forms of minimally invasive cardiac surgery that requires CPB...
  47. ncbi request reprint Prospective study on cardiopulmonary bypass prime reduction and its effect on intraoperative blood product and hemoconcentrator use
    Michael A Sobieski
    Division of Cardiac Surgery, Advocate Christ Medical Center, Oak Lawn, IL, USA
    Perfusion 20:31-7. 2005
    ..Evaluate the feasibility and clinical significance of crystalloid prime reduction during the initiation of cardiopulmonary bypass (CPB) using a modified bridge on the cardioplegia delivery system...
  48. doi request reprint Clinical management of continuous-flow left ventricular assist devices in advanced heart failure
    Mark S Slaughter
    University of Louisville, Louisville, Kentucky, USA
    J Heart Lung Transplant 29:S1-39. 2010
    ..Ongoing trials with other continuous-flow devices may produce additional information in the future for improving clinical management of patients with these devices...
  49. doi request reprint Destination therapy: one-year outcomes in patients with a body mass index greater than 30
    Laura A Coyle
    Mechanical Assist Device Program, Advocate Christ Medical Center, Oak Lawn, IL, USA
    Artif Organs 34:93-7. 2010
    ..2 vs. 1.6), and survival (63% vs. 65%). Our initial results demonstrate that morbidly obese patients with end-stage heart failure with a contraindication for transplant may successfully undergo implantation of an LVAD for DT...
  50. ncbi request reprint Utilization of acoustic signatures to identify HeartMate XVE device end-of-life
    Mark S Slaughter
    Mechanical Assist Device Program, Advocate Christ Medical Center, Oak Lawn, Illinois 60453, USA
    J Heart Lung Transplant 26:579-83. 2007
    ..In this study we assess a non-invasive technique using acoustic signals generated from the HeartMate XVE LVAD to potentially identify impending device end-of-life issues...
  51. ncbi request reprint Efficacy of Subcutaneous Electrocardiogram Leads for Synchronous Timing During Chronic Counterpulsation Therapy
    Stephen R Carnahan
    Department of Bioengineering, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA Department of Cardiovascular and Thoracic Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY, USA
    ASAIO J . 2016
    ..These findings demonstrate the efficacy of subcutaneous ECG leads for long-term CPD timing and potential use as an alternative method for MCS device timing...
  52. pmc Infection, Oxidative Stress and Changes in Circulating Regulatory T cells of Heart Failure Patients Supported by Continuous-Flow Ventricular Assist Devices
    Nandan K Mondal
    Department of Cardiovascular and Thoracic Surgery, Cardiovascular Innovation Institute, University of Louisville School of Medicine, Louisville, Kentucky, USA Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    ASAIO J . 2016
    ..Elevated OS and rise in Tregs were more prominent in CF-VAD patients with infection. In conclusion, OS and compromised immune system may be important indicators of systemic response of the body to CF-VAD among HF patients with infection...
  53. doi request reprint Feasibility Study of Pulsatile Left Ventricular Assist Device for Prolonged Ex Vivo Lung Perfusion
    Erin M Schumer
    Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Kentucky
    Ann Thorac Surg 99:1961-7; discussion 1967-8. 2015
    ..In this feasibility study, we tested the hypothesis that a pulsatile flow (PF) pump will provide better EVLP support than a CF pump through delivery of physiologic hemodynamics...
  54. doi request reprint Impact of cardiac resynchronization therapy on clinical outcomes in patients with continuous-flow left ventricular assist devices
    Rakesh Gopinathannair
    Division of Cardiovascular Medicine, University of Louisville, Louisville, Kentucky Electronic address
    J Card Fail 21:226-32. 2015
    ..We sought to determine if CRT-D improved clinical outcomes in CF-LVAD patients compared with ICDs alone...
  55. pmc Early feasibility testing and engineering development of a sutureless beating heart connector for left ventricular assist devices
    Steven C Koenig
    From the Department of Cardiovascular and Thoracic Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky Department of Bioengineering, University of Louisville, Louisville, Kentucky and APK Advanced Medical Technologies, Atlanta, Georgia
    ASAIO J 60:617-25. 2014
    ..In chronic animals before necropsy, no signs of leakage or disruption at the attachment site were observed at systolic LV pressures >200 mm Hg. ..
  56. pmc Early feasibility testing and engineering development of the transapical approach for the HeartWare MVAD ventricular assist system
    Daniel Tamez
    From the HeartWare, Inc, Miami Lakes, Florida Division of Thoracic and Cardiovascular Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky Department of Bioengineering, University of Louisville, Louisville, Kentucky and Research Resources Facilities RRF, University of Louisville, Louisville, Kentucky
    ASAIO J 60:170-7. 2014
    ..Potential advantages of the MVAD Pump include flow support in the same direction as the native ventricle, elimination of cardiopulmonary bypass, and minimally invasive implantation. ..
  57. doi request reprint Preoperative hematocrit is a powerful predictor of adverse outcomes in coronary artery bypass graft surgery: a report from the Society of Thoracic Surgeons Adult Cardiac Surgery Database
    Matthew L Williams
    Department of Surgery, University of Louisville, Louisville, Kentucky Electronic address
    Ann Thorac Surg 96:1628-34; discussion 1634. 2013
    ..In this study, analyses were performed to determine the impact of preoperative HCT on perioperative morbidity and mortality among patients undergoing isolated CABG...
  58. doi request reprint Fault detection in rotary blood pumps using motor speed response
    Kevin G Soucy
    Department of Bioengineering, Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky 40202, USA
    ASAIO J 59:410-9. 2013
    ..5-6.2 cP), which should be accounted for in clinical application. The proposed VAD fault detection algorithm may deliver a convenient and nonintrusive way to minimize catastrophic device failures. ..
  59. doi request reprint Novel thrombosis risk index as predictor of left ventricular assist device thrombosis
    Jaimin R Trivedi
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky, USA
    ASAIO J 59:380-3. 2013
    ..Fibrinogen and D-dimer assays are currently being evaluated in these patients for their possible inclusion and added value to the TRI. ..
  60. doi request reprint Rotary pumps and diminished pulsatility: do we need a pulse?
    Kevin G Soucy
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    ASAIO J 59:355-66. 2013
    ..There may also be the added benefit of specific control strategies for managing CVAD therapy, potentially improving the rate of myocardial recovery and successful weaning of mechanical circulatory support. ..
  61. doi request reprint Off-pump and on-pump coronary revascularization in patients with low ejection fraction: a report from the society of thoracic surgeons national database
    W Brent Keeling
    Division of Cardiothoracic Surgery, Emory University, Atlanta, Georgia, USA
    Ann Thorac Surg 96:83-8: discussion 88-9. 2013
    ..The purpose of this study was to evaluate outcomes of patients with low ejection fraction who underwent surgical coronary revascularization with or without cardiopulmonary bypass (CPB)...
  62. doi request reprint Management of recurrent leaks following postinfarction ventricular septal defect repairs
    Sameh Sayfo
    Division of Cardiovascular Medicine, University of Louisville of School of Medicine, Louisville, Kentucky 40202, USA
    J Card Surg 27:576-80. 2012
    ..We discuss the management of recurrent leaks and surgical techniques aimed at decreasing residual defects...
  63. doi request reprint Prospective clinical study of a novel left atrial appendage occlusion device
    A David Slater
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky 40202, USA
    Ann Thorac Surg 93:2035-8; discussion 2038-40. 2012
    ..This Food and Drug Administration-approved investigational device exempt trial assessed the safety and efficacy of a novel device for external left atrial appendage (LAA) exclusion...
  64. ncbi request reprint Results of a multicenter clinical trial with the Thoratec Implantable Ventricular Assist Device
    Mark S Slaughter
    Advocate Christ Medical Center, Oak Lawn, Ill 60453, USA
    J Thorac Cardiovasc Surg 133:1573-80. 2007
    ..3 m(2). Results of the multicenter clinical trial are reviewed...
  65. pmc Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial
    Roberto Bolli
    Divisions of Cardiovascular Medicine, University of Louisville, Louisville, KY 40202, USA
    Lancet 378:1847-57. 2011
    ..We undertook a phase 1 trial (Stem Cell Infusion in Patients with Ischemic cardiOmyopathy [SCIPIO]) of autologous CSCs for the treatment of heart failure resulting from ischaemic heart disease...
  66. ncbi request reprint Minimally invasive mitral valve repair using the da Vinci robotic system
    Antone J Tatooles
    Division of Cardiac Surgery, Advocate Christ Medical Center, Oak Lawn, Illinois, USA
    Ann Thorac Surg 77:1978-82; discussion 1982-4. 2004
    ..We evaluated our da Vinci robotically assisted mitral valve repair experience toward achieving this goal...
  67. doi request reprint Development of an extracellular matrix delivery system for effective intramyocardial injection in ischemic tissue
    Mark S Slaughter
    From the Department of Cardiovascular and Thoracic Surgery, Cardiovascular Innovation Institute Department of Bioengineering, University of Louisville, Louisville, Kentucky and CorMatrix Cardiovascular, Inc, Roswell, Georgia
    ASAIO J 60:730-6. 2014
    ..0 ml) and depth of penetration (3-5 mm) under regulated injection pressure (150 psi CO2) into the ischemic region. Targeted intramyocardial delivery of P-ECM may improve efficacy and enable development of novel patient-specific therapy. ..
  68. doi request reprint Defining pulsatility during continuous-flow ventricular assist device support
    Kevin G Soucy
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, KY 40202, USA
    J Heart Lung Transplant 32:581-7. 2013
    ..A review of methods for quantifying vascular pulsatility and their application as a research tool for investigating physiologic responses to CVAD support are presented...
  69. doi request reprint Catheter ablation of atrial flutter in patients with left ventricular assist device improves symptoms of right heart failure
    Rashmi U Hottigoudar
    Division of Cardiovascular Medicine, University of Louisville, Louisville, KY 40241, USA
    Congest Heart Fail 19:165-71. 2013
    ..Catheter ablation of AFL in LVAD patients is safe and highly effective, resulting in immediate and significant improvement in symptoms of RHF, and should be considered first-line therapy for AFL in these patients. ..
  70. doi request reprint Reducing the effects of the systemic inflammatory response to cardiopulmonary bypass: can single dose steroids blunt systemic inflammatory response syndrome?
    Michael A Sobieski
    Division of Cardiac Surgery, Advocate Christ Medical Center, Oak Lawn, Illinois, USA
    ASAIO J 54:203-6. 2008
    ..Despite the significant reductions in IL-6 and PNE, there was no effect on clinical outcomes. Additional studies are needed to demonstrate a clinically significant effect on patient outcomes...
  71. pmc Embol-X intra-aortic filtration system: capturing particulate emboli in the cardiac surgery patient
    Michael A Sobieski
    Division of Cardiac Surgery, Advocate Christ Medical Center, Oak Lawn, Illinois, USA
    J Extra Corpor Technol 37:222-6. 2005
    ..Clearly, the reduction of particulate matter by as much as 95% justifies its use in cardiac surgery patients identified with an increased pre-operative embolic risk...
  72. doi request reprint Improvement in early oxygen uptake kinetics with left ventricular assist device support
    Chad M Feldman
    Internal Medicine, Advocate Christ Medical Center, Oak Lawn, Illinois, USA
    ASAIO J 54:406-11. 2008
    ..7 seconds to 35.8 +/- 13.3 seconds (p = 0.046) with LVAD support. Improved oxygen kinetics suggests improved peripheral utilization of oxygen, and may offer an additional clinical parameter to predict the likelihood of sustained recovery...
  73. ncbi request reprint Home discharge experience with the Thoratec TLC-II portable driver
    Mark S Slaughter
    Mechanical Assist Device Program, Advocate Christ Medical Center, Oak Lawn, IL 60453, USA
    ASAIO J 53:132-5. 2007
    ..There were no readmissions for device malfunction, emergency battery utilization or back-up unit use. These results demonstrate that the Thoratec TLC-II portable driver is safe, reliable, and can be effectively managed at home...
  74. doi request reprint Blood trauma testing for mechanical circulatory support devices
    Guruprasad A Giridharan
    Department of Bioengineering, University of Louisville, Louisville, KY, USA
    Biomed Instrum Technol 45:334-9. 2011
    ..Standardization of hemolysis testing procedures and transparency of results may enable better blood trauma characterization of MCS devices to facilitate the FDA 510(k) and PMA submission processes and improve clinical outcomes...
  75. doi request reprint Large animal models for left ventricular assist device research and development
    Gretel Monreal
    From the Cardiovascular Innovation Institute, University of Louisville, Louisville, Kentucky Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky Research Resources Facilities, University of Louisville, Louisville, Kentucky and Department of Bioengineering, University of Louisville, Louisville, Kentucky
    ASAIO J 60:2-8. 2014
    ..In this review, large animal species commonly used in cardiac research, techniques used to create chronic HF, and the combined applicability to preclinical LVAD R&D studies are presented. ..
  76. doi request reprint Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States: executive summary
    Michael A Acker
    Division of Cardiothoracic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Ann Thorac Surg 94:e163-8. 2012
    ....
  77. doi request reprint Open repair of blunt thoracic aortic injury remains relevant in the endovascular era
    Robert M Cannon
    University of Louisville, Department of Surgery, Louisville, KY 40201, USA
    J Am Coll Surg 214:943-9. 2012
    ..This study was undertaken to evaluate outcomes with open repair and TEVAR for BTAI...
  78. doi request reprint Coronary artery fistula: 64-slice computed tomographic delineation and correlation with multiplane transesophageal echocardiography and surgical findings
    Jonathan K Joshi
    Radiology Medicine Surgery, University of Louisville, Louisville, KY, USA
    Echocardiography 29:E69-71. 2012
    ..Findings were ultimately confirmed at cardiac catheterization. Coronary steal was clinically diagnosed and she underwent surgical ligation and resection of the fistula and aneurysm. Her subsequent course was uncomplicated...
  79. ncbi request reprint Management of aortic insufficiency with continuous flow left ventricular assist devices: bioprosthetic valve replacement
    Chad M Feldman
    Advocate Christ Medical Center, Mechanical Assist Device Program, Oak Lawn, Illinois 60453, USA
    J Heart Lung Transplant 25:1410-2. 2006
    ..We report on two patients with bioprosthetic aortic valve replacement for aortic insufficiency at the time of HeartMate II LVAD insertion...
  80. doi request reprint Fibrinolytic activation during long-term support with the HeartMate II left ventricular assist device
    Mark S Slaughter
    Cardiac Surgery Research, Advocate Christ Medical Center, Oak Lawn, Illinois 60453, USA
    ASAIO J 54:115-9. 2008
    ..Three nonfatal bleeding events but no thromboembolic events were observed. Fibrinolytic responses initially increase after LVAD implantation but then gradually normalize...
  81. doi request reprint Is female sex an independent risk factor for perioperative transfusion in coronary artery bypass graft surgery?
    Matthew L Williams
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, KY, USA
    J Am Coll Surg 212:362-6. 2011
    ..We evaluated female sex as an independent risk factor for red blood cell transfusion in CABG, while accounting for hematocrit...
  82. ncbi request reprint The Thoratec mobile computer: initial in-hospital and outpatient experience
    Michael A Sobieski
    Division of Cardiac Surgery, Advocate Christ Medical Center, Oak Lawn, IL 60453, USA
    ASAIO J 50:373-5. 2004
    ..Data were successfully obtained in all cases. Documentation of programmed settings and driver operation was achieved without difficulty...
  83. ncbi request reprint Antegrade versus retrograde cerebral protection in repair of acute ascending aortic dissection
    Matthew L Williams
    Division of Thoracic and Cardiovascular Surgery, University of Louisville, Louisville, Kentucky, USA
    Am Surg 78:349-51. 2012
    ..514 and 0.956, respectively). No compelling evidence for an advantage to either antegrade or retrograde cerebral perfusion was detected. Further study with a focus on neurologic outcomes is warranted...
  84. ncbi request reprint Destination therapy: the future is arriving
    Mark S Slaughter
    Department of Cardiothoracic Surgery, Mechanical Assist Device Program, Advocate Christ Medical Center, 4400 West 95th Street, Oak Lawn, IL 60453, USA
    Congest Heart Fail 11:155-6. 2005
  85. doi request reprint Mechanistic pathway(s) of acquired von willebrand syndrome with a continuous-flow ventricular assist device: in vitro findings
    Sujith Dassanayaka
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    ASAIO J 59:123-9. 2013
    ..A modest increase in plasma ADAMTS-13 from activated platelets may have contributed to this process but was not the major mechanism. Mechanical demolition was likely the dominant process and warrants further evaluation...
  86. doi request reprint Acute myocardial infarction complicated by cardiogenic shock: role of mechanical circulatory support
    Sanjeev Aggarwal
    University of Louisville, Cardiovascular Innovation Institute, Division of Thoracic and Cardiovascular Surgery, Louisville, KY 40202, USA
    Expert Rev Cardiovasc Ther 6:1223-35. 2008
    ..However, access to revascularization and VAD support, including percutaneous VADs, is currently limited and must improve to more effectively treat AMI-CS patients...
  87. ncbi request reprint Percutaneous endoscopic gastrostomy tube in a patient with a left ventricular assist device
    Mark S Slaughter
    Division Cardiac Surgery, Mechanical Assist Device Program, Advocate Christ Medical Center, 4400 W 95th Street, Suite 205, Oak Lawn, IL 60453, USA
    ASAIO J 49:611-2. 2003
    ..We believe that PEG placement should be cpnsidered in patients with an LVAD with swallowing difficulties or who are debilitated are not meeting their caloric requirements...