Affiliation: University of Pennsylvania
- CTCF binding site classes exhibit distinct evolutionary, genomic, epigenomic and transcriptomic featuresKobby Essien
Penn Center for Bioinformatics, Department of Genetics, 415 Curie Boulevard, University of Pennsylvania, Philadelphia, PA 19104, USA
Genome Biol 10:R131. 2009..It is possible that the differences in CTCF-DNA conformation at different binding sites underlie CTCF's functional diversity. If so, the CTCF binding sites may belong to distinct classes, each compatible with a specific functional role...
- Correlated changes between regulatory cis elements and condition-specific expression in paralogous gene familiesLarry N Singh
Penn Center for Bioinformatics, Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA
Nucleic Acids Res 38:738-49. 2010..Our work presents a novel means of investigating the cis regulatory changes potentially mediating expression divergence in paralogous gene families under specific conditions...
- Mimosa: Mixture model of co-expression to detect modulators of regulatory interactionMatthew Hansen
Department of Genetics, Penn Center for Bioinformatics, University of Pennsylvania, Pennsylvania, USA
Algorithms Mol Biol 5:4. 2010..CONCLUSIONS: While limited in some ways, as discussed, the work represents a novel approach to mine expression data and detect potential modulators of regulatory interactions...