J M Siegfried

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Lung cancer screening in high-risk populations
    J M Siegfried
    Department of Pharmacology, University of Pittsburgh and Lung Cancer Basic Research Program, University of Pittsburgh Cancer Institute, PA 15261, USA
    Clin Lung Cancer 1:100-6; discussion 107. 1999
  2. pmc Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers
    Yang Liu
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    BMC Cancer 7:74. 2007
  3. ncbi request reprint Signaling pathways involved in cyclooxygenase-2 induction by hepatocyte growth factor in non small-cell lung cancer
    Jill M Siegfried
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Pharmacol 72:769-79. 2007
  4. ncbi request reprint The clinical significance of hepatocyte growth factor for non-small cell lung cancer
    J M Siegfried
    Department of Pharmacology and University of Pittsburgh Cancer Institute, Lung Cancer Basic Science Program, University of Pittsburgh, Pennsylvania 15261, USA
    Ann Thorac Surg 66:1915-8. 1998
  5. ncbi request reprint Women and lung cancer: does oestrogen play a role?
    J M Siegfried
    Department of Pharmacology, University of Pittsburgh, University of Pittsburgh Cancer Institute, PA 15261, USA
    Lancet Oncol 2:506-13. 2001
  6. ncbi request reprint Expression of mRNA for gastrin-releasing peptide receptor by human bronchial epithelial cells. Association with prolonged tobacco exposure and responsiveness to bombesin-like peptides
    J M Siegfried
    Department of Pharmacology, University of Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 156:358-66. 1997
  7. ncbi request reprint Hepatocyte growth factor promotes tumor growth in a novel in vivo model of human lung cancer
    J M Pilewski
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Cell Mol Biol 24:556-62. 2001
  8. ncbi request reprint Expression of mRNA for three bombesin receptor subtypes in human bronchial epithelial cells
    M A DeMichele
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pennsylvania 15261
    Am J Respir Cell Mol Biol 11:66-74. 1994
  9. pmc HGF-independent potentiation of EGFR action by c-Met
    A M Dulak
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA
    Oncogene 30:3625-35. 2011
  10. ncbi request reprint Inhibition of human non-small cell lung tumors by a c-Met antisense/U6 expression plasmid strategy
    L P Stabile
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Gene Ther 11:325-35. 2004

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Lung cancer screening in high-risk populations
    J M Siegfried
    Department of Pharmacology, University of Pittsburgh and Lung Cancer Basic Research Program, University of Pittsburgh Cancer Institute, PA 15261, USA
    Clin Lung Cancer 1:100-6; discussion 107. 1999
    ..Lung cancer will continue to be a major public health problem in the next century. Advances in the field of early detection may make lung cancer screening practical and effective in the near future...
  2. pmc Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers
    Yang Liu
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    BMC Cancer 7:74. 2007
    ..We compare the results with the smoking status of the patients and the mutation status of the K-ras, p53, and EGFR genes determined previously on these same lung tumors...
  3. ncbi request reprint Signaling pathways involved in cyclooxygenase-2 induction by hepatocyte growth factor in non small-cell lung cancer
    Jill M Siegfried
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Pharmacol 72:769-79. 2007
    ..Targeting of both the HGF/c-Met and PGE(2) pathways with a neutralizing antibody to HGF and celecoxib resulted in enhanced anti-invasion effects in response to HGF...
  4. ncbi request reprint The clinical significance of hepatocyte growth factor for non-small cell lung cancer
    J M Siegfried
    Department of Pharmacology and University of Pittsburgh Cancer Institute, Lung Cancer Basic Science Program, University of Pittsburgh, Pennsylvania 15261, USA
    Ann Thorac Surg 66:1915-8. 1998
    ..Evidence from breast cancer patients suggests that HGF is a negative prognostic indicator for breast cancer and is associated with invasive disease...
  5. ncbi request reprint Women and lung cancer: does oestrogen play a role?
    J M Siegfried
    Department of Pharmacology, University of Pittsburgh, University of Pittsburgh Cancer Institute, PA 15261, USA
    Lancet Oncol 2:506-13. 2001
    ..Lung-cancer incidence and risk in women are discussed, and evidence for possible mechanisms of increased female risk are presented, including the role of oestrogen in the development of lung cancer...
  6. ncbi request reprint Expression of mRNA for gastrin-releasing peptide receptor by human bronchial epithelial cells. Association with prolonged tobacco exposure and responsiveness to bombesin-like peptides
    J M Siegfried
    Department of Pharmacology, University of Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 156:358-66. 1997
    ..These effects appear to persist after smoking cessation...
  7. ncbi request reprint Hepatocyte growth factor promotes tumor growth in a novel in vivo model of human lung cancer
    J M Pilewski
    Department of Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Cell Mol Biol 24:556-62. 2001
    ..These data demonstrate the usefulness of this novel in vivo model to study NSCLC, and show that HGF promotes both the growth and invasion of human lung cancer in vivo...
  8. ncbi request reprint Expression of mRNA for three bombesin receptor subtypes in human bronchial epithelial cells
    M A DeMichele
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pennsylvania 15261
    Am J Respir Cell Mol Biol 11:66-74. 1994
    ..Furthermore, GRP induced expression of the early-response gene, c-jun, in an HBE cell culture and an NSCLC cell line. GRP also promoted colony formation in the NSCLC cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  9. pmc HGF-independent potentiation of EGFR action by c-Met
    A M Dulak
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA
    Oncogene 30:3625-35. 2011
    ..Combined targeting of c-Met and EGFR leads to increased xenograft antitumor activity, demonstrating that inhibition of downstream and lateral signaling from the EGFR-c-Src-c-Met axis might be effective in treatment of NSCLC...
  10. ncbi request reprint Inhibition of human non-small cell lung tumors by a c-Met antisense/U6 expression plasmid strategy
    L P Stabile
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Gene Ther 11:325-35. 2004
    ..These results suggest that targeting the HGF/c-Met pathway may be an effective novel strategy to treat lung cancer patients...
  11. ncbi request reprint Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer
    S P Shriver
    Department of Pharmacology, Lung Cancer Program, University of Pittsburgh Cancer Institute, PA, USA
    J Natl Cancer Inst 92:24-33. 2000
    ..Increasing evidence demonstrates that women are more susceptible than men to tobacco carcinogenesis. We hypothesized that the susceptibility of women to the effects of tobacco may be associated with airway expression of GRPR...
  12. pmc Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts
    Diane L Carlisle
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA
    Respir Res 5:27. 2004
    ..We examined nAChR subunit expression in short-term cultures of human airway cells derived from a series of never smokers, ex-smokers, and active smokers...
  13. ncbi request reprint Mutation and polymorphism in the EGFR-TK domain associated with lung cancer
    Weiping Zhang
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
    J Thorac Oncol 1:635-47. 2006
    ..Somatic EGFR mutations are predictors of response to treatment with EGFR tyrosine kinase (TK) inhibitors (TKIs) for lung cancer, especially among never smokers. EGFR mutations may occur independently of other genetic alterations...
  14. ncbi request reprint Trinucleotide repeat length variation in the human ribosomal protein L14 gene (RPL14): localization to 3p21.3 and loss of heterozygosity in lung and oral cancers
    S P Shriver
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh, PA 15261, USA
    Mutat Res 406:9-23. 1998
    ..In addition, RPL14 shows significant differences in allele frequency distribution in ethnically-defined populations, making this sequence a useful marker for the study of ethnicity-adjusted lung cancer risk...
  15. ncbi request reprint Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells
    Diane L Carlisle
    Department of Pharmacology, University of Pittsburgh, E1340 Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Pulm Pharmacol Ther 20:629-41. 2007
    ..In addition, exposure of NSCLC patients to nicotine through use of nicotine replacement products or use of tobacco products may alter the efficacy of therapy with EGFR inhibitors...
  16. ncbi request reprint Gastrin-releasing peptide activates Akt through the epidermal growth factor receptor pathway and abrogates the effect of gefitinib
    Xuwan Liu
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Lab 2 7, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    Exp Cell Res 313:1361-72. 2007
    ..GRP appears to rescue NSCLC cells exposed to gefitinib through release of amphiregulin and activation of the Akt pathway, suggesting GRPR and/or EGFR autocrine pathways in NSCLC cells may modulate therapeutic response to EGFR inhibitors...
  17. ncbi request reprint No association between the XPD 312, 751, or XRCC1 399 polymorphisms and K-ras gene mutation in smoking non-small-cell lung cancer
    Wei Min Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Cancer Epidemiol Biomarkers Prev 13:673-5. 2004
  18. ncbi request reprint Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer
    Wei Min Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Carcinogenesis 24:1671-6. 2003
    ..These results suggest that individuals who smoke and have the XPD codon 312 Asp/Asp genotype may be at a greater risk of p53 mutations, especially if combined with other polymorphisms that may result in deficient DNA repair...
  19. ncbi request reprint Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen
    Laura P Stabile
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Cancer Res 62:2141-50. 2002
    ..Additionally, it is possible that antiestrogens may have therapeutic value to treat or prevent lung cancer...
  20. pmc Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Neoplasia 7:426-31. 2005
    ..Because a major effect of GRPR appears to be promoting the release of EGFR ligand, this study suggests that a greater inhibition of cell proliferation may occur by abrogating EGFR ligand release in consort with inhibition of EGFR...
  21. ncbi request reprint Use of ERCC1 polymorphism and extreme drug resistance assay to predict overall non-small cell lung cancer survival and responsiveness to platinum-based chemotherapy agents
    M Romkes
    University of Pittsburgh, Pittsburgh, PA University of Pittsburgh Medical Center, Pittsburgh, PA
    J Clin Oncol 26:8092. 2008
    ..Here, we evaluated the role of genetic variation in the ERCC1 gene on non- small cell lung cancer (NSCLC) survival in 81 cases that were also evaluated for EDR...
  22. ncbi request reprint Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer
    J M Siegfried
    Department of Pharmacology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15261, USA
    Pulm Pharmacol Ther 12:291-302. 1999
    ..If BLP ligand-receptor systems are to be targeted therapeutically in NSCLC, it will be necessary to inhibit both NMB and GRP...
  23. pmc Topographic analysis of K- ras mutations in histologically normal lung tissues and tumours of lung cancer patients
    P Keohavong
    Departments of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Br J Cancer 85:235-41. 2001
    ....
  24. ncbi request reprint Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects
    Laura P Stabile
    Department of Pharmacology and Otolaryngology, University of Pittsburgh and Lung and Thoracic Malignancy Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer Res 65:1459-70. 2005
    ..These studies provide evidence of a functional interaction between the ER and the EGFR pathways in NSCLC...
  25. ncbi request reprint Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation
    Wen Yue
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 13:4336-44. 2007
    ..The goal of this study is to identify novel genes frequently silenced by promoter hypermethylation in lung cancer...
  26. pmc Estrogen receptor beta (ERbeta) subtype-specific ligands increase transcription, p44/p42 mitogen activated protein kinase (MAPK) activation and growth in human non-small cell lung cancer cells
    Pamela A Hershberger
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Steroid Biochem Mol Biol 116:102-9. 2009
    ..008) and in vivo (p=0.05). We conclude that ERbeta mediates genomic and non-genomic responses to estrogen in 201T cells and that activation of both pathways may be necessary for increased proliferation of these cells...
  27. pmc HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer
    Lynn M Knowles
    Departments of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 15:3740-50. 2009
    ....
  28. pmc Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression
    Wen Yue
    Department of Pharmacology and Chemical Biolog, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 69:6339-46. 2009
    ..Collectively, these results suggest that epigenetic silencing of fibulin-5 promotes lung cancer invasion and metastasis by activating MMP-7 expression through the ERK pathway...
  29. pmc Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients
    Yang Liu
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Neoplasia 8:46-51. 2006
    ..Our results suggest an association between tobacco smoking and an increased incidence of aberrant promoter methylation of the p16 and MGMT genes in non-small cell lung cancer...
  30. ncbi request reprint Transgenic mice overexpressing hepatocyte growth factor in the airways show increased susceptibility to lung cancer
    Laura P Stabile
    Department of Pharmacology, University of Pittsburgh Cancer Institute, PA 15261, USA
    Carcinogenesis 27:1547-55. 2006
    ....
  31. ncbi request reprint Regulation of endogenous gene expression in human non-small cell lung cancer cells by estrogen receptor ligands
    Pamela A Hershberger
    Department of Pharmacology, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer Res 65:1598-605. 2005
    ..ICI 182,780 may therefore have therapeutic benefit in NSCLC...
  32. pmc NF-κB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-κB function
    F Sun
    University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Oncogene 35:2299-310. 2016
    ..These studies reveal an unexpected, NF-κB-independent but Tpl2-depenednt role of NF-κB1 in lung tumor suppression. These studies also reveal a previously unexplored role of p105/Tpl2 signaling in lung homeostasis. ..
  33. ncbi request reprint Multianalyte profiling of serum cytokines for detection of pancreatic cancer
    H J Zeh
    Division of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cancer Biomark 1:259-69. 2005
    ..4%. In conclusion, we demonstrated that analysis of multiple serum cytokines using a novel LabMAP technology is a promising approach for development of a diagnostic assay for pancreatic cancer...
  34. pmc Association of radiographic emphysema and airflow obstruction with lung cancer
    David O Wilson
    Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 178:738-44. 2008
    ..To study the relationship between emphysema and/or airflow obstruction and lung cancer in a high-risk population...
  35. pmc The Pittsburgh Lung Screening Study (PLuSS): outcomes within 3 years of a first computed tomography scan
    David O Wilson
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15232, USA
    Am J Respir Crit Care Med 178:956-61. 2008
    ..The role of computed tomography (CT) screening for lung cancer is controversial, currently under study, and not yet fully elucidated...
  36. pmc Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis
    Laura P Stabile
    Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Mol Cancer Ther 7:1913-22. 2008
    ..These preclinical results show that blocking the HGF/c-Met interaction with a single monoclonal antibody delivered systemically can have profound inhibitory effects on development of lung tumors...
  37. pmc Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas
    Weiping Zhang
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Mol Cancer Res 6:1946-56. 2008
    ..These results suggest that EGFR and MAPK are required for COX-2 induction by bradykinin. Up-regulation of the B2R in head and neck cancers suggests that this pathway is involved in HNSCC tumorigenesis...
  38. ncbi request reprint Lung cancer-derived bombesin-like peptides down-regulate the generation and function of human dendritic cells
    Valeria P Makarenkova
    Department of Pathology, University of Pittsburgh Medical Center and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Neuroimmunol 145:55-67. 2003
    ..This suggests a new mechanism of tumor escape and provides new targets for the immunopharmacological correction of immune effectors in cancer...
  39. ncbi request reprint Comparison of p53 mutations between adenocarcinoma and squamous cell carcinoma of the lung: unique spectra involving G to A transitions and G to T transversions in both histologic types
    Wei Min Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Lung Cancer 40:141-50. 2003
    ..Mutation in p53 was not found to be related to patient survival in this group of patients, while tumor size and degree of differentiation were poor survival predictors...
  40. ncbi request reprint Sex and gender differences in lung cancer
    Laura P Stabile
    Department of Pharmacology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    J Gend Specif Med 6:37-48. 2003
    ..Both sex and gender differences in smoking-related disease will be discussed in this review...
  41. pmc Estrogen receptor signaling in lung cancer
    Jill M Siegfried
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Semin Oncol 36:524-31. 2009
    ..An additional protein that recognizes 17beta-estradiol with high affinity, GPR30, also is expressed in lung tumors at high levels and may be responsible for some of the proliferation signals induced by estrogen...
  42. pmc Early changes in pulmonary gene expression following tobacco exposure shed light on the role of estrogen metabolism in lung carcinogenesis
    Jill M Siegfried
    University of Pittsburgh Cancer Institute, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pennsylvania, USA
    Cancer Prev Res (Phila) 3:692-5. 2010
    ..Actions of estrogens that contribute to lung carcinogenesis, especially in the presence of tobacco smoke, may involve both reactive intermediates that damage DNA and steroid hormone receptor signaling that promotes growth...
  43. ncbi request reprint Elevated hepatocyte growth factor level correlates with poor outcome in early-stage and late-stage adenocarcinoma of the lung
    Jill M Siegfried
    Department of Pharmacology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 1863, USA
    Chest 125:116S-9S. 2004
  44. ncbi request reprint Polymorphisms in DNA repair genes XPD and XRCC1 and p53 mutations in lung carcinomas of never-smokers
    Wei Min Gao
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Mol Carcinog 45:828-32. 2006
    ....
  45. ncbi request reprint Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract
    Shama Buch
    Center for Clinical Pharmacology, Department of Medicine, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA
    Mol Carcinog 42:222-8. 2005
    ..This is the first study to suggest an associative interaction between XPD and CCND1 genetic polymorphisms, tobacco exposure, and cancer risk...
  46. ncbi request reprint SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells
    Qing Zhang
    Department of Otolaryngology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 64:6166-73. 2004
    ..These results suggest that Src family kinases contribute to GRP-mediated EGFR growth and invasion pathways by facilitating cleavage and release of TGF-alpha and amphiregulin in HNSCC...
  47. ncbi request reprint Estrogen receptor pathways in lung cancer
    Laura P Stabile
    Department of Pharmacology, University of Pittsburgh, Hillman Cancer Center, UPCI Research Pavilion, Suite 2 18, Pittsburgh, PA 15213 1863, USA
    Curr Oncol Rep 6:259-67. 2004
    ..An understanding of these new developments in estrogen signaling and cross-talk pathways may pave the way for innovative combinatorial approaches for treatment of lung cancer and possibly chemoprevention...
  48. pmc Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma
    Priya Koppikar
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 14:4284-91. 2008
    ..This study was undertaken to elucidate the role of c-Src in the growth and invasion of HNSCC and to determine the effects of combined targeting of EGFR and Src kinases in HNSCC cell lines...
  49. ncbi request reprint Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer
    Qing Zhang
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Mol Cancer Ther 6:1414-24. 2007
    ..Cumulatively, these results suggest that GRPR targeting can enhance the antitumor effects of EGFR inhibitors in head and neck cancer...
  50. ncbi request reprint Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patients
    Bridget Hathaway
    Department of Otolaryngology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Laryngoscope 115:522-7. 2005
    ..Furthermore, we hypothesized that persistent immune dysregulation in patients cured of their disease may be reflected in altered cytokine profiles in the systemic circulation...
  51. ncbi request reprint Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma
    Sufi Mary Thomas
    Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Cancer Res 66:11831-9. 2006
    ..Combined blockade of both EGFR and GPCRs may be a rational strategy to treat cancers, including HNSCC that shows cross-talk between GPCR and EGFR signaling pathways...
  52. pmc Cross-talk between estrogen receptor and epidermal growth factor receptor in head and neck squamous cell carcinoma
    Ann Marie Egloff
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Clin Cancer Res 15:6529-40. 2009
    ....
  53. ncbi request reprint Association of the EGFR intron 1 CA repeat length with lung cancer risk
    Weiping Zhang
    Department of Pharmacology, University of Pittsburgh Cancer Institute, SPORE in Lung Cancer, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
    Mol Carcinog 46:372-80. 2007
    ..Our study, which is preliminary, demonstrates for the first time that shorter EGFR-CA repeats associate with lung cancer risk. The number of EGFR-CA repeats identifies a possible susceptible population to lung cancer...
  54. ncbi request reprint Non-small-cell lung cancer and breast carcinoma: chemotherapy and beyond
    Sarita Dubey
    Division of Hematology Oncology, University of California, San Francisco, CA 94115, USA
    Lancet Oncol 7:416-24. 2006
    ..The optimum application of hormonal manipulation to prevent or treat lung cancer will depend on a more-complete understanding of lung-specific ER signalling. Early trials have assessed the interaction between the ER and EGFR signalling...
  55. ncbi request reprint Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck
    Miriam N Lango
    Department of Otolaryngology, University of Pittsburgh School of Medicine, PA, USA
    J Natl Cancer Inst 94:375-83. 2002
    ....
  56. ncbi request reprint Hormone replacement therapy and decreased lung cancer survival
    Jill M Siegfried
    J Clin Oncol 24:9-10. 2006
  57. pmc Diagnostic accuracy of MALDI mass spectrometric analysis of unfractionated serum in lung cancer
    Pinar B Yildiz
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Thorac Oncol 2:893-901. 2007
    ..We hypothesized that matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) analysis of the most abundant peptides in the serum may distinguish lung cancer cases from matched controls...
  58. ncbi request reprint Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer
    Wen Yue
    Department of Pharmacology
    Carcinogenesis 29:84-92. 2008
    ..These observations suggested that epigenetic inactivation of Dkk3 activates the Wnt/beta-catenin pathway, thereby promoting the growth of lung cancer cells...