Affiliation: University of Rochester
- Evidence that msh1p plays multiple roles in mitochondrial base excision repairLeah Pogorzala
Department of Biology, University of Rochester, Rochester, New York 14627, USA
Genetics 182:699-709. 2009..In addition to this separation of function, we also found that the role of Msh1p in BER is unlikely to be involved in the avoidance of large-scale deletions and rearrangements...
- Ntg1p, the base excision repair protein, generates mutagenic intermediates in yeast mitochondrial DNANaina Phadnis
Department of Biology, University of Rochester, NY 14627 0211, USA
DNA Repair (Amst) 5:829-39. 2006..In addition, loss of Apn1p also suppressed mitochondrial point mutations. Our work suggests that both Ntg1p and Apn1p generate mutagenic intermediates in the yeast mitochondrial genome...
- The yeast MSH1 gene is not involved in DNA repair or recombination during meiosisElaine A Sia
Department of Biology, University of Rochester, River Campus Box 270211, Rochester, New York 14627 0211, USA
DNA Repair (Amst) 4:253-61. 2005..These data indicate that the MSH1 protein, unlike other MutS homologs in yeast, plays no role in DNA repair or recombination during meiosis...
- Overlapping contributions of Msh1p and putative recombination proteins Cce1p, Din7p, and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces cerevisiaeShona A Mookerjee
Department of Biology, University of Rochester, Rochester, NY 14627 0211, USA
Mutat Res 595:91-106. 2006..In addition, we demonstrate a novel role for Msh1p in mtDNA transmission, a role not predicted by studies of its nuclear homologs...
- Analysis of the functional domains of the mismatch repair homologue Msh1p and its role in mitochondrial genome maintenanceShona A Mookerjee
Department of Biology, University of Rochester, RC Box 270211, Rochester, NY 14627 0211, USA
Curr Genet 47:84-99. 2005..Our overall findings suggest that these additional predicted functions of Msh1p, including recombination surveillance and heteroduplex rejection, may be primarily responsible for its essential role in mtDNA stability...
- Evidence for a role of FEN1 in maintaining mitochondrial DNA integrityLIDZA KALIFA
Department of Biology, University of Rochester, NY 14627, United States
DNA Repair (Amst) 8:1242-9. 2009..Our findings demonstrate that Rad27p/FEN1 is localized in the mitochondrial compartment of both yeast and mice and that Rad27p has a significant role in maintaining mtDNA integrity...
- Analysis of repeat-mediated deletions in the mitochondrial genome of Saccharomyces cerevisiaeNaina Phadnis
Department of Biological Sciences, University of Rochester, Rochester, NY 14627, USA
Genetics 171:1549-59. 2005..We discuss how this reporter may be used to identify the proteins in yeast that have an impact on the generation of direct-repeat-mediated deletions...
- Analysis of Rev1p and Pol zeta in mitochondrial mutagenesis suggests an alternative pathway of damage toleranceLIDZA KALIFA
Department of Biology, University of Rochester, Rochester, NY 14627, United States
DNA Repair (Amst) 6:1732-9. 2007..Our data provides evidence for an alternative damage tolerance pathway that is specific to the mitochondrial compartment...
- DNA Repair and Mutagenesis in S cerevisiaeElaine Sia; Fiscal Year: 2005..The experiments in this proposal are aimed at understanding the processes of mutagenesis and repair of mitochondrial DNA in yeast, however, these studies may lead to insights into similar processes in human mitochondrial DNA. ..