Janet M Shaw

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc The role of Fis1p-Mdv1p interactions in mitochondrial fission complex assembly
    Mary Anne Karren
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Cell Biol 171:291-301. 2005
  2. pmc Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway
    Rebecca L Frederick
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 167:87-98. 2004
  3. pmc Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission
    Sajjan Koirala
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 110:E1342-51. 2013
  4. ncbi request reprint Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1
    Debjani Bhar
    Biochemistry Department, University of Utah School of Medicine, Salt Lake City, Utah 84112 5650, USA
    J Biol Chem 281:17312-20. 2006
  5. pmc A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover
    Elizabeth A Amiott
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Mol Biol Cell 20:5026-35. 2009
  6. pmc Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis
    Noriko Kondo-Okamoto
    Department of Biochemistry, University of Utah School of Medicine, 15 North Medical Drive East, Salt Lake City, UT 84112 5650, USA
    EMBO Rep 9:63-9. 2008
  7. pmc A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment
    Huyen T Bui
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    J Cell Biol 199:613-22. 2012
  8. pmc The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast
    Noriko Kondo-Okamoto
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Mol Biol Cell 17:3756-67. 2006
  9. pmc Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast
    Jason M Singer
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 100:7644-9. 2003
  10. pmc Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations
    Elizabeth A Amiott
    Department of Biochemistry, University of Utah School of Medicine, 15 N Medical Drive East, Salt Lake City, UT 84112, USA
    Exp Neurol 211:115-27. 2008

Collaborators

  • Koji Okamoto
  • Amy D Mozdy
  • Allan M Weissman
  • Katsumi Kitagawa
  • Peter B Kang
  • Christer S Ejsing
  • Gary N Drews
  • Markus Babst
  • Michael S Kay
  • Victoria H Lawson
  • Mickael M Cohen
  • Heidi L Schubert
  • Dennis R Voelker
  • Adam Frost
  • Barbara E Ainsworth
  • S DiMauro
  • Huyen T Bui
  • Sajjan Koirala
  • Rebecca L Frederick
  • Noriko Kondo-Okamoto
  • Elizabeth A Amiott
  • J Michael McCaffery
  • Agnieszka Lewandowska
  • Qian Guo
  • Mary Anne Karren
  • Debjani Bhar
  • Kerrie L McDonald
  • Emily M Coonrod
  • Shawn H Dolan
  • Tammy T Nguyen
  • Debra M Eckert
  • Steven W Gorsich
  • Marianne S Elston
  • Nicholas S Little
  • Raymond J Cook
  • Bruce G Robinson
  • Nanna L Meyer
  • Jason M Singer
  • Cory A Christensen
  • Raghav Kalia
  • Jane Macfarlane
  • Mirco Junker
  • Jae Yeon Choi
  • Mesut Bilgin
  • Mary A Karren
  • Daniel F Markgraf
  • Tom A Rapoport
  • Edward M Perkins
  • Christopher P Hill
  • Yann Saint-Georges
  • John V Conaglen
  • Andrew J J Law
  • Anthony J Gill
  • Adele Clarkson
  • Roderick J Clifton-Bligh
  • E Dale Abel
  • Jamie Soto
  • Paul Lott
  • Kevin M Flanigan
  • Jonathon F Parkinson
  • Cathy A Payne
  • Helen T Wheeler
  • Charlie Teo
  • Glenn Stone
  • Dianne J Reader
  • Michael T Biggs
  • Janice M Brewer
  • Lawrence Young
  • Maree G O'Sullivan
  • Daniel P Williams
  • Kentaro Ohkuni
  • Teresa K Anderson
  • James A Walker
  • Kyle W Cunningham
  • Andrew W Subudhi
  • Melinda M Manore
  • Barry B Shultz
  • Linda G Jones
  • Jessica Brown
  • Ryan H Brown

Detail Information

Publications28

  1. pmc The role of Fis1p-Mdv1p interactions in mitochondrial fission complex assembly
    Mary Anne Karren
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Cell Biol 171:291-301. 2005
    ..These studies suggest that the concave binding surface of the Fis1p TPR-like fold interacts with Mdv1p during mitochondrial fission and that Mdv1p facilitates Dnm1p recruitment into functional fission complexes...
  2. pmc Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway
    Rebecca L Frederick
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 167:87-98. 2004
    ..2003. J. Biol. Chem. 278:6495-6502), Gem1p is not required for pheromone-induced yeast cell death. Thus, Gem1p defines a novel mitochondrial morphology pathway which may integrate cell signaling events with mitochondrial dynamics...
  3. pmc Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission
    Sajjan Koirala
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 110:E1342-51. 2013
    ..This result demonstrates that an adaptor protein alters the architecture of a mitochondrial dynamin GTPase polymer in a manner that could facilitate membrane constriction and severing activity...
  4. ncbi request reprint Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1
    Debjani Bhar
    Biochemistry Department, University of Utah School of Medicine, Salt Lake City, Utah 84112 5650, USA
    J Biol Chem 281:17312-20. 2006
    ..Fis1p complexes. These dimers then assemble into multimers that subsequently promote the reorganization of Mdv1p into punctate fission complexes...
  5. pmc A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover
    Elizabeth A Amiott
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Mol Biol Cell 20:5026-35. 2009
    ....
  6. pmc Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis
    Noriko Kondo-Okamoto
    Department of Biochemistry, University of Utah School of Medicine, 15 North Medical Drive East, Salt Lake City, UT 84112 5650, USA
    EMBO Rep 9:63-9. 2008
    ..Our data indicate an unexpected role for Tom70 in recruitment of soluble proteins to the mitochondrial surface, and indicate that Tom71 has a specialized role in Mfb1-mediated mitochondrial morphogenesis...
  7. pmc A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment
    Huyen T Bui
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    J Cell Biol 199:613-22. 2012
    ..Based on the variability of Insert B sequences and adaptor proteins, we propose that Insert B domains and mitochondrial adaptors have coevolved to meet the unique requirements for mitochondrial fission of different organisms...
  8. pmc The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast
    Noriko Kondo-Okamoto
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Mol Biol Cell 17:3756-67. 2006
    ..We propose that Mfb1p operates in a novel pathway regulating mitochondrial tubular connectivity...
  9. pmc Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast
    Jason M Singer
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 100:7644-9. 2003
    ..These combined results strongly suggest that Mdm20p-dependent, N-terminal acetylation of Tpm1p by the NatB complex is required for Tpm1p association with, and stabilization of, actin filaments and cables...
  10. pmc Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations
    Elizabeth A Amiott
    Department of Biochemistry, University of Utah School of Medicine, 15 N Medical Drive East, Salt Lake City, UT 84112, USA
    Exp Neurol 211:115-27. 2008
    ..We discuss our results and those of others in terms of a comprehensive model for the mechanism(s) by which mutations in MFN2 may lead to CMT2A disease...
  11. pmc Mitochondrial association, protein phosphorylation, and degradation regulate the availability of the active Rab GTPase Ypt11 for mitochondrial inheritance
    Agnieszka Lewandowska
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Mol Biol Cell 24:1185-95. 2013
    ..We present a model that synthesizes these new features of Ypt11 function and regulation in mitochondrial inheritance...
  12. pmc Importance of mitochondrial dynamics during meiosis and sporulation
    Steven W Gorsich
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Mol Biol Cell 15:4369-81. 2004
    ..These results provide evidence of fitness defects caused by fission mutations and reveal new phenotypes associated with fission and fusion mutations...
  13. pmc The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent
    Qian Guo
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 7:e53523. 2012
    ..Rather, our functional and phylogenetic analyses indicate that Caf4 mitochondrial fission activity has diverged from that of Mdv1...
  14. pmc Multiple pathways influence mitochondrial inheritance in budding yeast
    Rebecca L Frederick
    Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Genetics 178:825-37. 2008
    ..This study demonstrates that multiple pathways influence mitochondrial inheritance in yeast and that Miro GTPases have conserved roles in mitochondrial distribution...
  15. pmc Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes
    Sajjan Koirala
    Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 191:1127-39. 2010
    ..Our results provide a framework for understanding how adaptors act as scaffolds to orient and stabilize the assembly of dynamins on membranes...
  16. ncbi request reprint A fuzzy mitochondrial fusion apparatus comes into focus
    Amy D Mozdy
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112, USA
    Nat Rev Mol Cell Biol 4:468-78. 2003
    ..Recent studies have revealed that Fzo has an evolutionarily conserved role in mitochondrial fusion, and they take the first strides in determining the molecular nature of such a role...
  17. pmc Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance
    Tammy T Nguyen
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Traffic 13:880-90. 2012
    ..Finally, we show that ERMES complexes are long-lived, and do not depend on the presence of Gem1. Our findings suggest that the ERMES complex may have primarily a structural role in maintaining mitochondrial morphology...
  18. pmc Dynamin assembly strategies and adaptor proteins in mitochondrial fission
    Huyen T Bui
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Curr Biol 23:R891-9. 2013
    ..Here, we review the structure and assembly properties of the yeast and mammalian mitochondrial dynamins and discuss what is known about the activities of their adaptor proteins. ..
  19. ncbi request reprint Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation
    Noriko Kondo-Okamoto
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 278:48997-9005. 2003
    ..Our data suggest that the double membrane-spanning topology of Mmm1p at the membrane contact site is critical for formation of tubular mitochondria...
  20. ncbi request reprint Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes
    Koji Okamoto
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84132 3201, USA
    Annu Rev Genet 39:503-36. 2005
    ..Here we review recent advances in the field of mitochondrial dynamics and highlight the importance of these pathways to human health...
  21. pmc Moving mitochondria: establishing distribution of an essential organelle
    Rebecca L Frederick
    Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA
    Traffic 8:1668-75. 2007
    ..Anchoring of stationary mitochondria also contributes to organelle retention at specific sites in the cell. Together, movement and anchoring ultimately determine mitochondrial distribution throughout the cell...
  22. pmc Mitochondrial GFA2 is required for synergid cell death in Arabidopsis
    Cory A Christensen
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    Plant Cell 14:2215-32. 2002
    ..GFA2 is targeted to mitochondria in Arabidopsis and partially complements a yeast mdj1 mutant, suggesting that GFA2 is the Arabidopsis ortholog of yeast Mdj1p. These data suggest a role for mitochondria in cell death in plants...
  23. ncbi request reprint Development and reproducibility of the bone loading history questionnaire
    Shawn H Dolan
    Department of Exercise and Sport Science, University of Utah, Salt Lake City, UT 84112 0920, USA
    Med Sci Sports Exerc 38:1121-31. 2006
    ..Additional purposes were to correlate bone loading units with areal bone mineral density (aBMD) and to determine whether low levels of bone loading increase the odds for low aBMD in healthy premenopausal women...
  24. pmc Mitochondrial dynamics and division in budding yeast
    Janet M Shaw
    Dept of Biology, University of Utah, 257 S 1400 E, Salt Lake City, UT 84112, USA
    Trends Cell Biol 12:178-84. 2002
    ..These and other new findings suggest a common mechanism for membrane fission events that has been conserved and adapted during eukaryotic evolution...
  25. ncbi request reprint Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion
    Emily M Coonrod
    Institute of Molecular Biology, University of Oregon, Eugene, OR 97401, USA
    Traffic 8:500-11. 2007
    ..These studies identify PCD2 as a functional domain of Ugo1p and provide the first experimental evidence for a multipass topology of this essential fusion component...
  26. ncbi request reprint Wnt pathway inhibitors are strongly down-regulated in pituitary tumors
    Marianne S Elston
    Cancer Genetics Unit, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    Endocrinology 149:1235-42. 2008
    ..In conclusion, our data suggest that WIF1 may be a tumor suppressor, specifically in nonfunctioning pituitary tumors, and that the Wnt pathways are important in pituitary tumorigenesis...
  27. ncbi request reprint Bone mineral density of olympic-level female winter sport athletes
    Nanna L Meyer
    The Institute for Sport Science and Medicine, The Orthopedic Specialty Hospital, Murray, UT 84107, USA
    Med Sci Sports Exerc 36:1594-601. 2004
    ..To compare areal bone mineral density (aBMD) of female winter sport athletes to healthy controls of similar age and body mass index (BMI)...
  28. ncbi request reprint IQGAP1 and IGFBP2: valuable biomarkers for determining prognosis in glioma patients
    Kerrie L McDonald
    Cancer Genetics, Kolling Institute of Medical Research, St Leonards, New South Wales, Australia
    J Neuropathol Exp Neurol 66:405-17. 2007
    ..Thus, IQGAP1 and IGFBP2 immunostaining supplements current histologic grading by offering additional prognostic and predictive information...