JEFFREY SEGAR

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. doi request reprint Renal adaptive changes and sodium handling in the fetal-to-newborn transition
    Jeffrey L Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, University of Iowa Children s Hospital, Iowa City, IA, USA Electronic address
    Semin Fetal Neonatal Med . 2016
  2. pmc Sex-specific programming of hypertension in offspring of late-gestation diabetic rats
    Ragheed Katkhuda
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Pediatr Res 72:352-61. 2012
  3. pmc Thyroid hormone is required for growth adaptation to pressure load in the ovine fetal heart
    Jeffrey L Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, University of Iowa Children s Hospital, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Exp Physiol 98:722-33. 2013
  4. doi request reprint Neonatal diuretic therapy: furosemide, thiazides, and spironolactone
    Jeffrey L Segar
    Division of Neonatology, Department of Pediatrics, University of Iowa Children s Hospital, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Clin Perinatol 39:209-20. 2012
  5. pmc Cardiomyopathy in offspring of diabetic rats is associated with activation of the MAPK and apoptotic pathways
    Benjamin E Reinking
    Departments of Pediatrics and Internal Medicine, University of Iowa, Iowa City, IA USA 52242 1083, USA
    Cardiovasc Diabetol 8:43. 2009
  6. ncbi request reprint Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs before hypertension
    Jeffrey L Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 291:R481-8. 2006
  7. ncbi request reprint Mechano- and chemoreceptor modulation of renal sympathetic nerve activity at birth in fetal sheep
    J L Segar
    Department of Pediatrics and Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol 276:R1295-301. 1999
  8. ncbi request reprint Inhibition of sympathetic responses at birth in sheep by lesion of the paraventricular nucleus
    Jeffrey L Segar
    Department of Pediatrics and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1395-403. 2002
  9. ncbi request reprint Responses of fetal ovine systemic and umbilical arteries to angiotensin II
    J L Segar
    Department of Pediatrics and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Res 49:826-33. 2001
  10. ncbi request reprint Glucocorticoid modulation of cardiovascular and autonomic function in preterm lambs: role of ANG II
    J L Segar
    Department of Pediatrics and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 280:R646-54. 2001

Research Grants

  1. SYMPATHETIC EXCITATORY RESPONSE AT BIRTH
    JEFFREY SEGAR; Fiscal Year: 2001
  2. Fetal Cardiac Hypertrophy: Vascular/Metabolic Adaptation
    JEFFREY SEGAR; Fiscal Year: 2004
  3. Fetal Programming of Coronary Artery Disease
    JEFFREY SEGAR; Fiscal Year: 2005

Collaborators

Detail Information

Publications39

  1. doi request reprint Renal adaptive changes and sodium handling in the fetal-to-newborn transition
    Jeffrey L Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, University of Iowa Children s Hospital, Iowa City, IA, USA Electronic address
    Semin Fetal Neonatal Med . 2016
    ..Clinical implications and guidelines to the provision of sodium to this vulnerable population are also discussed...
  2. pmc Sex-specific programming of hypertension in offspring of late-gestation diabetic rats
    Ragheed Katkhuda
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Pediatr Res 72:352-61. 2012
    ..We used a rat model of third-trimester maternal diabetes to test the hypothesis that adult offspring exposed to hyperglycemia in utero display increased blood pressure and alterations in vascular responsiveness...
  3. pmc Thyroid hormone is required for growth adaptation to pressure load in the ovine fetal heart
    Jeffrey L Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, University of Iowa Children s Hospital, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Exp Physiol 98:722-33. 2013
    ..Specifically, thyroid hormone is required for adaptive fetal cardiac growth in response to pressure overload...
  4. doi request reprint Neonatal diuretic therapy: furosemide, thiazides, and spironolactone
    Jeffrey L Segar
    Division of Neonatology, Department of Pediatrics, University of Iowa Children s Hospital, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Clin Perinatol 39:209-20. 2012
    ..If used in this population, limitations of diuretic therapy as well as significant side effects need to be understood and a rationale approach to clinical use developed on a patient-centered basis...
  5. pmc Cardiomyopathy in offspring of diabetic rats is associated with activation of the MAPK and apoptotic pathways
    Benjamin E Reinking
    Departments of Pediatrics and Internal Medicine, University of Iowa, Iowa City, IA USA 52242 1083, USA
    Cardiovasc Diabetol 8:43. 2009
    ..Newborn offspring of diabetic mothers can have a transient cardiomyopathy. We hypothesized that cardiomyopathic remodeling is associated with activation of the mitogen activated protein kinase (MAPK) signaling and apoptotic pathways...
  6. ncbi request reprint Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs before hypertension
    Jeffrey L Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 291:R481-8. 2006
    ..These findings suggest that resetting of the baroreflex, accompanied by increased sympathetic activity and altered nitric oxide-mediated compensatory vasodilatory function, may be important contributors to programming of hypertension...
  7. ncbi request reprint Mechano- and chemoreceptor modulation of renal sympathetic nerve activity at birth in fetal sheep
    J L Segar
    Department of Pediatrics and Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol 276:R1295-301. 1999
    ..On the other hand, these peripheral mechanisms appear to be involved in modulating endocrine responses at birth...
  8. ncbi request reprint Inhibition of sympathetic responses at birth in sheep by lesion of the paraventricular nucleus
    Jeffrey L Segar
    Department of Pediatrics and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1395-403. 2002
    ..The results of this study demonstrate that ablation of the PVN abolishes sympathoexcitation with birth at near-term gestation. The PVN may play a critical role in physiological adaptation at birth...
  9. ncbi request reprint Responses of fetal ovine systemic and umbilical arteries to angiotensin II
    J L Segar
    Department of Pediatrics and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Res 49:826-33. 2001
    ....
  10. ncbi request reprint Glucocorticoid modulation of cardiovascular and autonomic function in preterm lambs: role of ANG II
    J L Segar
    Department of Pediatrics and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 280:R646-54. 2001
    ..We speculate that augmented cardiovascular function in glucocorticoid-treated premature lambs is dependent, in part, on a generalized sympathoexcitatory response and that this effect of glucocorticoids is mediated by central mechanisms...
  11. ncbi request reprint Effects of fetal ovine adrenalectomy on sympathetic and baroreflex responses at birth
    Jeffrey L Segar
    Department of Pediatrics, Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 283:R460-7. 2002
    ..These results suggest that adrenal glucocorticoids contribute to cardiovascular regulation in the late-gestation fetus and newborn by modulating arterial baroreflex function and sympathetic activity...
  12. ncbi request reprint Angiotensin II in cardiac pressure-overload hypertrophy in fetal sheep
    J L Segar
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 281:R2037-47. 2001
    ..Elevated ANG II levels produce a selective increase in LV mass in the fetal sheep that is, in part, independent of increased systolic load...
  13. ncbi request reprint Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, USA
    Am J Physiol Regul Integr Comp Physiol 288:R46-53. 2005
    ..Glucocorticoid-induced alterations in coronary vascular smooth muscle structure or function may provide a mechanistic link between an adverse intrauterine environment and later cardiovascular disease...
  14. ncbi request reprint Late-gestation betamethasone enhances coronary artery responsiveness to angiotensin II in fetal sheep
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 286:R80-8. 2004
    ..These findings demonstrate that antenatal betamethasone exposure enhances coronary but not mesenteric artery vasoconstriction to ANG II by selectively upregulating coronary artery AT1 receptor protein expression...
  15. ncbi request reprint Activation of the mitogen-activated protein kinases and Akt in response to pulmonary artery banding in the fetal sheep heart is developmentally regulated
    Aaron K Olson
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Neonatology 93:145-52. 2008
    ..The fetal heart may also undergo hyperplasia, but the percentage of mitotically active cardiomyocytes decreases throughout gestation. The signaling pathways controlling growth and proliferation in the fetal heart are poorly understood...
  16. pmc Coronary endothelial function and vascular smooth muscle proliferation are programmed by early-gestation dexamethasone exposure in sheep
    Kenneth A Volk
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1607-14. 2010
    ....
  17. ncbi request reprint Murine aortic reactivity is programmed equally by maternal low protein diet or late gestation dexamethasone
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, IA, USA
    J Matern Fetal Neonatal Med 20:833-41. 2007
    ..We hypothesized that both maternal low protein diet and late gestation dexamethasone program murine offspring to develop hypertension, vascular dysfunction, and glucose intolerance...
  18. ncbi request reprint Metabolic adaptation of the fetal and postnatal ovine heart: regulatory role of hypoxia-inducible factors and nuclear respiratory factor-1
    Peter N Nau
    Department of Pediatrics, Division of Pediatric Cardiology, University of Iowa, Iowa City 52242, USA
    Pediatr Res 52:269-78. 2002
    ....
  19. ncbi request reprint Correlation between myocardial malate/aspartate shuttle activity and EAAT1 protein expression in hyper- and hypothyroidism
    J Carter Ralphe
    Department of Pediatrics, Roy and Lucille Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Am J Physiol Heart Circ Physiol 288:H2521-6. 2005
    ..EAAT1 regulation by thyroid hormone may facilitate increased metabolic demands of the cardiomyocyte during hyperthyroidism and impact cardiac function in hyperthyroidism...
  20. ncbi request reprint Neonatal vulnerability to ischemia and reperfusion: Cardioplegic arrest causes greater myocardial apoptosis in neonatal lambs than in mature lambs
    Mohsen Karimi
    Division of Cardiothoracic Surgery, University of Iowa College of Medicine, Iowa City, Iowa, USA
    J Thorac Cardiovasc Surg 127:490-7. 2004
    ..Because myocardial apoptosis is a part of normal fetal and postnatal maturation, we hypothesize that neonatal myocardium is more vulnerable to undergo myocardial apoptosis than mature myocardium after cardioplegic arrest...
  21. pmc Vascular nitric oxide and superoxide anion contribute to sex-specific programmed cardiovascular physiology in mice
    Robert D Roghair
    Dept of Pediatrics, Univ of Iowa Carver College of Medicine, Iowa City, 52242, USA
    Am J Physiol Regul Integr Comp Physiol 296:R651-62. 2009
    ..While maternal DI increased both superoxide-mediated vasoconstriction and nitric oxide mediated vasodilation, the balance of these factors favored the development of hypertension in males and hypotension in females...
  22. pmc Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Res 63:370-4. 2008
    ..This programming effect may predispose to progressive coronary endothelial dysfunction and coronary artery disease...
  23. pmc Effect of insulin and dexamethasone on fetal assimilation of maternal glucose
    Andrew W Norris
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 152:255-62. 2011
    ..Maternal insulin action has little effect on the inherent avidity of the fetal-placental unit for glucose but increases glucose utilization by maternal tissues, thus indirectly reducing the glucose available to the fetus...
  24. ncbi request reprint Endothelial superoxide production is altered in sheep programmed by early gestation dexamethasone exposure
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Neonatology 93:19-27. 2008
    ..Animal models have demonstrated that maternal undernutrition or early gestation glucocorticoid exposure induces endothelial dysfunction in the offspring...
  25. ncbi request reprint Regulation of myocardial glucose transporters GLUT1 and GLUT4 in chronically anemic fetal lambs
    J Carter Ralphe
    Department of Pediatrics, University of Iowa, 52242, USA
    Pediatr Res 58:713-8. 2005
    ..Unlike the postnatal heart, localization of GLUT4 to the cell membrane suggests the importance of GLUT4 in basal glucose uptake in the stressed fetal heart...
  26. ncbi request reprint The mitogen-activated protein kinases and Akt are developmentally regulated in the chronically anemic fetal sheep heart
    Aaron K Olson
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    J Soc Gynecol Investig 13:157-65. 2006
    ..The goal of the current study was to determine if volume loading the fetal heart resulting from chronic anemia affects regulation of Akt and the MAPKs and if this response is developmentally regulated...
  27. ncbi request reprint Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart
    Aaron K Olson
    Dept of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 290:H1587-95. 2006
    ..These findings indicate that the MAP kinase signaling pathways are active in the fetal heart and help to modulate the response of prenatal myocardium to a pressure load...
  28. ncbi request reprint Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria
    J Carter Ralphe
    Department of Pediatrics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Mol Cell Cardiol 37:33-41. 2004
    ..004). These data indicate that EAAT1 is expressed in myocardial mitochondria, and functions in the malate/aspartate shuttle, suggesting a role for EAAT1 in myocardial glutamate metabolism...
  29. ncbi request reprint Ontogeny of vascular growth factors in perinatal sheep myocardium
    Timothy L van Natta
    Department of Surgery, University of Iowa, Iowa City, Iowa 52242, USA
    J Soc Gynecol Investig 11:503-10. 2004
    ..To examine developmental changes in myocardial gene expression of previously identified regulators of vascular growth...
  30. pmc Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone before the onset of systemic hypertension
    Robert D Roghair
    Division of Neonatology, Department of Pediatrics, Children s Hospital of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1169-76. 2005
    ..Glucocorticoid-induced alterations in coronary physiology may provide a mechanistic link between an adverse intrauterine environment and later cardiovascular disease...
  31. ncbi request reprint Myocardial apoptosis after cardioplegic arrest in the neonatal lamb
    James M Hammel
    Department of Surgery, The University of Iowa College of Medicine, Iowa City, Iowa, USA
    J Thorac Cardiovasc Surg 125:1268-75. 2003
    ..Because the neonatal heart is in a proapoptotic state, we hypothesize that apoptosis is triggered after cardioplegic arrest in neonatal myocardium...
  32. pmc Fetal programming alters reactive oxygen species production in sheep cardiac mitochondria
    Nicholas H Von Bergen
    Department of Pediatrics, Carver College of Medicine, 200 Hawkins Drive, University of Iowa, Iowa City, IA 52242, USA
    Clin Sci (Lond) 116:659-68. 2009
    ..Greater mitochondrial H(2)O(2) release into the cell may play a role in the development of adult disease following exposure to an adverse intrauterine environment...
  33. ncbi request reprint Apoptosis-related mitochondrial dysfunction in the early postoperative neonatal lamb heart
    Christopher A Caldarone
    Division of Cardiovascular Surgery, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Ann Thorac Surg 78:948-55. 2004
    ..My colleagues and I therefore hypothesized that postoperative apoptotic myocytes represent a tip of the iceberg, with more myocytes upstream with apoptosis-related mitochondrial dysfunction (ARMD)...
  34. ncbi request reprint Effects of gestational age on myocardial blood flow and coronary flow reserve in pressure-loaded ovine fetal hearts
    Gregory B Dalshaug
    Department of Surgery, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Heart Circ Physiol 282:H1359-69. 2002
    ....
  35. pmc Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats
    Emily M Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Clin Sci (Lond) 117:129-38. 2009
    ..Thus the development of diabetes during pregnancy programmes gender-specific insulin resistance and vascular dysfunction in adult offspring...
  36. pmc Increased erythropoietin elimination in fetal sheep following chronic phlebotomy
    Kevin J Freise
    College of Pharmacy, The University of Iowa, 115 S Grand Ave, Iowa City, Iowa 52242, USA
    Pharm Res 24:1653-9. 2007
    ..To determine by pharmacokinetic (PK) means the role of erythropoietin-receptor (EPO-R) upregulation in fetuses on the elimination of erythropoietin (EPO)...
  37. pmc Localized fetomaternal hyperglycemia: spatial and kinetic definition by positron emission tomography
    Jianrong Yao
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
    PLoS ONE 5:e12027. 2010
    ..We approached this problem in the context of maternal diabetes and sought an approach to expose the developing fetus in vivo to isolated hyperglycemia in the pregnant rat...
  38. ncbi request reprint Myocardial vascular and metabolic adaptations in chronically anemic fetal sheep
    Christopher E Mascio
    Dept of Surgery, Univ of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1736-45. 2005
    ....
  39. ncbi request reprint Optimization of high-frequency oscillatory ventilation for the treatment of experimental pneumothorax
    Dan L Ellsbury
    Department of Pediatrics, Children s Hospital of Iowa, University of Iowa, Iowa City, IA 52242, USA
    Crit Care Med 30:1131-5. 2002
    ..To determine the effect of frequency, amplitude, inspiratory time, and mean airway pressure on gas flow through a chest tube in an animal model of pneumothorax treated with high-frequency oscillatory ventilation (HFOV)...

Research Grants3

  1. SYMPATHETIC EXCITATORY RESPONSE AT BIRTH
    JEFFREY SEGAR; Fiscal Year: 2001
    ....
  2. Fetal Cardiac Hypertrophy: Vascular/Metabolic Adaptation
    JEFFREY SEGAR; Fiscal Year: 2004
    ..The end result is hoped to be that the infant with a more 'normal' heart and circulatory physiology will have improved survival with less morbidity. ..
  3. Fetal Programming of Coronary Artery Disease
    JEFFREY SEGAR; Fiscal Year: 2005
    ..Only when the causes and mechanisms of hypertension and cardiovascular disease are understood in the context of a developmental process will it be possible to develop strategies for primary prevention. ..