Frank C Sciurba

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus
    Craig P Hersh
    Channing Division of Network Medicine, Boston, MA, USA
    BMC Pulm Med 14:164. 2014
  2. pmc Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD
    Craig P Hersh
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 14:42. 2013
  3. pmc Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study
    Nicholas D Giardino
    Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Respir Res 11:29. 2010
  4. pmc Relationship between pathologic characteristics of peripheral airways and outcome after lung volume reduction surgery in severe chronic obstructive pulmonary disease
    Frank C Sciurba
    Division of Pulmonary and Critical Care Medicine, Emphysema Research Center, University of Pittsburgh, Suite 1211, 3471 Fifth Avenue, PA 15213, USA
    Proc Am Thorac Soc 3:533-4. 2006
  5. doi request reprint A randomized study of endobronchial valves for advanced emphysema
    Frank C Sciurba
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    N Engl J Med 363:1233-44. 2010
  6. ncbi request reprint Physiologic similarities and differences between COPD and asthma
    Frank C Sciurba
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, 1211 Kaufmann Bldg, Pittsburgh, PA 15213, USA
    Chest 126:117S-124S; discussion 159S-161S. 2004
  7. ncbi request reprint Medical management of chronic obstructive pulmonary disease
    Frank C Sciurba
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, 1211 Kaufmann Building, Pittsburgh, PA 15213, USA
    Chest Surg Clin N Am 13:615-29. 2003
  8. pmc Radiographic emphysema predicts low bone mineral density in a tobacco-exposed cohort
    JESSICA BON
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 183:885-90. 2011
  9. pmc Asthma diagnosis and airway bronchodilator response in HIV-infected patients
    Matthew R Gingo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 129:708-714.e8. 2012
  10. pmc The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease
    Jessica M Bon
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 4:e6865. 2009

Detail Information

Publications85

  1. pmc Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus
    Craig P Hersh
    Channing Division of Network Medicine, Boston, MA, USA
    BMC Pulm Med 14:164. 2014
    ..However, the broader distinction between airway-predominant and emphysema-predominant COPD may be clinically relevant. The objective was to define clinical features of emphysema-predominant and non-emphysematous COPD patients...
  2. pmc Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD
    Craig P Hersh
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 14:42. 2013
    ..We sought to determine if measurements using paired inspiratory and expiratory CT scans may be better able to separate gas trapping due to emphysema from gas trapping due to small airway disease...
  3. pmc Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study
    Nicholas D Giardino
    Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Respir Res 11:29. 2010
    ..The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life and dyspnea...
  4. pmc Relationship between pathologic characteristics of peripheral airways and outcome after lung volume reduction surgery in severe chronic obstructive pulmonary disease
    Frank C Sciurba
    Division of Pulmonary and Critical Care Medicine, Emphysema Research Center, University of Pittsburgh, Suite 1211, 3471 Fifth Avenue, PA 15213, USA
    Proc Am Thorac Soc 3:533-4. 2006
  5. doi request reprint A randomized study of endobronchial valves for advanced emphysema
    Frank C Sciurba
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    N Engl J Med 363:1233-44. 2010
    ....
  6. ncbi request reprint Physiologic similarities and differences between COPD and asthma
    Frank C Sciurba
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, 1211 Kaufmann Bldg, Pittsburgh, PA 15213, USA
    Chest 126:117S-124S; discussion 159S-161S. 2004
    ..In particular, the subgroup of COPD patients having an airway-dominant phenotype becomes indistinguishable from asthmatic subjects with reversible disease that evolves into an incompletely reversible pattern...
  7. ncbi request reprint Medical management of chronic obstructive pulmonary disease
    Frank C Sciurba
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, 1211 Kaufmann Building, Pittsburgh, PA 15213, USA
    Chest Surg Clin N Am 13:615-29. 2003
    ..The focus on outcome parameters other than expiratory flow rates, such as symptoms, quality of life, exercise tolerance, and exacerbation frequency, might also allow effective development of novel disease-modifying agents...
  8. pmc Radiographic emphysema predicts low bone mineral density in a tobacco-exposed cohort
    JESSICA BON
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 183:885-90. 2011
    ..Whereas emphysema has been independently associated with vascular disease and other comorbidities, its association with BMD has not been well studied...
  9. pmc Asthma diagnosis and airway bronchodilator response in HIV-infected patients
    Matthew R Gingo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 129:708-714.e8. 2012
    ....
  10. pmc The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease
    Jessica M Bon
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 4:e6865. 2009
    ..A cross-sectional study was performed to examine the association of serum biomarkers with radiographic airway and parenchymal phenotypes of COPD...
  11. pmc Optimizing the 6-min walk test as a measure of exercise capacity in COPD
    Divay Chandra
    Emphysema Research Center, Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Chest 142:1545-52. 2012
    ..It is uncertain whether the effort and expense of performing a second walk for the 6-min walk test improves test performance. Hence, we attempted to quantify the improvement in 6-min walk distance if an additional walk were to be performed...
  12. doi request reprint Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment Trial
    Michael B Drummond
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Chest 134:497-506. 2008
    ..Little is known regarding the clinical characteristics and survival of nonhypoxemic emphysema patients using continuous oxygen. Analysis of data from the National Emphysema Treatment Trial (NETT) offers insight into this population...
  13. pmc The relationship between pulmonary emphysema and kidney function in smokers
    Divay Chandra
    Emphysema COPD Research Center, University of Pittsburgh, Pittsburgh, PA, USA
    Chest 142:655-62. 2012
    ..We hypothesized that kidney dysfunction would associate with emphysema rather than with airflow obstruction measured by the FEV₁...
  14. pmc Computerized identification of airway wall in CT examinations using a 3D active surface evolution approach
    Suicheng Gu
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Med Image Anal 17:283-96. 2013
    ..For a clinical chest CT examination, it took around 4 min for this scheme to identify the inner and outer airway walls on a modern PC...
  15. doi request reprint Exercise testing in severe emphysema: association with quality of life and lung function
    Cynthia D Brown
    Division of Pulmonary and Critical Care Medicine, University of Virginia, VA, USA
    COPD 5:117-24. 2008
    ..Moreover, the 6MWT may be a better test of functional capacity given its greater association with QOL measures whereas CPX is a better test of physiologic impairment...
  16. pmc Pulmonary function abnormalities in HIV-infected patients during the current antiretroviral therapy era
    Matthew R Gingo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 182:790-6. 2010
    ..The prevalence and exact phenotype of pulmonary abnormalities in the current era are unknown. In addition, these abnormalities may be underdiagnosed...
  17. pmc Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT
    Shinjini Kundu
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Eur Radiol 23:1564-72. 2013
    ....
  18. pmc Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease
    Cristine E Berry
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Chest 142:704-11. 2012
    ..However, different pathophysiologic mechanisms may influence how these distinct diseases affect HRQL, resulting in differing HRQL by pulmonary diagnosis among patients with similar severity of ventilatory impairment...
  19. pmc Quantitative computed tomography analysis, airflow obstruction, and lung cancer in the pittsburgh lung screening study
    David O Wilson
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Thorac Oncol 6:1200-5. 2011
    ..To study the relationship between emphysema, airflow obstruction, and lung cancer in a high-risk population, we performed quantitative analysis of screening computed tomography (CT) scans...
  20. pmc Design of the Endobronchial Valve for Emphysema Palliation Trial (VENT): a non-surgical method of lung volume reduction
    Charlie Strange
    Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC, USA
    BMC Pulm Med 7:10. 2007
    ....
  21. pmc Increased matrix metalloproteinase (MMPs) levels do not predict disease severity or progression in emphysema
    JEANINE M D'ARMIENTO
    Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 8:e56352. 2013
    ..This study aimed to determine whether bronchoalveolar lavage (BALF) or plasma MMP measurements correlated with disease severity or functional decline in emphysema...
  22. pmc Persistent pneumocystis colonization leads to the development of chronic obstructive pulmonary disease in a nonhuman primate model of AIDS
    Timothy W Shipley
    Department of Immunology, Division of Pulmonary, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Infect Dis 202:302-12. 2010
    ..Furthermore, this model allows examination of early host responses important to disease progression, thus identifying potential therapeutic targets for COPD...
  23. ncbi request reprint Size and morphology of the trachea before and after lung volume reduction surgery
    Joseph K Leader
    Department of Radiology, Imaging Research Division, University of Pittsburgh, 300 Halket St, Ste 4200, Pittsburgh, PA 15213, USA
    AJR Am J Roentgenol 183:315-21. 2004
    ..The purpose of this investigation was to determine the effect of lung volume reduction surgery on measured tracheal features...
  24. ncbi request reprint Emerging concepts in outcome assessment for COPD clinical trials
    Sanjay A Patel
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Semin Respir Crit Care Med 26:253-62. 2005
    ..Application of these and other emerging concepts in outcome assessment for COPD clinical trials will be examined...
  25. doi request reprint Computed tomographic-based quantification of emphysema and correlation to pulmonary function and mechanics
    George R Washko
    Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, Boston, Massachusetts 02115, USA
    COPD 5:177-86. 2008
    ..The CT based quantification of emphysema may augment pulmonary function testing in the characterization of COPD by providing complementary phenotypic information...
  26. ncbi request reprint Computerized estimation of the lung volume removed during lung volume reduction surgery
    Sebastien Gilbert
    Department of Surgery, University of Pittsburgh, Imaging Research Division, 300 Halket Street, Suite 4200, Pittsburgh, PA 15213, USA
    Acad Radiol 13:1379-86. 2006
    ..This study was designed to develop an automated method for estimating lung volume removed during lung volume reduction surgery (LVRS) using computed tomography (CT)...
  27. pmc Long-term comparative immunogenicity of protein conjugate and free polysaccharide pneumococcal vaccines in chronic obstructive pulmonary disease
    Mark T Dransfield
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Clin Infect Dis 55:e35-44. 2012
    ..We hypothesized that these advantages would persist at 1 and 2 years...
  28. pmc Optimal threshold in CT quantification of emphysema
    Zhimin Wang
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Eur Radiol 23:975-84. 2013
    ..To determine the optimal threshold by quantitatively assessing the extent of emphysema at the level of the entire lung and at the level of individual lobes using a large, diverse dataset of computed tomography (CT) examinations...
  29. pmc Three-dimensional airway tree architecture and pulmonary function
    Jiantao Pu
    University of Pittsburgh, Department of Radiology, PA 15213, USA
    Acad Radiol 19:1395-401. 2012
    ..The objective of this study was to investigate the correlation between airway tree architecture, as depicted on computed tomography, and pulmonary function...
  30. pmc Inverse association of plasma IL-13 and inflammatory chemokines with lung function impairment in stable COPD: a cross-sectional cohort study
    Janet S Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Respir Res 8:64. 2007
    ..A secondary goal was to assess whether unique markers associate with diffusion impairment, based on diffusion capacity of carbon monoxide (DLCO), independent of the forced expiratory volume in 1 second (FEV1)...
  31. ncbi request reprint Use of endobronchial valves for native lung hyperinflation associated with respiratory failure in a single-lung transplant recipient for emphysema
    Maria M Crespo
    Division of Pulmonary, Allergy and, Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Chest 131:214-6. 2007
    ..This report suggests the need for clinical trials to evaluate the effectiveness of EBVs in single-lung transplant recipients with less critical functional impairment associated with NLH...
  32. doi request reprint Peripheral T cell functions correlate with the severity of chronic obstructive pulmonary disease
    Xuehai Zhu
    Division of Pulmonary, Allergy and Critical Care, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Immunol 182:3270-7. 2009
    ....
  33. pmc Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers
    JESSICA BON
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e105066. 2014
    ..Emphysema and osteoporosis are epidemiologically associated diseases of cigarette smokers. The causal mechanism(s) linking these illnesses is unknown. We hypothesized autoimmune responses may be involved in both disorders...
  34. pmc Pneumocystis jirovecii colonization is associated with enhanced Th1 inflammatory gene expression in lungs of humans with chronic obstructive pulmonary disease
    Meghan E Fitzpatrick
    Department of Medicine, University of Pittsburgh, 3459 Fifth Avenue, Pittsburgh, Pennsylvania, 15213, USA
    Microbiol Immunol 58:202-11. 2014
    ..The finding of upregulation of these inflammatory genes in the setting of Pneumocystis colonization sheds light on infectious-immune relationships in COPD. ..
  35. pmc Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognoses
    Rehan A Kahloon
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 187:768-75. 2013
    ..Diverse autoantibodies are present in most patients with idiopathic pulmonary fibrosis (IPF). We hypothesized that specific autoantibodies may associate with IPF manifestations...
  36. pmc Plasma inflammatory mediators associated with bone metabolism in COPD
    Jessica M Bon
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    COPD 7:186-91. 2010
    ..Furthermore, they may be useful in monitoring disease activity, and serve as targets for biological therapy...
  37. pmc Association of radiographic emphysema and airflow obstruction with lung cancer
    David O Wilson
    Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 178:738-44. 2008
    ..To study the relationship between emphysema and/or airflow obstruction and lung cancer in a high-risk population...
  38. pmc Perfusion scintigraphy and patient selection for lung volume reduction surgery
    Divay Chandra
    Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 182:937-46. 2010
    ..It is unclear if lung perfusion can predict response to lung volume reduction surgery (LVRS)...
  39. pmc Pulmonary fissure integrity and collateral ventilation in COPD patients
    Jiantao Pu
    Imaging Research Center, Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Department of Radiology, The First Affiliated Hospital, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi Providence, P R China
    PLoS ONE 9:e96631. 2014
    ..To investigate whether the integrity (completeness) of pulmonary fissures affects pulmonary function in patients with chronic obstructive pulmonary disease (COPD)...
  40. pmc Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD)
    Sowmya P Lakshmi
    From the Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 and
    J Biol Chem 289:6383-93. 2014
    ....
  41. pmc Contributors to diffusion impairment in HIV-infected persons
    Matthew R Gingo
    University of Pittsburgh, Pittsburgh, PA
    Eur Respir J 43:195-203. 2014
    ..Never-smokers may have a unique phenotype of diffusing capacity impairment. The interaction of multiple factors may account for the pervasive nature of diffusing capacity impairment in HIV infection...
  42. pmc Plasma B lymphocyte stimulator and B cell differentiation in idiopathic pulmonary fibrosis patients
    Jianmin Xue
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 191:2089-95. 2013
    ..These findings have implications regarding IPF pathogenesis and illuminate the potential for novel treatment regimens that specifically target B cells in patients with this lung disease. ..
  43. pmc Autoantibodies in patients with chronic obstructive pulmonary disease
    Carol A Feghali-Bostwick
    Division of Pulmonary, Allergy, and Critical Care, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 177:156-63. 2008
    ..Adaptive immune responses are present in patients with chronic obstructive pulmonary disease (COPD), and it has been postulated that these processes could be autoreactive...
  44. pmc Computerized assessment of pulmonary fissure integrity using high resolution CT
    Jiantao Pu
    Department of Radiology, Imaging Research Center, University of Pittsburgh, 3362 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Med Phys 37:4661-72. 2010
    ..Knowledge of pulmonary interlobar fissure integrity is of interest in a number of clinical and investigational applications. The authors developed and tested a high resolution CT based automated computerized scheme for this purpose...
  45. pmc Integrating health status and survival data: the palliative effect of lung volume reduction surgery
    Roberto Benzo
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55902, USA
    Am J Respir Crit Care Med 180:239-46. 2009
    ..This practice tends to inflate the apparent benefits of interventions with a high risk of mortality. Assessing a composite QoL-death outcome is a potential solution to this problem...
  46. pmc Variability of spirometry in chronic obstructive pulmonary disease: results from two clinical trials
    Laura B Herpel
    The Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 173:1106-13. 2006
    ..This may be applied to determine criteria that can be used to assess a clinically meaningful change in spirometry...
  47. pmc A Computational geometry approach to automated pulmonary fissure segmentation in CT examinations
    Jiantao Pu
    Imaging Research Division, Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    IEEE Trans Med Imaging 28:710-9. 2009
    ..48 +/-0.92 to 2.04 +/-3.88 mm. The discrepancy of fissure detection results between the automated scheme and either radiologist is smaller in this dataset than the interreader variability...
  48. pmc Airway obstruction is increased in pneumocystis-colonized human immunodeficiency virus-infected outpatients
    Alison Morris
    University of Pittsburgh Medical Center, 628 NW MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Clin Microbiol 47:3773-6. 2009
    ..Pneumocystis-colonized subjects had worse obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting that Pneumocystis colonization may be important in HIV-associated chronic obstructive pulmonary disease...
  49. pmc Pneumocystis: a novel pathogen in chronic obstructive pulmonary disease?
    Alison Morris
    Division of Pulmonary, Allergy, and Critical Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    COPD 5:43-51. 2008
    ..Additional studies are needed to confirm the role of Pneumocystis in the pathogenesis of COPD, given that this agent might be a treatable co-factor in disease progression...
  50. ncbi request reprint Optimal protocol selection for cardiopulmonary exercise testing in severe COPD
    Roberto P Benzo
    Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Suite 1211 Kaufmann Building, 3471 Fifth Ave, Pittsburgh, PA 15213, USA
    Chest 132:1500-5. 2007
    ..We aimed to determine the optimal duration for a CPET to attain the peak oxygen consumption (VO2peak) in a group of patients with severe COPD using different carefully conducted workload protocols...
  51. pmc Bidirectional elastic image registration using B-spline affine transformation
    Suicheng Gu
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Comput Med Imaging Graph 38:306-14. 2014
    ..Our experiments showed that the proposed B-spline affine model could obtain reasonable registration accuracy...
  52. pmc Distribution of Pneumocystis jirovecii in lungs from colonized COPD patients
    Sheila Sivam
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Diagn Microbiol Infect Dis 71:24-8. 2011
    ....
  53. ncbi request reprint Altered T-cell phenotypes in chronic obstructive pulmonary disease
    Aneal Gadgil
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA
    Proc Am Thorac Soc 3:487-8. 2006
  54. pmc Relationship of pneumocystis antibody response to severity of chronic obstructive pulmonary disease
    Alison Morris
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 47:e64-8. 2008
    ..Undetectable anti-Pneumocystis antibody titer was an independent predictor of more-severe airway obstruction, although use of inhaled corticosteroids is a possible confounder of this effect...
  55. pmc A differential geometric approach to automated segmentation of human airway tree
    Jiantao Pu
    Imaging Research Division, Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    IEEE Trans Med Imaging 30:266-78. 2011
    ....
  56. doi request reprint Considerations and pitfalls in phenotyping and reclassification of chronic obstructive pulmonary disease
    JESSICA BON
    Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA
    Transl Res 162:252-7. 2013
    ....
  57. doi request reprint Deglutitive subglottic air pressure and respiratory system recoil
    Roxann Diez Gross
    Department of Otolaryngology, Eye and Ear Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Dysphagia 27:452-9. 2012
    ....
  58. pmc Outcomes of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease in the United States, 1998-2008
    Divay Chandra
    University of Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 185:152-9. 2012
    ..The patterns and outcomes of noninvasive, positive-pressure ventilation (NIPPV) use in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (COPD) nationwide are unknown...
  59. ncbi request reprint Automated detection and quantitative assessment of pulmonary airways depicted on CT images
    Bin Zheng
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Med Phys 34:2844-52. 2007
    ....
  60. doi request reprint Spontaneous bronchopleural fistula following lung volume reduction surgery for emphysema
    Arman Kilic
    Heart, Lung, and Esophageal Surgery Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Interact Cardiovasc Thorac Surg 8:442-3. 2009
    ..This case is an example of what may be a unique pathophysiologic mechanism of bronchopleural fistula formation--a 'stress rupture' of the lung parenchyma following lung volume reduction surgery...
  61. ncbi request reprint Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patients
    Josephia R Muindi
    Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA
    J Clin Pharmacol 48:96-107. 2008
    ..25). The authors conclude that intermittent therapy with high-dose ATRA produced the greatest ATRA exposure, but alternative approaches for limiting self-induced ATRA catabolism should be sought...
  62. pmc Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease
    Zhi Hua Chen
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 3:e3316. 2008
    ..Autophagy is a degradative process involving lysosomal turnover of cellular components, though its role in human diseases remains unclear...
  63. pmc Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study
    J Michael Wells
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama Birmingham, Birmingham, AL, USA
    BMC Pulm Med 16:169. 2016
    ..Demographic and clinical characteristics, lung function, and radiographic indices were analyzed with logistic regression models to identify predictors of the development of hypoxemia...
  64. pmc Integrative phenotyping framework (iPF): integrative clustering of multiple omics data identifies novel lung disease subphenotypes
    Sunghwan Kim
    Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, 15261, USA
    BMC Genomics 16:924. 2015
    ..Unlike continuous intensity measurements from most omics data sets, phenome data contain clinical variables that are binary, ordinal and categorical...
  65. pmc Respiratory symptoms and airway obstruction in HIV-infected subjects in the HAART era
    M Patricia George
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    PLoS ONE 4:e6328. 2009
    ..We evaluated respiratory symptoms and measured airway obstruction to identify the impact of HAART and other risk factors on respiratory symptoms and pulmonary function...
  66. pmc Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA
    COPD 8:21-9. 2011
    ..Leukotrienes have been implicated in the pathogenesis of acute exacerbations of COPD, but leukotriene modifiers have not been studied as a possible therapy for exacerbations...
  67. ncbi request reprint Association of chronic obstructive pulmonary disease severity and Pneumocystis colonization
    Alison Morris
    M S, Division of Pulmonary and Critical Care Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 170:408-13. 2004
    ..001) and was independent of smoking history. We conclude that there is a strong association between Pneumocystis colonization and severity of airflow obstruction in smokers, suggesting a possible pathogenic link with COPD progression...
  68. pmc A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation
    Bill B Chen
    Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Nat Immunol 14:470-9. 2013
    ..These studies identified a pathway of innate immunity that may be useful to detect subjects with altered immune responses during critical illness or provide a basis for therapeutic intervention targeting TRAF protein abundance...
  69. pmc Activity monitoring and energy expenditure in COPD patients: a validation study
    Sanjay A Patel
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    COPD 4:107-12. 2007
    ..68). This physiologic activity monitor provides a valid and reproducible estimate of energy expenditure during slow to moderate paced walking in a laboratory setting and represents an objective method to assess activity in COPD subjects...
  70. ncbi request reprint Automated lung segmentation in X-ray computed tomography: development and evaluation of a heuristic threshold-based scheme
    Joseph K Leader
    Department of Radiology, University of Pittsburgh, Imaging Research Division, 300 Halket St, Suite 4200, Pittsburgh, PA 15213, USA
    Acad Radiol 10:1224-36. 2003
    ..To develop and evaluate a reliable, fully-automated lung segmentation scheme for application in X-ray computed tomography...
  71. pmc The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis
    Jianmin Xue
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e14715. 2011
    ..We hypothesized that perturbations of human leukocyte antigen (HLA) allele frequencies, which are often seen among patients with immunologic diseases, may also be present in IPF patients...
  72. pmc Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease
    Wen Ning
    Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 101:14895-900. 2004
    ..Our study represents the first comprehensive analysis of gene expression on GOLD-2 versus GOLD-0 smokers and reveals previously unreported candidate genes that may serve as potential molecular targets in COPD...
  73. ncbi request reprint Exercise maintenance following pulmonary rehabilitation: effect of distractive stimuli
    Gerene S Bauldoff
    University of Pittsburgh School of Nursing, University of Pittsburgh School of Medicine, PA, USA
    Chest 122:948-54. 2002
    ....
  74. pmc Genetic determinants of emphysema distribution in the national emphysema treatment trial
    Dawn L DeMeo
    Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:42-8. 2007
    ....
  75. ncbi request reprint COPD phenotypes: the answers are in the noise
    Frank C Sciurba
    COPD 4:301-2. 2007
  76. pmc Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology
    James C Hogg
    University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Am J Respir Crit Care Med 176:454-9. 2007
    ..COPD is associated with reduced life expectancy...
  77. ncbi request reprint Feasibility of retinoids for the treatment of emphysema study
    Michael D Roth
    Division of Pulmonary and Critical Care, University of California, Los Angeles, CA 90095 1690, USA
    Chest 130:1334-45. 2006
    ..Retinoids promote alveolar septation in the developing lung and stimulate alveolar repair in some animal models of emphysema...
  78. pmc The effect of lung volume reduction surgery on chronic obstructive pulmonary disease exacerbations
    George R Washko
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 177:164-9. 2008
    ..The effect of LVRS on COPD exacerbations has not been as extensively studied, and whether improvement in postoperative lung function alters the risk of disease exacerbations is not known...
  79. ncbi request reprint Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD
    Francois Maltais
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 725 Chemin Ste Foy, Quebec, QC, G1V 4G5, Canada
    Chest 128:1168-78. 2005
    ..The present study was designed to gain further insight into the duration of improvements...
  80. ncbi request reprint The nature of small-airway obstruction in chronic obstructive pulmonary disease
    James C Hogg
    University of British Columbia, the Centre for Cardiovascular and Pulmonary Research, and St Paul s Hospital, Vancouver, Canada
    N Engl J Med 350:2645-53. 2004
    ..We examined the evolution of the pathological effects of airway obstruction in patients with COPD...
  81. ncbi request reprint A unique spirometric phenotype in COPD
    Jessica M Bon
    Am J Respir Crit Care Med 178:431-2. 2008
  82. ncbi request reprint Relative utility of 6-minute walk vs. incremental shuttle walk: does it depend upon functional status?
    Sanjay A Patel
    Respiration 72:331; author reply 332. 2005
  83. pmc Genetic association analysis of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:977-84. 2006
    ..This variation may reflect different COPD subtypes, which may have different genetic predispositions...
  84. ncbi request reprint Long-term follow-up of patients receiving lung-volume-reduction surgery versus medical therapy for severe emphysema by the National Emphysema Treatment Trial Research Group
    Keith S Naunheim
    St Louis University, 3635 Vista Blvd, St Louis, Mo 63110 0250, USA
    Ann Thorac Surg 82:431-43. 2006
    ..Two additional years of follow-up provide valuable information regarding durability...
  85. ncbi request reprint Physician and patient perceptions in COPD: the COPD Resource Network Needs Assessment Survey
    R Graham Barr
    Division of General Medicine, Department of Medicine, College of Physicians and Surgeons, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Med 118:1415. 2005
    ..National data are lacking on patient and physician perceptions of and patterns of care for COPD...