L Wayne Schultz

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. pmc Crystal structure of a pH-regulated luciferase catalyzing the bioluminescent oxidation of an open tetrapyrrole
    L Wayne Schultz
    Department of Structural Biology, Hauptman Woodward Medical Research Institute, State University of New York, Buffalo, NY 14203, USA
    Proc Natl Acad Sci U S A 102:1378-83. 2005
  2. pmc In vivo-validated essential genes identified in Acinetobacter baumannii by using human ascites overlap poorly with essential genes detected on laboratory media
    Timothy C Umland
    Hauptman Woodward Medical Research Institute, Buffalo, New York, USA
    MBio 3:. 2012
  3. doi request reprint Structure of shikimate kinase, an in vivo essential metabolic enzyme in the nosocomial pathogen Acinetobacter baumannii, in complex with shikimate
    Kristin A Sutton
    Hauptman Woodward Medical Research Institute, Buffalo, NY 14203, USA
    Acta Crystallogr D Biol Crystallogr 71:1736-44. 2015
  4. pmc Crystal structure of 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase from the ESKAPE pathogen Acinetobacter baumannii
    Kristin A Sutton
    Hauptman Woodward Medical Research Institute, Buffalo, NY 14203, USA
    Acta Crystallogr F Struct Biol Commun 72:179-87. 2016
  5. doi request reprint Influenza A polymerase subunit PB2 possesses overlapping binding sites for polymerase subunit PB1 and human MAVS proteins
    Deendayal Patel
    Hauptman Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY 14203, USA
    Virus Res 172:75-80. 2013
  6. doi request reprint Penicillin-binding protein 7/8 contributes to the survival of Acinetobacter baumannii in vitro and in vivo
    Thomas A Russo
    Veterans Administration Western New York Healthcare System, The Witebsky Center for Microbial Pathogenesis, Department of Medicine, State University of New York Buffalo, Buffalo, New York 14214, USA
    J Infect Dis 199:513-21. 2009
  7. pmc Severe acute respiratory syndrome coronavirus nsp9 dimerization is essential for efficient viral growth
    Zachary J Miknis
    Department of Structural Biology, State University of New York at Buffalo, Buffalo, New York 14203, USA
    J Virol 83:3007-18. 2009
  8. pmc The K1 capsular polysaccharide of Acinetobacter baumannii strain 307-0294 is a major virulence factor
    Thomas A Russo
    Veterans Administration Western New York Healthcare System, Department of Medicine, Division of Infectious Diseases, University at Buffalo, 3435 Main St, Biomedical Research Building Room 141, Buffalo, NY 14214, USA
    Infect Immun 78:3993-4000. 2010
  9. ncbi request reprint Characterization and crystallization of active domains of a novel luciferase from a marine dinoflagellate
    Liyun Liu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138 2020, USA
    Acta Crystallogr D Biol Crystallogr 59:761-4. 2003

Research Grants

Collaborators

  • T A Russo
  • Timothy C Umland
  • Kristin A Sutton
  • Jennifer Breen
  • Janet M Beanan
  • Ruth Olson
  • Ulrike Macdonald
  • Deendayal Patel
  • Zachary J Miknis
  • Liyun Liu
  • Ryan A Rimmer
  • Eric F Donaldson
  • Ralph S Baric
  • Hookang Im
  • Kurt L Krause
  • J Woodland Hastings
  • Pierre LeMagueres
  • Margaret Cegielski

Detail Information

Publications9

  1. pmc Crystal structure of a pH-regulated luciferase catalyzing the bioluminescent oxidation of an open tetrapyrrole
    L Wayne Schultz
    Department of Structural Biology, Hauptman Woodward Medical Research Institute, State University of New York, Buffalo, NY 14203, USA
    Proc Natl Acad Sci U S A 102:1378-83. 2005
    ..Molecular dynamics calculations indicate that, in response to changes in pH, these histidines could trigger a large molecular motion of the bundle, thereby exposing the active site to the substrate...
  2. pmc In vivo-validated essential genes identified in Acinetobacter baumannii by using human ascites overlap poorly with essential genes detected on laboratory media
    Timothy C Umland
    Hauptman Woodward Medical Research Institute, Buffalo, New York, USA
    MBio 3:. 2012
    ....
  3. doi request reprint Structure of shikimate kinase, an in vivo essential metabolic enzyme in the nosocomial pathogen Acinetobacter baumannii, in complex with shikimate
    Kristin A Sutton
    Hauptman Woodward Medical Research Institute, Buffalo, NY 14203, USA
    Acta Crystallogr D Biol Crystallogr 71:1736-44. 2015
    ..The impact of structural differences and sequence divergence between SKs from pathogenic bacteria that may influence antibiotic-development efforts is discussed...
  4. pmc Crystal structure of 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase from the ESKAPE pathogen Acinetobacter baumannii
    Kristin A Sutton
    Hauptman Woodward Medical Research Institute, Buffalo, NY 14203, USA
    Acta Crystallogr F Struct Biol Commun 72:179-87. 2016
    ..The crystal structure, determined to 2.37 Å resolution, is described in the context of a potential antimicrobial target and in comparison to EPSP synthases that are resistant or sensitive to the herbicide glyphosate...
  5. doi request reprint Influenza A polymerase subunit PB2 possesses overlapping binding sites for polymerase subunit PB1 and human MAVS proteins
    Deendayal Patel
    Hauptman Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY 14203, USA
    Virus Res 172:75-80. 2013
    ..Additionally, the results of this study suggest a new strategy to develop influenza A therapeutics by simultaneously blocking PB2-MAVS and PB2-PB1 protein-protein interactions and their resulting activities...
  6. doi request reprint Penicillin-binding protein 7/8 contributes to the survival of Acinetobacter baumannii in vitro and in vivo
    Thomas A Russo
    Veterans Administration Western New York Healthcare System, The Witebsky Center for Microbial Pathogenesis, Department of Medicine, State University of New York Buffalo, Buffalo, New York 14214, USA
    J Infect Dis 199:513-21. 2009
    ..Acinetobacter baumannii is a bacterial pathogen of increasing medical importance. Little is known about genes important for its survival in vivo...
  7. pmc Severe acute respiratory syndrome coronavirus nsp9 dimerization is essential for efficient viral growth
    Zachary J Miknis
    Department of Structural Biology, State University of New York at Buffalo, Buffalo, New York 14203, USA
    J Virol 83:3007-18. 2009
    ..Together, these data indicate that dimerization of SARS-CoV nsp9 at the GXXXG motif is not critical for RNA binding but is necessary for viral replication...
  8. pmc The K1 capsular polysaccharide of Acinetobacter baumannii strain 307-0294 is a major virulence factor
    Thomas A Russo
    Veterans Administration Western New York Healthcare System, Department of Medicine, Division of Infectious Diseases, University at Buffalo, 3435 Main St, Biomedical Research Building Room 141, Buffalo, NY 14214, USA
    Infect Immun 78:3993-4000. 2010
    ..Therefore, the results from this study have important biologic and translational implications and, to the best of our knowledge, are the first to address the role of capsule in the pathogenesis of A. baumannii infection...
  9. ncbi request reprint Characterization and crystallization of active domains of a novel luciferase from a marine dinoflagellate
    Liyun Liu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138 2020, USA
    Acta Crystallogr D Biol Crystallogr 59:761-4. 2003
    ..7, c = 180.3 A. They diffract to 2.9 A on a rotating anode. Crystals of D3-LCF were grown from PEG 2000 in space group P2(1)2(1)2(1), with unit-cell parameters a = 58.86, b = 63.98, c = 95.76 A. They diffract to 2.3 A on a rotating anode...

Research Grants1

  1. STRUCTURAL STUDIES OF SARS AND MHV REPLICASE PROTEINS
    L Schultz; Fiscal Year: 2005
    ..In collaboration with Dr. Mark Denison of Vanderbilt University, we will generate structure based hypotheses that will be tested in SARS-CoV and MHV reverse genetics systems developed in his laboratory. ..