Earl Sawai

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques
    E T Sawai
    Department of Medical Pathology, University of California, Davis 95616, USA
    Curr Biol 6:1519-27. 1996
  2. ncbi request reprint Suppression of breast cancer growth and angiogenesis by an antisense oligodeoxynucleotide to p21(Waf1/Cip1)
    Robert H Weiss
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, CA 95616, USA
    Cancer Lett 189:39-48. 2003
  3. ncbi request reprint Contributions of mouse biology to breast cancer research
    Robert D Cardiff
    University of California, Davis, USA
    Comp Med 52:12-31. 2002
  4. pmc Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor
    Akrit Sodhi
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:4821-6. 2004
  5. ncbi request reprint Feline immunodeficiency virus Orf-A localizes to the nucleus and induces cell cycle arrest
    Malou C Gemeniano
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Virology 325:167-74. 2004
  6. ncbi request reprint The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma
    Silvia Montaner
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore, USA
    Cancer Res 66:168-74. 2006
  7. ncbi request reprint The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor
    Akrit Sodhi
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Cell 10:133-43. 2006

Research Grants

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques
    E T Sawai
    Department of Medical Pathology, University of California, Davis 95616, USA
    Curr Biol 6:1519-27. 1996
    ..In tissue culture cells expressing Nef, this viral protein interacts with a cellular serine kinase, designated Nef-associated kinase...
  2. ncbi request reprint Suppression of breast cancer growth and angiogenesis by an antisense oligodeoxynucleotide to p21(Waf1/Cip1)
    Robert H Weiss
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, CA 95616, USA
    Cancer Lett 189:39-48. 2003
    ....
  3. ncbi request reprint Contributions of mouse biology to breast cancer research
    Robert D Cardiff
    University of California, Davis, USA
    Comp Med 52:12-31. 2002
  4. pmc Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor
    Akrit Sodhi
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:4821-6. 2004
    ..Both were associated with a decrease in Akt activity. These results identify Akt as an essential player in vGPCR sarcomagenesis and demonstrate the therapeutic potential of drugs targeting this pathway in the treatment of KS...
  5. ncbi request reprint Feline immunodeficiency virus Orf-A localizes to the nucleus and induces cell cycle arrest
    Malou C Gemeniano
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Virology 325:167-74. 2004
    ..Our findings reveal that Orf-A is a nuclear protein that expresses properties similar to those reported for human immunodeficiency virus-1 (HIV-1)-encoded Vpr...
  6. ncbi request reprint The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma
    Silvia Montaner
    Department of Diagnostic Sciences and Pathology, University of Maryland, Baltimore, USA
    Cancer Res 66:168-74. 2006
    ....
  7. ncbi request reprint The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor
    Akrit Sodhi
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Cell 10:133-43. 2006
    ..Collectively, these results implicate mTOR in KS initiation and suggest that the sarcomagenic potential of KSHV may be a direct consequence of the profound sensitivity of endothelial cells to vGPCR dysregulation of the TSC2/mTOR pathway...

Research Grants1

  1. PATHOGENIC CONVERSION OF ATTENUATED SIV VACCINES
    Earl Sawai; Fiscal Year: 2003
    ..Accordingly, the proposed studies will provide critical insight into molecular changes in the viral genome that are necessary for pathogenic conversion of live-attenuated viral vaccines. ..