J Savory

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Age-related hippocampal changes in Bcl-2:Bax ratio, oxidative stress, redox-active iron and apoptosis associated with aluminum-induced neurodegeneration: increased susceptibility with aging
    J Savory
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Neurotoxicology 20:805-17. 1999
  2. ncbi request reprint Supplementation of the diet with silicic acid to reduce body burden of aluminum: a miracle cure or useless treatment for Alzheimer's disease?
    John Savory
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    J Alzheimers Dis 10:25-7. 2006
  3. ncbi request reprint Is amyloid beta-peptide neurotoxic or neuroprotective and what is its role in the binding of metal ions?
    John Savory
    Department of Pathology, Health Sciences Center, University of Virginia, P O Box 168, Charlottesville 22908, USA
    Neurobiol Aging 23:1089-92. 2002
  4. ncbi request reprint Advances in instrumental methods for the measurement and speciation of trace metals
    J Savory
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Ann Clin Lab Sci 29:118-26. 1999
  5. ncbi request reprint Co-involvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits
    O Ghribi
    Department of Pathology, University of Virginia Health Sciences Center, Box 168, Charlottesville, VA 22908, USA
    Brain Res 903:66-73. 2001
  6. ncbi request reprint GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-XL and inhibiting mitochondrial Bax translocation
    O Ghribi
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Neurobiol Dis 8:764-73. 2001
  7. ncbi request reprint Lithium inhibits Abeta-induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation
    Othman Ghribi
    Department of Pathology, University of Virginia, Charlottesville, Virginia, USA
    J Neurosci Res 71:853-62. 2003
  8. ncbi request reprint Neuronal cytoskeletal lesions induced in the CNS by intraventricular and intravenous aluminium maltol in rabbits
    C D Katsetos
    Department of Pathology, University of Virginia School of Medicine, Charlottesville 22908
    Neuropathol Appl Neurobiol 16:511-28. 1990
  9. ncbi request reprint Aluminium maltol-induced neurocytoskeletal changes in fetal rabbit midbrain in matrix culture
    C D Hewitt
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908
    Neuropathol Appl Neurobiol 17:47-60. 1991
  10. ncbi request reprint Lithium inhibits aluminum-induced apoptosis in rabbit hippocampus, by preventing cytochrome c translocation, Bcl-2 decrease, Bax elevation and caspase-3 activation
    Othman Ghribi
    Department of Pathology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908 0214, USA
    J Neurochem 82:137-45. 2002

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Age-related hippocampal changes in Bcl-2:Bax ratio, oxidative stress, redox-active iron and apoptosis associated with aluminum-induced neurodegeneration: increased susceptibility with aging
    J Savory
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Neurotoxicology 20:805-17. 1999
    ..These are novel observations which may have important implications for aiding in our understanding of the pathogenesis of neurodegeneration occurring in Alzheimer's disease...
  2. ncbi request reprint Supplementation of the diet with silicic acid to reduce body burden of aluminum: a miracle cure or useless treatment for Alzheimer's disease?
    John Savory
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    J Alzheimers Dis 10:25-7. 2006
  3. ncbi request reprint Is amyloid beta-peptide neurotoxic or neuroprotective and what is its role in the binding of metal ions?
    John Savory
    Department of Pathology, Health Sciences Center, University of Virginia, P O Box 168, Charlottesville 22908, USA
    Neurobiol Aging 23:1089-92. 2002
  4. ncbi request reprint Advances in instrumental methods for the measurement and speciation of trace metals
    J Savory
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Ann Clin Lab Sci 29:118-26. 1999
    ..Refinement of these methods as well as more widely available instruments for microanalysis will add greatly to continued advances in our knowledge of the role of trace metals in biology and medicine...
  5. ncbi request reprint Co-involvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits
    O Ghribi
    Department of Pathology, University of Virginia Health Sciences Center, Box 168, Charlottesville, VA 22908, USA
    Brain Res 903:66-73. 2001
    ..Furthermore, as assessed by Western blot analysis, these effects are accompanied by a decrease in Bcl-2 and an increase in Bax reactivity in the endoplasmic reticulum...
  6. ncbi request reprint GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-XL and inhibiting mitochondrial Bax translocation
    O Ghribi
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Neurobiol Dis 8:764-73. 2001
    ..Treatment with GDNF may represent a therapeutic strategy to reverse the neuronal death associated with Alzheimer's disease and may exert its effect on apoptosis-regulatory proteins...
  7. ncbi request reprint Lithium inhibits Abeta-induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation
    Othman Ghribi
    Department of Pathology, University of Virginia, Charlottesville, Virginia, USA
    J Neurosci Res 71:853-62. 2003
    ....
  8. ncbi request reprint Neuronal cytoskeletal lesions induced in the CNS by intraventricular and intravenous aluminium maltol in rabbits
    C D Katsetos
    Department of Pathology, University of Virginia School of Medicine, Charlottesville 22908
    Neuropathol Appl Neurobiol 16:511-28. 1990
    ..The NFD lesions are compared with those of senile dementia of the Alzheimer type (SDAT) and motor neuron disease...
  9. ncbi request reprint Aluminium maltol-induced neurocytoskeletal changes in fetal rabbit midbrain in matrix culture
    C D Hewitt
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908
    Neuropathol Appl Neurobiol 17:47-60. 1991
    ..These studies may aid in the assessment of the possible role of aluminium in the aetiology of human neurodegenerative disorders...
  10. ncbi request reprint Lithium inhibits aluminum-induced apoptosis in rabbit hippocampus, by preventing cytochrome c translocation, Bcl-2 decrease, Bax elevation and caspase-3 activation
    Othman Ghribi
    Department of Pathology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908 0214, USA
    J Neurochem 82:137-45. 2002
    ..We propose that the neuroprotective effect of lithium involves the modulation of apoptosis-regulatory proteins present in the subcellular organelles of rabbit brain...
  11. ncbi request reprint Abeta(1-42) and aluminum induce stress in the endoplasmic reticulum in rabbit hippocampus, involving nuclear translocation of gadd 153 and NF-kappaB
    O Ghribi
    Department of Pathology, University of Virginia Health Sciences Center, Box 168, Charlottesville, VA 22908, USA
    Brain Res Mol Brain Res 96:30-8. 2001
    ..These findings indicate that the ER may play a role in regulating apoptosis in vivo, and could be of significance in the pathology of neurodegeneration and related disorders...
  12. ncbi request reprint Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease
    John Savory
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    J Alzheimers Dis 10:135-44. 2006
    ..Finally, we will examine data on the possible cellular mechanisms underlying aluminum neurotoxicity, and potential neuroprotective strategies against aluminum toxicity...
  13. ncbi request reprint The endoplasmic reticulum is the main site for caspase-3 activation following aluminum-induced neurotoxicity in rabbit hippocampus
    Othman Ghribi
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Neurosci Lett 324:217-21. 2002
    ..Inhibition of the latter enzyme by directly targeting its main site of activation could represent a strategy to prevent this adverse event...
  14. ncbi request reprint Neurofibrillary lesions in experimental aluminum-induced encephalopathy and Alzheimer's disease share immunoreactivity for amyloid precursor protein, A beta, alpha 1-antichymotrypsin and ubiquitin-protein conjugates
    Y Huang
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Brain Res 771:213-20. 1997
    ..This study provides additional support for immunochemical similarities between Al-induced NFD in rabbits and the neurofibrillary tangles in human subjects with Alzheimer's disease...
  15. ncbi request reprint Genetic algorithm for scheduling of laboratory personnel
    J C Boyd
    Department of Pathology, University of Virginia Health System, PO Box 800214, Charlottesville, VA 22908, USA
    Clin Chem 47:118-23. 2001
    ....
  16. ncbi request reprint GDNF regulates the A beta-induced endoplasmic reticulum stress response in rabbit hippocampus by inhibiting the activation of gadd 153 and the JNK and ERK kinases
    Othman Ghribi
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Neurobiol Dis 16:417-27. 2004
    ....
  17. ncbi request reprint Massive caffeine overdose requiring vasopressin infusion and hemodialysis
    Christopher P Holstege
    Division of Medical Toxicology, Department of Emergency Medicine, University of Virginia, Charlottesville, Virginia 22908 0699, USA
    J Toxicol Clin Toxicol 41:1003-7. 2003
    ..We describe the highest-reported serum concentration of caffeine in a patient who survived and discuss the first-reported use of vasopressin and hemodialysis in a caffeine-poisoned patient...
  18. ncbi request reprint MPP+ induces the endoplasmic reticulum stress response in rabbit brain involving activation of the ATF-6 and NF-kappaB signaling pathways
    Othman Ghribi
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neuropathol Exp Neurol 62:1144-53. 2003
    ..We propose that pharmacological agents that inhibit the perturbation of endoplasmic reticulum function or the activation of JNK may represent a potential therapeutic approach for the prevention of neurotoxin-induced Parkinson disease...
  19. ncbi request reprint Abeta(1-42)-induced JNK and ERK activation in rabbit hippocampus is differentially regulated by lithium but is not involved in the phosphorylation of tau
    Othman Ghribi
    Department of Pathology, Health Sciences Center, University of Virginia, P O Box 800214, Charlottesville, VA 22908, USA
    Brain Res Mol Brain Res 119:201-6. 2003
    ..Our results demonstrate that lithium, at this dose, effectively inhibits the Abeta-induced apoptosis but has no effect on tau phosphorylation, and that MAP kinases are not involved in the phosphorylation of tau...
  20. ncbi request reprint Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain
    John Savory
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    J Inorg Biochem 97:151-4. 2003
    ..This animal model system involving neurotoxicity induced by an aluminum compound provides new information on mechanisms of neurodegeneration and neuroprotection...
  21. ncbi request reprint Can studies of aluminum toxicity in vivo and in vitro provide relevant information on the pathogenesis and etiology of Alzheimer's disease?
    John Savory
    Department of Pathology, University of Virginia, Charlottesville, VA, USA
    J Alzheimers Dis 11:429-30; discussion 431-2. 2007
  22. ncbi request reprint Robotics and the changing face of the clinical laboratory
    J C Boyd
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Clin Chem 42:1901-10. 1996
    ..Thus, laboratory workers will need to be actively involved in implementing this new wave of laboratory automation, becoming well-versed in computers, electronics, and systems engineering...
  23. ncbi request reprint Aluminum-induced dendritic pathology revisited: cytochemical and electron microscopic studies of rabbit cortical pyramidal neurons
    Michael S Forbes
    Department of Pathology, University of Virginia School of Medicine, Charlottesville 22908, USA
    Ann Clin Lab Sci 32:75-86. 2002
    ..This suggests that protein subunits that are already present in the neurons under normal circumstances are recruited, in the presence of aluminum, to form NFAs through the directed assembly of masses of oriented filaments...
  24. ncbi request reprint Evaluation of nine automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications. Part 2
    W L Roberts
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Clin Chem 47:418-25. 2001
    ..This application requires higher sensitivity assays than have traditionally been available in the clinical laboratory...
  25. ncbi request reprint The significance of environmental factors in the etiology of Alzheimer's disease
    William B Grant
    12 Sir Francis Wyatt Place, Newport News, VA 23606 3660, USA
    J Alzheimers Dis 4:179-89. 2002
    ..Diet, aluminum, and viral infections may increase the prevalence of AD by eliciting inflammation, which may cause the neurological damage that results in AD...
  26. ncbi request reprint Aluminum maltolate-induced toxicity in NT2 cells occurs through apoptosis and includes cytochrome c release
    Kathleen J S Griffioen
    Department of Biology and Chemistry, Liberty University, 1971 University Blvd, Lynchburg, VA 24502, USA
    Neurotoxicology 25:859-67. 2004
    ..The release of cytochrome c was demonstrated with Western blot analysis. This in vitro model using human cells adds to our understanding of Al neurotoxicity and could provide insight into the neurodegenerative processes in human disease...
  27. ncbi request reprint Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis
    David A DeWitt
    Department of Biology, Liberty University, Lynchburg, VA 24502, USA
    J Alzheimers Dis 9:195-205. 2006
    ....