Theodore D Satterthwaite

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth
    Theodore D Satterthwaite
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Neuroimage 124:1115-9. 2016
  2. doi request reprint Towards an Individualized Delineation of Functional Neuroanatomy
    Theodore D Satterthwaite
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA Electronic address
    Neuron 87:471-3. 2015
  3. pmc How can studies of resting-state functional connectivity help us understand psychosis as a disorder of brain development?
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States Electronic address
    Curr Opin Neurobiol 30:85-91. 2015
  4. pmc Impact of puberty on the evolution of cerebral perfusion during adolescence
    Theodore D Satterthwaite
    Brain and Behavior Laboratory, Department of Psychiatry, Department of Radiology, Center for Biomedical Image Computing and Analytics
    Proc Natl Acad Sci U S A 111:8643-8. 2014
  5. pmc Sex differences in the effect of puberty on hippocampal morphology
    Theodore D Satterthwaite
    Perelman School of Medicine, University of Pennsylvania Electronic address
    J Am Acad Child Adolesc Psychiatry 53:341-50.e1. 2014
  6. pmc Neuroimaging of the Philadelphia neurodevelopmental cohort
    Theodore D Satterthwaite
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Neuroimage 86:544-53. 2014
  7. pmc Heterogeneous impact of motion on fundamental patterns of developmental changes in functional connectivity during youth
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Neuroimage 83:45-57. 2013
  8. pmc An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA
    Neuroimage 64:240-56. 2013
  9. pmc Being right is its own reward: load and performance related ventral striatum activation to correct responses during a working memory task in youth
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 61:723-9. 2012
  10. pmc Impact of in-scanner head motion on multiple measures of functional connectivity: relevance for studies of neurodevelopment in youth
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 60:623-32. 2012

Collaborators

Detail Information

Publications43

  1. pmc The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth
    Theodore D Satterthwaite
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Neuroimage 124:1115-9. 2016
    ....
  2. doi request reprint Towards an Individualized Delineation of Functional Neuroanatomy
    Theodore D Satterthwaite
    Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA Electronic address
    Neuron 87:471-3. 2015
    ..Laumann et al. (2015) present data from one highly sampled individual and show unique fine-grained differences representing subject-specific functional architecture. ..
  3. pmc How can studies of resting-state functional connectivity help us understand psychosis as a disorder of brain development?
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States Electronic address
    Curr Opin Neurobiol 30:85-91. 2015
    ....
  4. pmc Impact of puberty on the evolution of cerebral perfusion during adolescence
    Theodore D Satterthwaite
    Brain and Behavior Laboratory, Department of Psychiatry, Department of Radiology, Center for Biomedical Image Computing and Analytics
    Proc Natl Acad Sci U S A 111:8643-8. 2014
    ..Taken together, these results delineate sex-specific growth curves for CBF during youth and for the first time to our knowledge link such differential patterns of development to the effects of puberty. ..
  5. pmc Sex differences in the effect of puberty on hippocampal morphology
    Theodore D Satterthwaite
    Perelman School of Medicine, University of Pennsylvania Electronic address
    J Am Acad Child Adolesc Psychiatry 53:341-50.e1. 2014
    ..Here we examine whether sex differences exist in the effect of puberty on the morphology of the hippocampus and amygdala...
  6. pmc Neuroimaging of the Philadelphia neurodevelopmental cohort
    Theodore D Satterthwaite
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Neuroimage 86:544-53. 2014
    ..Finally, we describe mechanisms in place for data sharing that will allow the PNC to become a freely available public resource to advance our understanding of normal and pathological brain development. ..
  7. pmc Heterogeneous impact of motion on fundamental patterns of developmental changes in functional connectivity during youth
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Neuroimage 83:45-57. 2013
    ....
  8. pmc An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA
    Neuroimage 64:240-56. 2013
    ..These results demonstrate that the effect of motion on rsfc-MRI can be substantially attenuated through improved preprocessing procedures, but not completely removed...
  9. pmc Being right is its own reward: load and performance related ventral striatum activation to correct responses during a working memory task in youth
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 61:723-9. 2012
    ..These findings provide evidence for scalable intrinsic reinforcement signals during standard cognitive tasks, and suggest a novel link between motivation and cognition during adolescent development...
  10. pmc Impact of in-scanner head motion on multiple measures of functional connectivity: relevance for studies of neurodevelopment in youth
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 60:623-32. 2012
    ..The results demonstrate the pervasive influence of motion on multiple types functional connectivity analysis, and underline the importance of accounting for motion in studies of neurodevelopment...
  11. pmc Opposing amygdala and ventral striatum connectivity during emotion identification
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Cogn 76:353-63. 2011
    ..These results indicate that activity in the amygdala and ventral striatum may be inversely related, and that both regions may provide opposing affective bias signals during emotion identification...
  12. pmc Frontolimbic responses to emotional face memory: the neural correlates of first impressions
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Hum Brain Mapp 30:3748-58. 2009
    ..The results indicate that a network of frontolimbic regions may provide emotional bias signals during facial recognition...
  13. pmc Functional maturation of the executive system during adolescence
    Theodore D Satterthwaite
    Departments of Psychiatry and Radiology, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia PA 19104, Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia PA 19104, and Philadelphia Veterans Administration Medical Center, Philadelphia PA 19104
    J Neurosci 33:16249-61. 2013
    ..These results delineate a process of functional maturation of the executive system, and suggest that this process allows for the improvement of cognitive capability seen during adolescence. ..
  14. pmc Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challenge
    Daniel H Wolf
    Department of Psychiatry, University of Pennsylvania, 10th Floor Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 218:503-12. 2011
    ..Pharmacological modulation of emotion-processing deficits and related neural abnormalities may provide useful phenotypes for pathophysiological investigation...
  15. doi request reprint Common Dimensional Reward Deficits Across Mood and Psychotic Disorders: A Connectome-Wide Association Study
    Anup Sharma
    From the Departments of Psychiatry, Psychology, Biostatistics and Epidemiology, Radiology, Bioengineering, Perelman School of Medicine, and the Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia
    Am J Psychiatry . 2017
    ..Here, the authors explore the entire functional connectome in relation to reward responsivity across a population of adults with heterogeneous psychopathology...
  16. pmc The impact of quality assurance assessment on diffusion tensor imaging outcomes in a large-scale population-based cohort
    David R Roalf
    Neuropsychiatry Section, Department of Psychiatry, USA Electronic address
    Neuroimage 125:903-19. 2016
    ....
  17. pmc Persistence of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort: a prospective two-year follow-up
    Monica E Calkins
    Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    World Psychiatry 16:62-76. 2017
    ..Neurocognition, brain structure and function, and genomics may be integrated with clinical data to provide early indices of symptom persistence and worsening in youths at risk for psychosis...
  18. pmc Linked Sex Differences in Cognition and Functional Connectivity in Youth
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cereb Cortex 25:2383-94. 2015
    ..Taken together, these results demonstrate for the first time that sex differences in patterns of cognition are in part represented on a neural level through divergent patterns of brain connectivity. ..
  19. pmc Functional neuroimaging abnormalities in youth with psychosis spectrum symptoms
    Daniel H Wolf
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    JAMA Psychiatry 72:456-65. 2015
    ....
  20. pmc Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophrenia
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 167:418-26. 2010
    ..The authors used an affective face recognition paradigm to examine possible interactions between cognitive and affective neural systems in schizophrenia...
  21. pmc Common and Dissociable Mechanisms of Executive System Dysfunction Across Psychiatric Disorders in Youth
    Sheila Shanmugan
    From the Departments of Psychiatry, of Biostatistics and Epidemiology, of Radiology, and of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia the NIMH Mood and Anxiety Disorders Program, Bethesda, Md the Center for Applied Genomics, Children s Hospital of Philadelphia and the Philadelphia Veterans Administration Medical Center, Philadelphia
    Am J Psychiatry 173:517-26. 2016
    ..The authors hypothesize that common and dissociable patterns of dysfunction would be present...
  22. pmc Establishing a link between sex-related differences in the structural connectome and behaviour
    Birkan Tunc
    Center for Biomedical Image Computing and Analytics, Department of Radiology
    Philos Trans R Soc Lond B Biol Sci 371:20150111. 2016
    ..We also showed that these behavioural and structural patterns correlate with each other, establishing a reliable link between brain and behaviour. ..
  23. pmc Structural Brain Abnormalities in Youth With Psychosis Spectrum Symptoms
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia
    JAMA Psychiatry 73:515-24. 2016
    ..However, it is unclear when aberrations emerge in the disease process and if such deficits are present in association with less severe psychosis spectrum (PS) symptoms in youth...
  24. ncbi request reprint Temporal Lobe Volume Decrements in Psychosis Spectrum Youths
    David R Roalf
    Department of Psychiatry, Neuropsychiatry Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
    Schizophr Bull . 2016
    ..These MRI measures may therefore serve as important confirmatory biomarkers denoting a worrisome preclinical trajectory among at-risk youths, and the specific pattern of deficits may predict specific symptom profiles...
  25. pmc Development of an itemwise efficiency scoring method: Concurrent, convergent, discriminant, and neuroimaging-based predictive validity assessed in a large community sample
    Tyler M Moore
    Department of Psychiatry, University of Pennsylvania
    Psychol Assess 28:1529-1542. 2016
    ..PsycINFO Database Record..
  26. pmc Subject-level measurement of local cortical coupling
    Simon N Vandekar
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Neuroimage 133:88-97. 2016
    ..R code to estimate subject-level coupling maps from any two cortical surfaces generated by FreeSurfer is made publicly available along with this manuscript. ..
  27. pmc Elevated Amygdala Perfusion Mediates Developmental Sex Differences in Trait Anxiety
    Antonia N Kaczkurkin
    Departments of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
    Biol Psychiatry 80:775-785. 2016
    ..However, few studies relate developmental differences in symptoms of anxiety and depression to brain development. Cerebral blood flow is one brain phenotype that is known to have marked developmental sex differences...
  28. pmc Within-individual variability in neurocognitive performance: age- and sex-related differences in children and youths from ages 8 to 21
    David R Roalf
    Department of Psychiatry, University of Pennsylvania
    Neuropsychology 28:506-18. 2014
    ..Developmental studies focus on average performance in single domains but ignore consistency of performance across domains. Within-individual variability (WIV) provides an index of that evenness and is a potential marker of development...
  29. doi request reprint Neurocognitive growth charting in psychosis spectrum youths
    Ruben C Gur
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia
    JAMA Psychiatry 71:366-74. 2014
    ..We hypothesized that psychosis spectrum youths have delayed neurocognitive age relative to chronological age. We expected larger lags with increased symptom severity and in late adolescence and early adulthood...
  30. pmc MUSE: MUlti-atlas region Segmentation utilizing Ensembles of registration algorithms and parameters, and locally optimal atlas selection
    Jimit Doshi
    Center for Biomedical Image Computing and Analytics CBICA, University of Pennsylvania, Philadelphia, PA, USA
    Neuroimage 127:186-95. 2016
    ..MUSE is publicly available both as a downloadable software package, and as an application that can be run on the CBICA Image Processing Portal (https://ipp.cbica.upenn.edu), a web based platform for remote processing of medical images. ..
  31. pmc Sex differences in the structural connectome of the human brain
    Madhura Ingalhalikar
    Section of Biomedical Image Analysis and Center for Magnetic Resonance and Optical Imaging, Department of Radiology, and Department of Neuropsychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
    Proc Natl Acad Sci U S A 111:823-8. 2014
    ....
  32. pmc Divergent relationship of depression severity to social reward responses among patients with bipolar versus unipolar depression
    Anup Sharma
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Psychiatry Res 254:18-25. 2016
    ..Taken together, these results provide initial evidence that deficits in social reward processing are differentially related to depression severity in the two disorders. ..
  33. pmc Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 40:2258-68. 2015
    ..Reward system dysfunction thus represents a common brain mechanism with relevance that spans categories of psychiatric diagnosis. ..
  34. pmc The Philadelphia Neurodevelopmental Cohort: constructing a deep phenotyping collaborative
    Monica E Calkins
    Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Child Psychol Psychiatry 56:1356-69. 2015
    ..We also evaluate the structure of the assessment tools and their criterion validity...
  35. pmc Striatal intrinsic reinforcement signals during recognition memory: relationship to response bias and dysregulation in schizophrenia
    Daniel H Wolf
    Department of Psychiatry, University of Pennsylvania Philadelphia, PA, USA
    Front Behav Neurosci 5:81. 2011
    ..These findings highlight the importance of accounting for intrinsic motivation and reward when studying cognitive tasks, and add to growing evidence of reward circuit dysfunction in schizophrenia that may impact cognition and function...
  36. pmc Control-group feature normalization for multivariate pattern analysis of structural MRI data using the support vector machine
    Kristin A Linn
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA Electronic address
    Neuroimage 132:157-66. 2016
    ..We show that control-based normalization leads to better reproducibility of estimated multivariate disease patterns and improves the classifier performance in many cases. ..
  37. pmc Heritability of subcortical and limbic brain volume and shape in multiplex-multigenerational families with schizophrenia
    David R Roalf
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Electronic address
    Biol Psychiatry 77:137-46. 2015
    ..We estimate the heritability of subcortical and hippocampal brain volumes in multiplex-multigenerational families and the heritability of subregions using advanced shape analysis...
  38. pmc Disrupted anatomic networks in the 22q11.2 deletion syndrome
    J Eric Schmitt
    Brain Behavior Laboratory, Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Radiology, Division of Neuroradiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage Clin 12:420-8. 2016
    ..Multiple global graph theoretical statistics were decreased in 22q11DS. These results are consistent with prior studies demonstrating decreased connectivity in 22q11DS using other neuroimaging methodologies. ..
  39. pmc Emergence of system roles in normative neurodevelopment
    Shi Gu
    Applied Mathematics and Computational Science, University of Pennsylvania, Philadelphia, PA 19104 Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104
    Proc Natl Acad Sci U S A 112:13681-6. 2015
    ..Moreover, individual variability in these roles is correlated with cognitive performance. Collectively, these results suggest that dynamic maturation of network modules in youth may be a critical driver for the development of cognition. ..
  40. pmc Identifying Sparse Connectivity Patterns in the brain using resting-state fMRI
    Harini Eavani
    Center for Biomedical Image Computing and Analytics, University of Pennsylvania, USA Electronic address
    Neuroimage 105:286-99. 2015
    ..These findings substantiate existing knowledge of intrinsic functional connectivity and provide novel insights into the functional organization of the human brain. ..
  41. pmc Amotivation in schizophrenia: integrated assessment with behavioral, clinical, and imaging measures
    Daniel H Wolf
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
    Schizophr Bull 40:1328-37. 2014
    ..Integrating behavioral measures such as the PRT will facilitate translational efforts to identify biomarkers of amotivation and to assess response to novel therapeutic interventions. ..
  42. pmc A meta-analysis of the risk of acute extrapyramidal symptoms with intramuscular antipsychotics for the treatment of agitation
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market St, 2nd Floor, Philadelphia, PA 19104, USA
    J Clin Psychiatry 69:1869-79. 2008
    ..We examined the evidence for a decreased risk of extrapyramidal symptoms (EPS) with intramuscular second-generation antipsychotics (SGAs) versus intramuscular haloperidol alone or in combination with an anticholinergic agent...
  43. ncbi request reprint Dissociable but inter-related systems of cognitive control and reward during decision making: evidence from pupillometry and event-related fMRI
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 37:1017-31. 2007
    ..These results are consistent with the interpretation that reward signals may bias recruitment of frontal networks that are linked to allocation of cognitive resources...