Maureen A Sartor

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Current status and future perspectives for sequencing livestock genomes
    Yongsheng Bai
    Center for Computational Medicine and Bioinformatics and Department of Computational Medicine and Bioinformatics, The University of Michigan, 100 Washtenaw Ave, 2017 Palmer Commons, Ann Arbor, Michigan 48109 2218, USA
    J Anim Sci Biotechnol 3:8. 2012
  2. pmc Genome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes
    Henriette O'Geen
    Genome Center, University of California at Davis, Davis, CA 95616, USA
    BMC Genomics 11:689. 2010
  3. pmc ConceptGen: a gene set enrichment and gene set relation mapping tool
    Maureen A Sartor
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 26:456-63. 2010
  4. pmc Bisphenol A-associated alterations in the expression and epigenetic regulation of genes encoding xenobiotic metabolizing enzymes in human fetal liver
    Muna S Nahar
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan
    Environ Mol Mutagen 55:184-95. 2014
  5. pmc LRpath analysis reveals common pathways dysregulated via DNA methylation across cancer types
    Jung H Kim
    Department of Computational Medicine and Bioinformatics, Medical School, University of Michigan, Ann Arbor, MI, USA
    BMC Genomics 13:526. 2012
  6. pmc Microarray analysis reveals novel features of the muscle aging process in men and women
    Dongmei Liu
    Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48108, USA
    J Gerontol A Biol Sci Med Sci 68:1035-44. 2013
  7. pmc Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics
    Justin A Colacino
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    PLoS ONE 8:e54742. 2013
  8. pmc Bisphenol A-associated epigenomic changes in prepubescent girls: a cross-sectional study in Gharbiah, Egypt
    Jung H Kim
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Environ Health 12:33. 2013
  9. pmc Resistance exercise training influences skeletal muscle immune activation: a microarray analysis
    Paul M Gordon
    University of Michigan, Ann Arbor, Michigan 48108, USA
    J Appl Physiol (1985) 112:443-53. 2012
  10. pmc A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder
    Richard C McEachin
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    BMC Syst Biol 4:158. 2010

Collaborators

Detail Information

Publications31

  1. pmc Current status and future perspectives for sequencing livestock genomes
    Yongsheng Bai
    Center for Computational Medicine and Bioinformatics and Department of Computational Medicine and Bioinformatics, The University of Michigan, 100 Washtenaw Ave, 2017 Palmer Commons, Ann Arbor, Michigan 48109 2218, USA
    J Anim Sci Biotechnol 3:8. 2012
    ..It is clear that NGS technologies will be able to assist animal scientists to efficiently raise animals and to better prevent infectious diseases so that overall costs of animal production can be decreased...
  2. pmc Genome-wide binding of the orphan nuclear receptor TR4 suggests its general role in fundamental biological processes
    Henriette O'Geen
    Genome Center, University of California at Davis, Davis, CA 95616, USA
    BMC Genomics 11:689. 2010
    ..The orphan nuclear receptor TR4 (human testicular receptor 4 or NR2C2) plays a pivotal role in a variety of biological and metabolic processes. With no known ligand and few known target genes, the mode of TR4 function was unclear...
  3. pmc ConceptGen: a gene set enrichment and gene set relation mapping tool
    Maureen A Sartor
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 26:456-63. 2010
    ..Accomplishing these tasks requires a unified framework for agglomeration of data from various genomic resources, novel visualizations, and user functionality...
  4. pmc Bisphenol A-associated alterations in the expression and epigenetic regulation of genes encoding xenobiotic metabolizing enzymes in human fetal liver
    Muna S Nahar
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan
    Environ Mol Mutagen 55:184-95. 2014
    ....
  5. pmc LRpath analysis reveals common pathways dysregulated via DNA methylation across cancer types
    Jung H Kim
    Department of Computational Medicine and Bioinformatics, Medical School, University of Michigan, Ann Arbor, MI, USA
    BMC Genomics 13:526. 2012
    ..The ability of our logistic regression-based gene set enrichment method to implicate important biological pathways in high-throughput data is well established...
  6. pmc Microarray analysis reveals novel features of the muscle aging process in men and women
    Dongmei Liu
    Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI 48108, USA
    J Gerontol A Biol Sci Med Sci 68:1035-44. 2013
    ..The effect of aging results in sexual dimorphic alterations in the skeletal muscle transcriptome, which may modify the risk for developing musculoskeletal and metabolic diseases in men and women. ..
  7. pmc Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics
    Justin A Colacino
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    PLoS ONE 8:e54742. 2013
    ..These findings provide insight into the epigenetic regulation of viral vs. chemical carcinogenesis and could provide novel targets for development of individualized therapeutic and prevention regimens based on environmental exposures...
  8. pmc Bisphenol A-associated epigenomic changes in prepubescent girls: a cross-sectional study in Gharbiah, Egypt
    Jung H Kim
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Environ Health 12:33. 2013
    ..Thus, we conducted an environmental epidemiology study of BPA exposure and CpG methylation in pre-adolescent girls from Gharbiah, Egypt hypothesizing that methylation profiles exhibit exposure-dependent trends...
  9. pmc Resistance exercise training influences skeletal muscle immune activation: a microarray analysis
    Paul M Gordon
    University of Michigan, Ann Arbor, Michigan 48108, USA
    J Appl Physiol (1985) 112:443-53. 2012
    ....
  10. pmc A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder
    Richard C McEachin
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    BMC Syst Biol 4:158. 2010
    ..We initially hypothesized a gene-by-environment interaction where lithium, acting as an environmental influence, impacts signal transduction pathways leading to differential expression of genes important in the etiology of BD mania...
  11. pmc NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas
    Shama Virani
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
    BMC Cancer 15:825. 2015
    ..Here, we test the hypothesis that specific candidate gene methylation markers (CCNA1, NDN, CD1A, DCC, p16, GADD45A) are associated with tumor recurrence and survival, in a well-characterized, prospective, cohort of 346 HNSCC patients...
  12. pmc Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data
    Alla Karnovsky
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109 2218, USA
    Bioinformatics 28:373-80. 2012
    ..g. transcriptomics, proteomics), and incorporate prior knowledge of pathways and molecular interactions...
  13. pmc Perinatal bisphenol A exposure promotes dose-dependent alterations of the mouse methylome
    Jung H Kim
    Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, Michigan, USA
    BMC Genomics 15:30. 2014
    ..Here, we undertake the first genome-wide characterization of DNA methylation profiles in the liver of murine offspring exposed perinatally to multiple doses of BPA through the maternal diet...
  14. pmc Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex
    Kelly M Bakulski
    Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    J Alzheimers Dis 29:571-88. 2012
    ..Identification of epigenetic biomarkers of LOAD risk may allow for the development of novel diagnostic and therapeutic targets...
  15. pmc Convergence of genetic influences in comorbidity
    Richard C McEachin
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48105, USA
    BMC Bioinformatics 13:S8. 2012
    ..The Rank Product (RP) method overcomes limitations posed by Fisher assumptions, though RP was not designed for GWA data...
  16. pmc Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas
    Justin A Colacino
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
    Epigenetics 7:883-91. 2012
    ..These preliminary results suggest that intake of folate, vitamin A and vitamin B12 may be associated with the tumor DNA methylation profile in HNC and enhance tumor suppression...
  17. pmc Appearance frequency modulated gene set enrichment testing
    Jun Ma
    Department of EECS, University of Michigan, Ann Arbor, USA
    BMC Bioinformatics 12:81. 2011
    ....
  18. pmc Novel bioinformatics method for identification of genome-wide non-canonical spliced regions using RNA-Seq data
    Yongsheng Bai
    Department of Computational Medicine and Bioinformatics, and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America Morgridge Institute for Research, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 9:e100864. 2014
    ..Strikingly, other examples of targeted, unconventional splicing of short mRNA regions have yet to be reported...
  19. pmc THINK Back: KNowledge-based Interpretation of High Throughput data
    Fernando Farfán
    Computer Science and Engineering Department, University of Michigan, Ann Arbor, MI, USA
    BMC Bioinformatics 13:S4. 2012
    ....
  20. pmc Genomic binding and regulation of gene expression by the thyroid carcinoma-associated PAX8-PPARG fusion protein
    Yanxiao Zhang
    Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA
    Oncotarget 6:40418-32. 2015
    ..Our data highlight the complexity of PPFP as a transcription factor and the numerous ways that it regulates thyroid oncogenesis. ..
  21. pmc Regulation of the human endogenous retrovirus K (HML-2) transcriptome by the HIV-1 Tat protein
    Marta J Gonzalez-Hernandez
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA Program in Immunology, University of Michigan, Ann Arbor, Michigan, USA
    J Virol 88:8924-35. 2014
    ..Quantitative reverse transcription-PCR validation of the sequencing data was performed on Tat-treated PBLs of seven donors using provirus-specific primers and corroborated the results with a substantial degree of quantitative similarity...
  22. pmc A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways
    Neil Warner
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Sci Signal 6:rs3. 2013
    ..Overall, the genes identified here provide a resource to facilitate the elucidation of the molecular mechanisms that regulate NOD2- and NF-κB-mediated inflammation...
  23. pmc Metab2MeSH: annotating compounds with medical subject headings
    Maureen A Sartor
    National Center for Integrative Biomedical Informatics, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 28:1408-10. 2012
    ..These annotations provide links from compounds to biomedical literature and complement existing resources such as PubChem and the Human Metabolome Database...
  24. pmc LRpath: a logistic regression approach for identifying enriched biological groups in gene expression data
    Maureen A Sartor
    Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI, USA
    Bioinformatics 25:211-7. 2009
    ..Several statistical methods are commonly used in this context, but the question of the optimal approach has still not been resolved...
  25. pmc MethylSig: a whole genome DNA methylation analysis pipeline
    Yongseok Park
    Department of Computational Medicine and Bioinformatics, Pathology Department, Department of Environmental Health Sciences, Department of Otolaryngology and Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 30:2414-22. 2014
    ..One challenging question is how best to test for significant methylation differences between groups of biological samples in order to minimize false positive findings...
  26. pmc PePr: a peak-calling prioritization pipeline to identify consistent or differential peaks from replicated ChIP-Seq data
    Yanxiao Zhang
    Department of Computational Medicine and Bioinformatics, Department of Biostatistics and Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 30:2568-75. 2014
    ..However, tools that can perform group comparisons are currently lacking...
  27. pmc Broad-Enrich: functional interpretation of large sets of broad genomic regions
    Raymond G Cavalcante
    Department of Computational Medicine and Bioinformatics, Department of Biostatistics and Center of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 30:i393-400. 2014
    ..These approaches work well for transcription factors, but histone modifications often occur over broad domains, and across multiple genes...
  28. pmc Genome-wide methylation and expression differences in HPV(+) and HPV(-) squamous cell carcinoma cell lines are consistent with divergent mechanisms of carcinogenesis
    Maureen A Sartor
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA
    Epigenetics 6:777-87. 2011
    ..Distinct HPV(+) and HPV(-) epigenetic profiles should provide clues to novel targets for development of individualized therapeutic strategies...
  29. pmc Skeletal muscle gene expression in response to resistance exercise: sex specific regulation
    Dongmei Liu
    Dept of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, USA
    BMC Genomics 11:659. 2010
    ..A logistic regression-based method (LRpath), following Bayesian moderated t-statistic (IMBT), was used to test gene functional groups and biological pathways enriched with differentially expressed genes...
  30. pmc An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer
    Xiao Song Wang
    Michigan Center for Translational Pathology, Ann Arbor, Michigan, USA
    Nat Biotechnol 27:1005-11. 2009
    ..Knockdown of NFE2 decreased proliferation and invasion of H1792 cells. Together, these results present a systematic analysis of gene fusions in cancer and describe key characteristics that assist in new fusion discovery...
  31. pmc Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder
    Richard C McEachin
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
    BMC Med Genet 11:14. 2010
    ..Therefore, we hypothesized a common underlying genetic etiology, interacting with nicotine exposure, influencing susceptibility to both BD and TUD...