Carolyn I Sartor

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Postmastectomy radiotherapy in intermediate-risk patients: the gray zone
    Carolyn I Sartor
    University of North Carolina School of Medicine, 101 Manning Drive, Chapel Hill, NC 27599, USA
    Curr Oncol Rep 8:29-34. 2006
  2. ncbi request reprint Effect of addition of adjuvant paclitaxel on radiotherapy delivery and locoregional control of node-positive breast cancer: cancer and leukemia group B 9344
    Carolyn I Sartor
    Dept of Radiation Oncology, University of North Carolina School of Medicine, CB7512, Chapel Hill, NC 27599, USA
    J Clin Oncol 23:30-40. 2005
  3. ncbi request reprint Axillary lymph node count is lower after neoadjuvant chemotherapy
    Heather Neuman
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Surg 191:827-9. 2006
  4. ncbi request reprint In vivo intraoperative radiotherapy: a novel approach to radiotherapy for early stage breast cancer
    Karyn B Stitzenberg
    Department of Surgery, University of North Carolina, Chapel Hill, NC, USA
    Ann Surg Oncol 14:1515-6. 2007
  5. ncbi request reprint The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes
    Lisa A Carey
    Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7305, USA
    Clin Cancer Res 13:2329-34. 2007
  6. doi request reprint Local control following single-dose intraoperative radiotherapy prior to surgical excision of early-stage breast cancer
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Ann Surg Oncol 18:939-45. 2011
  7. pmc Cosmetic outcomes for accelerated partial breast irradiation before surgical excision of early-stage breast cancer using single-dose intraoperative radiotherapy
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Int J Radiat Oncol Biol Phys 79:400-7. 2011
  8. pmc Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA
    Clin Cancer Res 16:912-23. 2010
  9. doi request reprint Radiosensitization of chemotherapy-refractory, locally advanced or locally recurrent breast cancer with trastuzumab: a phase II trial
    Janet K Horton
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Int J Radiat Oncol Biol Phys 76:998-1004. 2010
  10. ncbi request reprint Staged sentinel lymph node biopsy before mastectomy facilitates surgical planning for breast cancer patients
    Nancy Klauber-Demore
    Division of Surgical Oncology, University of North Carolina at Chapel Hill, 3010 Old Clinic Bldg, CB No 7213, Chapel Hill, NC 27599, USA
    Am J Surg 190:595-7. 2005

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Postmastectomy radiotherapy in intermediate-risk patients: the gray zone
    Carolyn I Sartor
    University of North Carolina School of Medicine, 101 Manning Drive, Chapel Hill, NC 27599, USA
    Curr Oncol Rep 8:29-34. 2006
    ..Nonetheless, a clear consensus on the role of postmastectomy radiotherapy remains elusive for patients who are at intermediate risk of locoregional recurrence after mastectomy...
  2. ncbi request reprint Effect of addition of adjuvant paclitaxel on radiotherapy delivery and locoregional control of node-positive breast cancer: cancer and leukemia group B 9344
    Carolyn I Sartor
    Dept of Radiation Oncology, University of North Carolina School of Medicine, CB7512, Chapel Hill, NC 27599, USA
    J Clin Oncol 23:30-40. 2005
    ....
  3. ncbi request reprint Axillary lymph node count is lower after neoadjuvant chemotherapy
    Heather Neuman
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Surg 191:827-9. 2006
    ..We postulated that despite aggressive ALND, a lower lymph node count is more frequent after neoadjuvant chemotherapy...
  4. ncbi request reprint In vivo intraoperative radiotherapy: a novel approach to radiotherapy for early stage breast cancer
    Karyn B Stitzenberg
    Department of Surgery, University of North Carolina, Chapel Hill, NC, USA
    Ann Surg Oncol 14:1515-6. 2007
    ..We are investigating the feasibility of partial breast irradiation using a single fraction of IORT delivered to the tumor in vivo prior to surgical resection...
  5. ncbi request reprint The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes
    Lisa A Carey
    Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7305, USA
    Clin Cancer Res 13:2329-34. 2007
    ..Gene expression analysis identifies several breast cancer subtypes. We examined the relationship of neoadjuvant chemotherapy response to outcome among these breast cancer subtypes...
  6. doi request reprint Local control following single-dose intraoperative radiotherapy prior to surgical excision of early-stage breast cancer
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Ann Surg Oncol 18:939-45. 2011
    ..This study details our completed, single-institution trial...
  7. pmc Cosmetic outcomes for accelerated partial breast irradiation before surgical excision of early-stage breast cancer using single-dose intraoperative radiotherapy
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Int J Radiat Oncol Biol Phys 79:400-7. 2011
    ..Determine cosmetic outcome and toxicity profile of intraoperative radiation delivered before tumor excision for patients with early-stage breast cancer...
  8. pmc Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status
    Randall J Kimple
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA
    Clin Cancer Res 16:912-23. 2010
    ..We investigated the effects of inhibition of EGFR/HER2 signaling on pancreatic cancer to elucidate the role(s) of EGFR/HER2 in radiosensitization and to provide evidence in support of further clinical investigations...
  9. doi request reprint Radiosensitization of chemotherapy-refractory, locally advanced or locally recurrent breast cancer with trastuzumab: a phase II trial
    Janet K Horton
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Int J Radiat Oncol Biol Phys 76:998-1004. 2010
    ..The present Phase II trial evaluated trastuzumab plus radiotherapy in patients with HER2-positive, chemotherapy-refractory, locally advanced or locoregionally recurrent breast cancer...
  10. ncbi request reprint Staged sentinel lymph node biopsy before mastectomy facilitates surgical planning for breast cancer patients
    Nancy Klauber-Demore
    Division of Surgical Oncology, University of North Carolina at Chapel Hill, 3010 Old Clinic Bldg, CB No 7213, Chapel Hill, NC 27599, USA
    Am J Surg 190:595-7. 2005
    ..The purpose of this study was to determine how performing an SLN biopsy (SLNB) before the definitive operation would influence subsequent surgical procedures...
  11. ncbi request reprint American Joint Committee on Cancer tumor-node-metastasis stage after neoadjuvant chemotherapy and breast cancer outcome
    Lisa A Carey
    Division of Hematology Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7305, USA
    J Natl Cancer Inst 97:1137-42. 2005
    ....
  12. doi request reprint Phase 2 study of pre-excision single-dose intraoperative radiation therapy for early-stage breast cancers: six-year update with application of the ASTRO accelerated partial breast irradiation consensus statement criteria
    Noam A Vanderwalde
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cancer 119:1736-43. 2013
    ..Intraoperative radiation therapy (IORT) allows delivery of high-dose radiation at the time of lumpectomy, potentially sparing adjuvant daily radiation. A phase 2 study of pre-excision IORT was performed for early-stage breast cancer...
  13. pmc Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK
    Maria J Sambade
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, NC 27599, USA
    Radiother Oncol 93:639-44. 2009
    ..The purpose of this study was to identify the downstream signaling pathways responsible for lapatinib-mediated radiosensitization in breast cancer...
  14. pmc The HER4 cytoplasmic domain, but not its C terminus, inhibits mammary cell proliferation
    Shu Mang Feng
    University of North Carolina Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina 27599, USA
    Mol Endocrinol 21:1861-76. 2007
    ..These results indicate that surface HER4 tyrosine phosphorylation and ligand-dependent release of s80HER4 are necessary, and s80HER4 signaling is sufficient for HER4-dependent growth inhibition...
  15. ncbi request reprint Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance
    Hong Zhou
    Department of Radiation Oncology, University of North Carolina School of Medicine and UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA
    Int J Radiat Oncol Biol Phys 58:344-52. 2004
    ....
  16. ncbi request reprint Feasibility of breast preserving therapy with single fraction in situ radiotherapy delivered intraoperatively
    David W Ollila
    Department of Surgery, UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, 3010 Old Clinic Building, CB 7213, Chapel Hill, NC 27599 7213, USA
    Ann Surg Oncol 14:660-9. 2007
    ..We adapted the technique of Veronesi to deliver IORT prior to tumor excision to improve delivery to the region at risk and reduce the volume of normal tissue irradiated...
  17. pmc EGFR associated expression profiles vary with breast tumor subtype
    Katherine A Hoadley
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Genomics 8:258. 2007
    ..An EGFR-associated gene expression signature was identified in the basal-like SUM102 cell line and was used to classify a diverse set of sporadic breast tumors...
  18. ncbi request reprint Size of residual lymph node metastasis after neoadjuvant chemotherapy in locally advanced breast cancer patients is prognostic
    Nancy Klauber-Demore
    Department of Surgery, University of North Carolina at Chapel Hill, 27599, USA
    Ann Surg Oncol 13:685-91. 2006
    ..We examined the residual lymph node metastasis size in patients after treatment with neoadjuvant chemotherapy to determine the relevance of metastasis size on outcome...
  19. ncbi request reprint Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis
    Lynn B Eckert
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Cancer Res 64:4585-92. 2004
    ....
  20. ncbi request reprint High-resolution axillary ultrasound is a poor prognostic test for determining pathologic lymph node status in patients undergoing neoadjuvant chemotherapy for locally advanced breast cancer
    Nancy Klauber-Demore
    Department of Surgery, University of North Carolina at Chapel Hill, 3010 Old Clinic Bldg, CB No 7213, Chapel Hill, NC 27599, USA
    Am J Surg 188:386-9. 2004
    ..The purpose of this study was to evaluate the efficacy of high-resolution axillary ultrasound in detecting axillary lymph node metastases after neoadjuvant chemotherapy in patients with locally advanced breast cancer...
  21. ncbi request reprint Molecular targets as therapeutic strategies in the management of breast cancer
    Carolyn I Sartor
    Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA
    Semin Radiat Oncol 12:341-51. 2002
    ..In this overview, I discuss three targets relevant to breast cancer (the epidermal growth factor receptor family, angiogenesis, and NF-kappa B), and therapeutic approaches directed against these targets are discussed...
  22. ncbi request reprint Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance
    Theresa M Grana
    Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599 7512, USA
    Cancer Res 63:7807-14. 2003
    ....
  23. ncbi request reprint Inhibition of HER-2/neu kinase impairs androgen receptor recruitment to the androgen responsive enhancer
    Yuanbo Liu
    Lineberger Comprehensive Cancer Center, Department of Radiation Oncology, University of North Carolina, 102 Mason Farm Road, Chapel Hill, NC 27599, USA
    Cancer Res 65:3404-9. 2005
    ..These results show that HER-2 signaling is required for optimal transcriptional activity of AR in prostate cancer cells and suggest that HER-2 inhibition may provide a novel strategy to disrupt AR function in prostate cancer...
  24. pmc Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1
    Rebecca S Muraoka-Cook
    Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, 102 Mason Farm Road, Chapel Hill, NC 27599, USA
    Mol Cell Biol 26:6412-24. 2006
    ..BRCA1-positive MECs displayed heregulin-dependent mitotic delay; however, the isogenic BRCA1-negative MECs did not. These results suggest that heregulin-mediated growth inhibition in HER4-postive breast cancer cells requires BRCA1...
  25. ncbi request reprint Mechanisms of disease: Radiosensitization by epidermal growth factor receptor inhibitors
    Carolyn I Sartor
    University of North Carolina Lineberger Comprehensive Cancer Breast Cancer Program, UNC School of Medicine, Chapel Hill, NC 27599, USA
    Nat Clin Pract Oncol 1:80-7. 2004
    ..This review will explore potential mechanisms of radiosensitization by EGFR inhibitors...
  26. pmc The EGF receptor family--multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4
    H Shelton Earp
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Trans Am Clin Climatol Assoc 114:315-33; discussion 333-4. 2003
    ..The present work delineates a role for HER4 in breast cancer cell differentiation and demonstrates that HER4 is both necessary and sufficient to produce an anti-proliferative signal. These..
  27. ncbi request reprint Epidermal growth factor family receptors and inhibitors: radiation response modulators
    Carolyn I Sartor
    Department of Radiation Oncology and UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Semin Radiat Oncol 13:22-30. 2003
    ..Further investigation of the radiation response modulation by EGFR family members and their inhibitors will lead to optimization of this promising therapeutic approach...
  28. ncbi request reprint Central nervous system metastases in women after multimodality therapy for high risk breast cancer
    Lisa A Carey
    Division of Hematology Oncology, Department of Medicine, University of North Carolina, 3009 Old Clinic Building, Chapel Hill, NC, 27599 7305, USA
    Breast Cancer Res Treat 88:273-80. 2004
    ..This increase may reflect altered failure patterns from adjuvant therapy, more effective systemic therapy with improved control in non-CNS sites, or a resistant breast cancer subtype...
  29. ncbi request reprint Comparison of three concomitant boost techniques for early-stage breast cancer
    Janet K Horton
    Department of Radiation Oncology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
    Int J Radiat Oncol Biol Phys 64:168-75. 2006
    ..Interest is growing in RT regimens, such as concomitant boost, that decrease overall treatment time, lessening the time/cost burden to patients and facilities...
  30. ncbi request reprint Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-independent signaling pathways
    Theresa M Grana
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Cancer Res 62:4142-50. 2002
    ....
  31. ncbi request reprint Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia
    Marc L Citron
    ProHEALTH Care Associates, LLP, 2800 Marcus Ave, Lake Success, NY 11042, USA
    J Clin Oncol 21:1431-9. 2003
    ....
  32. ncbi request reprint The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells
    Anjali Naresh
    Department of Biochemistry, Tulane University Health Sciences Center, Tulane Cancer Center, LA 70112 2699, USA
    Cancer Res 66:6412-20. 2006
    ..Thus, we propose that ligand-induced mitochondrial accumulation of 4ICD represents a unique mechanism of action for transmembrane receptors, directly coupling a cell surface signal to the tumor cell mitochondrial apoptotic pathway...
  33. ncbi request reprint Is less more? Lessons in radiation schedules in breast cancer
    Carolyn I Sartor
    J Natl Cancer Inst 94:1114-5. 2002
  34. ncbi request reprint Radiation therapy and biologics: a ripe opportunity?
    Joel E Tepper
    Nat Clin Pract Oncol 3:463. 2006