Youssef Sari

Summary

Affiliation: University of Toledo
Country: USA

Publications

  1. pmc Potential drugs and methods for preventing or delaying the progression of Huntington's disease
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, OH 43614, USA
    Recent Pat CNS Drug Discov 6:80-90. 2011
  2. pmc Effects of ceftriaxone on ethanol, nicotine or sucrose intake by alcohol-preferring (P) rats and its association with GLT-1 expression
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, USA Electronic address
    Neuroscience 326:117-25. 2016
  3. ncbi request reprint Targeting Dopaminergic System for Treating Nicotine Dependence
    Sawsan Abuhamdah
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA
    Cent Nerv Syst Agents Med Chem 16:137-42. 2016
  4. pmc Experimental methods for testing the effects of neurotrophic peptide, ADNF-9, against alcohol-induced apoptosis during pregnancy in c57bl/6 mice
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, USA
    J Vis Exp . 2013
  5. ncbi request reprint Monoamine Oxidase Inhibitors Extracted from Tobacco Smoke as Neuroprotective Factors for Potential Treatment of Parkinson's Disease
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, HEB282G, Toledo, OH 43614 USA
    CNS Neurol Disord Drug Targets 14:777-85. 2015
  6. pmc Potential therapeutic drugs and methods for the treatment of amyotrophic lateral sclerosis
    G Yacila
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614 USA
    Curr Med Chem 21:3583-93. 2014
  7. pmc Therapeutic perspectives of drugs targeting Toll-like receptors based on immune physiopathology theory of Alzheimer's disease
    Andrew R Schneider
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA
    CNS Neurol Disord Drug Targets 13:909-20. 2014
  8. pmc Ceftriaxone treatment affects the levels of GLT1 and ENT1 as well as ethanol intake in alcohol-preferring rats
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43614, USA
    J Mol Neurosci 51:779-87. 2013
  9. pmc Effects of ceftriaxone on the acquisition and maintenance of ethanol drinking in peri-adolescent and adult female alcohol-preferring (P) rats
    Y Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, USA
    Neuroscience 241:229-38. 2013
  10. pmc Role of 5-hydroxytryptamine 1B (5-HT1B) receptors in the regulation of ethanol intake in rodents
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, USA
    J Psychopharmacol 27:3-12. 2013

Collaborators

  • Doo Sup Choi
  • R L Bell
  • Yusuf S Althobaiti
  • P S S Rao
  • Fahad S Alshehri
  • Fawaz Alasmari
  • Alqassem Y Hakami
  • Sujan C Das
  • Sawsan Abuhamdah
  • Sunil Goodwani
  • Atiah H Almalki
  • G Yacila
  • Andrew R Schneider
  • Abeer M Qrunfleh
  • Shakir D Alsharari
  • Salim S Al-Rejaie
  • Ashraf Khalil
  • Alaa M Hammad
  • Hannah Saternos
  • Adnan Alazizi

Detail Information

Publications32

  1. pmc Potential drugs and methods for preventing or delaying the progression of Huntington's disease
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, OH 43614, USA
    Recent Pat CNS Drug Discov 6:80-90. 2011
    ..There are current patented drugs that are currently being considered as potential therapeutics for HD. These patented drugs may provide promising therapy for HD...
  2. pmc Effects of ceftriaxone on ethanol, nicotine or sucrose intake by alcohol-preferring (P) rats and its association with GLT-1 expression
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, USA Electronic address
    Neuroscience 326:117-25. 2016
    ....
  3. ncbi request reprint Targeting Dopaminergic System for Treating Nicotine Dependence
    Sawsan Abuhamdah
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA
    Cent Nerv Syst Agents Med Chem 16:137-42. 2016
    ..Cigarette smoking increases the risk of numerous health problems, including heart diseases, stroke, atherosclerosis and many types of cancer, including lung, stomach and bladder cancers...
  4. pmc Experimental methods for testing the effects of neurotrophic peptide, ADNF-9, against alcohol-induced apoptosis during pregnancy in c57bl/6 mice
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, USA
    J Vis Exp . 2013
    ..Together, these visual and textual techniques might be a source for investigating prenatal exposure of harmful agents in fetal brains...
  5. ncbi request reprint Monoamine Oxidase Inhibitors Extracted from Tobacco Smoke as Neuroprotective Factors for Potential Treatment of Parkinson's Disease
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, HEB282G, Toledo, OH 43614 USA
    CNS Neurol Disord Drug Targets 14:777-85. 2015
    ....
  6. pmc Potential therapeutic drugs and methods for the treatment of amyotrophic lateral sclerosis
    G Yacila
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614 USA
    Curr Med Chem 21:3583-93. 2014
    ..Interestingly, the uses of stem cell therapy and immunotherapy are promising for the treatment of ALS...
  7. pmc Therapeutic perspectives of drugs targeting Toll-like receptors based on immune physiopathology theory of Alzheimer's disease
    Andrew R Schneider
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA
    CNS Neurol Disord Drug Targets 13:909-20. 2014
    ..The primary drug therapy methods and patents discussed include the use of neurotrophic factors and targeting of the amyloid precursor protein cleavage pathway as prevention of β-amyloid formation and tau aggregation. ..
  8. pmc Ceftriaxone treatment affects the levels of GLT1 and ENT1 as well as ethanol intake in alcohol-preferring rats
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43614, USA
    J Mol Neurosci 51:779-87. 2013
    ..Importantly, CEF treatment reversed these effects in both NAc core and shell. These findings provide evidence for potential regulatory effects of CEF on both GLT1 and ENT1 expression in reducing ethanol intake...
  9. pmc Effects of ceftriaxone on the acquisition and maintenance of ethanol drinking in peri-adolescent and adult female alcohol-preferring (P) rats
    Y Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, USA
    Neuroscience 241:229-38. 2013
    ..These findings provide further support for GLT1-associated mechanisms in high alcohol-consuming behavior, and hold promise for the development of effective treatments targeting alcohol abuse and dependence...
  10. pmc Role of 5-hydroxytryptamine 1B (5-HT1B) receptors in the regulation of ethanol intake in rodents
    Youssef Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, USA
    J Psychopharmacol 27:3-12. 2013
    ..This review on the role of 5-HT1B receptors in neurotransmitter release and consequent alcohol intake provides important information about the potential therapeutic role of 5-HT1B receptors for the treatment of alcohol dependence...
  11. pmc Glutamate transporter 1: target for the treatment of alcohol dependence
    P S S Rao
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA
    Curr Med Chem 19:5148-56. 2012
    ..Importantly, ceftriaxone is currently in clinical trials for the treatment of amyotrophic lateral sclerosis. This review provides information about the potential therapeutic role of GLT1 for the treatment of alcohol abuse and dependence...
  12. pmc Neurotrophic peptides, ADNF-9 and NAP, prevent alcohol-induced apoptosis at midgestation in fetal brains of C57BL/6 mouse
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 3000 Arlington Avenue, Toledo, OH 43614, USA
    J Mol Neurosci 49:150-6. 2013
    ..These findings may pave the path toward potential therapeutics against alcohol intoxication during pregnancy stages...
  13. pmc Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats
    Y Sari
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, Toledo, OH 43614, United States
    Neuroscience 227:327-35. 2012
    ..These findings demonstrated that neuroimmunophilin GPI-1046 attenuates ethanol intake in part through the upregulation of GLT1 in PFC and NAc-core...
  14. pmc Activity-dependent neurotrophic factor-derived peptide prevents alcohol-induced apoptosis, in part, through Bcl2 and c-Jun N-terminal kinase signaling pathways in fetal brain of C57BL/6 mouse
    Y Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 3000 Arlington Ave Toledo, OH 43614, USA
    Neuroscience 202:465-73. 2012
    ..The neuroprotective mechanism of action of ADNF-9 provides a direction for potential therapeutics against alcohol-induced neural damage involving mitochondrial dysfunction...
  15. pmc Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Health Science Campus, 3000 Arlington Avenue, Toledo, OH 43614, USA
    Alcohol Alcohol 46:239-46. 2011
    ..We hypothesized that because glutamate transporter 1 (GLT1) is responsible for the removal of most extracellular glutamate, up-regulation or activation of GLT1 would attenuate ethanol consumption...
  16. pmc Neuroprotective peptide ADNF-9 in fetal brain of C57BL/6 mice exposed prenatally to alcohol
    Youssef Sari
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA
    J Biomed Sci 18:77. 2011
    ....
  17. pmc Effects of cefazolin and cefoperazone on glutamate transporter 1 isoforms and cystine/glutamate exchanger as well as alcohol drinking behavior in male alcohol-preferring rats
    Fawaz Alasmari
    Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA
    Brain Res 1634:150-7. 2016
    ..Overall, our findings suggest that cefazolin and cefoperazone may be considered as potential compounds for the treatment of ethanol dependence. ..
  18. pmc Ceftriaxone, a beta-lactam antibiotic, attenuates relapse-like ethanol-drinking behavior in alcohol-preferring rats
    Abeer M Qrunfleh
    Department of Pharmacology, University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Toledo, OH 43614, USA
    J Psychopharmacol 27:541-9. 2013
    ..In addition, CEF has no effect on relapse-like sucrose-drinking behavior. These findings suggest that ceftriaxone might be used as a potential therapeutic treatment for the attenuation of relapse-like ethanol-drinking behavior...
  19. pmc Binge ethanol withdrawal: Effects on post-withdrawal ethanol intake, glutamate-glutamine cycle and monoamine tissue content in P rat model
    Sujan C Das
    Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, United States
    Behav Brain Res 303:120-5. 2016
    ..The tissue content of DA was significantly lower in both mPFC and NAc, whereas tissue content of serotonin was unchanged in both mPFC and NAc. These findings provide important information of the critical role of GLT-1 in context of AWS...
  20. pmc Targeting glutamate homeostasis for potential treatment of nicotine dependence
    Fawaz Alasmari
    Department of Pharmacology and Experimental Therapeutics, University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Toledo, OH, USA
    Brain Res Bull 121:1-8. 2016
    ....
  21. doi request reprint Effects of repeated high-dose methamphetamine and ceftriaxone post-treatments on tissue content of dopamine and serotonin as well as glutamate and glutamine
    Yusuf S Althobaiti
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, Toledo, OH, United States
    Neurosci Lett 634:25-31. 2016
    ..These findings demonstrate for the first time the attenuating effects of CEF post-treatment on METH induced alterations in the tissue contents of dopamine, glutamate, and glutamine...
  22. pmc Effects of Ceftriaxone on Glial Glutamate Transporters in Wistar Rats Administered Sequential Ethanol and Methamphetamine
    Yusuf S Althobaiti
    Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Toledo, OH, USA
    Front Neurosci 10:427. 2016
    ..These findings suggest the potential therapeutic role of CEF against METH- or ethanol/METH-induced hyperglutamatergic state and hyperthermia...
  23. pmc Amoxicillin and amoxicillin/clavulanate reduce ethanol intake and increase GLT-1 expression as well as AKT phosphorylation in mesocorticolimbic regions
    Sunil Goodwani
    The University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, Toledo, OH, USA
    Brain Res 1622:397-408. 2015
    ..Thus, GLT-1 and pAKT may serve as molecular targets for the treatment of alcohol and drug abuse/dependence...
  24. pmc Effects of Administered Ethanol and Methamphetamine on Glial Glutamate Transporters in Rat Striatum and Hippocampus
    Fahad S Alshehri
    Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Health Science Campus, 3000 Arlington Avenue, Toledo, OH, 43614, USA
    J Mol Neurosci . 2016
    ..These findings demonstrated that sequential exposure to EtOH and MA has additive effect in downregulation of GLT-1 and this effect can be attenuated by CEF treatment...
  25. pmc Effects of orally administered Augmentin on glutamate transporter 1, cystine-glutamate exchanger expression and ethanol intake in alcohol-preferring rats
    Alqassem Y Hakami
    Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA
    Behav Brain Res 320:316-322. 2016
    ..There was no effect of orally administered Augmentin on GLAST expression in either NAc or PFC. These findings present strong evidence that oral administration of Augmentin can be used as an alternative to parenteral treatment...
  26. pmc Role of the serotonergic system in alcohol dependence: from animal models to clinics
    Youssef Sari
    Department of Pharmacology, Health Science Campus, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, Ohio, USA
    Prog Mol Biol Transl Sci 98:401-43. 2011
    ....
  27. pmc Effects of ampicillin on cystine/glutamate antiporter and glutamate transporter 1 isoforms as well as ethanol drinking in male P rats
    Fawaz Alasmari
    Department of Pharmacology and Experimental Therapeutics, University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Toledo, OH, USA
    Neurosci Lett 600:148-52. 2015
    ..Our findings provide significant role of ampicillin on upregulating xCT and GLT-1 isoforms expression, might be suggested as possible targets for the attenuation of ethanol consumption. ..
  28. pmc Effects of Amoxicillin and Augmentin on Cystine-Glutamate Exchanger and Glutamate Transporter 1 Isoforms as well as Ethanol Intake in Alcohol-Preferring Rats
    Alqassem Y Hakami
    Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Toledo, OH, USA
    Front Neurosci 10:171. 2016
    ..These findings demonstrated that Augmentin and amoxicillin have the potential to upregulate GLT-1 isoforms and xCT expression, and consequently attenuate ethanol dependence. ..
  29. pmc Alcohol Interactions with Psychostimulants: An Overview of Animal and Human Studies
    Yusuf S Althobaiti
    University of Toledo, College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology and Experimental Therapeutics, Toledo, OH, USA
    J Addict Res Ther 7:. 2016
    ..Further studies are needed to investigate the pharmacokinetics, pharmacodynamics, and neurochemical changes on co-abuse of alcohol and psychostimulants...
  30. pmc Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol
    P S S Rao
    Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Health Science Campus, 3000 Arlington Avenue, HEB282G, Toledo, OH, 43614, USA
    Psychopharmacology (Berl) 232:2333-42. 2015
    ..Glial glutamate transporter 1 (GLT1) is one of them that regulates the majority of extracellular glutamate concentration. In addition, cystine/glutamate antiporter (xCT) is another transporter that regulates extracellular glutamate...
  31. pmc Effects of ceftriaxone on chronic ethanol consumption: a potential role for xCT and GLT1 modulation of glutamate levels in male P rats
    P S S Rao
    College of Pharmacy and Pharmaceutical Sciences, Department of Pharmacology, University of Toledo, 3000 Arlington Avenue, HEB282G, Toledo, OH, 43614, USA
    J Mol Neurosci 54:71-7. 2014
    ..These might be due in part through the upregulation of both xCT and GLT1 levels in brain reward regions. Thus, the drug has a potential therapeutic action for the treatment of alcohol dependence...