Adam B Salmon

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat
    Viviana I Perez
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 106:3059-64. 2009
  2. pmc Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?
    Adam B Salmon
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Free Radic Biol Med 48:642-55. 2010
  3. pmc Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice
    Adam B Salmon
    Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, USA The Sam and Ann Barshop Institute for Longevity and Aging Studies and Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Electronic address
    Redox Biol 10:251-256. 2016
  4. pmc Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process?
    Adam B Salmon
    Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78245, USA
    Antioxidants (Basel) 5:. 2016
  5. pmc Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I
    Adam B Salmon
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Molecular Medicine, and the Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, Audie L Murphy Veterans Affairs Hospital, San Antonio, Texas
    Am J Physiol Endocrinol Metab 308:E545-53. 2015
  6. pmc Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase
    Yuhong Liu
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Biochem Biophys Res Commun 438:78-83. 2013
  7. pmc Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration
    Youngmok C Jang
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    FASEB J 24:1376-90. 2010
  8. pmc Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice
    Wilson C Fok
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, Texas, USA
    J Gerontol A Biol Sci Med Sci 68:108-16. 2013
  9. pmc Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span
    Adam B Salmon
    Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Dr, San Antonio, TX 78245 3207, USA
    FASEB J 23:3601-8. 2009
  10. pmc Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function
    Giovanna Muscogiuri
    Diabetes Division, University of Texas Health Science Center, San Antonio, Texas
    Diabetes 62:4201-7. 2013

Collaborators

Detail Information

Publications23

  1. pmc Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat
    Viviana I Perez
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 106:3059-64. 2009
    ..These pivotal mechanistic interspecies differences may contribute to the divergent aging profiles and strongly implicate maintenance of protein stability and integrity in successful aging...
  2. pmc Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?
    Adam B Salmon
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Free Radic Biol Med 48:642-55. 2010
    ..Under these conditions, enhanced antioxidant defenses exert an "antiaging" action, leading to changes in life span, age-related pathology, and physiological function as predicted by the oxidative stress theory of aging...
  3. pmc Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice
    Adam B Salmon
    Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, USA The Sam and Ann Barshop Institute for Longevity and Aging Studies and Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Electronic address
    Redox Biol 10:251-256. 2016
    ..With these and our previous data, we conclude that the increasing MsrA expression in mice has differential effects on aging and healthy aging that are dependent on the target of its subcellular localization...
  4. pmc Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process?
    Adam B Salmon
    Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78245, USA
    Antioxidants (Basel) 5:. 2016
    ..Understanding how obesity can alter cellular physiology beyond that directly related to metabolic function could open new therapeutic areas of approach to extend the period of healthy aging among people of all body composition. ..
  5. pmc Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I
    Adam B Salmon
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Molecular Medicine, and the Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, Audie L Murphy Veterans Affairs Hospital, San Antonio, Texas
    Am J Physiol Endocrinol Metab 308:E545-53. 2015
    ....
  6. pmc Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase
    Yuhong Liu
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Biochem Biophys Res Commun 438:78-83. 2013
    ..Together, our data suggest that targeting reduced oxidative damage in general may be a more applicable therapeutic target to prevent insulin resistance than is improving mitochondrial function. ..
  7. pmc Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration
    Youngmok C Jang
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    FASEB J 24:1376-90. 2010
    ....
  8. pmc Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice
    Wilson C Fok
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, Texas, USA
    J Gerontol A Biol Sci Med Sci 68:108-16. 2013
    ....
  9. pmc Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span
    Adam B Salmon
    Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Dr, San Antonio, TX 78245 3207, USA
    FASEB J 23:3601-8. 2009
    ..Thus, our results show that MsrA regulates sensitivity to oxidative stress in mice but has no effect on aging, as determined by life span...
  10. pmc Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function
    Giovanna Muscogiuri
    Diabetes Division, University of Texas Health Science Center, San Antonio, Texas
    Diabetes 62:4201-7. 2013
    ....
  11. pmc The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis
    Adam B Salmon
    Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Dr, San Antonio, TX 78245 3207, USA
    FASEB J 23:2317-26. 2009
    ..Together, these data suggest that long lifespan in some bat species might be regulated by very efficient maintenance of protein homeostasis...
  12. pmc Methionine sulfoxide reductase A affects insulin resistance by protecting insulin receptor function
    Jennalynn Styskal
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Free Radic Biol Med 56:123-32. 2013
    ..In addition, these data support a novel hypothesis that obesity-induced insulin resistance is caused in part by reduced function of insulin signaling proteins arising from protein oxidation...
  13. pmc Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?
    Jennalynn Styskal
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245 3207, USA
    Free Radic Biol Med 52:46-58. 2012
    ....
  14. pmc Overexpression of Mn superoxide dismutase does not increase life span in mice
    Youngmok C Jang
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78245 3207, USA
    J Gerontol A Biol Sci Med Sci 64:1114-25. 2009
    ..However, this change in MnSOD expression did not alter either life span or age-related pathology...
  15. pmc Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice
    Yiqiang Zhang
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Arch Biochem Biophys 576:39-48. 2015
    ..Together, this first comprehensive assessment of longitudinal, functional changes in high fat-fed mice suggests that obesity may induce segmental acceleration of some of the aging process. ..
  16. pmc Rapamycin-induced metabolic defects are reversible in both lean and obese mice
    Yuhong Liu
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio TX 78245, USA
    Aging (Albany NY) 6:742-54. 2014
    ..The reversible nature of rapamycin's alterations of metabolic function suggests that these potentially detrimental side-effects might be managed through alternative dosing strategies or concurrent treatment options. ..
  17. pmc Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome
    Wilson C Fok
    Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 9:e83988. 2014
    ..Our findings show that rapamycin has a major effect on the transcriptome and point to several pathways that would likely impact the longevity. ..
  18. pmc Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer
    Randy Strong
    Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA
    Aging Cell 15:872-84. 2016
    ..Neither fish oil nor UDCA extended lifespan. These results underscore the reproducibility of ITP longevity studies and illustrate the importance of identifying optimal doses in lifespan studies. ..
  19. pmc MsrA Overexpression Targeted to the Mitochondria, but Not Cytosol, Preserves Insulin Sensitivity in Diet-Induced Obese Mice
    JennaLynn Hunnicut
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 10:e0139844. 2015
    ..Our data suggest that identification of targets that maintain and regulate the integrity of the mitochondrial proteome, particular against oxidative damage, may play essential roles in the protection against metabolic disease. ..
  20. doi request reprint The paradoxical role of thioredoxin on oxidative stress and aging
    Geneva M Cunningham
    Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, United States
    Arch Biochem Biophys 576:32-8. 2015
    ..To critically test the role of oxidative stress on aging and investigate changes in redox-sensitive signaling pathways, further study is required. ..
  21. pmc Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate
    Matthew Lelegren
    Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, USA
    Pathobiol Aging Age Relat Dis 6:31793. 2016
    ..Further, long-term treatment did not significantly alter body weight, daily activity, blood lipid concentrations, or glucose metabolism in this cohort...
  22. pmc Dynamic differences in oxidative stress and the regulation of metabolism with age in visceral versus subcutaneous adipose
    Roy Liu
    The Sam and Ann Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Redox Biol 6:401-8. 2015
    ..Together, our data identify molecular mechanisms by which visceral and subcutaneous adipose differ with age and suggest potential targetable means to preserve healthy adipose aging. ..