Genomes and Genes
Affiliation: University of Virginia
- The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family StudyMichele M Sale
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, USA
BMC Endocr Disord 7:1. 2007..We wished to evaluate contributions of known UCP1 and UCP2 variants to metabolic traits in the Insulin Resistance and Atherosclerosis (IRAS) Family Study...
- Significant linkage at chromosome 19q for otitis media with effusion and/or recurrent otitis media (COME/ROM)Wei Min Chen
Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA
BMC Med Genet 12:124. 2011..We carried out a nonparametric linkage analysis, modeling marker-to-marker linkage disequilibrium...
- Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathyTennille S Leak
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
BMC Med Genet 11:22. 2010..Ordered subset linkage analysis (OSA) revealed a linkage peak on chromosome 7p in the subset of families with earlier age of T2D diagnosis...
- Evaluation of 15 functional candidate genes for association with chronic otitis media with effusion and/or recurrent otitis media (COME/ROM)Michele M Sale
Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America
PLoS ONE 6:e22297. 2011..The candidate gene variants examined do not appear to make a major contribution to COME/ROM susceptibility, despite a priori evidence from functional or animal model studies for a role in COME/ROM pathology...
- Genome-wide linkage scan in Gullah-speaking African American families with type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR)Michele M Sale
Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
Diabetes 58:260-7. 2009..Affected relative pairs with type 2 diabetes were recruited through the Sea Islands Genetic African American Registry (Project SuGAR)...
- Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathyMichele M Sale
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Diabetes 56:2638-42. 2007..Our objective was to investigate the importance of TCF7L2 in a larger African-American case-control population...
- Robust relationship inference in genome-wide association studiesAni Manichaikul
Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
Bioinformatics 26:2867-73. 2010..Existing algorithms for relationship inference have a major weakness of estimating allele frequencies at each SNP from the entire sample, under a strong assumption of homogeneous population structure. This assumption is often untenable...
- Cardiovascular risk in Gullah African Americans with high familial risk of type 2 diabetes mellitus: project SuGARKelly J Hunt
From the Department of Public Health Sciences and the College of Nursing, Medical University of South Carolina, Charleston, and the Health Equity and Rural Outreach Innovation Center, Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina, the Department of Nutrition Sciences, University of Alabama at Birmingham, and the Center for Public Health Genomics, University of Virginia, Charlottesville
South Med J 107:607-14. 2014..To determine the prevalence of cardiovascular disease, levels of cardiovascular risk factors, and extent of preventive care in Gullah African Americans with a high familial risk of type 2 diabetes mellitus...
- 16S rRNA survey revealed complex bacterial communities and evidence of bacterial interference on human adenoidsTiantian Ren
Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
Environ Microbiol 15:535-47. 2013..Co-occurrence analyses revealed evidence consistent with the bacterial interference theory in that multiple common pathogens showed 'non-coexistence' relationships with non-pathogenic members of the commensal microflora...
- Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke riskF C Hsu
Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
Neurology 77:1543-50. 2011..We investigated genes for enzymes and cofactors in the Hcy metabolic pathway for association with Hcy and determined whether associated single nucleotide polymorphisms (SNPs) influenced recurrent stroke risk...
- Genetic contributors to diabetes and dyslipidemia in African AmericansMichele M Sale; Fiscal Year: 2010..We propose applying this proven strategy to identify new therapeutic targets and allow translation to novel diagnostic, prevention, and treatment strategies for type 2 diabetes. ..