Akihiko Saitoh

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Effect of Host Genetic Variation on the Pharmacokinetics and Clinical Response of Non-nucleoside Reverse Transcriptase Inhibitors
    Akihiko Saitoh
    University of California, San Diego Department of Pediatrics Division of Infectious Diseases 9500 Gilman Drive, La Jolla, CA 92093 0672 Telephone 858 534 7258
    Futur HIV Ther 2:69-81. 2008
  2. ncbi Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0672, USA
    J Acquir Immune Defic Syndr 45:280-5. 2007
  3. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondrial DNA and RNA in human skeletal muscle cells
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 52:2825-30. 2008
  4. doi Clinical outcomes after an unstructured treatment interruption in children and adolescents with perinatally acquired HIV infection
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0672, USA
    Pediatrics 121:e513-21. 2008
  5. ncbi CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 21:2191-9. 2007
  6. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondria in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 51:4236-42. 2007
  7. pmc CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Acquir Immune Defic Syndr 54:285-9. 2010
  8. ncbi Persistence of human immunodeficiency virus (HIV) type 1 DNA in peripheral blood despite prolonged suppression of plasma HIV-1 RNA in children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 185:1409-16. 2002
  9. ncbi An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 19:371-80. 2005
  10. pmc Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla 92093 0672, USA
    J Allergy Clin Immunol 117:909-15. 2006

Research Grants

  1. The Impact of HLA in Children Receiving HAART
    Akihiko Saitoh; Fiscal Year: 2008

Detail Information

Publications18

  1. pmc Effect of Host Genetic Variation on the Pharmacokinetics and Clinical Response of Non-nucleoside Reverse Transcriptase Inhibitors
    Akihiko Saitoh
    University of California, San Diego Department of Pediatrics Division of Infectious Diseases 9500 Gilman Drive, La Jolla, CA 92093 0672 Telephone 858 534 7258
    Futur HIV Ther 2:69-81. 2008
    ..Further studies are needed to identify the associations of CYP2B6 genetic variants with the development of NNRTI resistant viruses...
  2. ncbi Efavirenz pharmacokinetics in HIV-1-infected children are associated with CYP2B6-G516T polymorphism
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0672, USA
    J Acquir Immune Defic Syndr 45:280-5. 2007
    ..The impact of CYP2B6-G516T polymorphisms on EFV concentrations may be different in children because of differences in liver maturation and drug dosage...
  3. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondrial DNA and RNA in human skeletal muscle cells
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 52:2825-30. 2008
    ..These findings may be of particular importance in developing countries, where ddI is widely used for first-line treatment of HIV-infected children...
  4. doi Clinical outcomes after an unstructured treatment interruption in children and adolescents with perinatally acquired HIV infection
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0672, USA
    Pediatrics 121:e513-21. 2008
    ..The objective of this study was to investigate the actual prevalence and clinical outcomes of a treatment interruption in children and adolescents with perinatally acquired HIV-1 infection...
  5. ncbi CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 21:2191-9. 2007
    ....
  6. pmc Impact of nucleoside reverse transcriptase inhibitors on mitochondria in human immunodeficiency virus type 1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    Antimicrob Agents Chemother 51:4236-42. 2007
    ..This may be of particular importance in resource-limited countries where didanosine is widely used for the treatment of HIV-infected children...
  7. pmc CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Acquir Immune Defic Syndr 54:285-9. 2010
    ....
  8. ncbi Persistence of human immunodeficiency virus (HIV) type 1 DNA in peripheral blood despite prolonged suppression of plasma HIV-1 RNA in children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 185:1409-16. 2002
    ..Thus, despite prolonged maintenance of undetectable levels of plasma HIV-1 RNA, HIV-1 DNA remains detectable in PBMC of children and may be a useful marker of further virus suppression...
  9. ncbi An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0672, USA
    AIDS 19:371-80. 2005
    ..This research examined the impact of single nucleotide polymorphisms (SNP) of MDR1 and CYP genes on nelfinavir and efavirenz pharmacokinetics and the response to highly active antiretroviral therapy (HAART) in HIV-1 infected children...
  10. pmc Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla 92093 0672, USA
    J Allergy Clin Immunol 117:909-15. 2006
    ....
  11. ncbi Longitudinal analysis of lymphocyte ratios and HIV-1 intracellular DNA levels in children
    Akihiko Saitoh
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093 0672, USA
    J Infect Dis 189:1216-20. 2004
    ..These data suggest that the increased proportion of naive lymphocytes found in children are less susceptible to HIV-1 infection than are the memory lymphocytes that dominate immune reconstitution in adults...
  12. ncbi Myelomeningocele in an infant with intrauterine exposure to efavirenz
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0672, USA
    J Perinatol 25:555-6. 2005
    ..Thus, we suggest that efavirenz only be prescribed for women of childbearing potential when no other comparable antiretroviral options are available...
  13. ncbi Mitochondrial dysfunction: prevention of HIV-1 mother-to-infant transmission outweighs fear
    Stephen A Spector
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, CA, USA
    AIDS 20:1777-8. 2006
  14. ncbi Prediction of neurologic sequelae in childhood tuberculous meningitis: a review of 20 cases and proposal of a novel scoring system
    Akihiko Saitoh
    Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, CA, USA
    Pediatr Infect Dis J 24:207-12. 2005
    ..In the current era of critical care medicine and corticosteroid therapy, a new scoring system is needed to predict NS more accurately in children with TBM...
  15. doi Risk Factors for Bloodstream Infection After Living-donor Liver Transplantation in Children
    Kensuke Shoji
    From the Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan Transplantation Center, National Center for Child Health and Development, Tokyo, Japan Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California, San Diego, La Jolla Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan and Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, La Jolla
    Pediatr Infect Dis J 34:1063-8. 2015
    ..However, information regarding the risk factors for BSI in children after LT is limited...
  16. ncbi Fulminant bacterial meningitis complicating sphenoid sinusitis
    Akihiko Saitoh
    Division of Pediatric Infectious Diseases, University of California, San Diego, La Jolla 92093, USA
    Pediatr Emerg Care 19:415-7. 2003
  17. ncbi Treatment of infants coinfected with HIV-1 and cytomegalovirus with combination antiretrovirals and ganciclovir
    Akihiko Saitoh
    J Allergy Clin Immunol 114:983-5. 2004
  18. ncbi Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz
    Elizabeth A Lowenhaupt
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
    Clin Infect Dis 45:e128-30. 2007
    ..We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T...

Research Grants1

  1. The Impact of HLA in Children Receiving HAART
    Akihiko Saitoh; Fiscal Year: 2008
    ..This application for a Mentored Patient-Oriented Research Career Developmental Award (K23) seeks support for Akihiko Saitoh, M.D...