RALPH LEWIS SACCO

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Ideal cardiovascular health predicts lower risks of myocardial infarction, stroke, and vascular death across whites, blacks, and hispanics: the northern Manhattan study
    Chuanhui Dong
    Department of Neurology, University of Miami, CRB 13, 1120 NW 14th St, Miami, FL 33136, USA
    Circulation 125:2975-84. 2012
  2. pmc A follow-up study for left ventricular mass on chromosome 12p11 identifies potential candidate genes
    David Della-Morte
    Department of Neurology, Evelyn F McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, USA
    BMC Med Genet 12:100. 2011
  3. pmc Novel quantitative trait locus is mapped to chromosome 12p11 for left ventricular mass in Dominican families: the Family Study of Stroke Risk and Carotid Atherosclerosis
    Liyong Wang
    Department of Human Genetics, Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA
    BMC Med Genet 10:74. 2009
  4. pmc Moderate alcohol consumption is associated with better endothelial function: a cross sectional study
    Keiko Suzuki
    Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY, USA
    BMC Cardiovasc Disord 9:8. 2009
  5. pmc Lipids and carotid plaque in the Northern Manhattan Study (NOMAS)
    Hannah Gardener
    Department of Neurology, Miller School of Medicine, University of Miami, FL, USA
    BMC Cardiovasc Disord 9:55. 2009
  6. pmc Improving global vascular risk prediction with behavioral and anthropometric factors. The multiethnic NOMAS (Northern Manhattan Cohort Study)
    Ralph L Sacco
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Am Coll Cardiol 54:2303-11. 2009
  7. pmc Heritability and linkage analysis for carotid intima-media thickness: the family study of stroke risk and carotid atherosclerosis
    Ralph L Sacco
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Stroke 40:2307-12. 2009
  8. pmc The 2006 William Feinberg lecture: shifting the paradigm from stroke to global vascular risk estimation
    Ralph L Sacco
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Stroke 38:1980-7. 2007
  9. doi request reprint The new American Heart Association 2020 goal: achieving ideal cardiovascular health
    Ralph L Sacco
    Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Cardiovasc Med (Hagerstown) 12:255-7. 2011
  10. pmc Genomewide linkage and peakwide association analyses of carotid plaque in Caribbean Hispanics
    Chuanhui Dong
    Evelyn F McKnight Center for Age related Memory Loss, Department of Neurology, Miller Schoolof Medicine, University of Miami, Miami, FL, USA
    Stroke 41:2750-6. 2010

Research Grants

Detail Information

Publications94

  1. pmc Ideal cardiovascular health predicts lower risks of myocardial infarction, stroke, and vascular death across whites, blacks, and hispanics: the northern Manhattan study
    Chuanhui Dong
    Department of Neurology, University of Miami, CRB 13, 1120 NW 14th St, Miami, FL 33136, USA
    Circulation 125:2975-84. 2012
    ..This study sought to evaluate the relationship between the number of ideal CVH metrics and cardiovascular risk, overall and by event subtype, in a multiethnic community-based prospective cohort...
  2. pmc A follow-up study for left ventricular mass on chromosome 12p11 identifies potential candidate genes
    David Della-Morte
    Department of Neurology, Evelyn F McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, USA
    BMC Med Genet 12:100. 2011
    ..In the present study, we use association analysis to further study the genetic effect on LVM...
  3. pmc Novel quantitative trait locus is mapped to chromosome 12p11 for left ventricular mass in Dominican families: the Family Study of Stroke Risk and Carotid Atherosclerosis
    Liyong Wang
    Department of Human Genetics, Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA
    BMC Med Genet 10:74. 2009
    ..The genetic basis of LVM is unclear although a high heritability has been suggested. We sought to map quantitative trait loci (QTL) for LVM using large Dominican families...
  4. pmc Moderate alcohol consumption is associated with better endothelial function: a cross sectional study
    Keiko Suzuki
    Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY, USA
    BMC Cardiovasc Disord 9:8. 2009
    ....
  5. pmc Lipids and carotid plaque in the Northern Manhattan Study (NOMAS)
    Hannah Gardener
    Department of Neurology, Miller School of Medicine, University of Miami, FL, USA
    BMC Cardiovasc Disord 9:55. 2009
    ..The objective of this cross-sectional analysis was to investigate the relation between blood lipids and carotid plaque...
  6. pmc Improving global vascular risk prediction with behavioral and anthropometric factors. The multiethnic NOMAS (Northern Manhattan Cohort Study)
    Ralph L Sacco
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Am Coll Cardiol 54:2303-11. 2009
    ..This study sought to improve global vascular risk prediction with behavioral and anthropometric factors...
  7. pmc Heritability and linkage analysis for carotid intima-media thickness: the family study of stroke risk and carotid atherosclerosis
    Ralph L Sacco
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Stroke 40:2307-12. 2009
    ..The aim of this study was to identify quantitative trait loci (QTL) for carotid intima-media thickness (CIMT) a risk factor for stroke and cardiovascular disease...
  8. pmc The 2006 William Feinberg lecture: shifting the paradigm from stroke to global vascular risk estimation
    Ralph L Sacco
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Stroke 38:1980-7. 2007
    ..The ultimate public health benefit, however, will depend on not only identification of global vascular risk but also the realization that we can modify this risk and prove the prediction models wrong...
  9. doi request reprint The new American Heart Association 2020 goal: achieving ideal cardiovascular health
    Ralph L Sacco
    Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Cardiovasc Med (Hagerstown) 12:255-7. 2011
    ..The AHA has identified Life's Simple 7 as the key health factors aimed at achieving ideal cardiovascular health...
  10. pmc Genomewide linkage and peakwide association analyses of carotid plaque in Caribbean Hispanics
    Chuanhui Dong
    Evelyn F McKnight Center for Age related Memory Loss, Department of Neurology, Miller Schoolof Medicine, University of Miami, Miami, FL, USA
    Stroke 41:2750-6. 2010
    ..Atherosclerosis is a complex subclinical cardiovascular disorder with a substantial genetic component. This study sought to identify genetic loci influencing carotid plaque in 2 independent samples...
  11. ncbi request reprint Homocysteine and the risk of ischemic stroke in a triethnic cohort: the NOrthern MAnhattan Study
    Ralph L Sacco
    Department of Neurology, Columbia University College of Physicians and Surgeons and the Mailman School of Public Health, New York, NY, USA
    Stroke 35:2263-9. 2004
    ..We investigated the association between mild to moderate fasting tHcy level and the incidence of ischemic stroke, myocardial infarction, and vascular death in a multiethnic prospective study...
  12. pmc Design of a family study among high-risk Caribbean Hispanics: the Northern Manhattan Family Study
    Ralph L Sacco
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Ethn Dis 17:351-7. 2007
    ..Understanding the gene environment interaction is the critical next step toward the development of new and unique approaches to disease prevention and interventions...
  13. pmc Endothelial dysfunction is associated with carotid plaque: a cross-sectional study from the population based Northern Manhattan Study
    Tatjana Rundek
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, USA
    BMC Cardiovasc Disord 6:35. 2006
    ..The objective of this study was to determine whether endothelial dysfunction is independently associated with carotid plaque in a community of northern Manhattan...
  14. pmc Snoring and insomnia are not associated with subclinical atherosclerosis in the Northern Manhattan Study
    Alberto Ramos-Sepulveda
    Department of Neurology, Miller School of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Int J Stroke 5:264-8. 2010
    ..We investigated the relationship between markers of subclinical atherosclerosis, insomnia, snoring, and carotid intima-media thickness, in the Northern Manhattan Study...
  15. pmc A candidate gene study revealed sex-specific association between the OLR1 gene and carotid plaque
    Liyong Wang
    Dr John T Macdonald Foundation, Department of Human Genetics, Miller School of Medicine, University of Miami, Clinical Research Building, Suite CRB 13, 1120 NW 14th Street, Miami, FL 33136, USA
    Stroke 42:588-92. 2011
    ..We sought to examine the sex-dependent associations between genes involved in lipid metabolism and carotid atherosclerotic plaque, a subclinical precursor of stroke...
  16. pmc Patent foramen ovale and migraine: a cross-sectional study from the Northern Manhattan Study (NOMAS)
    Tatjana Rundek
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Circulation 118:1419-24. 2008
    ..The objective of this study was to examine the association between PFO and migraine among stroke-free individuals in an urban, population-based, multiethnic cohort...
  17. pmc Risk factor management to prevent first stroke
    Tatjana Rundek
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Neurol Clin 26:1007-45, ix. 2008
    ..Finally, prognostic scores to assess an individual risk for a first stroke are reviewed...
  18. pmc Carotid plaque and candidate genes related to inflammation and endothelial function in Hispanics from northern Manhattan
    Hannah Gardener
    Department of Neurology, University of Miami, Miller School of Medicine, PO Box 016960 M 877, Miami, FL 33101, USA
    Stroke 42:889-96. 2011
    ..The genetic influence on carotid atherosclerotic plaque is mostly unknown. This study examines the association between carotid plaque and single nucleotide polymorphisms in selected genes implicated in inflammation and endothelial function...
  19. ncbi request reprint Interleukin-2 levels are associated with carotid artery intima-media thickness
    Mitchell S V Elkind
    Department of Neurology, Neurology Stroke Division, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, Rm 641, New York, NY 10032, USA
    Atherosclerosis 180:181-7. 2005
    ..To show that serum interleukin levels are associated with carotid intima-media thickness (IMT)...
  20. ncbi request reprint Ischemic stroke subtype incidence among whites, blacks, and Hispanics: the Northern Manhattan Study
    Halina White
    Department of Neurology, College of Physicians and Surgeons, USA
    Circulation 111:1327-31. 2005
    ..The aim of this population-based study was to determine ischemic stroke subtype incidence rates for whites, blacks, and Hispanics living in one community...
  21. pmc Insulin resistance and risk of ischemic stroke among nondiabetic individuals from the northern Manhattan study
    Tatjana Rundek
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Arch Neurol 67:1195-200. 2010
    ..Whether insulin resistance predicts ischemic stroke (IS) is still a matter of debate...
  22. pmc Genetic linkage of serum homocysteine in Dominican families: the Family Study of Stroke Risk and Carotid Atherosclerosis
    David Della-Morte
    Department of Neurology, Miller School of Medicine, University of Miami, Clinical Research Building, Miami, Fla 33136, USA
    Stroke 41:1356-62. 2010
    ..However, the exact mechanism of documented and novel total homocysteine quantitative trait loci to that risk is unknown...
  23. ncbi request reprint Stroke in the young in the northern Manhattan stroke study
    Bradley S Jacobs
    Wayne State University Detroit Medical Center Comprehensive Stroke Program, Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Stroke 33:2789-93. 2002
    ..The purpose of this study was to determine stroke incidence rates in these populations and to compare rates among various race-ethnic, sex, and age groups...
  24. pmc Metabolic syndrome increases carotid artery stiffness: the Northern Manhattan Study
    David Della-Morte
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Int J Stroke 5:138-44. 2010
    ..The metabolic syndrome and its components are established cardiovascular disease risk factors and may also increase arterial stiffness; however, data regarding this are limited...
  25. pmc A comprehensive genetic study on left atrium size in Caribbean Hispanics identifies potential candidate genes in 17p10
    Liyong Wang
    John T McDonald Department of Human Genetics, John P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Circ Cardiovasc Genet 3:386-92. 2010
    ..Genetic factors contributing to the LA dimension are poorly understood. We sought to map susceptibility genes for LA size in a large Dominican family data set and an independent population-based sample from the Northern Manhattan Study...
  26. pmc Metabolic syndrome and ischemic stroke risk: Northern Manhattan Study
    Bernadette Boden-Albala
    Department of Neurology, Columbia University College of Physicians and Surgeons, Mailman School of Public Health, New York, NY, USA
    Stroke 39:30-5. 2008
    ..More than 47 million individuals in the United States meet the criteria for the metabolic syndrome. The relation between the metabolic syndrome and stroke risk in multiethnic populations has not been well characterized...
  27. doi request reprint Diabetes, fasting glucose levels, and risk of ischemic stroke and vascular events: findings from the Northern Manhattan Study (NOMAS)
    Bernadette Boden-Albala
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Diabetes Care 31:1132-7. 2008
    ..We explored the relationship between FBG among diabetic subjects and risk of ischemic stroke in a multiethnic prospective cohort...
  28. ncbi request reprint Risk of myocardial infarction or vascular death after first ischemic stroke: the Northern Manhattan Study
    Mandip S Dhamoon
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Stroke 38:1752-8. 2007
    ..We determined the absolute 5-year risk of cardiovascular outcomes and their predictors after first ischemic stroke in a multiethnic cohort...
  29. pmc Alcohol intake, carotid plaque, and cognition: the Northern Manhattan Study
    Clinton B Wright
    Division of Stroke and Critical Care, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Stroke 37:1160-4. 2006
    ..Few studies to clarify the importance of vascular disease have included direct measures of atherosclerosis or minority populations at higher risk of vascular disease and dementia...
  30. ncbi request reprint Abdominal obesity and risk of ischemic stroke: the Northern Manhattan Stroke Study
    Seung Han Suk
    Department of Neurology, Columbia University College of Physicians and Surgeons and the Mailman School of Public Health, New York, NY, USA
    Stroke 34:1586-92. 2003
    ..The relationship between abdominal obesity and ischemic stroke remains less clear. Our aim was to evaluate abdominal obesity as an independent risk factor for ischemic stroke in a multiethnic community...
  31. pmc Lipoprotein-associated phospholipase A2 activity and risk of recurrent stroke
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, Columbia University, and Columbia Presbyterian Medical Center, New York Presbyterian Hospital, New York, NY, USA
    Cerebrovasc Dis 27:42-50. 2009
    ..Lp-PLA(2) mass correlates only moderately with levels of Lp-PLA(2) activity. The relationship of Lp-PLA(2) activity to risk of stroke recurrence is unknown. We hypothesized that Lp-PLA(2) activity levels would predict risk of recurrence...
  32. pmc Increased stroke risk and lipoprotein(a) in a multiethnic community: the Northern Manhattan Stroke Study
    Bernadette Boden-Albala
    Department of Neurology, Columbia University College of Physicians and Surgeons and the Mailman School of Public Health, New York, NY, USA
    Cerebrovasc Dis 30:237-43. 2010
    ..Elevated lipoprotein(a) [Lp(a)] is associated with ischemic stroke (IS) among Whites, but data is sparse for non-White populations...
  33. ncbi request reprint Lacunar infarct or deep intracerebral hemorrhage: who gets which? The Northern Manhattan Study
    Daniel L Labovitz
    Department of Neurology, New York University School of Medicine, New York, NY 10016, USA
    Neurology 68:606-8. 2007
    ..We compared LAC to DICH cases derived from a population-based incidence study. In multivariate analysis, LAC cases were significantly older, more likely to have diabetes, and had higher cholesterol than DICH cases...
  34. ncbi request reprint The metabolic syndrome and subclinical carotid atherosclerosis: the Northern Manhattan Study
    Tatjana Rundek
    Department of Neurology, Division of Stroke and Critical Care, Columbia University and Mailman School of Public Health, New York, NY, USA
    J Cardiometab Syndr 2:24-9. 2007
    ..67). Additionally, the number of MetS components was significantly associated with plaque prevalence. Further studies are needed to understand the role of the MetS in the progression from subclinical to clinical atherosclerotic disease...
  35. pmc Tumor necrosis factor receptor levels are associated with carotid atherosclerosis
    Mitchell S Elkind
    Department of Neurology, College of Physicians and Surgeons, Columbia University, and the Columbia Presbyterian Medical Center of New York Presbyterian Hospital, New York, NY, USA
    Stroke 33:31-7. 2002
    ..We sought to determine whether tumor necrosis factor-alpha (TNF-alpha) and TNF receptor levels are associated with carotid plaque thickness...
  36. pmc Reported alcohol consumption and cognitive decline: The northern Manhattan study
    Clinton B Wright
    Division of Stroke and Critical Care, Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Neuroepidemiology 27:201-7. 2006
    ..Moderate alcohol intake may slow cognitive decline, and both vascular and neurodegenerative mechanisms have been implicated...
  37. pmc Early depressed mood after stroke predicts long-term disability: the Northern Manhattan Stroke Study (NOMASS)
    Joshua Z Willey
    Department of Neurology, University of California, San Francisco, CA, USA
    Stroke 41:1896-900. 2010
    ..Depression is highly prevalent after stroke and may influence recovery. We aimed to determine whether depressed mood acutely after stroke predicts subsequent disability and mortality...
  38. pmc Dietary total fat intake and ischemic stroke risk: the Northern Manhattan Study
    Bernadette Boden-Albala
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, N Y, USA
    Neuroepidemiology 32:296-301. 2009
    ..We hypothesized that total dietary fat as part of a Western diet is associated with increased risk of ischemic stroke...
  39. pmc Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke
    Ralph L Sacco
    Miller School of Medicine, University of Miami, Miami, USA
    N Engl J Med 359:1238-51. 2008
    ..Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel...
  40. pmc Patent foramen ovale, cardiac valve thickening, and antiphospholipid antibodies as risk factors for subsequent vascular events: the PICSS-APASS study
    Kumar Rajamani
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    Stroke 40:2337-42. 2009
    ..PFO is associated with cryptogenic ischemic stroke. Also, the presence of aPL is associated with ischemic cerebrovascular disease...
  41. pmc Infectious burden and risk of stroke: the northern Manhattan study
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Arch Neurol 67:33-8. 2010
    ....
  42. pmc Stroke location and association with fatal cardiac outcomes: Northern Manhattan Study (NOMAS)
    Fred Rincon
    Department of Neurology, College of Physicians and Surgeons Columbia University, New York, NY 10032, USA
    Stroke 39:2425-31. 2008
    ..We sought to determine the association between stroke location and cardiac death or MI in a multiethnic community-based cohort...
  43. ncbi request reprint Moderate alcohol consumption reduces risk of ischemic stroke: the Northern Manhattan Study
    Mitchell S V Elkind
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 37:13-9. 2006
    ..Moderate alcohol consumption is protective against coronary disease, but its relationship to ischemic stroke (IS) is controversial...
  44. ncbi request reprint Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic stroke
    Steven R Levine
    Department of Neurology, Mt Sinai School of Medicine, New York, NY 10029 6574, USA
    JAMA 291:576-84. 2004
    ..The presence of antiphospholipid antibodies (aPL) has been associated with vascular occlusive events. However, the role of aPL in predicting ischemic events, particularly recurrent ischemic stroke, is controversial...
  45. pmc Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study
    Clinton B Wright
    Department of Neurology, Columbia University College of Physicians and Surgeons and the Mailman School of Public Health, New York, NY, USA
    Stroke 36:1207-11. 2005
    ..White matter hyperintensities may be a risk factor for both, but studies of the relationship between tHcy and quantitative measures of white matter hyperintensity volume (WMHV) are lacking, especially in minority populations...
  46. ncbi request reprint Lipid-lowering agent use at ischemic stroke onset is associated with decreased mortality
    Mitchell S V Elkind
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurology 65:253-8. 2005
    ..The authors hypothesized that patients with ischemic stroke taking LLAs would have better outcomes than patients not taking LLAs...
  47. ncbi request reprint Efficacy of aspirin plus extended-release dipyridamole in preventing recurrent stroke in high-risk populations
    Ralph L Sacco
    Department of Neurology, College of Physicians and Surgeons and the Mailman School of Public Health, Columbia University, Neurological Institute, New York, NY 10032, USA
    Arch Neurol 62:403-8. 2005
    ..To assess the efficacy of aspirin plus extended-release dipyridamole compared with aspirin alone for the prevention of recurrent stroke among high-risk groups...
  48. pmc Carotid artery distensibility: a reliability study
    Elisa Cuadrado Godia
    Department of Neurology, Division of Stroke, Columbia University and Mailman School of Public Health, New York, New York, USA
    J Ultrasound Med 26:1157-65. 2007
    ..The objective of this study was to evaluate the inter-reader reliability of sonographic measurements of common carotid artery (CCA) diameters and derived metrics of CD...
  49. pmc High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART)
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, New York, N Y, USA
    Cerebrovasc Dis 28:266-75. 2009
    ..We sought to determine whether lovastatin at doses above those currently approved can be administered safely within 24 h after an acute ischemic stroke...
  50. ncbi request reprint Experimental treatments for acute ischaemic stroke
    Ralph L Sacco
    Department of Neurology, College of Physicians and Surgeons Columbia University, New York, NY, USA
    Lancet 369:331-41. 2007
    ..The findings of these randomised trials are anticipated to allow improved treatment of patients with acute stroke...
  51. pmc Lipid profile components and risk of ischemic stroke: the Northern Manhattan Study (NOMAS)
    Joshua Z Willey
    Department of Neurology, College of Physicians and Surgeons, Joseph P Mailman School of Public Health, Columbia University, and the Columbia University Medical Center of New York Presbyterian Hospital, New York, NY 10032, USA
    Arch Neurol 66:1400-6. 2009
    ..To explore the relationship between lipid profile components and incident ischemic stroke in a stroke-free prospective cohort...
  52. pmc High-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2 stability before and after stroke and myocardial infarction
    Mitchell S V Elkind
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Stroke 40:3233-7. 2009
    ..Little is known, however, about the stability of these markers over time, and in particular, about the effects of acute vascular events on these marker levels...
  53. ncbi request reprint Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies
    E Clarke Haley
    Department of Neurology, University of Virginia Health System, Charlottesville, VA 22901, USA
    Stroke 36:1006-10. 2005
    ..Both trials reported that gavestinel was ineffective in ischemic stroke. This analysis reports the results in those with primary intracerebral hemorrhage...
  54. pmc Relation between socioeconomic status, race-ethnicity, and left ventricular mass: the Northern Manhattan study
    Carlos J Rodriguez
    Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Hypertension 43:775-9. 2004
    ..3 g/m2.7 for blacks, 0.0 g/m2.7 for whites, and 1.0 g/m2.7 for Hispanics. Lower SES is an independent predictor of increased LVM among hypertensive and normotensive blacks...
  55. pmc Relationship between periodontal disease, tooth loss, and carotid artery plaque: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)
    Moise Desvarieux
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA
    Stroke 34:2120-5. 2003
    ..Chronic infections, including periodontal infections, may predispose to cardiovascular disease. The present study investigates the relationship of periodontal disease and tooth loss with subclinical atherosclerosis...
  56. ncbi request reprint Ultrasound assessment of subclinical cardiovascular disease in a community-based multiethnic population and comparison to the Framingham score
    Yukio Abe
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Am J Cardiol 98:1374-8. 2006
    ..In the intermediate FRS category, FRS appears to underestimate the coronary risk more in women than in men and more in whites and especially in blacks than in Hispanics...
  57. pmc Left ventricular mass and geometry and the risk of ischemic stroke
    Marco R Di Tullio
    Department of Medicine, Sergievsky Center, Columbia Presbyterian Medical Center, 630 W 168th St, New York, NY 10032, USA
    Stroke 34:2380-4. 2003
    ..The effect of LV geometry on stroke risk has not been defined. The aim of the present study was to evaluate whether LVH and LV geometry are independently associated with increased ischemic stroke risk in a multiethnic population...
  58. pmc Carotid plaque surface irregularity predicts ischemic stroke: the northern Manhattan study
    Shyam Prabhakaran
    The Neurological Institute, Columbia University, Stroke and Critical Care Division, 710 W 168th Street, Room 640, New York, NY 10032, USA
    Stroke 37:2696-701. 2006
    ..Using a prospective cohort design, we evaluated the association of carotid plaque surface irregularity and the risk of ischemic stroke in a multiethnic population...
  59. ncbi request reprint Patent foramen ovale and the risk of ischemic stroke in a multiethnic population
    Marco R Di Tullio
    Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    J Am Coll Cardiol 49:797-802. 2007
    ..We sought to assess the risk of ischemic stroke from a patent foramen ovale (PFO) in the multiethnic prospective cohort of northern Manhattan...
  60. pmc Left ventricular systolic dysfunction and the risk of ischemic stroke in a multiethnic population
    Allison G Hays
    Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Stroke 37:1715-9. 2006
    ..The stroke risk associated with LVD, especially of mild degree, in the general population is unclear. The purpose of this study was to evaluate the relationship between LVD and ischemic stroke in a multiethnic cohort...
  61. ncbi request reprint Atrial anatomy in non-cardioembolic stroke patients: effect of medical therapy
    Shunichi Homma
    Department of Medicine, New York, New York 10032, USA
    J Am Coll Cardiol 42:1066-72. 2003
    ....
  62. ncbi request reprint Incidence of adult brain arteriovenous malformation hemorrhage in a prospective population-based stroke survey
    Christian Stapf
    Stroke Center The Neurological Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Cerebrovasc Dis 13:43-6. 2002
    ..We investigated the incidence of first-ever AVM hemorrhage in adults based on population data from the Northern Manhattan Stroke Study (NOMASS)...
  63. ncbi request reprint Reducing the risk of stroke in diabetes: what have we learned that is new?
    Ralph L Sacco
    Neurology and Public Health, Columbia University, College of Physicians and Surgeons, The New York Presbyterian Hospital, New York 10032, USA
    Diabetes Obes Metab 4:S27-34. 2002
    ..Wide-scale adherence to these guideline recommendations for the prevention of primary and secondary stroke would significantly benefit the public health...
  64. ncbi request reprint Additional impact of electrocardiographic over echocardiographic diagnosis of left ventricular hypertrophy for predicting the risk of ischemic stroke
    Shun Kohsaka
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am Heart J 149:181-6. 2005
    ..The purpose of this study is to determine if electrocardiographically derived criteria for LVH provide additional prognostic value over echocardiography for predicting ischemic stroke in a multiethnic population...
  65. ncbi request reprint Selection of anticoagulants or antiplatelet-aggregating agents for prevention of stroke
    Eugene D Kaplan
    Stroke Service, Neurological Institute, Columbia University, 710 West 168 Street, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 2:31-7. 2002
    ..The aim of this article is to provide an overview of the recent guidelines, recommendations, and clinical trial results using antithrombotic therapy for stroke prevention...
  66. pmc Genetic and environmental contributions to carotid intima-media thickness and obesity phenotypes in the Northern Manhattan Family Study
    Suh Hang Hank Juo
    Columbia University Genome Center, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Stroke 35:2243-7. 2004
    ..The genetic basis of IMT and obesity has not been well-characterized in Caribbean Hispanics. The purpose of this study was to examine the genetic and environmental contributions to IMT and obesity in this population...
  67. ncbi request reprint Physical activity attenuates the effect of increased left ventricular mass on the risk of ischemic stroke: The Northern Manhattan Stroke Study
    Carlos J Rodriguez
    Department of Medicine, Columbia University, New York, New York 10032, USA
    J Am Coll Cardiol 39:1482-8. 2002
    ..The goal of this study was to determine whether the risk of ischemic stroke associated with increased left ventricular mass (LVM) is modified by physical activity (PA)...
  68. ncbi request reprint Effect of aspirin and warfarin therapy in stroke patients with valvular strands
    Shunichi Homma
    Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Stroke 35:1436-42. 2004
    ..The recurrent rate of adverse events in stroke patients with valvular strands has not been defined and, importantly, there are no randomized studies to evaluate efficacy of antithrombotic therapies in these patients...
  69. pmc Carotid intima-media thickness is associated with allelic variants of stromelysin-1, interleukin-6, and hepatic lipase genes: the Northern Manhattan Prospective Cohort Study
    Tanja Rundek
    Neurological Institute, New York Presbyterian Hospital, Columbia University, New York, NY 10032, USA
    Stroke 33:1420-3. 2002
    ..The objective of this study was to determine the association between carotid IMT and functional promoter variants of stromelysin-1 (MMP3: -1612 5A>6A), interleukin-6 (IL6: -174G>C), and hepatic lipase (HL: -480C>T) genes...
  70. ncbi request reprint Effect of medical treatment in stroke patients with patent foramen ovale: patent foramen ovale in Cryptogenic Stroke Study
    Shunichi Homma
    Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 W 168th St, New York, NY 10032, USA
    Circulation 105:2625-31. 2002
    ..Patent foramen ovale (PFO) is associated with stroke, but there are no randomized studies to evaluate the efficacy of antithrombotic therapies...
  71. ncbi request reprint Impact of aortic stiffness on ischemic stroke in elderly patients
    Kenichi Sugioka
    Department of Medicine, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Stroke 33:2077-81. 2002
    ..The atherosclerotic process also affects aortic distensibility, which can also be assessed by TEE. The purpose of this study was to evaluate the possible association of aortic stiffness by TEE with ischemic stroke in elderly patients...
  72. ncbi request reprint Apolipoproteins and carotid artery atherosclerosis in an elderly multiethnic population: the Northern Manhattan stroke study
    Jiann Shing Jeng
    Departments of Neurology, Columbia University, New York, NY, USA
    Atherosclerosis 165:317-25. 2002
    ..4, CI: 0.2-0.8). Thus, in an elderly population, apo A-I and B were determinants of moderate-severe CAA, and the degree of association varied by race/ethnicity..
  73. ncbi request reprint Race-ethnic differences in patent foramen ovale, atrial septal aneurysm, and right atrial anatomy among ischemic stroke patients
    Carlos J Rodriguez
    Columbia University, College of Physicians and Surgeons, Department of Medicine, Division of Cardiology, 630 W 168th St, New York, NY 10032, USA
    Stroke 34:2097-102. 2003
    ..In particular, little is known about whether patent foramen ovale (PFO), atrial septal aneurysm (ASA), and other atrial anomalies associated with cryptogenic stroke differ among minority populations...
  74. pmc Electrocardiographic left atrial abnormalities and risk of ischemic stroke
    Shun Kohsaka
    Department of Cardiology, Texas Heart Institute, Baylor College of Medicine, Houston, Texas, USA
    Stroke 36:2481-3. 2005
    ..We evaluated the association between electrocardiographic left atrial abnormality (ECG-LAA) and ischemic stroke, especially whether ECG-LAA provides additional prognostic information to that provided by echocardiography...
  75. pmc Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)
    Moise Desvarieux
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minn, USA
    Circulation 111:576-82. 2005
    ..Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and subclinical atherosclerosis...
  76. ncbi request reprint Factors associated with in-hospital mortality after administration of thrombolysis in acute ischemic stroke patients: an analysis of the nationwide inpatient sample 1999 to 2002
    Brian T Bateman
    Columbia Presbyterian Medical College for Physicians and Surgeons, Columbia University, New York, NY, USA
    Stroke 37:440-6. 2006
    ..We therefore examined outcomes in acute stroke patients treated with thrombolysis using the largest discharge database available in the United States for the years 1999 to 2002...
  77. ncbi request reprint Presence of calcified carotid plaque predicts vascular events: the Northern Manhattan Study
    Shyam Prabhakaran
    Rush University Medical Center, Department of Neurological Sciences, 1725 W Harrison Street, Suite 1121, Chicago, IL 60612, USA shyam
    Atherosclerosis 195:e197-201. 2007
    ..The prognostic implications of carotid plaque calcification (CPC) relative to subsequent vascular events are unclear. Our aim was to determine the association between CPC and risk of vascular events in a prospective multi-ethnic cohort...
  78. pmc Genetic contribution to brachial artery flow-mediated dilation: the Northern Manhattan Family Study
    Keiko Suzuki
    Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Atherosclerosis 197:212-6. 2008
    ..The importance of genetic contribution to FMD and baseline brachial artery diameter has not been shown in Hispanic populations. The purpose of this study was to estimate the heritability of FMD...
  79. ncbi request reprint Comparison of warfarin versus aspirin for the prevention of recurrent stroke or death: subgroup analyses from the Warfarin-Aspirin Recurrent Stroke Study
    Ralph L Sacco
    Columbia University and Mailman School of Public Health, Neurological Institute of the New York Presbyterian Hospital, New York, NY, USA
    Cerebrovasc Dis 22:4-12. 2006
    ..We performed a combination of prespecified and exploratory subgroup analyses to detect any treatment differences among various baseline subgroups in the Warfarin-Aspirin Recurrent Stroke Study (WARSS) cohort...
  80. ncbi request reprint Prognostic implications of left ventricular mass among Hispanics: the Northern Manhattan Study
    Carlos J Rodriguez
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Hypertension 48:87-92. 2006
    ..Our findings identify the Hispanic population with increased LVM as a high-risk subgroup...
  81. ncbi request reprint Alterations in plasma complement levels after human ischemic stroke
    J Mocco
    Department of Neurological Surgery, Columbia University, New York, New York 10032, USA
    Neurosurgery 59:28-33; discussion 28-33. 2006
    ..To assess the applicability of these findings to humans, we evaluated the characteristics and time course of human complement activation after stroke...
  82. pmc Levels of acute phase proteins remain stable after ischemic stroke
    Mitchell S V Elkind
    Gertrude H, Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    BMC Neurol 6:37. 2006
    ..Inflammation and inflammatory biomarkers play an important role in atherosclerosis and cardiovascular disease. Little information is available, however, on time course of serum markers of inflammation after stroke...
  83. pmc Carotid artery plaque thickness is associated with increased serum calcium levels: the Northern Manhattan study
    Mishaela R Rubin
    Department of Medicine, Columbia University College of Physicians and Surgeons, PH8W 864, 630 W 168th St, New York, NY 10032, USA
    Atherosclerosis 194:426-32. 2007
    ..We investigated the association between serum calcium and carotid plaque thickness, a powerful early predictor of clinical coronary and cerebrovascular events...
  84. ncbi request reprint Convulsive status epilepticus after ischemic stroke and intracerebral hemorrhage: frequency, predictors, and impact on outcome in a large administrative dataset
    Brian T Bateman
    Columbia Presbyterian Medical College for Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurocrit Care 7:187-93. 2007
    ..We examined the occurrence of GCSE in acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) using a large discharge database...
  85. ncbi request reprint Consent for intravenous thrombolysis in acute stroke: review and future directions
    Stephanie R White-Bateman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    Arch Neurol 64:785-92. 2007
    ....
  86. ncbi request reprint Evolving concepts regarding transient ischemic attacks
    Bernardo Liberato
    Neurological Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Curr Atheroscler Rep 7:274-9. 2005
    ..The recognition and treatment of TIA provides an excellent opportunity for stroke prevention that is often missed or poorly recognized among physicians...
  87. ncbi request reprint Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable
    Marc Fisher
    UMass Memorial Healthcare Center, 119 Belmont St, Worcester, MA 01605, USA
    Stroke 36:1808-13. 2005
    ..A fourth (STAIR-IV) was held to discuss relevant issues related to acute stroke drug development and regulatory approval...
  88. pmc Heritability of left ventricular mass and other morphologic variables in Caribbean Hispanic subjects: the Northern Manhattan Family Study
    Suh Hang Hank Juo
    J Am Coll Cardiol 46:735-7. 2005
  89. ncbi request reprint Patent foramen ovale and stroke
    Shunichi Homma
    Division of Cardiology, Columbia University, New York, NY, USA
    Circulation 112:1063-72. 2005
  90. pmc Association between diabetes mellitus and left ventricular hypertrophy in a multiethnic population
    Kazuo Eguchi
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
    Am J Cardiol 101:1787-91. 2008
    ..Presence of T2DM increased the risk of LV hypertrophy by about 1.5-fold, and it possibly interacted with central obesity...
  91. ncbi request reprint Epidemiology of stroke in young adults: race/ethnic differences
    Ji Y Chong
    Columbia University Neurological Institute, 710 W 168th St, NY 10032 2603, USA
    J Thromb Thrombolysis 20:77-83. 2005
    ..Furthermore, analysis of race/ethnic differences in stroke subtypes may help clarify mechanisms of stroke in young adults and potential race-ethnic differences in early stroke risk factors...
  92. ncbi request reprint Impact of abnormal diffusion-weighted imaging results on short-term outcome following transient ischemic attack
    Shyam Prabhakaran
    Rush University Medical Center, Department of Neurological Sciences, 1725 W Harrison St, Ste 1121, Chicago, IL 60612, USA
    Arch Neurol 64:1105-9. 2007
    ....
  93. ncbi request reprint Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on C
    Ralph L Sacco
    Circulation 113:e409-49. 2006
    ....
  94. ncbi request reprint Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Counc
    Larry B Goldstein
    Circulation 113:e873-923. 2006
    ..This guideline provides an overview of the evidence on various established and potential stroke risk factors and provides recommendations for the reduction of stroke risk...

Research Grants1

  1. STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGION
    Ralph Sacco; Fiscal Year: 2007
    ..abstract_text> ..