Genomes and Genes
Affiliation: University of Alabama at Birmingham
- Functionally competent antigen-specific CD127(hi) memory CD8+ T cells are preserved only in HIV-infected individuals receiving early treatmentSteffanie Sabbaj
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
J Infect Dis 195:108-17. 2007..These studies show that functionally competent subsets of antigen-specific memory CD8+ T cells in HIV-infected individuals are maintained but only if control of viremia is attained early during the course of infection...
- Glycoprotein B vaccine is capable of boosting both antibody and CD4 T-cell responses to cytomegalovirus in chronically infected womenSteffanie Sabbaj
Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
J Infect Dis 203:1534-41. 2011..These data suggest that this vaccine is capable of boosting immunity in a population of CMV-infected women and warrants additional evaluation to determine whether these boosted responses may prevent mother to child transmission of CMV...
- Cross-reactive CD8+ T cell epitopes identified in US adolescent minoritiesSteffanie Sabbaj
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Acquir Immune Defic Syndr 33:426-38. 2003..Frequent recognition of several of these CTL epitopes in persons of diverse racial backgrounds bodes well for the development of a broadly reactive HIV-1 vaccine...
- Menstrual blood as a potential source of endometrial derived CD3+ T cellsSteffanie Sabbaj
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 6:e28894. 2011..These data may open new avenues of investigation for cell mediated immune studies involving the female reproductive tract without the need for biopsies...
- CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptidesAnju Bansal
Department of Medicine, University of Alabama at Birmingham, 20th Street South, Birmingham, AL 35294, USA
AIDS 19:241-50. 2005..To understand the mechanisms underlying the differential targeting of T-cell responses during HIV-1 disease progression...
- T cell responses in HIV type 1-infected adolescent minorities share similar epitope specificities with whites despite significant differences in HLA class I allelesAnju Bansal
Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
AIDS Res Hum Retroviruses 19:1017-26. 2003..Hence host genetic variation among different racial groups may have less impact on the utility of candidate HIV-1 vaccines than previously suspected...
- CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcriptionAnju Bansal
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Exp Med 207:51-9. 2010..These findings indicate that the HIV-1 genome might encode and deploy a large potential repertoire of unconventional epitopes to enhance vaccine-induced antiviral immunity...
- Breast milk-derived antigen-specific CD8+ T cells: an extralymphoid effector memory cell population in humansSteffanie Sabbaj
Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
J Immunol 174:2951-6. 2005..These results demonstrate a population of extralymphoid CD8(+) T cells with an effector memory phenotype in humans, which could contribute to enhanced local virologic control and the relative lack of HIV transmission via this route...
- Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell helpMichael J Fuller
Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
J Immunol 174:5926-30. 2005..Analyses of cytokine-producing activities by both mouse and human CD8 T cells further document that the extended maintenance of T cells in a CD127(low) state has functional consequences which manifest as an impairment of IL-2 production...
- Human immunodeficiency virus-specific CD8(+) T cells in human breast milkSteffanie Sabbaj
Departments of Medicine, University of Alabama at Birmingham, 35294 2170, USA
J Virol 76:7365-73. 2002..Their presence suggests a role in limiting transmission and provides a rationale for vaccine strategies to enhance these responses...
- Hormonal contraception and HIV-1 infection: medroxyprogesterone acetate suppresses innate and adaptive immune mechanismsRichard P H Huijbregts
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
Endocrinology 154:1282-95. 2013..The presented results suggest that MPA suppresses both innate and adaptive arms of the immune system resulting in a reduction of host resistance to invading pathogens...
- Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppressionOlusimidele T Akinsiku
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
J Acquir Immune Defic Syndr 58:132-40. 2011..To further investigate this, we measured the capacity of virus-specific CD8 T cells to inhibit HIV-1 replication in an in vitro suppression assay...
- Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllersLatonya D Williams
University of Alabama at Birmingham, Department of Medicine, Birmingham, AL 35294, USA
J Virol 85:2316-24. 2011..Our results demonstrate that HIV-1-specific IL-21-producing CD8 T cells are induced following primary infection and enriched in elite controllers, suggesting a critical role for these cells in the maintenance of viremia control...
- HIV-specific CD8+ T cells from elite controllers are primed for survivalJiyu Yan
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Virol 87:5170-81. 2013..Furthermore, a better understanding of cellular markers that can be utilized to predict response durability in disease- or vaccine-elicited responses will advance the field...
- CD8 T-cell proliferative capacity is compromised in primary HIV-1 infectionSonya L Heath
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
J Acquir Immune Defic Syndr 56:213-21. 2011..Furthermore, the heterogeneity of this population suggests that a simple measure of an effective vaccine response remains elusive...
- Immune activation is associated with CD8 T cell interleukin-21 production in HIV-1-infected individualsLatonya D Williams
Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
J Virol 88:10259-63. 2014..Instead, IL-21 production by CD8 T cells was associated with high levels of activation, suggesting that these cells emerge as a consequence of excessive chronic immune activation rather than CD4 lymphopenia. ..
- Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasmaBradley H Edwards
Department of Medicine, University of Alabama, 845 19th Street South, BBRB 226, Birmingham, AL 35294, USA
J Virol 76:2298-305. 2002..These data serve as strong evidence that major histocompatibility complex class I presentation of Gag peptides is an essential feature for any HIV-1 vaccine designed to elicit optimal CD8+ T-cell responses...
- Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individualsJiri Mestecky
Departments of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
AIDS Res Hum Retroviruses 20:972-88. 2004..Therefore, in striking contrast to other mucosally encountered microbial infections, HIV-1 does not induce vigorous specific IgA responses in any body fluid examined or in ASC in peripheral blood...
- Brief Report: Enhanced Allogeneic Cellular Responses to Mismatched HLA-B Antigens Results in More Efficient Killing of HIV Infected CellsSteffanie Sabbaj
Departments of Medicine Microbiology, University of Alabama at Birmingham, Birmingham, AL and Emory Vaccine Center at Yerkes National Primate Research Center and Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA
J Acquir Immune Defic Syndr 71:493-7. 2016..These findings suggest a novel mechanism for protection against HIV infection. ..
- Dimorphic HLA-B signal peptides differentially influence HLA-E- and natural killer cell-mediated cytolysis of HIV-1-infected target cellsA M Merino
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
Clin Exp Immunol 174:414-23. 2013..Overall, our experiments indicate that the anti-HIV-1 function mediated by NK cells is compromised by P2-M, corroborating the association of HLA-B genotype encoding P2-M with accelerated HIV-1 acquisition. ..
- Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitisYudong Liu
Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294
J Immunol 192:59-72. 2014..Inhibition of the JAK/STAT pathway has clinical efficacy in multiple preclinical models of MS, suggesting the feasibility of the JAK/STAT pathway as a target for neuroinflammatory diseases. ..
- Host factor transcriptional regulation contributes to preferential expression of HIV type 1 in IL-4-producing CD4 T cellsMingce Zhang
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
J Immunol 189:2746-57. 2012....