J B Rubins
Affiliation: University of Minnesota
- Pneumococcal disease in the elderly: what is preventing vaccine efficacy?J B Rubins
Pulmonary Diseases, Veterans Affairs Medical Center and Department of Medicine, University of Minnesota School of Medicine, Minneapolis 55417, USA
Drugs Aging 18:305-11. 2001....
- Community-acquired pneumonia. Tailoring management of adult patients according to risk categoryJ B Rubins
Pulmonary Disease Section, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
Postgrad Med 102:45-7, 52, 55-62. 1997..Failure of the patient to respond to empirical antibiotic therapy within 72 hours should direct the clinician to consider unusual or resistant organisms or noninfectious causes of pneumonitis...
- Lovastatin induces apoptosis in malignant mesothelioma cellsJ B Rubins
Department of Medicine, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, USA
Am J Respir Crit Care Med 157:1616-22. 1998..Thus, lovastatin is a commercially available and clinically well-tolerated agent that reduces viability and induces apoptosis of mesothelioma cells, and may provide the basis for adjunctive treatments of patients with mesothelioma...
- Magnitude, duration, quality, and function of pneumococcal vaccine responses in elderly adultsJ B Rubins
Pulmonary Section, Department of Medicine, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
J Infect Dis 178:431-40. 1998..Thus, despite the adequate mean immune responses of the elderly as a group, a substantial proportion of elderly persons may have poor responses to the currently available pneumococcal vaccine...
- Diagnosis of venous thromboembolism. Step-by-step approach to a still lethal diseaseJ B Rubins
Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
Postgrad Med 108:175-80; quiz 16. 2000..The algorithm presented in this article facilitates the practical and efficient use of available resources in diagnosing and treating VTE...
- Identification of clinical risk factors for nosocomial pneumococcal bacteremiaJ B Rubins
Department of Pulmonary Disease, and Center for Chronic Diseases Outcome Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
Clin Infect Dis 29:178-83. 1999..5%, compared with 1.2% among nonbacteremic controls (P < .00001). We conclude that NPB is a highly lethal infection that is associated with distinct but identifiable clinical risks, symptoms, and signs...
- Temporal trends in survival after surgical resection of localized non-small cell lung cancerJ B Rubins
Pulmonary Division 111N, Department of Medicine, Minneapolis Veterans Affairs Medical Center, University of Minnesota, 1 Veterans Drive, Minneapolis, MN 55417, USA
Lung Cancer 28:21-7. 2000..We conclude that perioperative mortality after resection of localized NSCLC improved, but subsequent postoperative survival for these patients did not significantly improve over the 45-year period studied...
- Determination of antibody responses of elderly adults to all 23 capsular polysaccharides after pneumococcal vaccinationJ B Rubins
Pulmonary Diseases, Veterans Affairs Medical Center, University of Minnesota School of Medicine, Minneapolis, Minnesota 55417, USA
Infect Immun 67:5979-84. 1999..However, no particular group of vaccine polysaccharides could be used as a marker for adequate immune responses if only postvaccination sera were analyzed...
- Killing of Streptococcus pneumoniae by capsular polysaccharide-specific polymeric IgA, complement, and phagocytesE N Janoff
Infectious Disease Section, Department of Medicine, Veterans Affairs Medical Center and University of Minnesota Medical School, Minneapolis, Minnesota 55417, USA
J Clin Invest 104:1139-47. 1999..pneumoniae in the presence or absence of inflammation. These data suggest mechanisms whereby pIgA may serve to control pneumococcal infections locally and upon the pathogen's entry into the bloodstream...
- Inhibition of mesothelioma cell growth in vitro by doxycyclineJ B Rubins
Pulmonary Diseases and Oncology, Department of Medicine, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
J Lab Clin Med 138:101-6. 2001..Thus doxycycline may have a role as adjuvant therapy for malignant mesothelioma...
- Immune activation and virologic response to immunization in recent HIV type 1 seroconvertersE N Janoff
Department of Medicine, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
AIDS Res Hum Retroviruses 15:837-45. 1999..Thus, respiratory bacterial vaccines appear immunogenic and safe early in HIV-1 infection...
- Effect of anesthetics on pathogenesis of experimentally induced murine pneumococcal pneumoniaJ B Rubins
Veterans Affairs Medical Center, and Department of Medicine, University of Minnesota School of Medicine, Minneapolis, USA
Comp Med 50:292-5. 2000....
- Mechanisms of G1 checkpoint loss in resected early stage non-small cell lung cancerJ X Zhou
Department of Research Service, Minneapolis Veterans Affairs Medical Center, University of Minnesota Medical School, Minneapolis, MN 55417, USA
Lung Cancer 32:27-38. 2001..Although loss of p16INK4a function remains tightly correlated with pRB expression, loss of other regulatory elements in NSCLC such as p53 mutation and cyclin D1 over-expression appear independent of loss of the p16INK4a gene product...
- Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumoniaJ B Rubins
Veterans Affairs Medical Center, and Department of Medicine, University of Minnesota, Minneapolis 55417, USA
Infect Immun 65:2975-7. 1997..Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-gamma gene knockout mice, suggesting a protective role for IFN-gamma in host response to pneumococcal disease...
- Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumoniaJ B Rubins
Pulmonary Disease Division, Veterans Affairs Medical Center, Minneapolis, Minnesota
J Clin Invest 95:142-50. 1995..Moreover, both the cytotoxic and the complement-activating activities of pneumolysin may contribute independently to the acute pulmonary injury and the high rates of bacteremia which characterize pneumococcal pneumonia...