Mark A Rosen
Affiliation: University of Pennsylvania
- Dynamic contrast-enhanced magnetic resonance imaging for assessing tumor vascularity and vascular effects of targeted therapies in renal cell carcinomaMark A Rosen
Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Clin Cancer Res 13:770s-776s. 2007..DCE-MRI can be used to monitor the vascular changes induced by such therapies. Future efforts must be directed to standardizing image acquisition and analysis techniques to quantify tumor vascular responses...
- MRI assessment of early tumor response in metastatic renal cell carcinoma patients treated with sorafenibHyunseon Christine Kang
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
AJR Am J Roentgenol 200:120-6. 2013..The purpose of this study was to examine early MRI changes in renal cell carcinoma (RCC) treated with the antiangiogenic agent sorafenib and to identify MRI biomarkers of RCC response to sorafenib...
- Optical malignancy parameters for monitoring progression of breast cancer neoadjuvant chemotherapyDavid R Busch
Dept of Physics and Astronomy, University of Pennsylvania, 209 S 33rd St, Philadelphia, PA 19104 USA
Biomed Opt Express 4:105-21. 2013..Though preliminary, the study shows how to use the malignancy parameter for separating responders from partial-responders and demonstrates the potential utility of the methodology compared to traditional DOT quantification schemes...
- Computer aided automatic detection of malignant lesions in diffuse optical mammographyDavid R Busch
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Med Phys 37:1840-9. 2010..The methodology is tested in a population of 35 biopsy-confirmed malignant lesions...
- Neoadjuvant Chemotherapy for Breast Cancer: Functional Tumor Volume by MR Imaging Predicts Recurrence-free Survival-Results from the ACRIN 6657/CALGB 150007 I-SPY 1 TRIALNola M Hylton
From the Departments of Radiology N M H, D C N and Surgery L J E, University of California, San Francisco, 1600 Divisadero St, Room C250, Box 1667, San Francisco, CA 94115 Department of Biostatistics C A G and Center for Statistical Sciences C A G, H S M, Brown University, Providence, RI American College of Radiology Imaging Network ACRIN, Philadelphia, Pa C A G, H S M, M D S Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa M A R, M D S Department of Radiology, University of Washington, Seattle, Wash C D L, S C P Department of Radiology, University of Alabama, Birmingham, Ala W K B Department of Radiology, Medical College of South Carolina, Charleston, SC E D P Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY E A M Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex P T W Department of Radiology, Georgetown University, Washington, DC S M P and Department of Radiology, University of Chicago, Chicago, Ill G M N
Radiology 279:44-55. 2016..Models combining MR imaging, histopathology, and breast cancer subtype demonstrated the strongest predictive performance in this study. (©) RSNA, 2015 Online supplemental material is available for this article. ..
- Automatic coil selection for streak artifact reduction in radial MRIYiqun Xue
Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 67:470-6. 2012..The results demonstrate that the proposed strategy substantially improves the image quality and show excellent agreement with images reconstructed with manually determined coil selection...
- Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signaturesSo Hyun Chung
Department of Physics and Astronomy, University of Pennsylvania, 209 S 33rd St, Philadelphia, PA, 19104, USA
Breast Cancer Res 17:72. 2015..g., Ki67 proliferation markers, CD34 stained vasculature markers and nuclear morphology...
- A multichannel Markov random field framework for tumor segmentation with an application to classification of gene expression-based breast cancer recurrence riskAhmed B Ashraf
Computational Breast Imaging Group, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
IEEE Trans Med Imaging 32:637-48. 2013..88 as compared to 0.79, 0.76, 0.75, and 0.66 when using normalized cuts, single channel MRF, FCM, and FCM-VES, respectively, for segmentation...
- Blood flow reduction in breast tissue due to mammographic compressionDavid R Busch
Division of Neurology, Children s Hospital of Philadelphia, Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, 19104 Electronic address
Acad Radiol 21:151-61. 2014..Because many breast-imaging technologies derive contrast from the deformed breast, these load-dependent vascular responses affect contrast agent-enhanced and hemoglobin-based breast imaging...
- Frequency of malignancy seen in probably benign lesions at contrast-enhanced breast MR imaging: findings from ACRIN 6667Susan P Weinstein
Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce St, 1 Silverstein Building, Philadelphia, PA 19104, USA
Radiology 255:731-7. 2010....
- Respiratory motion-compensated radial dynamic contrast-enhanced (DCE)-MRI of chest and abdominal lesionsWei Lin
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
Magn Reson Med 60:1135-46. 2008..The performance of the proposed radial DCE-MRI technique is evaluated in subjects with lung and liver lesions, and results demonstrate that excellent pixelwise perfusion maps can be obtained with the proposed methodology...
- Pilot study of DCE-MRI to predict progression-free survival with sorafenib therapy in renal cell carcinomaKeith T Flaherty
Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 7:496-501. 2008..Sorafenib is a novel RAF and VEGF receptor tyrosine kinase inhibitor. We conducted this study to (a) determine if sorafenib is anti-angiogenic, and (b) to relate anti-angiogenic effect to outcome...
- Automatic correction of in-plane bulk motion artifacts in self-navigated radial MRISungheon Kim
Department of Radiology, Molecular Imaging Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Imaging 26:367-78. 2008..Substantial motion correction with relative error of less than 5% was achieved by using either first- or second-order model with the image metrics. This study demonstrates the potential of the method for motion-sensitive applications...
- Phase I/II Trial of Imatinib and Bevacizumab in Patients With Advanced Melanoma and Other Advanced CancersKeith T Flaherty
Developmental Therapeutics Program, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania, USA Cancer Therapeutics Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA
Oncologist 20:952-9. 2015..Vascular endothelial growth factor and platelet-derived growth factor signaling in the tumor microenvironment appear to cooperate in promoting tumor angiogenesis...
- Computerized image analysis for identifying triple-negative breast cancers and differentiating them from other molecular subtypes of breast cancer on dynamic contrast-enhanced MR images: a feasibility studyShannon C Agner
From the Department of Biomedical Engineering, Rutgers University, 599 Taylor Rd, Room 213, Piscataway, NJ 08854 S C A Departments of Radiology M A R, S E, M D S and Pathology M D F, P Z, C M, University of Pennsylvania, Philadelphia, Pa Department of Pathology and Anatomical Science, State University of New York at the University at Buffalo, Buffalo, NY J E T and Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio A M
Radiology 272:91-9. 2014....
- Non-invasive assessment of tumor neovasculature: techniques and clinical applicationsRodolfo Perini
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Cancer Metastasis Rev 27:615-30. 2008....
- Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRIRegine Choe
Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104 6396, USA
Med Phys 32:1128-39. 2005..A decrease in total hemoglobin concentration contrast between tumor and normal tissue was also observed over time. The results demonstrate the potential of DOT for measuring physiological parameters of breast lesions during chemotherapy...
- Breast reconstruction with a transverse rectus abdominis myocutaneous flap: spectrum of normal and abnormal MR imaging findingsRonit Karpati Devon
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
Radiographics 24:1287-99. 2004..MR imaging allows differentiation between benign and malignant findings in patients with palpable abnormalities or pain after TRAM flap reconstruction...
- Locally advanced breast cancer: MR imaging for prediction of response to neoadjuvant chemotherapy--results from ACRIN 6657/I-SPY TRIALNola M Hylton
Department of Radiology, University of California, San Francisco, 1600 Divisadero St, C250, Box 1667, San Francisco, CA 94115, USA
Radiology 263:663-72. 2012..To compare magnetic resonance (MR) imaging findings and clinical assessment for prediction of pathologic response to neoadjuvant chemotherapy (NACT) in patients with stage II or III breast cancer...
- Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomographyRegine Choe
University of Pennsylvania, Department of Physics, 209 S 33rd Street, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 14:024020. 2009..90 to 0.99, suggesting good discriminatory power. The data demonstrate that benign and malignant lesions can be distinguished by quantitative three-dimensional DOT...
- Transcytolemmal water exchange in pharmacokinetic analysis of dynamic contrast-enhanced MRI data in squamous cell carcinoma of the head and neckSungheon Kim
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Magn Reson Imaging 26:1607-17. 2007..To investigate the effect of transcytolemmal water exchange on the dynamic contrast-enhanced (DCE) T(1)-weighted MRI of human squamous cell carcinomas of the head and neck (HNSCC)...
- High frame-rate simultaneous bilateral breast DCE-MRILawrence Dougherty
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 57:220-5. 2007..In 11 of these cases there was a significant finding in the contralateral breast. DCE images of both breasts can be acquired simultaneously, resulting in high-resolution images as well as rapid sampling of the contrast kinetics...
- Gadolinium susceptibility artifact causing false positive stenosis isolated to the proximal common carotid artery in 3D dynamic contrast medium enhanced MR angiography of the thorax--a brief review of causes and preventionA Temel Tirkes
Department of Radiology, Hospital of University of Pennsylvania, 3400 Spruce Street, 1st Floor Founders MRI Learning Center, Philadelphia, PA 19104 4283, USA
Int J Cardiovasc Imaging 19:151-5. 2003..The cause of the artifact, its identification and prevention is reviewed...
- Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumorsDavid J Vaughn
Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Cancer 121:1463-8. 2015..The authors conducted an open-label, phase 2 study to determine the efficacy and safety of palbociclib in patients with incurable, refractory, retinoblastoma protein (pRB)-expressing GCTs...
- Endorectal T2-weighted MRI does not differentiate between favorable and adverse pathologic features in men with prostate cancer who would qualify for active surveillanceThomas J Guzzo
Department of Surgery, Division of Urology, The Hospital of University of Pennsylvania, Philadelphia, PA, USA
Urol Oncol 30:301-5. 2012..The goal of our study was to evaluate the ability of endorectal MRI (eMRI) to predict adverse pathologic features in patients who would otherwise qualify for an AS program...
- Prostate MR imaging at 3T with a longitudinal array endorectal surface coil and phased array body coilDavid Y Kim
Department of Radiology, Weill Cornell Medical College, New York, New York, USA
J Magn Reson Imaging 27:1327-30. 2008..To demonstrate the feasibility of using a double loop phased array endorectal coil combined with a phased array body coil to image the prostate at 3T...
- US MR imaging correlation in pathologic conditions of the scrotumWoojin Kim
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Radiographics 27:1239-53. 2007..Finally, MR imaging can demonstrate an intraabdominal undescended testis, which can be difficult to detect with US, and is superior to US in differentiation between an undescended testis and testicular agenesis...
- Innovations and challenges in renal cell carcinoma: summary statement from the Second Cambridge ConferenceMichael B Atkins
Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Clin Cancer Res 13:667s-670s. 2007....
- Ejaculatory function in stage T1 nonseminomatous germ cell tumors: retroperitoneal lymph node dissection versus surveillance--a decision analysisPeter Langenstroer
University of Kansas Medical Center, Kansas City, USA
J Urol 168:1396-401. 2002....