Carlos A Roncal-Jimenez

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Aging-associated renal disease in mice is fructokinase dependent
    Carlos A Roncal-Jimenez
    Division of Renal Diseases and Hypertension, University of Colorado, Aurora, Colorado
    Am J Physiol Renal Physiol 311:F722-F730. 2016
  2. pmc Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake
    Carlos A Roncal-Jimenez
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80016, USA
    Metabolism 60:1259-70. 2011
  3. pmc High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
    Takuji Ishimoto
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO
    Hepatology 58:1632-43. 2013
  4. pmc Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver
    Miguel A Lanaspa
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 7:e48801. 2012
  5. pmc Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver
    Miguel A Lanaspa
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 7:e47948. 2012
  6. pmc Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy
    Miguel A Lanaspa
    The Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Denver, Colorado
    J Am Soc Nephrol 25:2526-38. 2014
  7. pmc Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver
    Miguel A Lanaspa
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Denver, CO 80045, USA
    J Biol Chem 287:40732-44. 2012
  8. pmc Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice
    Zhilin Song 宋志林
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Aurora, Colorado
    J Neurophysiol 117:646-654. 2017
  9. pmc Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids
    Christina Cicerchi
    School of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    FASEB J 28:3339-50. 2014
  10. pmc Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel
    Miguel A Lanaspa
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America
    PLoS ONE 10:e0123509. 2015

Collaborators

Detail Information

Publications14

  1. pmc Aging-associated renal disease in mice is fructokinase dependent
    Carlos A Roncal-Jimenez
    Division of Renal Diseases and Hypertension, University of Colorado, Aurora, Colorado
    Am J Physiol Renal Physiol 311:F722-F730. 2016
    ....
  2. pmc Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake
    Carlos A Roncal-Jimenez
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80016, USA
    Metabolism 60:1259-70. 2011
    ..Sucrose, at concentrations ingested by a subset of Americans, can accelerate metabolic syndrome, fatty liver, and type 2 diabetes mellitus in male breeder rats; and the effects are independent of excess energy intake...
  3. pmc High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
    Takuji Ishimoto
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO
    Hepatology 58:1632-43. 2013
    ..These changes were prevented in the fructokinase knockout mice...
  4. pmc Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver
    Miguel A Lanaspa
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 7:e48801. 2012
    ..We present the novel finding that uric acid inhibits AMPK kinase activity in fructose-fed hepatocytes thus providing new insights into the pathogenesis of fatty liver...
  5. pmc Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver
    Miguel A Lanaspa
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 7:e47948. 2012
    ..Since subjects sensitive to fructose often develop phenotypes associated with hyperuricemia, uric acid may be an underlying factor in sensitizing hepatocytes to fructose metabolism during the development of fatty liver...
  6. pmc Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy
    Miguel A Lanaspa
    The Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Denver, Colorado
    J Am Soc Nephrol 25:2526-38. 2014
    ..These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease. ..
  7. pmc Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver
    Miguel A Lanaspa
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Denver, CO 80045, USA
    J Biol Chem 287:40732-44. 2012
    ..Uric acid is an independent risk factor in fructose-induced fatty liver, but whether it is a marker or a cause remains unknown...
  8. pmc Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice
    Zhilin Song 宋志林
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Aurora, Colorado
    J Neurophysiol 117:646-654. 2017
    ..Exogenous fructose increases vasopressin release in hypothalamic explants dependent on fructokinase. Nevertheless, circulating vasopressin is maintained and urinary concentrating is not impaired...
  9. pmc Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids
    Christina Cicerchi
    School of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    FASEB J 28:3339-50. 2014
    ..The uricase mutation in the Miocene likely provided a survival advantage to help maintain glucose levels under conditions of near starvation, but today likely has a role in the pathogenesis of diabetes...
  10. pmc Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel
    Miguel A Lanaspa
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America
    PLoS ONE 10:e0123509. 2015
    ..These data illuminate the opposing forces of metabolism of AMP by AMPD2 and its availability to activate AMPK as a switch that governs fat metabolism in the liver of hibernating ground squirrel. ..
  11. pmc Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study
    Masanari Kuwabara
    University of Colorado Denver, School of Medicine, Division of Renal Diseases and Hypertension, Aurora, Colorado, United States of America
    PLoS ONE 12:e0169137. 2017
    ..Here we tested the hypothesis that elevated serum sodium, which reflects serum osmolality, may be an independent risk factor for the development of CKD...
  12. pmc Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice
    Takuji Ishimoto
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:4320-5. 2012
    ..These studies provide insights into the mechanisms by which fructose causes obesity and metabolic syndrome...
  13. doi request reprint Mesoamerican Nephropathy or Global Warming Nephropathy?
    Carlos A Roncal-Jimenez
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
    Blood Purif 41:135-8. 2016
    ..The epidemic is postulated to be increasing due to the effects of global warming...
  14. doi request reprint Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-κB-dependent pathway
    Michiko Shimada
    Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USA
    Nephrol Dial Transplant 27:81-9. 2012
    ..CD80 expression is known to be induced by Toll-like receptor (TLR) ligands in dendritic cells. We therefore evaluated the ability of TLR to induce CD80 in human cultured podocytes...