Robert D Roghair

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Impact of maternal dexamethasone on coronary PGE(2) production and prostaglandin-dependent coronary reactivity
    Robert D Roghair
    Department of Pediatrics, 1270 CBRB, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 303:R513-9. 2012
  2. pmc Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Res 63:370-4. 2008
  3. pmc Vascular nitric oxide and superoxide anion contribute to sex-specific programmed cardiovascular physiology in mice
    Robert D Roghair
    Dept of Pediatrics, Univ of Iowa Carver College of Medicine, Iowa City, 52242, USA
    Am J Physiol Regul Integr Comp Physiol 296:R651-62. 2009
  4. pmc Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Clin Sci (Lond) 121:427-36. 2011
  5. ncbi request reprint Naturally occurring perinatal growth restriction in mice programs cardiovascular and endocrine function in a sex- and strain-dependent manner
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa, IA 52242, USA
    Pediatr Res 62:399-404. 2007
  6. ncbi request reprint Endothelial superoxide production is altered in sheep programmed by early gestation dexamethasone exposure
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Neonatology 93:19-27. 2008
  7. pmc Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone before the onset of systemic hypertension
    Robert D Roghair
    Division of Neonatology, Department of Pediatrics, Children s Hospital of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1169-76. 2005
  8. pmc Sex-specific programming of hypertension in offspring of late-gestation diabetic rats
    Ragheed Katkhuda
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Pediatr Res 72:352-61. 2012
  9. ncbi request reprint Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, USA
    Am J Physiol Regul Integr Comp Physiol 288:R46-53. 2005
  10. pmc Coronary endothelial function and vascular smooth muscle proliferation are programmed by early-gestation dexamethasone exposure in sheep
    Kenneth A Volk
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1607-14. 2010

Collaborators

Detail Information

Publications28

  1. pmc Impact of maternal dexamethasone on coronary PGE(2) production and prostaglandin-dependent coronary reactivity
    Robert D Roghair
    Department of Pediatrics, 1270 CBRB, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 303:R513-9. 2012
    ..Programmed inhibition of vasodilatory prostanoid production may link an adverse intrauterine environment with adult coronary artery disease...
  2. pmc Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Res 63:370-4. 2008
    ..This programming effect may predispose to progressive coronary endothelial dysfunction and coronary artery disease...
  3. pmc Vascular nitric oxide and superoxide anion contribute to sex-specific programmed cardiovascular physiology in mice
    Robert D Roghair
    Dept of Pediatrics, Univ of Iowa Carver College of Medicine, Iowa City, 52242, USA
    Am J Physiol Regul Integr Comp Physiol 296:R651-62. 2009
    ..While maternal DI increased both superoxide-mediated vasoconstriction and nitric oxide mediated vasodilation, the balance of these factors favored the development of hypertension in males and hypotension in females...
  4. pmc Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Clin Sci (Lond) 121:427-36. 2011
    ....
  5. ncbi request reprint Naturally occurring perinatal growth restriction in mice programs cardiovascular and endocrine function in a sex- and strain-dependent manner
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa, IA 52242, USA
    Pediatr Res 62:399-404. 2007
    ..Strain-and sex-specific genetic susceptibilities emphasize the need to consider genetic predisposition when evaluating the role of the perinatal environmental in the inception of adult disease...
  6. ncbi request reprint Endothelial superoxide production is altered in sheep programmed by early gestation dexamethasone exposure
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Neonatology 93:19-27. 2008
    ..Animal models have demonstrated that maternal undernutrition or early gestation glucocorticoid exposure induces endothelial dysfunction in the offspring...
  7. pmc Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone before the onset of systemic hypertension
    Robert D Roghair
    Division of Neonatology, Department of Pediatrics, Children s Hospital of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1169-76. 2005
    ..Glucocorticoid-induced alterations in coronary physiology may provide a mechanistic link between an adverse intrauterine environment and later cardiovascular disease...
  8. pmc Sex-specific programming of hypertension in offspring of late-gestation diabetic rats
    Ragheed Katkhuda
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Pediatr Res 72:352-61. 2012
    ..We used a rat model of third-trimester maternal diabetes to test the hypothesis that adult offspring exposed to hyperglycemia in utero display increased blood pressure and alterations in vascular responsiveness...
  9. ncbi request reprint Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, USA
    Am J Physiol Regul Integr Comp Physiol 288:R46-53. 2005
    ..Glucocorticoid-induced alterations in coronary vascular smooth muscle structure or function may provide a mechanistic link between an adverse intrauterine environment and later cardiovascular disease...
  10. pmc Coronary endothelial function and vascular smooth muscle proliferation are programmed by early-gestation dexamethasone exposure in sheep
    Kenneth A Volk
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1607-14. 2010
    ....
  11. ncbi request reprint Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs before hypertension
    Jeffrey L Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Regul Integr Comp Physiol 291:R481-8. 2006
    ..These findings suggest that resetting of the baroreflex, accompanied by increased sympathetic activity and altered nitric oxide-mediated compensatory vasodilatory function, may be important contributors to programming of hypertension...
  12. pmc Neonatal leptin administration alters regional brain volumes and blocks neonatal growth restriction-induced behavioral and cardiovascular dysfunction in male mice
    Gwen E Erkonen
    Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Res 69:406-12. 2011
    ..In conclusion, the effects of neonatal leptin administration are modulated by concurrent growth and gender. In growth restricted male mice, physiologic leptin replacement improves adult neurocardiovascular outcomes...
  13. ncbi request reprint Murine aortic reactivity is programmed equally by maternal low protein diet or late gestation dexamethasone
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, IA, USA
    J Matern Fetal Neonatal Med 20:833-41. 2007
    ..We hypothesized that both maternal low protein diet and late gestation dexamethasone program murine offspring to develop hypertension, vascular dysfunction, and glucose intolerance...
  14. ncbi request reprint Late-gestation betamethasone enhances coronary artery responsiveness to angiotensin II in fetal sheep
    Robert D Roghair
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Regul Integr Comp Physiol 286:R80-8. 2004
    ..These findings demonstrate that antenatal betamethasone exposure enhances coronary but not mesenteric artery vasoconstriction to ANG II by selectively upregulating coronary artery AT1 receptor protein expression...
  15. pmc Fetal programming alters reactive oxygen species production in sheep cardiac mitochondria
    Nicholas H Von Bergen
    Department of Pediatrics, Carver College of Medicine, 200 Hawkins Drive, University of Iowa, Iowa City, IA 52242, USA
    Clin Sci (Lond) 116:659-68. 2009
    ..Greater mitochondrial H(2)O(2) release into the cell may play a role in the development of adult disease following exposure to an adverse intrauterine environment...
  16. pmc Impact of neonatal sertraline exposure on the post-myocardial infarction outcomes of adult male mice
    Sarah E Haskell
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA
    J Cardiovasc Pharmacol 62:479-84. 2013
    ..Neonatal SSRI exposure did not significantly alter post-MI survival. We conclude that the preexisting SSRI-induced small left heart syndrome may provide protection from post-MI ventricular dilation...
  17. pmc Neonatal catch up growth increases diabetes susceptibility but improves behavioral and cardiovascular outcomes of low birth weight male mice
    Gregory M Hermann
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Pediatr Res 66:53-8. 2009
    ..These studies support the importance of the perinatal environment in the resetting of adult disease susceptibility and suggest an earlier window of vulnerability among growth restricted female mice...
  18. pmc Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats
    Emily M Segar
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Clin Sci (Lond) 117:129-38. 2009
    ..Thus the development of diabetes during pregnancy programmes gender-specific insulin resistance and vascular dysfunction in adult offspring...
  19. pmc Sertraline exposure leads to small left heart syndrome in adult mice
    Sarah E Haskell
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Pediatr Res 73:286-93. 2013
    ..We hypothesized that SSRI exposure decreases left-ventricular (LV) volumes and increases adult sympathetic nervous system activation, resulting in increased adult heart rates...
  20. pmc Neonatal macrosomia is an independent risk factor for adult metabolic syndrome
    Gregory M Hermann
    Department of Pediatrics, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    Neonatology 98:238-44. 2010
    ..Weight in infancy correlates with risk of type 2 diabetes, hypertension, and obesity in adulthood. Clinical observations have been confounded by obesity-prone genotypes and obesity-linked lifestyles...
  21. pmc Neonatal leptin deficiency reduces frontal cortex volumes and programs adult hyperactivity in mice
    Benjamin C Dexter
    Departments of Pediatrics Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States
    Behav Brain Res 263:115-21. 2014
    ..We speculate neonatal leptin deficiency may contribute to the adverse neurodevelopmental outcomes associated with perinatal growth restriction, and postnatal leptin therapy may be protective...
  22. pmc Neonatal growth restriction-related leptin deficiency enhances leptin-triggered sympathetic activation and central angiotensin II receptor-dependent stress-evoked hypertension
    Veronica Peotta
    Department of Pediatrics, University of Iowa, Iowa City, Iowa
    Pediatr Res 80:244-51. 2016
    ....
  23. pmc Oral oestrogen reverses ovariectomy-induced morning surge hypertension in growth-restricted mice
    Sarah E Haskell
    Stead Family Department of Pediatrics, University of Iowa, Iowa City, IA 52242, U S A
    Clin Sci (Lond) 130:613-23. 2016
    ....
  24. pmc Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets
    Jinny J Guo
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, United States
    J Cyst Fibros 13:251-9. 2014
    ..We hypothesized that compared to wild-type or CFTR-null aorta, aorta from CFTR-F508del (dF) piglets will have reduced endoplasmic reticulum calcium mobilization and decreased vasoconstriction...
  25. pmc Neonatal SSRI Exposure Programs a Hypermetabolic State in Adult Mice
    Gary J Kummet
    Department of Pediatrics, Carver College of Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Nutr Metab 2012:431574. 2012
    ..Ovarian status modulated central TPH2 expression, but not adult energy balance, suggesting programmed neural connectivity or enhanced melatonin production may play a more important role in the post-SSRI hypermetabolic syndrome...
  26. pmc Reduced blood pressure of CFTR-F508del carriers correlates with diminished arterial reactivity rather than circulating blood volume in mice
    Veronica A Peotta
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
    PLoS ONE 9:e96756. 2014
    ....
  27. pmc Growth restriction, leptin, and the programming of adult behavior in mice
    Lauritz R Meyer
    Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States of America Electronic address
    Behav Brain Res 275:131-5. 2014
    ..We speculate neonatal leptin deficiency may contribute to the adverse neurodevelopmental outcomes associated with postnatal growth restriction, and postnatal leptin therapy may be protective. ..
  28. pmc Perinatal outcomes of pregnancies complicated by maternal depression with or without selective serotonin reuptake inhibitor therapy
    Holly J Engelstad
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Neonatology 105:149-54. 2014
    ..Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed psychotropics for major depressive disorder during pregnancy and are used in up to 6.2% of pregnancies...