David R Roalf

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc The impact of quality assurance assessment on diffusion tensor imaging outcomes in a large-scale population-based cohort
    David R Roalf
    Neuropsychiatry Section, Department of Psychiatry, USA Electronic address
    Neuroimage 125:903-19. 2016
  2. pmc White matter microstructure in schizophrenia: associations to neurocognition and clinical symptomatology
    David R Roalf
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, United States Electronic address
    Schizophr Res 161:42-9. 2015
  3. pmc Heritability of subcortical and limbic brain volume and shape in multiplex-multigenerational families with schizophrenia
    David R Roalf
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Electronic address
    Biol Psychiatry 77:137-46. 2015
  4. pmc Comparative accuracies of two common screening instruments for classification of Alzheimer's disease, mild cognitive impairment, and healthy aging
    David R Roalf
    Department of Psychiatry, Neuropsychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 9:529-37. 2013
  5. pmc Neurocognitive performance stability in a multiplex multigenerational study of schizophrenia
    David R Roalf
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Schizophr Bull 39:1008-17. 2013
  6. pmc White matter organization and neurocognitive performance variability in schizophrenia
    David R Roalf
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, United States
    Schizophr Res 143:172-8. 2013
  7. pmc Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Schizophr Res 90:221-8. 2007
  8. ncbi request reprint Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 28:1444-61. 2006
  9. pmc Persistence of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort: a prospective two-year follow-up
    Monica E Calkins
    Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    World Psychiatry 16:62-76. 2017
  10. ncbi request reprint Temporal Lobe Volume Decrements in Psychosis Spectrum Youths
    David R Roalf
    Department of Psychiatry, Neuropsychiatry Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
    Schizophr Bull . 2016

Collaborators

Detail Information

Publications32

  1. pmc The impact of quality assurance assessment on diffusion tensor imaging outcomes in a large-scale population-based cohort
    David R Roalf
    Neuropsychiatry Section, Department of Psychiatry, USA Electronic address
    Neuroimage 125:903-19. 2016
    ....
  2. pmc White matter microstructure in schizophrenia: associations to neurocognition and clinical symptomatology
    David R Roalf
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, United States Electronic address
    Schizophr Res 161:42-9. 2015
    ..However, identification of the most salient WM aberrations to neurocognition and clinical symptoms is limited by relatively small samples with divergent results...
  3. pmc Heritability of subcortical and limbic brain volume and shape in multiplex-multigenerational families with schizophrenia
    David R Roalf
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania Electronic address
    Biol Psychiatry 77:137-46. 2015
    ..We estimate the heritability of subcortical and hippocampal brain volumes in multiplex-multigenerational families and the heritability of subregions using advanced shape analysis...
  4. pmc Comparative accuracies of two common screening instruments for classification of Alzheimer's disease, mild cognitive impairment, and healthy aging
    David R Roalf
    Department of Psychiatry, Neuropsychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 9:529-37. 2013
    ....
  5. pmc Neurocognitive performance stability in a multiplex multigenerational study of schizophrenia
    David R Roalf
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Schizophr Bull 39:1008-17. 2013
    ..These findings suggest that measures of mean performance and IIV of speed during a CNB may provide useful information about the genetic susceptibility in schizophrenia. ..
  6. pmc White matter organization and neurocognitive performance variability in schizophrenia
    David R Roalf
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, United States
    Schizophr Res 143:172-8. 2013
    ..However, the neural basis of WIV has not been studied in patients with schizophrenia...
  7. pmc Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Schizophr Res 90:221-8. 2007
    ..Phenotypic variation in PTC sensitivity is thought to be genetic in origin and suggests greater illness risk for those subjects with recessive taster alleles...
  8. ncbi request reprint Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Exp Neuropsychol 28:1444-61. 2006
    ....
  9. pmc Persistence of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort: a prospective two-year follow-up
    Monica E Calkins
    Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    World Psychiatry 16:62-76. 2017
    ..Neurocognition, brain structure and function, and genomics may be integrated with clinical data to provide early indices of symptom persistence and worsening in youths at risk for psychosis...
  10. ncbi request reprint Temporal Lobe Volume Decrements in Psychosis Spectrum Youths
    David R Roalf
    Department of Psychiatry, Neuropsychiatry Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
    Schizophr Bull . 2016
    ..These MRI measures may therefore serve as important confirmatory biomarkers denoting a worrisome preclinical trajectory among at-risk youths, and the specific pattern of deficits may predict specific symptom profiles...
  11. ncbi request reprint Unirhinal olfactory function in schizophrenia patients and first-degree relatives
    David R Roalf
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neuropsychiatry Clin Neurosci 18:389-96. 2006
    ....
  12. pmc Structural Brain Abnormalities in Youth With Psychosis Spectrum Symptoms
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia
    JAMA Psychiatry 73:515-24. 2016
    ..However, it is unclear when aberrations emerge in the disease process and if such deficits are present in association with less severe psychosis spectrum (PS) symptoms in youth...
  13. pmc Common and Dissociable Mechanisms of Executive System Dysfunction Across Psychiatric Disorders in Youth
    Sheila Shanmugan
    From the Departments of Psychiatry, of Biostatistics and Epidemiology, of Radiology, and of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia the NIMH Mood and Anxiety Disorders Program, Bethesda, Md the Center for Applied Genomics, Children s Hospital of Philadelphia and the Philadelphia Veterans Administration Medical Center, Philadelphia
    Am J Psychiatry 173:517-26. 2016
    ..The authors hypothesize that common and dissociable patterns of dysfunction would be present...
  14. ncbi request reprint Apolipoprotein E genotype and odor identification in schizophrenia
    Paul J Moberg
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Neuropsychiatry Clin Neurosci 18:231-3. 2006
    ..No significant associations between ApoE status and olfaction were observed in either diagnostic group. The authors concluded that olfactory deficits in schizophrenia do not appear to be mediated by the ApoE allele...
  15. pmc Disrupted anatomic networks in the 22q11.2 deletion syndrome
    J Eric Schmitt
    Brain Behavior Laboratory, Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Radiology, Division of Neuroradiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage Clin 12:420-8. 2016
    ..Multiple global graph theoretical statistics were decreased in 22q11DS. These results are consistent with prior studies demonstrating decreased connectivity in 22q11DS using other neuroimaging methodologies. ..
  16. pmc Elevated Amygdala Perfusion Mediates Developmental Sex Differences in Trait Anxiety
    Antonia N Kaczkurkin
    Departments of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
    Biol Psychiatry 80:775-785. 2016
    ..However, few studies relate developmental differences in symptoms of anxiety and depression to brain development. Cerebral blood flow is one brain phenotype that is known to have marked developmental sex differences...
  17. pmc Odor Identification Screening Improves Diagnostic Classification in Incipient Alzheimer's Disease
    Megan Quarmley
    Department of Psychiatry, Philadelphia, PA, USA
    J Alzheimers Dis 55:1497-1507. 2017
    ..Here we examine the improvement in diagnostic accuracy of Alzheimer's disease (AD) and mild cognitive impairment (MCI) when assessing both cognitive functioning and odor identification...
  18. pmc Subject-level measurement of local cortical coupling
    Simon N Vandekar
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Neuroimage 133:88-97. 2016
    ..R code to estimate subject-level coupling maps from any two cortical surfaces generated by FreeSurfer is made publicly available along with this manuscript. ..
  19. pmc Linked Sex Differences in Cognition and Functional Connectivity in Youth
    Theodore D Satterthwaite
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cereb Cortex 25:2383-94. 2015
    ..Taken together, these results demonstrate for the first time that sex differences in patterns of cognition are in part represented on a neural level through divergent patterns of brain connectivity. ..
  20. pmc Within-Individual Variability: An Index for Subtle Change in Neurocognition in Mild Cognitive Impairment
    David R Roalf
    Department of Psychiatry, Philadelphia, PA, USA
    J Alzheimers Dis 54:325-35. 2016
    ..Typically, studies focus on average or mean performance, but ignore consistency of performance across domains. WIV (within-individual variability) provides an index of this consistency and is a potential marker of cognitive decline...
  21. pmc Development of an itemwise efficiency scoring method: Concurrent, convergent, discriminant, and neuroimaging-based predictive validity assessed in a large community sample
    Tyler M Moore
    Department of Psychiatry, University of Pennsylvania
    Psychol Assess 28:1529-1542. 2016
    ..PsycINFO Database Record..
  22. pmc Within-individual variability in neurocognitive performance: age- and sex-related differences in children and youths from ages 8 to 21
    David R Roalf
    Department of Psychiatry, University of Pennsylvania
    Neuropsychology 28:506-18. 2014
    ..Developmental studies focus on average performance in single domains but ignore consistency of performance across domains. Within-individual variability (WIV) provides an index of that evenness and is a potential marker of development...
  23. pmc The Philadelphia Neurodevelopmental Cohort: constructing a deep phenotyping collaborative
    Monica E Calkins
    Department of Psychiatry, Neuropsychiatry Section, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Child Psychol Psychiatry 56:1356-69. 2015
    ..We also evaluate the structure of the assessment tools and their criterion validity...
  24. ncbi request reprint Smaller nasal volumes as stigmata of aberrant neurodevelopment in schizophrenia
    Paul J Moberg
    Brain Behavior Laboratory, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Psychiatry 161:2314-6. 2004
    ....
  25. ncbi request reprint Phenylthiocarbamide (PTC) perception in Parkinson disease
    Paul J Moberg
    Parkinson s Disease Research, Education, and Clinical Center, Philadelphia Veterans Affairs Medical Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cogn Behav Neurol 20:145-8. 2007
    ..To examine phenylthiocarbamide (PTC) sensitivity in Parkinson disease (PD) patients and healthy volunteers to determine whether taster status represented a simple vulnerability marker for PD...
  26. ncbi request reprint Phenylthiocarbamide perception in patients with schizophrenia and first-degree family members
    Paul J Moberg
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Psychiatry 162:788-90. 2005
    ..The authors examined PTC sensitivity in schizophrenia patients and their non-ill relatives to determine whether this represented a vulnerability marker...
  27. pmc Defining and validating a short form Montreal Cognitive Assessment (s-MoCA) for use in neurodegenerative disease
    David R Roalf
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 87:1303-1310. 2016
    ..Yet, administration time is too long for many clinical settings...
  28. pmc A quantitative meta-analysis of olfactory dysfunction in mild cognitive impairment
    David R Roalf
    Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry . 2016
    ..The aim of the present comprehensive meta-analysis was to investigate the nature of olfactory deficits in mild cognitive impairment (MCI)...
  29. pmc The Philadelphia Neurodevelopmental Cohort: A publicly available resource for the study of normal and abnormal brain development in youth
    Theodore D Satterthwaite
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Electronic address
    Neuroimage 124:1115-9. 2016
    ....
  30. ncbi request reprint Decrements in volume of anterior ventromedial temporal lobe and olfactory dysfunction in schizophrenia
    Bruce I Turetsky
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Arch Gen Psychiatry 60:1193-200. 2003
    ..Patients with schizophrenia exhibit olfactory deficits, but it is unclear whether these represent a specific abnormality. The link between olfactory impairments and regional brain abnormalities has yet to be established...
  31. pmc Aberrant Cortical Morphometry in the 22q11.2 Deletion Syndrome
    J Eric Schmitt
    Brain Behavior Laboratory, Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania Department of Radiology, Hospital of the University of Pennsylvania
    Biol Psychiatry 78:135-43. 2015
    ..2 deletion syndrome (22q11DS). Although this condition is associated with morphologic brain abnormalities, simultaneous examination of multiple high-resolution measures of cortical structure has not been performed...
  32. pmc Mapping glutamate in subcortical brain structures using high-resolution GluCEST MRI
    Kejia Cai
    University of Pennsylvania, Radiology, Philadelphia, PA, USA
    NMR Biomed 26:1278-84. 2013
    ..These findings suggest that high-resolution GluCEST MRI of subcortical brain structures may prove to be a useful tool in diagnosis of brain disorders or treatment responses...