E F Rissman

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Gestational exposure to low dose bisphenol A alters social behavior in juvenile mice
    JENNIFER T WOLSTENHOLME
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
    PLoS ONE 6:e25448. 2011
  2. pmc Neural growth hormone implicated in body weight sex differences
    Paul J Bonthuis
    PO Box 800733, University of Virginia School of Medicine, Charlottesville, Virginia 22908
    Endocrinology 154:3826-35. 2013
  3. pmc Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression
    JENNIFER T WOLSTENHOLME
    Department of Biochemistry and Molecular Genetics, University of Virginia, P O Box 800733, Charlottesville, Virginia 22908, USA
    Endocrinology 153:3828-38. 2012
  4. pmc Sexual dimorphism of growth hormone in the hypothalamus: regulation by estradiol
    Melisande L Addison
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Endocrinology 153:1898-907. 2012
  5. ncbi request reprint Sex with knockout models: behavioral studies of estrogen receptor alpha
    E F Rissman
    Department of Biology, Neuroscience Graduate Program, Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Brain Res 835:80-90. 1999
  6. ncbi request reprint Olfactory bulbectomy blocks mating-induced ovulation in musk shrews (Suncus murinus)
    E F Rissman
    Biology Department, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903, USA
    Biol Reprod 62:1052-8. 2000
  7. pmc Roles of oestrogen receptors alpha and beta in behavioural neuroendocrinology: beyond Yin/Yang
    E F Rissman
    Department of Biochemistry and Molecular Genetics, Program in Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Neuroendocrinol 20:873-9. 2008
  8. ncbi request reprint Estrogen receptor beta regulates sexually dimorphic neural responses to estradiol
    J L Temple
    Program in Neuroscience, Department of Biology, University of Virginia, Charlottesville, Virginia 22903, USA
    Endocrinology 142:510-3. 2001
  9. pmc Regulation of progestin receptors in medial amygdala: estradiol, phytoestrogens and sex
    A E Kudwa
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Physiol Behav 97:146-50. 2009
  10. ncbi request reprint Oestrogen receptor alpha is essential for female-directed chemo-investigatory behaviour but is not required for the pheromone-induced luteinizing hormone surge in male mice
    S R Wersinger
    Department of Biology, Neuroscience Program, University of Virginia, Gilmer Hall, Charlottesville, VA 22903, USA
    J Neuroendocrinol 12:103-10. 2000

Collaborators

Detail Information

Publications78

  1. pmc Gestational exposure to low dose bisphenol A alters social behavior in juvenile mice
    JENNIFER T WOLSTENHOLME
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
    PLoS ONE 6:e25448. 2011
    ..We propose that BPA affects DNA methylation of Sc1a1 during neural development. Sex differences in juvenile social interactions are affected by BPA and in particular this compound modifies behavior in females...
  2. pmc Neural growth hormone implicated in body weight sex differences
    Paul J Bonthuis
    PO Box 800733, University of Virginia School of Medicine, Charlottesville, Virginia 22908
    Endocrinology 154:3826-35. 2013
    ..We propose that X inactivation-escaping genes modulate Gh expression and food intake, and this is part of the mechanism by which individuals with 2 X chromosomes are heavier than individuals with a single X chromosome. ..
  3. pmc Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression
    JENNIFER T WOLSTENHOLME
    Department of Biochemistry and Molecular Genetics, University of Virginia, P O Box 800733, Charlottesville, Virginia 22908, USA
    Endocrinology 153:3828-38. 2012
    ..Heritable effects of an endocrine-disrupting chemical have implications for complex neurological diseases and highlight the importance of considering gene-environment interactions in the etiology of complex disease...
  4. pmc Sexual dimorphism of growth hormone in the hypothalamus: regulation by estradiol
    Melisande L Addison
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Endocrinology 153:1898-907. 2012
    ..Interestingly, estradiol enhances Gh mRNA in females only, suggesting that multiple factors orchestrate this sexual dimorphism...
  5. ncbi request reprint Sex with knockout models: behavioral studies of estrogen receptor alpha
    E F Rissman
    Department of Biology, Neuroscience Graduate Program, Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Brain Res 835:80-90. 1999
    ..Based on these data we hypothesize that ERalpha mediates many of the effects of estrogen on sexual behavior, learning, and memory...
  6. ncbi request reprint Olfactory bulbectomy blocks mating-induced ovulation in musk shrews (Suncus murinus)
    E F Rissman
    Biology Department, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903, USA
    Biol Reprod 62:1052-8. 2000
    ..In sum, female musk shrews can display receptivity and engage in copulation without olfactory inputs. However, the olfactory system is essential for mating-induced ovulation...
  7. pmc Roles of oestrogen receptors alpha and beta in behavioural neuroendocrinology: beyond Yin/Yang
    E F Rissman
    Department of Biochemistry and Molecular Genetics, Program in Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Neuroendocrinol 20:873-9. 2008
    ..Future studies on all of these topics will inform us about how ER selective ligands might affect oestrogen functions at the organismal level...
  8. ncbi request reprint Estrogen receptor beta regulates sexually dimorphic neural responses to estradiol
    J L Temple
    Program in Neuroscience, Department of Biology, University of Virginia, Charlottesville, Virginia 22903, USA
    Endocrinology 142:510-3. 2001
    ..Our results show that ERbeta influences several sexually dimorphic neural responses to estrogen. Moreover the data clearly show that ERbeta can modulate neural expression of ERalpha...
  9. pmc Regulation of progestin receptors in medial amygdala: estradiol, phytoestrogens and sex
    A E Kudwa
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Physiol Behav 97:146-50. 2009
    ..We hypothesize that both aromatization of androgens to estrogens and dietary sources of additional estrogens are part of the normal requirement for sex differences in the rodent brain...
  10. ncbi request reprint Oestrogen receptor alpha is essential for female-directed chemo-investigatory behaviour but is not required for the pheromone-induced luteinizing hormone surge in male mice
    S R Wersinger
    Department of Biology, Neuroscience Program, University of Virginia, Gilmer Hall, Charlottesville, VA 22903, USA
    J Neuroendocrinol 12:103-10. 2000
    ..Responses to female pheromones do not require ERalpha. However, normal male sexual performance requires the ERalpha gene...
  11. ncbi request reprint Novel effects of estradiol and estrogen receptor alpha and beta on cognitive function
    H N Fugger
    Neuroscience Program, University of Virginia, Charlottesville, VA 22904, USA
    Brain Res 883:258-64. 2000
    ..The results indicate an important role for ERalpha, relative to ERbeta, in the establishment of cognitive function and suggest that E(2) modulates memory function via a novel estrogenic mechanism...
  12. ncbi request reprint Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene
    S R Wersinger
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Horm Behav 32:176-83. 1997
    ..However, it is clear that the ER alpha plays a key role in the expression of masculine sexual behavior and in the regulation of androgen receptors in a neuronal cell population involved in the display of motivated behaviors...
  13. ncbi request reprint Double oestrogen receptor alpha and beta knockout mice reveal differences in neural oestrogen-mediated progestin receptor induction and female sexual behaviour
    A E Kudwa
    Neuroscience Graduate Program, University of Virginia Medical School, Charlottesville, VA 22908, USA
    J Neuroendocrinol 15:978-83. 2003
    ..However, despite the presence of PR in VMH, females lacking a functional ERalpha gene do not display sexual behaviour, via either ligand-dependent or -independent activation...
  14. ncbi request reprint Aggression and arginine vasopressin immunoreactivity regulation by androgen receptor and estrogen receptor alpha
    E M Scordalakes
    Department of Biology, University of Virginia Medical School, Charlottesville, VA, USA
    Genes Brain Behav 3:20-6. 2004
    ..In sum we have shown that E2 acts via ER alpha to regulate aggression in male mice. In contrast both ER alpha and AR contribute to AVP-ir in limbic brain regions...
  15. ncbi request reprint Food availability affects neural estrogen receptor immunoreactivity in prepubertal mice
    J N Roemmich
    Department of Pediatrics, University of Virginia, Charlottesville 22903, USA
    Endocrinology 138:5366-73. 1997
    ..In female mice, underfeeding may stall puberty by reducing the number of ER-ir cells in brain areas important for signal transmission of GnRH release...
  16. ncbi request reprint Sex differences in the activational effect of ERalpha on spatial learning
    H N Fugger
    Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia, 22903, USA
    Horm Behav 34:163-70. 1998
    ..Because ligand-bound ERalpha appears to operate differently in male and female mice we hypothesize that the ability of ERalpha to affect learning is organized during development...
  17. ncbi request reprint Roles of estrogen receptors alpha and beta in differentiation of mouse sexual behavior
    A E Kudwa
    Program in Neuroscience, University of Virginia Medical School, Charlottesville, 22908, USA
    Neuroscience 138:921-8. 2006
    ..In sum, estradiol can have selective effects on distinct behavioral processes via selective interactions with its two receptors, estrogen receptor alpha and estrogen receptor beta...
  18. pmc Effects of organisational oestradiol on adult immunoreactive oestrogen receptors (alpha and beta) in the male mouse brain
    A E Kudwa
    Neuroscience Graduate Program, University of Virginia, Charlottesville, VA 22908, USA
    J Neuroendocrinol 19:767-72. 2007
    ..Furthermore, although both ERalpha and beta-ir cell numbers are altered by the disruption of the aromatase gene, ERbeta is altered in a more robust and region-specific manner...
  19. pmc Effects of sex chromosome aneuploidy on male sexual behavior
    J H Park
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Genes Brain Behav 7:609-17. 2008
    ..The results implicate novel roles for sex chromosome genes in sexual behaviors...
  20. ncbi request reprint Sex differences in mammalian and chicken-II gonadotropin-releasing hormone immunoreactivity in musk shrew brain
    E F Rissman
    Department of Biology, University of Virginia, Charlottesville, Virginia, 22903, USA
    Gen Comp Endocrinol 112:346-55. 1998
    ..These data suggest that the phylogenetically conserved cGnRH-II form is regulated by ovarian hormones and, thus, may be involved in the brain-pituitary-gonadal feedback axis...
  21. ncbi request reprint Coumestrol antagonizes neuroendocrine actions of estrogen via the estrogen receptor alpha
    D A Jacob
    Department of Biology and Neuroscience Program, University of Virginia, Charlottesville 22904-4328, USA
    Exp Biol Med (Maywood) 226:301-6. 2001
    ..ERalphaKO females in all treatment groups had high levels of LH. Taken together, the results show that coumestrol has anti-estrogenic actions in the brain and pituitary and that ERalpha mediates these effects...
  22. ncbi request reprint Rapid neural Fos responses to oestradiol in oestrogen receptor alphabeta double knockout mice
    E Dominguez-Salazar
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Neuroendocrinol 18:195-202. 2006
    ..We speculate that oestradiol has rapid effects in the OPT and CG2 via a novel mechanism that does not require either classic oestrogen receptor...
  23. ncbi request reprint Estrogen receptor beta modulates estradiol induction of progestin receptor immunoreactivity in male, but not in female, mouse medial preoptic area
    Andrea E Kudwa
    Department of Biochemistry and Molecular Genetics, University of Virginia, Medical School, Charlottesville, Virginia 22908, USA
    Endocrinology 145:4500-6. 2004
    ..We hypothesize that the two ERs have dependent and independent roles in sexual differentiation of neuroendocrine function...
  24. pmc Sex differences in juvenile mouse social behavior are influenced by sex chromosomes and social context
    K H Cox
    Department of Biochemistry and Molecular Genetics and Graduate Program in Neuroscience, University of Virginia School of Medicine, Charlottesville, VA, USA
    Genes Brain Behav 10:465-72. 2011
    ..These data may have relevance for understanding the etiology of sexually dimorphic disorders such as ASD...
  25. ncbi request reprint Dopamine activates masculine sexual behavior independent of the estrogen receptor alpha
    S R Wersinger
    University of Virginia, Department of Biology, Charlottesville, Virginia 22903, USA
    J Neurosci 20:4248-54. 2000
    ..Moreover, dopamine can activate sexual behavior via a mechanism that either acts on an ER other than ERalpha or via an estrogen-independent pathway...
  26. ncbi request reprint Steroid feedback on gonadotropin release and pituitary gonadotropin subunit mRNA in mice lacking a functional estrogen receptor alpha
    S R Wersinger
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Endocrine 11:137-43. 1999
    ..Although E2 can exert negative feedback effects on LH release in both males and females by actions at the ERalpha, the androgen receptor plays the primary physiological role in the male mouse...
  27. ncbi request reprint Estrogen receptor function as revealed by knockout studies: neuroendocrine and behavioral aspects
    E F Rissman
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Horm Behav 31:232-43. 1997
    ....
  28. ncbi request reprint Roles of estrogen receptor alpha and androgen receptor in the regulation of neuronal nitric oxide synthase
    Elka M Scordalakes
    Biology Department, University of Virginia, Charlottesville, Virginia 22903, USA
    J Comp Neurol 453:336-44. 2002
    ..Thus, we show that ERalpha and AR interact to regulate nNOS in male and female brain in a site-specific manner...
  29. ncbi request reprint Estrogen receptor-alpha (ERalpha), but not ERbeta, modulates estrogen stimulation of the ERalpha-truncated variant, TERP-1
    Derek A Schreihofer
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 143:4196-202. 2002
    ..We conclude that ERalpha is critical for E2 stimulation, but not basal expression, of the TERP promoter, and that testosterone may act through the androgen receptor to stimulate the TERP-1 promoter in males...
  30. ncbi request reprint An evolutionarily conserved form of gonadotropin-releasing hormone coordinates energy and reproductive behavior
    Jennifer L Temple
    Program in Neuroscience, University of Virginia Medical School, Charlottesville, Virginia 22908, USA
    Endocrinology 144:13-9. 2003
    ..Our results lead us to hypothesize that the role of the evolutionarily conserved GnRH-II peptide is to coordinate reproductive behavior as appropriate to the organism's energetic condition...
  31. pmc Sex differences in social investigation: effects of androgen receptors, hormones and test partner
    L D Tejada
    Neuroscience Graduate Program, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Neuroendocrinol 24:1144-53. 2012
    ..However, 'male-like' levels of investigation of a female stimulus may depend on neonatal activation of the classic nuclear AR...
  32. ncbi request reprint Dopamine D5 receptor modulates male and female sexual behavior in mice
    A E Kudwa
    Neuroscience Graduate Program, University of Virginia Medical School, Charlottesville, VA 22908, USA
    Psychopharmacology (Berl) 180:206-14. 2005
    ..We used a D5 knockout (D5KO) mouse to assess the role of D5 DAR in mouse sexual behavior. Both sexes of D5KO mice are fertile and exhibit only minor disruptions in exploratory locomotion, startle, and prepulse inhibition responses...
  33. ncbi request reprint Distribution of estrogen receptor-beta-like immunoreactivity in rat forebrain
    X Li
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Neuroendocrinology 66:63-7. 1997
    ..In these areas immunoreactivity was noted throughout the perikarya and in cell processes. The data suggest that ER beta mediates estrogen's actions in a subset of hypothalamic and limbic neurons...
  34. ncbi request reprint Androgen receptor is essential for sexual differentiation of responses to olfactory cues in mice
    Cristian Bodo
    Department of Biochemistry and Molecular Genetics and Graduate Program in Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    Eur J Neurosci 25:2182-90. 2007
    ..Our results support data collected in humans suggesting a role for the androgen receptor in sexual differentiation of social preferences and neural responses to pheromones...
  35. ncbi request reprint Background matters: the effects of estrogen receptor alpha gene disruption on male sexual behavior are modified by background strain
    Emilio Dominguez-Salazar
    Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, Charlottesville, VA 22908, USA
    Horm Behav 46:482-90. 2004
    ..Our data suggest that genetic background has dramatic effects on male sexual behavior and its dependence on the ERalpha gene...
  36. pmc A previously uncharacterized role for estrogen receptor beta: defeminization of male brain and behavior
    Andrea E Kudwa
    Program in Neuroscience, University of Virginia Medical School, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 102:4608-12. 2005
    ..Based on these results, we hypothesize that ERbeta is involved in defeminization of brain and behavior. This aspect of ERbeta function may lead to developments in our understanding of neural-based sexually dimorphic human behaviors...
  37. ncbi request reprint Estrogen receptor alpha influences socially motivated behaviors
    Dennis B Imwalle
    Department of Biology, University of Virginia, Charlottesville, Virginia 22903, USA
    Horm Behav 42:484-91. 2002
    ..Taken together, the results of these experiments suggest the ERalphaKO males avoid contact with other conspecifics, perhaps due to an inability to be aroused by social cues...
  38. pmc Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes
    J T Wolstenholme
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Genes Brain Behav 12:166-80. 2013
    ..Our results also indicate an interaction between gonadal development and sex chromosome number that could further elucidate the role of sex chromosome genes and hormones in the sexual differentiation of behavior...
  39. pmc Oestrogen-independent, experience-induced maternal behaviour in female mice
    D S Stolzenberg
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Neuroendocrinol 23:345-54. 2011
    ....
  40. ncbi request reprint Behavioral regulation of gonadotropin-releasing hormone
    E F Rissman
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Biol Reprod 54:413-9. 1996
    ..The use of comparative animal models provides us with new insights into neuronal plasticity, neuroendoimmunology, and reproductive biology...
  41. pmc Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus)
    Karolina Bojkowska
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, PO Box 800733, VA 22908, USA
    Horm Behav 53:342-50. 2008
    ..We hypothesize that interactions between NPY and GnRH II maintain energy homeostasis and reproduction in the musk shrew...
  42. pmc Androgen- and estrogen-independent regulation of copulatory behavior following castration in male B6D2F1 mice
    Jin Ho Park
    Department of Biochemistry and Molecular Genetics and Program in Neuroscience, University of Virginia Medical School, Charlottesville, VA 22908, USA
    Horm Behav 56:254-63. 2009
    ..Taken together our results suggest that non-gonadal androgens and estrogens do not maintain copulatory behavior in B6D2F1 mice which display copulatory behavior after castration...
  43. ncbi request reprint Impairment of spatial learning by estradiol treatment in female mice is attenuated by estradiol exposure during development
    D Bradley Imwalle
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908 0733, USA
    Horm Behav 50:693-8. 2006
    ..Thus, exposure to estradiol during neonatal development can counteract the deleterious effects of EB on adult spatial learning...
  44. ncbi request reprint Gonadotropin-releasing hormone-II messenger ribonucleic acid and protein content in the mammalian brain are modulated by food intake
    Alexander S Kauffman
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 147:5069-77. 2006
    ..We postulate that this highly conserved neuropeptide functions similarly in other mammals, including humans, to fine-tune reproductive efforts with periods of sufficient energy resources...
  45. ncbi request reprint New roles for estrogen receptor beta in behavior and neuroendocrinology
    Cristian Bodo
    Graduate Program in Neuroscience, Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, 22908, USA
    Front Neuroendocrinol 27:217-32. 2006
    ..Exciting avenues for future research include; in vivo interactions between ERalpha and ERbeta, actions of non-estrogenic ligands with ERbeta, and the role of ERbeta in sexual differentiation...
  46. pmc Amyloid beta precursor protein regulates male sexual behavior
    Jin Ho Park
    Department of Biochemistry and Molecular Genetics, and Neuroscience Graduate Program, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Neurosci 30:9967-72. 2010
    ..Our results reveal a novel and unexpected relationship between APP and male sexual behavior. We speculate that declining APP during normal aging in males may contribute to the loss of sexual function...
  47. ncbi request reprint A critical role for the evolutionarily conserved gonadotropin-releasing hormone II: mediation of energy status and female sexual behavior
    Alexander S Kauffman
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 145:3639-46. 2004
    ..We speculate that GnRH-II acts via its own receptor as a regulatory signal in mammals to ensure that reproduction is synchronized with energetically favorable conditions...
  48. ncbi request reprint Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice
    Alexander S Kauffman
    Department of Biochemistry and Molecular Genetics, University of Virginia, 1229 Jordan Hall, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Horm Behav 48:141-51. 2005
    ..Furthermore, our sexual behavior and locomotor findings suggest species-specific differences in the mechanism and/or location of GALP action in the brains of rats and mice...
  49. ncbi request reprint Of mice and missing data: what we know (and need to learn) about male sexual behavior
    Melissa Burns-Cusato
    Department of Biochemistry and Molecular Genetics, Jordan Hall, 1300 Jefferson Park Avenue, P O Box 800733, University of Virginia Medical School, Charlottesville, VA 22909, USA
    Physiol Behav 83:217-32. 2004
    ....
  50. pmc Disruption of estrogen receptor beta gene impairs spatial learning in female mice
    Emilie F Rissman
    Department of Biology and Internal Medicine, University of Virginia, Charlottesville, VA 22903, USA
    Proc Natl Acad Sci U S A 99:3996-4001. 2002
    ..These data show that ERbeta is required for optimal spatial learning and may have implications for hormone replacement therapy in women...
  51. ncbi request reprint The evolutionarily conserved gonadotropin-releasing hormone II modifies food intake
    Alexander S Kauffman
    University of Virginia Medical School, P O Box 800733, Jordan Hall, Room 1229, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Endocrinology 145:686-91. 2004
    ..We conclude that, in addition to its permissive role in regulating reproduction, GnRH II may also modulate food intake in mammals. Because GnRH II is present in primate brain, it may also serve a similar function in humans...
  52. ncbi request reprint Oestrogen's masculine side: mediation of mating in male mice
    Elka M Scordalakes
    Department of Biology, University of Virginia, Charlottesville, VA 22903, USA
    Reproduction 124:331-8. 2002
    ..As has been shown in male rats, in mice dopamine agonist release is likely to be an essential component of the neural pathway that mediates male sexual behaviour...
  53. ncbi request reprint Cortisol facilitates induction of sexual behavior in the female musk shrew (Suncus murinus)
    P A Schiml
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Behav Neurosci 113:166-75. 1999
    ..These results indicate that cortisol facilitates, rather than inhibits, sexual behavior in this species and expands the comparative understanding of hypothalamic-pituitary-adrenal (HPA) effects on reproduction...
  54. pmc Sex chromosome complement affects social interactions in mice
    Anika A McPhie-Lalmansingh
    Department of Biochemistry and Molecular Genetics, Program in Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Horm Behav 54:565-70. 2008
    ..Taken together, these data show that sex chromosome complement affects social interaction style in mice...
  55. ncbi request reprint Aggression in male mice lacking functional estrogen receptor alpha
    Elka M Scordalakes
    Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, Charlottesville 22908, USA
    Behav Neurosci 117:38-45. 2003
    ..Results suggest that ERalpha is essential for normal social behavior, perhaps via processing of chemoinvestigatory cues, which are required to discriminate males from females...
  56. ncbi request reprint The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior
    Alexander S Kauffman
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 27:8826-35. 2007
    ..However, GPR54 is necessary for proper male-like development of several sexually dimorphic traits, likely by regulating GnRH-mediated androgen secretion during "critical windows" in perinatal development...
  57. ncbi request reprint Both estrogen receptor-alpha and -beta are required for sexual differentiation of the anteroventral periventricular area in mice
    Cristian Bodo
    Program in Neuroscience C B, A E K, E F R, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 147:415-20. 2006
    ..Our data demonstrate that both ERalpha and ERbeta are involved in the sexual differentiation of the AVPV in mice...
  58. ncbi request reprint Mating behavior is controlled by acute changes in metabolic fuels
    Jennifer L Temple
    Program in Neuroscience and Department of Biology, University of Virginia, Charlottesville, Virginia 22903, USA
    Am J Physiol Regul Integr Comp Physiol 282:R782-90. 2002
    ..Therefore, female musk shrews rely on continuous food intake and monitor multiple cues acutely, including glucose availability and fatty acid oxidation. This ensures that mating does not occur when adequate energy is unavailable...
  59. pmc The androgen receptor is selectively involved in organization of sexually dimorphic social behaviors in mice
    Cristian Bodo
    Department of Biochemistry and Molecular Genetics, P O Box 800733, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Endocrinology 149:4142-50. 2008
    ..Our data demonstrate that organization of social and olfactory preferences in mice can be affected by perinatal DHT and lends support to the role of androgen receptor in organization of sexual differentiation of brain and behaviors...
  60. ncbi request reprint Estrogen receptors are essential for female sexual receptivity
    E F Rissman
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Endocrinology 138:507-10. 1997
    ..In sum, the data show that ER is required for the display of sexual receptivity, but is not essential for female attractivity...
  61. ncbi request reprint Temporal aspects of female musk shrew (Suncus murinus) sexual behavior
    P A Schiml
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    J Comp Psychol 113:85-90. 1999
    ..Because this is the 1st experiment to use a pacing test paradigm in a species with induced ovulation, the authors speculate that the absence of pacing behavior during mating may be shown by other species that have induced ovulation...
  62. ncbi request reprint Sex chromosome complement and gonadal sex influence aggressive and parental behaviors in mice
    Jessica D Gatewood
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Neurosci 26:2335-42. 2006
    ..Identifying the specific X and/or Y genes involved will increase our understanding of normal and abnormal aggression and parental behavior, including behavioral abnormalities associated with mental illness...
  63. ncbi request reprint Nutrition, reproduction, and behavior
    Jennifer L Temple
    Program in Neuroscience, Department of Biology, University of Virginia, Charlottesville, VA 22903, USA
    Prog Brain Res 141:303-14. 2002
  64. pmc Of mice and rats: key species variations in the sexual differentiation of brain and behavior
    P J Bonthuis
    Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, United States
    Front Neuroendocrinol 31:341-58. 2010
    ..Moving forward, investigators must answer fundamental questions about their chosen organism, and attend to both species and strain differences as they select the optimal animal models for their research questions...
  65. ncbi request reprint Evidence that the type-2 gonadotrophin-releasing hormone (GnRH) receptor mediates the behavioural effects of GnRH-II on feeding and reproduction in musk shrews
    A S Kauffman
    Department of Biochemistry and Molecular Genetics and the Graduate Program in Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    J Neuroendocrinol 17:489-97. 2005
    ..Collectively, these results indicate that GnRH-II does not act via the type-1 GnRH receptor to regulate mammalian behaviour but likely activates the type-2 GnRH receptor...
  66. pmc Acquisition of sexual receptivity: roles of chromatin acetylation, estrogen receptor-alpha, and ovarian hormones
    Paul J Bonthuis
    Department of Biochemistry and Molecular Genetics and Neuroscience Graduate Program, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Endocrinology 152:3172-81. 2011
    ..Evidence is provided that the actions of sodium butyrate on receptivity require activated estrogen receptor-α and progesterone...
  67. pmc Sex differences in histone modifications in the neonatal mouse brain
    Houng Wei Tsai
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, 22908, USA
    Epigenetics 4:47-53. 2009
    ..This is the first demonstration that histone modification is associated with neural sexual differentiation...
  68. ncbi request reprint Dietary phytoestrogens dampen female sexual behavior in mice with a disrupted aromatase enzyme gene
    Andrea E Kudwa
    Department of Biomedical Sciences, Colorado State University, CO, USA
    Behav Neurosci 121:356-61. 2007
    ..The authors' findings suggest that dietary phytoestrogen consumption may partially defeminize adult female sexual behavior in the mouse...
  69. ncbi request reprint Regulation of Kiss1 gene expression in the brain of the female mouse
    Jeremy T Smith
    Department of Physiology and Biophysics, Health Sciences Building, G 424, School of Medicine, University of Washington, Box 357290, Seattle, Washington 98195 7290, USA
    Endocrinology 146:3686-92. 2005
    ....
  70. ncbi request reprint Estrogen receptor-alpha is required for estrogen-induced mu-opioid receptor internalization
    Paul E Micevych
    Laboratory of Neuroendocrinology of the Brain Research Institute, Department of Neurobiology, Mental Retardation Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurosci Res 71:802-10. 2003
    ..The results of the present experiments indicate that ERalpha is required for estrogen-induced MOR internalization and suggest that ERalpha can mediate rapid actions of estrogen...
  71. ncbi request reprint Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice
    D Bradley Imwalle
    Department of Animal Science Rutgers, The State University of New Jersey, New Brunswick, NJ 08901 8525, USA
    Physiol Behav 84:157-63. 2005
    ..We hypothesize that ERbeta is required during development to modulate the effects of estrogen on anxiety and catecholamine concentrations in female mouse brains...
  72. ncbi request reprint Lack of functional estrogen receptor beta gene disrupts pubertal male sexual behavior
    Jennifer L Temple
    Cellular and Developmental Neurobiology Section, National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 4156, USA
    Horm Behav 44:427-34. 2003
    ..Furthermore, our data suggest that a primary role of ERbeta may be to regulate ejaculatory behavior...
  73. ncbi request reprint A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits
    Geert J De Vries
    Center for Neuroendocrine Studies, University of Massachusetts, Amherst, Massachusetts 01003 9333, USA
    J Neurosci 22:9005-14. 2002
    ..Moreover, two male groups differing only in the form of their Sry gene showed differences in behavior. The results show that sex chromosome genes contribute directly to the development of a sex difference in the brain...
  74. pmc Neurobiology of escalated aggression and violence
    Klaus A Miczek
    Department of Psychology, Tufts University, Medford, Massachusetts 02155, USA
    J Neurosci 27:11803-6. 2007
    ....
  75. pmc Neuronal nitric oxide synthase and calbindin delineate sex differences in the developing hypothalamus and preoptic area
    Michelle Edelmann
    Colorado State University, Fort Collins, Colorado 80523, USA
    Dev Neurobiol 67:1371-81. 2007
    ..We suggest that NO as an effector molecule and calbindin as a molecular biomarker illuminate key aspects of sexual differentiation in the developing mouse brain...
  76. pmc Aggressive behaviors in adult SF-1 knockout mice that are not exposed to gonadal steroids during development
    Neza Grgurevic
    Center for Animal Genomics, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia
    Behav Neurosci 122:876-84. 2008
    ....
  77. pmc Diversity of actions of GnRHs mediated by ligand-induced selective signaling
    Robert P Millar
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Front Neuroendocrinol 29:17-35. 2008
    ..This ligand-induced selective-signaling recruits certain pathways while by-passing others and has implications in developing more selective GnRH analogs for highly specific therapeutic intervention...
  78. ncbi request reprint Two perspectives on the origin of sex differences in the brain
    Arthur P Arnold
    Department of Physiological Science, and Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Ann N Y Acad Sci 1007:176-88. 2003
    ..This paper reviews the evidence that genetic sex of brain cells influences their sexual phenotype, and critically discusses the relative advantages of various experimental approaches to study this effect...