Diego E Rincon-Limas

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Drosophila models of proteinopathies: the little fly that could
    Diego E Rincon-Limas
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0236, USA
    Curr Pharm Des 18:1108-22. 2012
  2. pmc Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking
    Jonatan Sanchez-Garcia
    Department of Neurology, McKnight Brain Institute
    Hum Mol Genet 22:4253-66. 2013
  3. pmc The ER stress factor XBP1s prevents amyloid-beta neurotoxicity
    Sergio Casas-Tinto
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Hum Mol Genet 20:2144-60. 2011
  4. pmc Sequence-dependent prion protein misfolding and neurotoxicity
    Pedro Fernandez-Funez
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 285:36897-908. 2010
  5. pmc Exploring prion protein biology in flies: genetics and beyond
    Diego E Rincon-Limas
    Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
    Prion 4:1-8. 2010
  6. pmc Differential activation of the ER stress factor XBP1 by oligomeric assemblies
    Diana L Castillo-Carranza
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Neurochem Res 37:1707-17. 2012
  7. doi request reprint p∆TubHA4C, a new versatile vector for constitutive expression in Drosophila
    Yan Zhang
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA
    Mol Biol Rep 40:5407-15. 2013
  8. pmc Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease
    Pedro Fernandez-Funez
    Department of Neurology, McKnight Brain Institute, Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease and Genetics Institute, University of Florida, Gainesville, FL 32611, USA
    Hum Mol Genet 24:6093-105. 2015
  9. pmc Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila
    Yan Zhang
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 9:e88522. 2014
  10. pmc Modeling the complex pathology of Alzheimer's disease in Drosophila
    Pedro Fernandez-Funez
    McKnight Brain Institute, Department of Neurology, University of Florida, Gainesville, FL 32611, USA Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32611, USA Genetics Institute, University of Florida, Gainesville, FL 32611, USA Electronic address
    Exp Neurol 274:58-71. 2015

Collaborators

Detail Information

Publications12

  1. pmc Drosophila models of proteinopathies: the little fly that could
    Diego E Rincon-Limas
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0236, USA
    Curr Pharm Des 18:1108-22. 2012
    ..To remain relevant in this competitive environment, Drosophila models will need to expand their flexible, innovative, and multidisciplinary approaches to find new discoveries and translational applications...
  2. pmc Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking
    Jonatan Sanchez-Garcia
    Department of Neurology, McKnight Brain Institute
    Hum Mol Genet 22:4253-66. 2013
    ....
  3. pmc The ER stress factor XBP1s prevents amyloid-beta neurotoxicity
    Sergio Casas-Tinto
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Hum Mol Genet 20:2144-60. 2011
    ..These results underscore the functional relevance of XBP1s in Aβ toxicity, and uncover the potential of XBP1 and RyR as targets for AD therapeutics...
  4. pmc Sequence-dependent prion protein misfolding and neurotoxicity
    Pedro Fernandez-Funez
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    J Biol Chem 285:36897-908. 2010
    ..How these properties are encoded in the amino acid sequence remains to be elucidated...
  5. pmc Exploring prion protein biology in flies: genetics and beyond
    Diego E Rincon-Limas
    Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
    Prion 4:1-8. 2010
    ....
  6. pmc Differential activation of the ER stress factor XBP1 by oligomeric assemblies
    Diana L Castillo-Carranza
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Neurochem Res 37:1707-17. 2012
    ..These results illustrate the biological complexity of these structurally related assemblies and argue that oligomer toxicity depends on the activation of amyloid-specific cellular responses...
  7. doi request reprint p∆TubHA4C, a new versatile vector for constitutive expression in Drosophila
    Yan Zhang
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA
    Mol Biol Rep 40:5407-15. 2013
    ..We found that the modified 0.9 kb ΔTub promoter induced similar expression levels to the intact 2.6 kb α1t promoter, supporting the inclusion of all critical regulatory elements in the new and flexible ∆TubHA4C vector. ..
  8. pmc Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease
    Pedro Fernandez-Funez
    Department of Neurology, McKnight Brain Institute, Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease and Genetics Institute, University of Florida, Gainesville, FL 32611, USA
    Hum Mol Genet 24:6093-105. 2015
    ..Overall, we demonstrate the feasibility of using Drosophila as a first step for characterizing neuroprotective anti-Aß scFvs in vivo and identifying scFv combinations with synergistic neuroprotective activities. ..
  9. pmc Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila
    Yan Zhang
    Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 9:e88522. 2014
    ..These findings can have important therapeutic applications for the devastating prion diseases and other related proteinopathies. ..
  10. pmc Modeling the complex pathology of Alzheimer's disease in Drosophila
    Pedro Fernandez-Funez
    McKnight Brain Institute, Department of Neurology, University of Florida, Gainesville, FL 32611, USA Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32611, USA Genetics Institute, University of Florida, Gainesville, FL 32611, USA Electronic address
    Exp Neurol 274:58-71. 2015
    ....
  11. pmc In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms
    Pedro Fernandez-Funez
    Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
    PLoS Genet 5:e1000507. 2009
    ..Overall, we provide new insight into the mechanisms of spontaneous accumulation of neurotoxic PrP and uncover the potential therapeutic role of Hsp70 in treating these devastating disorders...