Wito Richter

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia
    Elise Blanchard
    1Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, 513 Parnassus Ave, Box 0556, San Francisco, CA 94143 0556, USA
    FASEB J 28:791-801. 2014
  2. pmc PDE4 as a target for cognition enhancement
    Wito Richter
    University of California San Francisco, Department of Obstetrics, Gynecology and Reproductive Sciences, San Francisco, CA 94143 0556, USA
    Expert Opin Ther Targets 17:1011-27. 2013
  3. pmc Conserved expression and functions of PDE4 in rodent and human heart
    Wito Richter
    Department of Gynecology, Obstetrics, and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, Box 0556, 513 Parnassus Avenue, San Francisco, CA 94143 0556, USA
    Basic Res Cardiol 106:249-62. 2011
  4. pmc The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s)
    Moses Xie
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, U S A
    Biochem J 459:539-50. 2014
  5. pmc PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts
    Brigitte E Blackman
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco School of Medicine, San Francisco, California 94143, USA
    J Biol Chem 286:12590-601. 2011
  6. pmc Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP
    Moses Xie
    Department of Gynecology, Obstetrics and Reproductive Sciences, University of California San Francisco, 513 Parnassus Ave, Box 0556, San Francisco, CA 94143 0556, USA
    Mol Pharmacol 80:281-93. 2011
  7. pmc β1-adrenergic receptor antagonists signal via PDE4 translocation
    Wito Richter
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California 94143, USA
    EMBO Rep 14:276-83. 2013
  8. pmc A CaMKII/PDE4D negative feedback regulates cAMP signaling
    Delphine Mika
    Center for Reproductive Sciences and Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 112:2023-8. 2015
  9. pmc Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts
    Matthew D Bruss
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94143, USA
    J Biol Chem 283:22430-42. 2008
  10. pmc PDE4B mediates local feedback regulation of β₁-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes
    Delphine Mika
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 127:1033-42. 2014

Collaborators

Detail Information

Publications10

  1. pmc Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia
    Elise Blanchard
    1Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, 513 Parnassus Ave, Box 0556, San Francisco, CA 94143 0556, USA
    FASEB J 28:791-801. 2014
    ..Taken together, our results implicate PDE4 as an important determinant of CFTR activity in airway epithelia, and support the use of PDE4 inhibitors to potentiate the therapeutic benefits of CFTR correctors and potentiators...
  2. pmc PDE4 as a target for cognition enhancement
    Wito Richter
    University of California San Francisco, Department of Obstetrics, Gynecology and Reproductive Sciences, San Francisco, CA 94143 0556, USA
    Expert Opin Ther Targets 17:1011-27. 2013
    ..Consequently, cyclic nucleotide phosphodiesterases (PDEs), the enzymes that inactivate the cyclic nucleotides, are promising targets for the development of cognition-enhancing drugs...
  3. pmc Conserved expression and functions of PDE4 in rodent and human heart
    Wito Richter
    Department of Gynecology, Obstetrics, and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, Box 0556, 513 Parnassus Avenue, San Francisco, CA 94143 0556, USA
    Basic Res Cardiol 106:249-62. 2011
    ..These differences may explain the distinct pharmacological effects of PDE4 inhibition in rodent and human hearts...
  4. pmc The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s)
    Moses Xie
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, U S A
    Biochem J 459:539-50. 2014
    ..As a result, individual PDE4 protomers may independently mediate protein-protein interactions, providing a mechanism whereby PDE4s contribute to the assembly of macromolecular signalling complexes...
  5. pmc PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts
    Brigitte E Blackman
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco School of Medicine, San Francisco, California 94143, USA
    J Biol Chem 286:12590-601. 2011
    ..These findings demonstrate that PDE4D and PDE4B have specialized functions in mouse embryonic fibroblasts with PDE4B controlling cAMP in a discrete subdomain near the plasma membrane...
  6. pmc Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP
    Moses Xie
    Department of Gynecology, Obstetrics and Reproductive Sciences, University of California San Francisco, 513 Parnassus Ave, Box 0556, San Francisco, CA 94143 0556, USA
    Mol Pharmacol 80:281-93. 2011
    ..Whether this regulation occurs in cells remains to be confirmed experimentally under conditions that do not affect PDE activity...
  7. pmc β1-adrenergic receptor antagonists signal via PDE4 translocation
    Wito Richter
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California 94143, USA
    EMBO Rep 14:276-83. 2013
    ..Our study identifies receptor/PDE4 complex dissociation as a novel mechanism of antagonist action that contributes to the pharmacological properties of β1AR antagonists and might be shared by other receptor subtypes...
  8. pmc A CaMKII/PDE4D negative feedback regulates cAMP signaling
    Delphine Mika
    Center for Reproductive Sciences and Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 112:2023-8. 2015
    ..This regulation establishes a negative feedback loop necessary to maintain cAMP/CaMKII homeostasis, revealing a previously unidentified function for PDE4D as a critical integrator of cAMP/PKA and Ca(2+)/CaMKII signaling. ..
  9. pmc Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts
    Matthew D Bruss
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94143, USA
    J Biol Chem 283:22430-42. 2008
    ..Finally, PDE4D ablation affected the kinetics of beta2AR desensitization as well as the interaction of the receptor with Galphai. These findings demonstrate that PDE4D plays a major role in shaping the beta2AR signal...
  10. pmc PDE4B mediates local feedback regulation of β₁-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes
    Delphine Mika
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 127:1033-42. 2014
    ..Disruption of this feedback augments local cAMP/PKA signals, leading to an increased intracellular Ca(2+) level and contraction rate. ..