J M Rho
Affiliation: University of Washington
- The pharmacologic basis of antiepileptic drug actionJ M Rho
Department of Neurology, University of Washington School of Medicine, Seattle, USA
Epilepsia 40:1471-83. 1999..This review summarizes our current understanding of the molecular targets of clinically significant AEDs, comparing and contrasting their differing mechanisms of action...
- Age-dependent differences in flurothyl seizure sensitivity in mice treated with a ketogenic dietJ M Rho
Department of Neurology, University of Washington School of Medicine, Seattle 98195, USA
Epilepsy Res 37:233-40. 1999..In our discussion of animal models of the KGD, we highlight the need to understand better the impact of important variables such as dietary composition, genetic background, and mode of seizure induction in the study of the KGD...
- Evidence of altered inhibition in layer V pyramidal neurons from neocortex of Kcna1-null miceJ F van Brederode
Department of Neurology, University of Washington, Seattle, WA 98195, USA
Neuroscience 103:921-9. 2001....
- Norepinephrine is required for the anticonvulsant effect of the ketogenic dietP Szot
Geriatric Research, Education and Clinical Center GRECC 182B, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Brain Res Dev Brain Res 129:211-4. 2001..These results suggest that an intact, functional noradrenergic nervous system is required for the KD to exert an anticonvulsant effect...
- Lamotrigine-induced tic disorder: report of five pediatric casesM A Sotero de Menezes
Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
Epilepsia 41:862-7. 2000..To describe the clinical spectrum of lamotrigine (LTG)-induced tics (an uncommon side effect) in children...
- Effects of flunarizine on spontaneous synaptic currents in rat neocortexP T Golumbek
Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA
Naunyn Schmiedebergs Arch Pharmacol 370:176-82. 2004..Our data suggest that the clinical activity of flunarizine may in part be a consequence of reducing spontaneous synaptic currents in the neocortex, especially under conditions of heightened neuronal activity...
- Developmental seizure susceptibility of kv1.1 potassium channel knockout miceJ M Rho
Department of Neurology and Pediatrics, Geriatric Research, Education and Clinical Center, Puget Sound Health Care System, University of Washington, Seattle, WA, USA
Dev Neurosci 21:320-7. 1999..The Kv1. 1 knockout mouse possesses many features desirable in a developmental animal epilepsy model and represents a clinically relevant model of early-onset epilepsies...
- Single channel properties of hyperpolarization-activated cation currents in acutely dissociated rat hippocampal neuronesT A Simeone
Department of Anatomy and Neurobiology, University of California, Irvine, 92697, USA
J Physiol 568:371-80. 2005....