K Ren

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Activity-triggered tetrapartite neuron-glial interactions following peripheral injury
    Ke Ren
    Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, USA Program in Neuroscience, University of Maryland, Baltimore, USA Electronic address
    Curr Opin Pharmacol 26:16-25. 2016
  2. pmc Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade
    Wei Guo
    Department of Neural and Pain Sciences, Dental School Program in Neuroscience, University of Maryland, 650 W, Baltimore St, Baltimore, Maryland 21201, USA
    Mol Pain 10:35. 2014
  3. pmc Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury
    Bryan Chai
    Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 8:78. 2012
  4. pmc Chemokine signaling involving chemokine (C-C motif) ligand 2 plays a role in descending pain facilitation
    Wei Guo
    Department of Neural and Pain Sciences, School of Dentistry and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    Neurosci Bull 28:193-207. 2012
  5. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
  6. pmc Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors
    Kohei Shimizu
    Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 5:75. 2009
  7. pmc Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia
    Guang Bai
    Department of Neural and Pain Sciences, University of Maryland, Baltimore, Maryland 21117, USA
    Mol Pain 6:51. 2010
  8. pmc Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial pain
    Wei Guo
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 6:40. 2010
  9. pmc Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammation
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    BMC Complement Altern Med 8:20. 2008
  10. pmc Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammation
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    BMC Complement Altern Med 7:27. 2007

Research Grants

Collaborators

Detail Information

Publications81

  1. pmc Activity-triggered tetrapartite neuron-glial interactions following peripheral injury
    Ke Ren
    Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, USA Program in Neuroscience, University of Maryland, Baltimore, USA Electronic address
    Curr Opin Pharmacol 26:16-25. 2016
    ....
  2. pmc Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade
    Wei Guo
    Department of Neural and Pain Sciences, Dental School Program in Neuroscience, University of Maryland, 650 W, Baltimore St, Baltimore, Maryland 21201, USA
    Mol Pain 10:35. 2014
    ..However, the mechanisms underlying the activation of the 5-HT3 receptor and its contribution to facilitation of pain remain unclear...
  3. pmc Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury
    Bryan Chai
    Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 8:78. 2012
    ..Here we investigated the involvement of the RVM-Vi/Vc circuitry in mediating contralateral orofacial hyperalgesia after an injection of CFA into the masseter muscle...
  4. pmc Chemokine signaling involving chemokine (C-C motif) ligand 2 plays a role in descending pain facilitation
    Wei Guo
    Department of Neural and Pain Sciences, School of Dentistry and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    Neurosci Bull 28:193-207. 2012
    ....
  5. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
    ..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
  6. pmc Differential involvement of trigeminal transition zone and laminated subnucleus caudalis in orofacial deep and cutaneous hyperalgesia: the effects of interleukin-10 and glial inhibitors
    Kohei Shimizu
    Department of Neural and Pain Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 5:75. 2009
    ....
  7. pmc Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia
    Guang Bai
    Department of Neural and Pain Sciences, University of Maryland, Baltimore, Maryland 21117, USA
    Mol Pain 6:51. 2010
    ....
  8. pmc Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial pain
    Wei Guo
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 6:40. 2010
    ..Here we report a model of constant myogenic orofacial pain that lasts for months...
  9. pmc Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammation
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    BMC Complement Altern Med 8:20. 2008
    ..This study investigated the mechanisms of EA anti-inflammation, using a rat model of complete Freund's adjuvant (CFA)-induced hind paw inflammation and hyperalgesia...
  10. pmc Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammation
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    BMC Complement Altern Med 7:27. 2007
    ..However, the mechanisms are not clear. The present study investigated the biochemical mechanisms of EA anti-inflammation in a rat model...
  11. pmc Neonatal local noxious insult affects gene expression in the spinal dorsal horn of adult rats
    Ke Ren
    Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 1:27. 2005
    ..These findings suggest that changes in gene expression may be involved in the long-term nociceptive effects of neonatal noxious insult at the spinal level...
  12. pmc Interactions between the immune and nervous systems in pain
    Ke Ren
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland, USA
    Nat Med 16:1267-76. 2010
    ..A greater understanding of the role of the immune system in pain processing and modulation reveals potential targets for analgesic drug development and new therapeutic opportunities for managing chronic pain...
  13. ncbi request reprint Pain facilitation and activity-dependent plasticity in pain modulatory circuitry: role of BDNF-TrkB signaling and NMDA receptors
    Ke Ren
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, 650 W Baltimore St, Baltimore, MD 21201 1586, USA
    Mol Neurobiol 35:224-35. 2007
    ..Further studies will elucidate cellular and molecular mechanisms of pain sensitization and further our understanding of principles of central nervous system plasticity and responsiveness to environmental challenge...
  14. ncbi request reprint Progesterone attenuates persistent inflammatory hyperalgesia in female rats: involvement of spinal NMDA receptor mechanisms
    K Ren
    Department of Oral and Craniofacial Biological Sciences, Rm 5A26, Dental School, University of Maryland, 666 W Baltimore St, 21201, Baltimore, MD, USA
    Brain Res 865:272-7. 2000
    ....
  15. pmc Electroacupuncture inhibition of hyperalgesia in an inflammatory pain rat model: involvement of distinct spinal serotonin and norepinephrine receptor subtypes
    Y Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 685 W Baltimore St MSTF, Rm 8 22, Baltimore, MD 21201, USA
    Br J Anaesth 109:245-52. 2012
    ..This study investigates the involvement of spinal alpha(2)-adrenoceptors (α2-ARs) and 5-hydroxytryptamine (serotonin) receptors (5-HTRs) in EA effects on an inflammatory pain rat model...
  16. pmc Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla
    S C LaGraize
    University of Maryland Dental School, Department of Neural and Pain, Sciences, Program in Neuroscience, 650 W Baltimore Street, 8 South, Baltimore, MD 21201, USA
    Neuroscience 171:1341-56. 2010
    ....
  17. pmc Suckling and sucrose ingestion suppress persistent hyperalgesia and spinal Fos expression after forepaw inflammation in infant rats
    K Ren
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Proc Natl Acad Sci U S A 94:1471-5. 1997
    ..These findings may provide new clinical approaches for engaging endogenous analgesic mechanisms in infants following tissue injury and inflammation...
  18. ncbi request reprint A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats
    Lixing Lao
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21201, USA
    Brain Res 1020:18-29. 2004
    ..The results suggest that the EA anti-hyperalgesia is parameter-dependent and point-specific, and they provide important information for designing further clinical acupuncture research on persistent inflammatory pain...
  19. ncbi request reprint Long-term effects of short-lasting early local inflammatory insult
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, 21201, USA
    Neuroreport 12:399-403. 2001
    ..These data suggest that early inflammatory insult may differentially affect the aspects of nociceptive circuitry involved in transient pain sensitivity and in inflammation-induced hyperalgesia...
  20. ncbi request reprint Selective upregulation of the flip-flop splice variants of AMPA receptor subunits in the rat spinal cord after hindpaw inflammation
    Q Q Zhou
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, MD 21201-1586, USA
    Brain Res Mol Brain Res 88:186-93. 2001
    ..Selective changes in the expression of the flip-flop splice variants of the AMPA receptor suggest a reorganization of the composition of the AMPA receptor complex and its involvement in the development of inflammatory hyperalgesia...
  21. ncbi request reprint Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Brain Res 1048:235-40. 2005
    ..These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia...
  22. ncbi request reprint Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation
    Rui Xin Zhang
    Complementary Medicine Program, Center for Integrative Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Brain Res 1020:12-7. 2004
    ..These results suggest selective involvement of mu and delta, but not kappa, receptors in EA-produced anti-hyperalgesia in rats. A combined EA and opioid drug protocol may provide an improved treatment strategy for inflammatory pain...
  23. pmc DAMGO in the central amygdala alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia
    R X Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA Electronic address
    Neuroscience 252:359-66. 2013
    ..The data demonstrate that morphine attenuates the affective component more powerfully than it does the sensory and suggests that the sensory and the emotional-affective dimensions are underpinned by different mechanisms...
  24. ncbi request reprint Characterization of basal and re-inflammation-associated long-term alteration in pain responsivity following short-lasting neonatal local inflammatory insult
    K Ren
    Department of Biomedical Sciences, University of Maryland, Baltimore, 5 A 12, HHH, 666 W Baltimore St, Baltimore, MD 21201, USA
    Pain 110:588-96. 2004
    ..These finding provide a framework within which the entire complex of long-term effects of early noxious experience can be understood and examined...
  25. ncbi request reprint Plasticity in excitatory amino acid receptor-mediated descending pain modulation after inflammation
    Yun Guan
    Department of Oral and Craniofacial Biological Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Pharmacol Exp Ther 300:513-20. 2002
    ..There is a time-dependent increase in EAA neurotransmission in the RVM after inflammation and NMDA receptors play an important role in AMPA-produced inhibition...
  26. ncbi request reprint Involvement of peripheral opioid mechanisms in electroacupuncture analgesia
    Grant G Zhang
    Complementary Medicine Program, University of Maryland School of Medicine, Baltimore, USA
    Explore (NY) 1:365-71. 2005
    ..These data strongly suggest that peripheral opioids are released by EA at the inflammatory site...
  27. ncbi request reprint Ontogeny of analgesia elicited by non-nutritive suckling in acute and persistent neonatal rat pain models
    V Anseloni
    Department of Biomedical Sciences, Program in Neuroscience, University of Maryland Dental School, 666 West Baltimore Street, Baltimore, MD 21201, USA
    Pain 109:507-13. 2004
    ..Orotactile stimulation during suckling effectively reduces transient pain elicited by thermal and mechanical stimuli, as well as persistent hyperalgesia and allodynia caused by inflammation...
  28. ncbi request reprint A brainstem substrate for analgesia elicited by intraoral sucrose
    V C Z Anseloni
    Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201, USA
    Neuroscience 133:231-43. 2005
    ..Intraoral sucrose activates neurons in the periaqueductal gray and nucleus raphe magnus, two key brainstem sites critically involved in descending pain modulation...
  29. ncbi request reprint The roles of NMDA receptor activation and nucleus reticularis gigantocellularis in the time-dependent changes in descending inhibition after inflammation
    R Terayama
    Department of Oral and Craniofacial Biological Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore 21201 1586, USA
    Pain 97:171-81. 2002
    ..At early time points, NMDA receptor and NGC activation enhance descending facilitation; as time progresses, the dose-response curve of NMDA shifts to the left and descending inhibition dominates and masks any descending facilitation...
  30. ncbi request reprint Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia
    Wei Guo
    Department of Oral and Craniofacial Biological Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Neurosci 22:6208-17. 2002
    ....
  31. ncbi request reprint Orofacial deep and cutaneous tissue inflammation and trigeminal neuronal activation. Implications for persistent temporomandibular pain
    H Imbe
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, MD, USA
    Cells Tissues Organs 169:238-47. 2001
    ..Since deep inputs may be more effective in inducing central neuronal excitation than cutaneous inputs, greater sensory disturbances may occur in pain conditions involving deep tissues than in those involving cutaneous tissues...
  32. pmc Electroacupuncture alleviates affective pain in an inflammatory pain rat model
    Y Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 520 W Lombard Street, Baltimore, MD 21201, USA
    Eur J Pain 16:170-81. 2012
    ..These data demonstrate that EA activates opioid receptors in the rACC to inhibit pain-induced affective responses and that EA may be an effective therapy for both the sensory-discriminative and the affective dimensions of pain...
  33. ncbi request reprint An improved method for assessing mechanical allodynia in the rat
    K Ren
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201 1586, USA
    Physiol Behav 67:711-6. 1999
    ..Importantly, this method can also be used in the orofacial region, and will facilitate studies on the mechanisms of persistent orofacial pain in animals...
  34. ncbi request reprint Inflammation-induced Fos protein expression in the rat spinal cord is enhanced following dorsolateral or ventrolateral funiculus lesions
    F Wei
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Brain Res 782:136-41. 1998
    ....
  35. pmc Interleukin 1beta facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation
    R X Zhang
    Center for Integrative Medicine, School of Medicine, 3rd Floor, James Kernan Hospital Mansion, University of Maryland, Baltimore, MD 21201, USA
    Neuroscience 154:1533-8. 2008
    ..The results suggest that spinal IL-1beta enhances NR1 phosphorylation to facilitate bone cancer pain...
  36. ncbi request reprint Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia
    Wei Guo
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 24:9161-73. 2004
    ..The group ImGluR-NMDAR coupling cascade leads to phosphorylation of the NMDAR and appears necessary for the initiation of spinal dorsal horn sensitization and behavioral hyperalgesia after inflammation...
  37. ncbi request reprint Anti-hyperalgesic and anti-inflammatory effects of the modified Chinese herbal formula Huo Luo Xiao Ling Dan (HLXL) in rats
    Lixing Lao
    Center for Integrative Medicine, School of Medicine, Department of Family Medicine, University of Maryland School of Medicine, 2200 Kernan Drive, 3rd Floor, Baltimore, MD 21207, USA
    Am J Chin Med 34:833-44. 2006
    ..The data suggest that HLXL dosage-dependently attenuates CFA-induced inflammation and hyperalgesia, at least in part by inhibiting noxious transmission at the dorsal horn of the spinal cord...
  38. pmc Role of interleukin-1beta during pain and inflammation
    Ke Ren
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, MD 21201 1586, USA
    Brain Res Rev 60:57-64. 2009
    ..Taken together, the evidence presented in the current review showing the importance of IL-1beta in animal and human pain states, suggests that blockade of IL-1beta be considered as a therapeutic opportunity...
  39. ncbi request reprint Changes in gene expression and neuronal phenotype in brain stem pain modulatory circuitry after inflammation
    Kenji Miki
    Department of Oral and Craniofacial Biological Sciences, Dental School, University of Maryland, 666 W Baltimore St, Baltimore, MD 21201, USA
    J Neurophysiol 87:750-60. 2002
    ..The functional phenotypic switch of RVM neurons provides a novel mechanism underlying activity-dependent plasticity and enhanced net descending inhibition after inflammation...
  40. ncbi request reprint Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed rats
    Bing Liu
    Center for Integrative Medicine, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Brain Res 1044:87-92. 2005
    ..The data suggest that EA-produced anti-hyperalgesia is mediated by PTX-sensitive Gi/o proteins and the relevant signaling pathways...
  41. pmc Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain
    Wei Guo
    Department of Biomedical Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 27:6006-18. 2007
    ..These findings provide evidence of astroglial activation by tissue injury, concomitant IL-1beta induction, and the coupling of NMDA receptor phosphorylation through IL-1 receptor signaling...
  42. pmc Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory system
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, 20 Penn Street, Baltimore, MD 21201, USA
    Brain Res 1186:171-9. 2007
    ..The results demonstrate that EA inhibits transmission of noxious messages and hyperalgesia by activating supraspinal neurons that project to the spinal cord...
  43. ncbi request reprint Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation
    Wei Guo
    Department of Biomedical Sciences, Program in Neuroscience, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 26:126-37. 2006
    ..Our findings also caution that application of BDNF for recovery from CNS disorders could lead to undesirable central pain...
  44. ncbi request reprint Changes in AMPA receptor phosphorylation in the rostral ventromedial medulla after inflammatory hyperalgesia in rats
    Yun Guan
    Department of Biomedical Sciences, Dental School and Program in Neuroscience University of Maryland, Rm 5A12, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Neurosci Lett 366:201-5. 2004
    ..These findings provide new evidence linking in vivo AMPA receptor phosphorylation in the RVM pain modulatory circuitry to the enhanced descending pain modulation after inflammation...
  45. pmc Neuron-glia crosstalk gets serious: role in pain hypersensitivity
    Ke Ren
    Department of Neural and Pain Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    Curr Opin Anaesthesiol 21:570-9. 2008
    ..The subsequent neuron-glia interactions contribute to pain hypersensitivity. This review will briefly discuss novel findings that have shed light on the cellular mechanisms of neuron-glia interactions in persistent pain...
  46. ncbi request reprint Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 78:793-7. 2004
    ..The results demonstrate that EA combined with INDO synergistically inhibits hyperalgesia and suggest an improved treatment strategy for inflammatory pain...
  47. pmc Osteoarthritis pain mechanisms: basic studies in animal models
    R X Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Osteoarthritis Cartilage 21:1308-15. 2013
    ..At present there are no satisfying agents for treating OA. To promote OA research and improved treatment, this review summarizes current preclinical evidence on the development of OA...
  48. pmc Electroacupuncture attenuates bone-cancer-induced hyperalgesia and inhibits spinal preprodynorphin expression in a rat model
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, HSF 2, Room S209, 20 Penn Street, Baltimore, MD 21201, USA
    Eur J Pain 12:870-8. 2008
    ..These results suggest that EA alleviates bone cancer pain at least in part by suppressing dynorphin expression, and they support the clinical use of EA in the treatment of cancer pain...
  49. ncbi request reprint Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat model
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Anesth Analg 105:1482-8, table of contents. 2007
    ....
  50. pmc Supraspinal glial-neuronal interactions contribute to descending pain facilitation
    Feng Wei
    Department of Neural and Pain Sciences, Dental School, Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 28:10482-95. 2008
    ..These studies have addressed a novel contribution of supraspinal astrocytes and associated cytokines as well as central glial-neuronal interactions to the enhancement of descending facilitation of neuropathic pain...
  51. ncbi request reprint Activation of spinal kainate receptors after inflammation: behavioral hyperalgesia and subunit gene expression
    Wei Guo
    Department of Oral and Craniofacial Biological Sciences, Dental School and Program in Neuroscience, University of Maryland, Room 5A26, 666 West Baltimore Street, Baltimore, MD 21201 1586, USA
    Eur J Pharmacol 452:309-18. 2002
    ..These results suggest that a selective upregulation of kainate receptor subunit expression contributes to inflammatory hyperalgesia...
  52. ncbi request reprint Age-dependency of analgesia elicited by intraoral sucrose in acute and persistent pain models
    Vanessa C Z Anseloni
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore 21201, USA
    Pain 97:93-103. 2002
    ....
  53. pmc IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pain 135:232-9. 2008
    ..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain...
  54. pmc Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain
    Feng Wei
    Department of Neural and Pain Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 30:8624-36. 2010
    ..These results indicate that the descending 5-HT from the RVM is an important contributor to pain facilitation during the development of persistent pain, and may not mediate opioid-induced descending inhibition in acute pain...
  55. ncbi request reprint Selective distribution and function of primary afferent nociceptive inputs from deep muscle tissue to the brainstem trigeminal transition zone
    Hu Wang
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Comp Neurol 498:390-402. 2006
    ..These findings provide further evidence to support a role of the trigeminal transition zone in response to orofacial deep injury...
  56. ncbi request reprint Inflammation-induced upregulation of AMPA receptor subunit expression in brain stem pain modulatory circuitry
    Yun Guan
    Program in Neuroscience, University of Maryland, Baltimore, MD 21201 1586, USA
    Pain 104:401-13. 2003
    ....
  57. ncbi request reprint Differential rostral projections of caudal brainstem neurons receiving trigeminal input after masseter inflammation
    Tetsuya Ikeda
    Department of Oral and Craniofacial Biological Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Comp Neurol 465:220-33. 2003
    ..The activation of Vi/Vc neurons and associated ascending pathways may facilitate somatoautonomic and somatovisceral integration and descending pain modulation after orofacial deep tissue injury...
  58. ncbi request reprint Brainstem mechanisms of persistent pain following injury
    Ronald Dubner
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 21201, USA
    J Orofac Pain 18:299-305. 2004
    ..The findings support our overall hypothesis that the ventral pole of Vi/Vc is involved in the coordination of bilateral sensorimotor functions of the trigeminal system associated with the response to deep tissue injury...
  59. ncbi request reprint Trigeminal transition zone/rostral ventromedial medulla connections and facilitation of orofacial hyperalgesia after masseter inflammation in rats
    Shinichi Sugiyo
    Department of Biomedical Sciences, Dental School, and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1586, USA
    J Comp Neurol 493:510-23. 2005
    ..The Vi/Vc-RVM pathway is activated after orofacial deep tissue injury and plays a critical role in facilitating orofacial hyperalgesia...
  60. ncbi request reprint Electroacupuncture attenuates inflammation in a rat model
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
    J Altern Complement Med 11:135-42. 2005
    ..However, clinical trials investigating the effectiveness of the anti-inflammatory effects of acupuncture have yielded inconsistent results, and the underlying mechanisms of acupuncture-produced anti-inflammation are unclear...
  61. ncbi request reprint Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Pain 118:125-36. 2005
    ..Further, bone cancer activates spinal glial cells, which may release IL-1beta and other cytokines and contribute to hyperalgesia...
  62. ncbi request reprint Electroacupuncture combined with MK-801 prolongs anti-hyperalgesia in rats with peripheral inflammation
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 81:146-51. 2005
    ..These results demonstrate that EA combined with a sub-effective dose of this NMDA receptor antagonist enhances anti-hyperalgesia, and this combination may provide an effective strategy for pain management...
  63. ncbi request reprint Electroacupuncture suppresses spinal expression of neurokinin-1 receptors induced by persistent inflammation in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Neurosci Lett 384:339-43. 2005
    ..This suggests that EA-induced suppression of hyperalgesia is involved, at least partly, in the suppression of the spinal NK-1 receptors induced by sustained peripheral nociceptive input...
  64. ncbi request reprint Endogenous mechanisms of sensory modulation
    R Dubner
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Pain . 1999
    ..These parallel brain mechanisms emphasize the saliency of pain experience as an important learned behavior for the survival of the organism, similar to sequential goal-directed behaviors in an operant task...
  65. ncbi request reprint Descending modulation in persistent pain: an update
    Ke Ren
    Department of Oral and Craniofacial Biological Sciences, Program in Neuroscience, University of Maryland Dental School, 666 West Baltimore Street, Room 5A12, Baltimore, MD 21201, USA
    Pain 100:1-6. 2002
  66. ncbi request reprint Interleukin-1ra inhibits Fos expression and hyperalgesia in rats
    Aihui Li
    Center for Integrative Medicine, School of Medicine, Department of Biomedical Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    Neuroreport 18:495-8. 2007
    ....
  67. ncbi request reprint Laminar-selective noradrenergic and serotoninergic modulation includes spinoparabrachial cells after inflammation
    F Wei
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore 21201, USA
    Neuroreport 10:1757-61. 1999
    ..Further, these pathways differentially suppress the responses of spinoparabrachial neurons in the deep and superficial dorsal horn...
  68. ncbi request reprint Antibody array analysis of peripheral and blood cytokine levels in rats after masseter inflammation
    Mineo Watanabe
    Department of Biomedical Sciences, Dental School, and Program in Neuroscience, University of Maryland, Rm 5A12, 666W Baltimore Street, Baltimore, MD 21201, USA
    Neurosci Lett 382:128-33. 2005
    ..The findings provide specific targets for further studying the involvement of cytokines in orofacial inflammation and hyperalgesia...
  69. ncbi request reprint Demonstration of a trigeminothalamic pathway to the oval paracentral intralaminar thalamic nucleus and its involvement in the processing of noxious orofacial deep inputs
    Shinichi Sugiyo
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Rm 5A26, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Brain Res 1097:116-22. 2006
    ..The present findings indicate a trigeminothalamic pathway to the OPC intralaminar nucleus involved in central processing of orofacial deep noxious input...
  70. ncbi request reprint Activation of trigeminal intranuclear pathway in rats with temporomandibular joint inflammation
    Takako Sato
    Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry, Tokyo, Japan
    J Oral Sci 47:65-9. 2005
    ..Fos/FG cells were only observed in the deep laminae of the Vc/C(1,2) zone. These findings suggest that Vi/Vc transition zone activity is modulated by activation of the caudal laminated zone after orofacial tissue injury...
  71. ncbi request reprint Involvement of dorsal column nucleus neurons in nociceptive transmission in aged rats
    Junichi Kitagawa
    Department of Physiology, School of Dentistry, Nihon University, Chiyoda ku, Tokyo, Japan
    J Neurophysiol 94:4178-87. 2005
    ..The present findings suggest that the hyperexcitability of GN neurons could be involved in abnormal noxious pain sensations with advancing age...
  72. ncbi request reprint Effect of chronic inflammation on dorsal horn nociceptive neurons in aged rats
    Junichi Kitagawa
    Department of Physiology, School of Dentistry, Nihon University, 1 8 13 Kandasurugadai, Chiyoda ku Tokyo, 101 8310, Japan
    J Neurophysiol 93:3594-604. 2005
    ....
  73. ncbi request reprint Central neuronal changes after nerve injury: neuroplastic influences of injury and aging
    Koichi Iwata
    Department of Physiology, School of Dentistry, Nihon University, Tokyo, Japan
    J Orofac Pain 18:293-8. 2004
    ..These observations suggest that the changes in neuronal activity in the aged rats likely corresponded to the changes observed in the rat model of peripheral nerve injury...
  74. ncbi request reprint Phosphorylation of Extracellular Signal-Regulated Kinase in medullary and upper cervical cord neurons following noxious tooth pulp stimulation
    Kohei Shimizu
    Department of Endodontics, School of Dentistry, Nihon University, 1 8 13 Kandasurugadai, Tokyo 101 8310, Japan
    Brain Res 1072:99-109. 2006
    ....
  75. ncbi request reprint Brain-derived neurotrophic factor prevents human immunodeficiency virus type 1 protein gp120 neurotoxicity in the rat nigrostriatal system
    Italo Mocchetti
    Department of Neuroscience, Georgetown University Medical Center, Research Bldg, 3970 Reservoir Rd, NW, Washington, DC 20057, USA
    Ann N Y Acad Sci 1122:144-54. 2007
    ..This study's results support the notion that gp120 produces a widespread neurotoxicity similar to that observed in HIV-positive individuals and that BDNF may be a suitable neuroprotective agent for HAD...
  76. ncbi request reprint Differential responses of rostral subnucleus caudalis and upper cervical dorsal horn neurons to mechanical and chemical stimulation of the parotid gland in rats
    Akiko Ogawa
    Department of Oral Diagnosis, School of Dentistry, Nihon University, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Brain Res 1106:123-33. 2006
    ..The present data indicate that the hyperalgesia and referred pain associated with parotitis may result from sensitization of C1/C2, but not Vi/Vc nociceptive neurons...
  77. ncbi request reprint Multiple calcium channels and kinases mediate alpha7 nicotinic receptor neuroprotection in PC12 cells
    Ke Ren
    Department of Pharmaceutics, University of Florida, Gainesville, Florida 32610, USA
    J Neurochem 94:926-33. 2005
    ..ERK1/2 but not JNK and p38 were activated by GTS-21, and the ERK phosphorylation inhibitors PD98059 and U0126 blocked protection...
  78. pmc Modulation of spontaneous hippocampal synaptic events with 5-hydroxyindole, 4OH-GTS-21, and rAAV-mediated alpha7 nicotinic receptor gene transfer
    Jeffrey S Thinschmidt
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida 32610, USA
    Brain Res 1203:51-60. 2008
    ....
  79. ncbi request reprint Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloid
    George S Bloom
    Departments of Biology, and Cell Biology, University of Virginia, Charlottesville, VA 22903, USA
    Biochim Biophys Acta 1739:116-24. 2005
    ....
  80. ncbi request reprint Trigeminal neuronal recording in animal models of orofacial pain
    Koichi Iwata
    Department of Physiology, Nihon University, School of Dentistry, Osaka, Japan
    Methods Mol Med 99:123-37. 2004
    ..Two different rat models with temporomandibular joint inflammation and inferior alveolar nerve transection are described...
  81. ncbi request reprint Brain-derived neurotrophic factor prevents the nigrostriatal degeneration induced by human immunodeficiency virus-1 glycoprotein 120 in vivo
    Rachel L Nosheny
    Department of Neuroscience, Georgetown University, EP04, New Research Building, 3970 Reservoir Road, NW Washington, DC, USA
    Eur J Neurosci 25:2275-84. 2007
    ..Our data suggest that down-regulation of CXCR4 expression may contribute to the neuroprotective activity of BDNF against gp120 toxicity in the basal ganglia...

Research Grants2

  1. GONADAL STEROID HORMONAL REGULATION OF PESISTENT PAIN
    Ke Ren; Fiscal Year: 2002
    ..The findings will be important for the development of new approaches to the management of these conditions. ..
  2. Cytokine pathways and orofacial pain
    Ke Ren; Fiscal Year: 2006
    ..The findings will further our understanding of the etiology and pathology of muscle-related TMJDs and facilitate the search for novel and efficient I approaches for the management of persistent orofacial pain. ..