J Ren

Summary

Affiliation: University of North Dakota
Country: USA

Publications

  1. pmc Measurement of Cardiac Mechanical Function in Isolated Ventricular Myocytes from Rats and Mice by Computerized Video-Based Imaging
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine 501 N Columbia Road, Grand Forks, ND 58203 USA
    Biol Proced Online 3:43-53. 2001
  2. ncbi request reprint Metformin but not glyburide prevents high glucose-induced abnormalities in relaxation and intracellular Ca2+ transients in adult rat ventricular myocytes
    J Ren
    University of North Dakota School of Medicine, Grand Forks, North Dakota, USA
    Diabetes 48:2059-65. 1999
  3. ncbi request reprint Short-term administration of insulin-like growth factor I (IGF-1) does not induce myocardial IGF-1 resistance
    Jun Ren
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    Growth Horm IGF Res 12:162-8. 2002
  4. ncbi request reprint Loss of cardiac contractile response to tetrahydropapaveroline with advanced age and hypertension
    J Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks 58203, USA
    Cell Mol Biol (Noisy-le-grand) 47:OL15-22. 2001
  5. ncbi request reprint Impaired cardiac excitation-contraction coupling in ventricular myocytes from Ames dwarf mice with IGF-I deficiency
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks 58203, USA
    Growth Horm IGF Res 12:99-105. 2002
  6. ncbi request reprint alpha2-Heremans Schmid glycoprotein, a putative inhibitor of tyrosine kinase, prevents glucose toxicity associated with cardiomyocyte dysfunction
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks 58203, USA
    Diabetes Metab Res Rev 18:305-10. 2002
  7. ncbi request reprint Influence of genetically predisposed diabetes on ethanol-induced depression of cardiac contraction in adult rat ventricular myocytes
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    Exp Physiol 87:293-8. 2002
  8. ncbi request reprint Influence of hypertension on acetaldehyde-induced vasorelaxation in rat thoracic aorta
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, ND 58203, USA
    Pharmacol Res 45:195-9. 2002
  9. ncbi request reprint Attenuated cardiac contractile responsiveness to insulin-like growth factor I in ventricular myocytes from biobreeding spontaneous diabetic rats
    J Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Cardiovasc Res 46:162-71. 2000
  10. ncbi request reprint Altered cardiac excitation-contraction coupling in ventricular myocytes from spontaneously diabetic BB rats
    J Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, North Dakota 58203, USA
    Am J Physiol Heart Circ Physiol 279:H238-44. 2000

Collaborators

Detail Information

Publications97

  1. pmc Measurement of Cardiac Mechanical Function in Isolated Ventricular Myocytes from Rats and Mice by Computerized Video-Based Imaging
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine 501 N Columbia Road, Grand Forks, ND 58203 USA
    Biol Proced Online 3:43-53. 2001
    ..The goal of this article is to describe the isolation of ventricular myocytes from both rats and mice, and the use of real-time beat-to-beat simultaneous recording of both myocyte contraction and intracellular Ca(2+) transient...
  2. ncbi request reprint Metformin but not glyburide prevents high glucose-induced abnormalities in relaxation and intracellular Ca2+ transients in adult rat ventricular myocytes
    J Ren
    University of North Dakota School of Medicine, Grand Forks, North Dakota, USA
    Diabetes 48:2059-65. 1999
    ....
  3. ncbi request reprint Short-term administration of insulin-like growth factor I (IGF-1) does not induce myocardial IGF-1 resistance
    Jun Ren
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    Growth Horm IGF Res 12:162-8. 2002
    ..These results suggest that short-term IGF-1 treatment is unlikely to induce IGF-1 resistance in myocardial contractile function...
  4. ncbi request reprint Loss of cardiac contractile response to tetrahydropapaveroline with advanced age and hypertension
    J Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks 58203, USA
    Cell Mol Biol (Noisy-le-grand) 47:OL15-22. 2001
    ..It is possible that altered intracellular Ca2+ responsiveness may be involved in THP-induced action...
  5. ncbi request reprint Impaired cardiac excitation-contraction coupling in ventricular myocytes from Ames dwarf mice with IGF-I deficiency
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks 58203, USA
    Growth Horm IGF Res 12:99-105. 2002
    ..These results suggest that deficiency in IGF-I may be directly associated with cardiac E-C coupling dysfunction at the ventricular myocyte level...
  6. ncbi request reprint alpha2-Heremans Schmid glycoprotein, a putative inhibitor of tyrosine kinase, prevents glucose toxicity associated with cardiomyocyte dysfunction
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks 58203, USA
    Diabetes Metab Res Rev 18:305-10. 2002
    ..The aim of the present study was to examine the effect of a putative inhibitor of tyrosine kinase phosphorylation, alpha(2)-Heremans Schmid glycoprotein (AHSG), on the mechanical dysfunction under a simulated diabetic environment...
  7. ncbi request reprint Influence of genetically predisposed diabetes on ethanol-induced depression of cardiac contraction in adult rat ventricular myocytes
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    Exp Physiol 87:293-8. 2002
    ..Collectively, these results suggest that the ethanol-induced depression in cardiac myocyte contraction may be 'shadowed' by genetically predisposed diabetes...
  8. ncbi request reprint Influence of hypertension on acetaldehyde-induced vasorelaxation in rat thoracic aorta
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, ND 58203, USA
    Pharmacol Res 45:195-9. 2002
    ..These data indicated that the ACA-induced vasorelaxant response, either endothelium-intact or-denuded, is altered by the hypertensive state...
  9. ncbi request reprint Attenuated cardiac contractile responsiveness to insulin-like growth factor I in ventricular myocytes from biobreeding spontaneous diabetic rats
    J Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Cardiovasc Res 46:162-71. 2000
    ..This study was to determine if IGF-1-induced cardiac contractile action is altered in rats genetically predisposed to diabetes...
  10. ncbi request reprint Altered cardiac excitation-contraction coupling in ventricular myocytes from spontaneously diabetic BB rats
    J Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, North Dakota 58203, USA
    Am J Physiol Heart Circ Physiol 279:H238-44. 2000
    ..These results suggest that the genetic diabetic state produces altered cardiac E-C coupling, in part, because of abnormalities of the myocyte, similar to that demonstrable after chemically induced diabetes or during human diabetes...
  11. ncbi request reprint Reduced contractile response to insulin and IGF-I in ventricular myocytes from genetically obese Zucker rats
    J Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, North Dakota 58203, USA
    Am J Physiol Heart Circ Physiol 279:H1708-14. 2000
    ..The mechanisms underlying this alteration may be related to the decreased receptor number and/or changes in intracellular Ca(2+) handling in these animals...
  12. ncbi request reprint Basal and ethanol-induced cardiac contractile response in lean and obese Zucker rat hearts
    J Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    J Biomed Sci 7:390-400. 2000
    ..Collectively, these results suggest altered cardiac contractile function and unchanged ethanol-induced depression in obesity...
  13. ncbi request reprint Characterization of contractile function in diabetic hypertensive cardiomyopathy in adult rat ventricular myocytes
    L E Wold
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    J Mol Cell Cardiol 33:1719-26. 2001
    ..These results confirmed observations at the multicellular levels that combination of diabetes and hypertension results in a greater impairment of cardiac contractile function than is seen with either disease alone...
  14. ncbi request reprint Influence of ovariectomy on ventricular myocyte contraction in simulated diabetes
    K K Hintz
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, N. Dak 58203, USA
    J Biomed Sci 8:307-13. 2001
    ..These data suggest that ovarian hormones play a role in the regulation of cardiac contractile function, and may have potentially protective effects against diabetes-associated cardiac dysfunction...
  15. ncbi request reprint Prenatal ethanol exposure alters ventricular myocyte contractile function in the offspring of rats: influence of maternal Mg2+ supplementation
    L E Wold
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    Cardiovasc Toxicol 1:215-24. 2001
    ....
  16. ncbi request reprint Isolated ventricular myocytes from copper-deficient rat hearts exhibit enhanced contractile function
    L E Wold
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, North Dakota 58203, USA
    Am J Physiol Heart Circ Physiol 281:H476-81. 2001
    ....
  17. pmc Ginsenosides Rb1 and Re decrease cardiac contraction in adult rat ventricular myocytes: role of nitric oxide
    G I Scott
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, North Dakota, ND 58203, USA
    Br J Pharmacol 134:1159-65. 2001
    ..05) stimulated NOS activity concentration-dependently. 3. This study demonstrated a direct depressant action of ginsenosides on cardiomyocyte contraction, which may be mediated in part through increased NO production...
  18. ncbi request reprint Insulin resistance induces hyperleptinemia, cardiac contractile dysfunction but not cardiac leptin resistance in ventricular myocytes
    K K Hintz
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA
    Int J Obes Relat Metab Disord 27:1196-203. 2003
    ..These data indicate that insulin resistance directly induces hyperleptinemia and cardiac contractile dysfunction, without affecting leptin-mediated cardiac contractile function at the myocyte level...
  19. ncbi request reprint Cardiac contractile function is enhanced in isolated ventricular myocytes from growth hormone transgenic mice
    P B Colligan
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, 501 N Columbia Road, Grand Forks, North Dakota 58203, USA
    J Endocrinol 173:257-64. 2002
    ..These results suggest that GH over-expression is associated with enhanced contractile function in isolated myocytes and that the impaired cardiac function observed in whole hearts may not be due to defects at the myocyte level...
  20. ncbi request reprint Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway
    Loren E Wold
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks 58203, USA
    Hypertension 39:69-74. 2002
    ..These data indicate that the leptin-induced cardiac contractile response is abolished by spontaneous hypertension, possibly because of mechanisms involving altered JAK/STAT, MAP kinase signaling, and NO response...
  21. ncbi request reprint Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes
    Jinhong Duan
    Department of Pharmacology, Physiology, and Therapeutics, Grand Forks, North Dakota 58203, USA
    Am J Physiol Heart Circ Physiol 282:H1216-22. 2002
    ..These data suggest that elevated cardiac ACA exposure due to enhanced ADH expression may play an important role in the development of alcoholic cardiomyopathy...
  22. ncbi request reprint IGF-I attenuates diabetes-induced cardiac contractile dysfunction in ventricular myocytes
    Faye L Norby
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, North Dakota 58203, USA
    Am J Physiol Endocrinol Metab 283:E658-66. 2002
    ..These results suggest that exogenous IGF-I treatment may ameliorate contractile disturbances in cardiomyocytes from diabetic animals and could provide therapeutic potential in the treatment of diabetic cardiomyopathy...
  23. ncbi request reprint Depressed contractile function and adrenergic responsiveness of cardiac myocytes in an experimental model of Parkinson disease, the MPTP-treated mouse
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Neurobiol Aging 25:131-8. 2004
    ..These results demonstrate substantial cardiac dysfunctions in this model of experimental Parkinson disease, probably due to reduced adrenergic responsiveness and SR Ca2+ load...
  24. ncbi request reprint Influence of prenatal alcohol exposure on myocardial contractile function in adult rat hearts: role of intracellular calcium and apoptosis
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    Alcohol Alcohol 37:30-7. 2002
    ..These results suggest that prenatal ethanol exposure alters myocardial contractile function and may contribute to the development of postnatal cardiac dysfunction through, in part, increased intracellular Ca(2+) loading and apoptosis...
  25. ncbi request reprint AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase
    Jamie R Privratsky
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, USA
    Hypertension 42:206-12. 2003
    ..Collectively, our data suggest that local Ang II, acting via AT1 receptor-mediated NADPH oxidase activation, is involved in hyperglycemia-induced cardiomyocyte dysfunction, which might play a role in diabetic cardiomyopathy...
  26. ncbi request reprint Prediabetic insulin resistance is not permissive to the development of cardiac resistance to insulin-like growth factor I in ventricular myocytes
    Kadon K Hintz
    Department of Physiology, Pharmacology and Therapeutics, University of North Dakota School of Medicine, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Diabetes Res Clin Pract 55:89-98. 2002
    ..These results indicated prediabetic insulin resistance alters cardiac contractile function at the myocytes level, but may not be permissive to cardiac contractile resistance to IGF-1...
  27. ncbi request reprint Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes
    Peter B Colligan
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Cell Mol Biol (Noisy-le-grand) 48:OL251-7. 2002
    ..These data suggest that alteration of ceramide signaling may play a role in the pathogenesis of diabetic cardiomyopathy...
  28. ncbi request reprint Impaired cardiac function and IGF-I response in myocytes from calmodulin-diabetic mice: role of Akt and RhoA
    Jinhong Duan
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203
    Am J Physiol Endocrinol Metab 284:E366-76. 2003
    ..These results validate diabetic cardiomyopathy in OVE26 mice due to reduced SERCA2, NCX, IGF-I response, and Akt activation associated with enhanced RhoA level, suggesting a therapeutic potential for Akt and RhoA...
  29. ncbi request reprint Streptozotocin directly impairs cardiac contractile function in isolated ventricular myocytes via a p38 map kinase-dependent oxidative stress mechanism
    Loren E Wold
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Biochem Biophys Res Commun 318:1066-71. 2004
    ..Thus, caution should be taken when assessing diabetic heart complications using STZ-induced diabetic models...
  30. ncbi request reprint Iso-S-petasin, a hypotensive sesquiterpene from Petasites formosanus, depresses cardiac contraction and intracellular Ca2+ transients in adult rat ventricular myocytes
    Lucy B Esberg
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    J Pharm Pharmacol 55:103-7. 2003
    ..The iso-S-petasin-induced decrease in CICR may play a role in its cardiac depressant effect...
  31. ncbi request reprint Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases
    Manuchair Ebadi
    Department of Pharmacology, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Curr Drug Targets 7:1513-29. 2006
    ..Its therapeutic efficacy in Alzheimer's disease remains uncertain. In Alzheimer's disease, short term studies of selegiline suggest a beneficial effect; whereas long term studies are less convincing...
  32. ncbi request reprint Diabetic cardiomyocyte dysfunction and myocyte insulin resistance: role of glucose-induced PKC activity
    Amy J Davidoff
    Department of Pharmacology, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA
    Mol Cell Biochem 262:155-63. 2004
    ..Our data support the view that PKC activation contributes to both diabetes-induced abnormal cardiomyocyte mechanics and insulin resistance, and that elevated glucose is sufficient to induce these effects...
  33. ncbi request reprint Influence of prenatal ethanol exposure on vascular contractile response in rat thoracic aorta
    Leigh Anne Turcotte
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Alcohol 26:75-81. 2002
    ..These findings seem to indicate that prenatal ethanol exposure contributes to alterations of both endothelium-dependent and endothelium-independent vascular contractile responses...
  34. ncbi request reprint Insulin-like growth factor I (IGF-1) supplementation prevents diabetes-induced alterations in coenzymes Q9 and Q10
    L E Wold
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND, USA
    Acta Diabetol 40:85-90. 2003
    ..These data suggest that IGF-1 antagonizes the diabetes-induced alterations in endogenous antioxidants including coenzyme Q(10), and hence may have a therapeutic role in diabetes...
  35. ncbi request reprint Comparison of cardiac excitation-contraction coupling in isolated ventricular myocytes between rat and mouse
    Kadon K Hintz
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 N Columbia Road, Grand Forks, ND 58203, USA
    Comp Biochem Physiol A Mol Integr Physiol 133:191-8. 2002
    ..These data suggest that inherent differences between strains or species should be taken into consideration when comparing results from these different animal models...
  36. ncbi request reprint Short-term acetaldehyde exposure depresses ventricular myocyte contraction: role of cytochrome P450 oxidase, xanthine oxidase, and lipid peroxidation
    Nicholas S Aberle
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Science, Grand Forks, USA
    Alcohol Clin Exp Res 27:577-83. 2003
    ..This study was designed to examine the role of cytochrome P450 oxidase 2E1 (CYP 2E1), xanthine oxidase, and lipid peroxidation in the short-term ACA exposure-induced mechanical defects in adult rat ventricular myocytes...
  37. ncbi request reprint Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion
    Kadon K Hintz
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks, USA
    Alcohol Clin Exp Res 27:1090-8. 2003
    ..This study was designed to examine the impact of enhanced acetaldehyde exposure on cardiac function via cardiac-specific overexpression of alcohol dehydrogenase (ADH) after alcohol intake...
  38. ncbi request reprint Acetaldehyde-induced cardiac contractile dysfunction may be alleviated by vitamin B1 but not by vitamins B6 or B12
    Nicholas S Aberle
    Deparment of Pharmacology, Physiology and Therapeutics, Univeresity of North Dakota School of Medicine and Health Science, Grand Forks, ND 58203, USA
    Alcohol Alcohol 39:450-4. 2004
    ..This study was designed to examine the effect of group B vitamin supplementation on short-term exposure of the main alcohol metabolite acetaldehyde (ACA)-induced cardiac contractile dysfunction in rat ventricular myocytes...
  39. ncbi request reprint Phytoestrogenic isoflavones daidzein and genistein reduce glucose-toxicity-induced cardiac contractile dysfunction in ventricular myocytes
    Kadon K Hintz
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, North Dakota, USA
    Endocr Res 30:215-23. 2004
    ....
  40. ncbi request reprint Sepsis-induced depressed contractile function of isolated ventricular myocytes is due to altered calcium transient properties
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks 58203, USA
    Shock 18:285-8. 2002
    ..5-3 mM). These results demonstrate that sepsis produces substantial deficits in cardiac myocytes function that can be attributed to altered calcium transient properties...
  41. ncbi request reprint Metallothionein alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of Ca2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme
    Loren E Wold
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, 58203, USA
    Free Radic Biol Med 40:1419-29. 2006
    ..Collectively, these data suggest a beneficial effect of MT in the therapeutics of diabetic cardiomyopathy, possibly through a mechanism related to NADPH oxidase, PARP and MHC isozyme switch...
  42. ncbi request reprint The cyclooxygenase-2 product prostaglandin E2 modulates cardiac contractile function in adult rat ventricular cardiomyocytes
    Aaron L Klein
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Pharmacol Res 49:99-103. 2004
    ..These data indicate that the myocardial contractile response of PGE(2) may be due to its direct cardiac contractile action at the single ventricular myocyte level, probably through a mechanism independent of intracellular Ca(2+) release...
  43. ncbi request reprint Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid
    Nicholas S Aberle
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Science, Grand Forks, ND 58203, USA
    Neurotoxicol Teratol 25:731-6. 2003
    ..Collectively, these data provided evidence that ACA and nicotine, either alone or in combination, directly depressed cardiomyocyte mechanical function possibly through mechanisms related to DNA damage...
  44. ncbi request reprint Tetramethylpyrazine elicits disparate responses in cardiac contraction and intracellular Ca(2+) transients in isolated adult rat ventricular myocytes
    Kadon K Hintz
    Department of Pharmacology, Physiology, and Therapeutics, School of Medicine and Health Science, University of North Dakota, Grand Forks, ND 58203, USA
    Vascul Pharmacol 40:213-7. 2003
    ..Our data demonstrate a direct positive inotropic effect of TMP in cardiac myocytes, which may be related, at least in part, to NO production...
  45. ncbi request reprint Doxorubicin induces cardiomyocyte dysfunction via a p38 MAP kinase-dependent oxidative stress mechanism
    Loren E Wold
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Cancer Detect Prev 29:294-9. 2005
    ..These data provide evidence that doxorubicin impairs cardiac contractile property in single myocytes through an oxidative stress-mediated pathway...
  46. ncbi request reprint Inhibition of cardiac myocyte contraction by 4-hydroxy-trans-2-nonenal
    Nicholas S Aberle
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA
    Cardiovasc Toxicol 4:21-8. 2004
    ..These findings reveal a possible role of HNE in the lipid peroxidation-associated cardiac contractile dysfunction that is likely mediated through HNE metabolism and mitogen-activated protein kinase activation...
  47. ncbi request reprint Comparison of cardiac contractile and intracellular Ca2+ response between estrogen and phytoestrogen alpha-zearalanol in ventricular myocytes
    Jinhong Duan
    Deparment of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Med, Grand Forks, ND 58203 USA
    Endocrine 24:33-8. 2004
    ..Our results revealed a direct cardiac stimulatory action from E2 but not from phytoestrogen ZAL on ventricular contraction, likely mediated through enhanced intracellular Ca2+ release...
  48. pmc Malondialdehyde inhibits cardiac contractile function in ventricular myocytes via a p38 mitogen-activated protein kinase-dependent mechanism
    David V Folden
    University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    Br J Pharmacol 139:1310-6. 2003
    ..3) These findings revealed a novel role of malondialdehyde and p38 MAP kinase in lipid peroxidation and oxidative stress-associated cardiac dysfunction...
  49. ncbi request reprint Leptin-induced suppression of cardiomyocyte contraction is amplified by ceramide
    Jun Ren
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    Peptides 27:1415-9. 2006
    ..In summary, our data demonstrated that ceramide sensitizes cardiac depressive effects of leptin and may contribute to hyperleptinemia-related cardiac contractile dysfunction...
  50. pmc Acute exposure of ceramide enhances cardiac contractile function in isolated ventricular myocytes
    David P Relling
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Br J Pharmacol 140:1163-8. 2003
    ..3. Our data suggest that ceramide acutely augments the contractile function of cardiac myocytes through an alternative mechanism(s) rather than PI-3-kinase, PKC, CAPP, or NO...
  51. ncbi request reprint Korean anti-inflammatory compound allergina enhances cardiac contractile function in isolated ventricular cardiomyocytes
    Nicholas S Aberle
    Department of Pharmacology, Physiology and Therapeutics, and Center for Biomedical Research, University of North Dakota Schoolof Medicine, Grand Forks, ND
    J Altern Complement Med 10:514-8. 2004
    ..However, the direct effect of Allergina on ventricular contractile function has not been defined...
  52. ncbi request reprint Dietary interaction of high fat and marginal copper deficiency on cardiac contractile function
    David P Relling
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, North Dakota, USA
    Obesity (Silver Spring) 15:1242-57. 2007
    ..However, the combined effect of the two on cardiac function is unknown. This study was designed to examine the interaction between high-fat and marginally copper-deficient diets on cardiomyocyte contractile function...
  53. ncbi request reprint Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats
    Loren E Wold
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, Grand Forks, ND, USA
    J Mol Cell Cardiol 39:297-307. 2005
    ..g. diabetes, obesity, syndrome X and hypertension)...
  54. ncbi request reprint Increases in insulin-like growth factor-1 level and peroxidative damage after gestational ethanol exposure in rats
    Jun Ren
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    Pharmacol Res 47:341-7. 2003
    ..Collectively, these data suggest that gestational ethanol exposure may lead to postpartum oxidative organ damage and a possible compensatory increase in organ IGF-1 levels...
  55. ncbi request reprint Anisodamine inhibits cardiac contraction and intracellular Ca(2+) transients in isolated adult rat ventricular myocytes
    Faye L Norby
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA
    Eur J Pharmacol 439:21-5. 2002
    ..This study demonstrated a direct cardiac depressive action of anisodamine at the myocyte level, which may be related to, at least in part, NO production and cholinoceptor antagonism...
  56. ncbi request reprint Japanese herbal medicine Toki-shakuyaku-san (TJ-23) enhances cardiac contractile function in isolated ventricular cardiomyocytes
    Nicholas S Aberle II
    Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine and Health Sciences
    J Pharmacol Sci 91:197-201. 2003
    ..This study demonstrated a direct cardiac stimulatory action of TJ-23 at the cardiomyocyte level, which may be related to, at least in part, a Na(+)/K(+)-ATPase and/or Na(+)/Ca(2+) exchanger-dependent mechanism...
  57. ncbi request reprint Leptin, leptin resistance and endothelial dysfunction in pre-eclampsia
    Cindy M Anderson
    Department of Pharmacology, Physiology and Therapeutics and College of Nursing, University of North Dakota School of Medicine, 501 N Columbia Road Grand Forks, ND 58203, USA
    Cell Mol Biol (Noisy-le-grand) 48:OL323-9. 2002
    ..This review summarizes recent findings regarding the putative changes of serum leptin levels during pre-eclampsia and the potential consequences on the vascular system...
  58. ncbi request reprint High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis
    David P Relling
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine, Grand Forks, North Dakota, USA
    J Hypertens 24:549-61. 2006
    ..Obesity is associated with dyslipidemia, which leads to elevated triglyceride and ceramide levels, apoptosis and compromised cardiac function...
  59. ncbi request reprint Cardiac nitric oxide synthases are elevated in dietary copper deficiency
    Jack T Saari
    U S Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA
    J Nutr Biochem 18:443-8. 2007
    ..Coupled with prior evidence of elevated cardiac nitrate/nitrite production in Cu-deficient rats, these data suggest multiple pathways for enhanced NO production that may contribute to altered cardiac function under dietary Cu deficiency...
  60. ncbi request reprint Oxidative stress and stress signaling: menace of diabetic cardiomyopathy
    Loren E Wold
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, Grand Forks, ND 58203, USA
    Acta Pharmacol Sin 26:908-17. 2005
    ..Many of these stress signaling pathways lead to activation of reactive oxygen species, major players in the development and progression of diabetic cardiomyopathy...
  61. ncbi request reprint Phytoestrogen alpha-zearalanol antagonizes homocysteine-induced imbalance of nitric oxide/endothelin-1 and apoptosis in human umbilical vein endothelial cells
    Jinhong Duan
    University of North Dakota School of Medicine, Grand Forks, ND Chinese Academy of Medical Sciences, Beijing, P R China
    Cell Biochem Biophys 45:137-45. 2006
    ..In summary, these results suggested that alpha-ZAL may effectively preserve Hcy-induced decrease in NO, increase in ET-1/NO ratio and apoptosis, which contributes to protective effects of phytoestrogens on endothelial function...
  62. ncbi request reprint Insulin-like growth factor-1 protects human dopaminergic SH-SY5Y cells from salsolinol-induced toxicity
    Shaik Shavali
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Grand Forks, ND 58203, USA
    Neurosci Lett 340:79-82. 2003
    ..These results suggest that IGF-1 may be a useful growth factor in the treatment of PD...
  63. doi request reprint Interaction between high-fat diet and alcohol dehydrogenase on ethanol-elicited cardiac depression in murine myocytes
    Jun Ren
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, 1000 E University Avenue, Dept 3375, University of Wyoming, Laramie, WY 82071, USA
    Obesity (Silver Spring) 15:2932-41. 2007
    ..This study was designed to examine the interaction between high-fat diet and the alcohol metabolizing enzyme alcohol dehydrogenase (ADH) on ethanol-induced cardiac depression...
  64. pmc Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction
    Qun Li
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    Rejuvenation Res 11:725-33. 2008
    ..Our data suggest that regulation of Akt, p53, adenosine monophosphate-activated protein kinase (AMPK) phosphorylation, and Klotho may play a role, at least in part, in IGF-1 deficiency-induced "desensitization" of cardiac aging...
  65. ncbi request reprint Cardiac overexpression of metallothionein rescues chronic alcohol intake-induced cardiomyocyte dysfunction: role of Akt, mammalian target of rapamycin and ribosomal p70s6 kinase
    Qun Li
    Division of Pharmaceutical Sciences, Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    Alcohol Alcohol 41:585-92. 2006
    ..This study was designed to examine the effect of cardiac overexpression of the antioxidant metallothionein on alcohol-induced cardiac contractile dysfunction and post-receptor insulin signaling...
  66. doi request reprint Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts
    Jun Ren
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY, USA
    Crit Care Med 36:2106-16. 2008
    ..This study was designed to examine the impact of glutathione depletion and the free radical scavenger, metallothionein (MT), on cardiac function...
  67. ncbi request reprint Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage
    Qun Li
    Div of Pharmaceutical Science and Center for Cardiovascular Research and Alternative Medicine, Univ of Wyoming, Laramie, WY 82071 3375, USA
    Am J Physiol Heart Circ Physiol 292:H1398-403. 2007
    ..Collectively, our data suggest a beneficial role of IGF-1 in aging-induced cardiac contractile dysfunction, possibly related to improved Ca(2+) uptake...
  68. ncbi request reprint Dietary Mg(2+) supplementation restores impaired vasoactive responses in isolated rat aorta induced by chronic ethanol consumption
    Ricardo A Brown
    Department of Biology, Morgan State University, Baltimore, MD 21251, USA
    Eur J Pharmacol 442:241-50. 2002
    ..These data suggest that chronic ethanol consumption contributes to alterations of endothelium-dependent and -independent vascular response. These alterations can be compensated by dietary Mg(2+) supplementation...
  69. ncbi request reprint Cardiac-specific overexpression of catalase prolongs lifespan and attenuates ageing-induced cardiomyocyte contractile dysfunction and protein damage
    Shan Wu
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming 82071 3375, USA
    Clin Exp Pharmacol Physiol 34:81-7. 2007
    ..3. In summary, the present data suggest that catalase protects cardiomyocytes from ageing-induced contractile defects and protein damage...
  70. pmc Cardiac overexpression of antioxidant catalase attenuates aging-induced cardiomyocyte relaxation dysfunction
    Jun Ren
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071 2000, United States
    Mech Ageing Dev 128:276-85. 2007
    ..Catalase restored NCX and Kv1.2 K+ channel but not SERCA2a level in aged mice. In summary, our data suggested that catalase protects cardiomyocytes from aging-induced contractile defect possibly via improved intracellular Ca2+ handling...
  71. pmc Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress
    Shi Yan Li
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming School of Pharmacy, Laramie, WY 82071, USA
    J Mol Cell Cardiol 44:992-1001. 2008
    ....
  72. ncbi request reprint Cardiac overexpression of metallothionein attenuates chronic alcohol intake-induced cardiomyocyte contractile dysfunction
    Qun Li
    Division of Pharmaceutical Sciences, Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    Cardiovasc Toxicol 6:173-82. 2006
    ..All of these alcohol- induced changes in cardiac proteins were nullified by the metallothionein transgene. In summary, our findings suggest a beneficial role of antioxidants in alcohol-induced cardiomyocyte dysfunction...
  73. ncbi request reprint Influence of gender on oxidative stress, lipid peroxidation, protein damage and apoptosis in hearts and brains from spontaneously hypertensive rats
    Jun Ren
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    Clin Exp Pharmacol Physiol 34:432-8. 2007
    ..3. In summary, these results suggest that gender affects hypertension-associated oxidative stress, lipid and protein damage, apoptosis in heart and brain tissues and cardiomyocyte contractile function...
  74. ncbi request reprint Fitness or fatness--the debate continues for the role of leptin in obesity-associated heart dysfunction
    Feng Dong
    Center for Cardiovascular Research and Alternative Medicine, Division of Pharmaceutical Sciences, University of Wyoming, Laramie, WY 82071, USA
    Curr Diabetes Rev 3:159-64. 2007
    ....
  75. doi request reprint IGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction
    Jun Ren
    School of Pharmacy, University of Wyoming, Laramie, WY 82071, USA
    Am J Physiol Regul Integr Comp Physiol 294:R793-802. 2008
    ..These results revealed that IGF-I benefits diabetic hearts via Rho inhibition and antagonism of diabetes-induced decrease in pAkt, eNOS uncoupling, and K+ channel expression...
  76. ncbi request reprint Metallothionein prevents high-fat diet induced cardiac contractile dysfunction: role of peroxisome proliferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis
    Feng Dong
    Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    Diabetes 56:2201-12. 2007
    ..These data suggest that metallothionein may protect against high-fat diet-induced cardiac dysfunction possibly associated with upregulation of PGC-1alpha and preservation of mitochondrial biogenesis...
  77. ncbi request reprint Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression
    Qun Li
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    Aging Cell 6:799-806. 2007
    ..Our data suggest a beneficial role for IGF-1 in aging-induced survival, cardiac intracellular Ca2+ homeostasis, protein damage and apoptosis possibly related to pro- and anti-apoptotic proteins...
  78. ncbi request reprint Swim training sensitizes myocardial response to insulin: role of Akt-dependent eNOS activation
    Quan Jiang Zhang
    Department of Physiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Cardiovasc Res 75:369-80. 2007
    ..This study was designed to examine the effect of swim training on myocardial response to insulin with a special focus on the endogenous endothelial nitric oxide synthase (eNOS)-nitric oxide (NO) cascade...
  79. ncbi request reprint Influence of hypertension on tetrahydropapaveroline-induced vasorelaxation in rat thoracic aorta
    Ricardo A Brown
    Department of Biology, Morgan State University, Baltimore, MD 21251, USA
    Endocr Res 28:19-26. 2002
    ..These data indicate that the THP-induced endothelium-dependent vasorelaxant response is altered by the hypertensive state...
  80. ncbi request reprint Cardiac-specific overexpression of catalase rescues ventricular myocytes from ethanol-induced cardiac contractile defect
    Xiaochun Zhang
    Division of Pharmaceutical Sciences, University of Wyoming College of Health Sciences, WY 82071 3375, Laramie, USA
    J Mol Cell Cardiol 35:645-52. 2003
    ..In conclusion, our data suggest that catalase overexpression may protect cardiac myocytes from ethanol-induced contractile defect, partially through improved intracellular Ca(2+) handling and Akt signaling...
  81. ncbi request reprint Sucrose-induced cardiomyocyte dysfunction is both preventable and reversible with clinically relevant treatments
    Amy J Davidoff
    Univ of New England, College of Osteopathic Medicine, 11 Hills Beach Rd, Biddeford, ME 04005, USA
    Am J Physiol Endocrinol Metab 286:E718-24. 2004
    ....
  82. ncbi request reprint Influence of hypertension on cardiac contractile response of human erythrocyte-derived depressing factor in ventricular myocytes
    Jun Ren
    Division of Pharmaceutical Sciences, University of Wyoming College of Health Sciences, Laramie, Wyoming 82071 3375, USA
    J Hypertens 21:1183-90. 2003
    ..However, its cardiac response is unknown...
  83. ncbi request reprint Paradoxical effects of pyruvate on cardiac contractile function under normal and high glucose in ventricular myocytes
    Jun Ren
    Division of Pharmaceutical Sciences, University of Wyoming College of Health Sciences, Laramie, WY 82071 3375, USA
    Pharmacol Res 48:25-9. 2003
    ..These data suggest that pyruvate may paradoxical affect cardiac mechanical function under different glucose settings and therefore warrant caution when applying pyruvate therapeutically...
  84. ncbi request reprint Impact of gender on basal and insulin-like growth factor I-regulated nitric oxide synthase activity in adult rat left ventricular myocytes
    Lucy B Esberg
    Division of Pharmaceutical Sciences and Graduate Neuroscience Program, University of Wyoming College of Health Sciences, P O Box 3375, Laramie, WY 82071 3375, USA
    Comp Biochem Physiol A Mol Integr Physiol 138:141-6. 2004
    ....
  85. ncbi request reprint High glucose induces cardiac insulin-like growth factor I resistance in ventricular myocytes: role of Akt and ERK activation
    Jun Ren
    University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
    Cardiovasc Res 57:738-48. 2003
    ..This study was designed to examine the impact of high glucose on IGF-1-induced contractile response and activation of serine-threonine kinase Akt as well as extracellular signal-regulated kinase (ERK1/2) in cardiac myocytes...
  86. ncbi request reprint Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins
    Shi Yan Li
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071 3375, USA
    Cell Biochem Biophys 42:1-12. 2005
    ....
  87. ncbi request reprint A newly synthetic chromium complex--chromium(phenylalanine)3 improves insulin responsiveness and reduces whole body glucose tolerance
    Xiaoping Yang
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Wyoming, Laramie, WY 82071, USA
    FEBS Lett 579:1458-64. 2005
    ..Collectively, these data suggest that Cr(pa)3 may represent a novel, less-toxic chromium supplement with potential therapeutic value to improve insulin sensitivity and glycemic control in type II diabetes...
  88. ncbi request reprint Increased contractility of cardiomyocytes from copper-deficient rats is associated with upregulation of cardiac IGF-I receptor
    Feng Dong
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming, USA
    Am J Physiol Heart Circ Physiol 289:H78-84. 2005
    ..We conclude that enhanced sensitivity to IGF-I, as indicated by an increase in IGF-I receptor protein, accounts for the increased contractility of Cu-deficient cardiomyocytes and may presage cardiac failure...
  89. ncbi request reprint Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production
    Gang Ye
    Department of Pediatrics, University of Louisville School of Medicine, 570 S Preston Street, Louisville, KY 40202, USA
    Diabetes 52:777-83. 2003
    ..These data show that diabetes induces damage at the level of individual myocyte. Damage can be attributed to ROS production, and diabetes increases ROS production via angiotensin II and flavoprotein enzyme-dependent pathways...
  90. ncbi request reprint Influence of gender on ethanol-induced ventricular myocyte contractile depression in transgenic mice with cardiac overexpression of alcohol dehydrogenase
    Jinhong Duan
    Division of Pharmaceutical Sciences, University of Wyoming College of Health Sciences, Laramie, WY 82071 3375, USA
    Comp Biochem Physiol A Mol Integr Physiol 134:607-14. 2003
    ..These data suggest that females may be more sensitive to ACA-induced cardiac contractile depression than male, which may attribute to the gender-related difference of alcoholic cardiomyopathy...
  91. ncbi request reprint Cardiac overexpression of catalase antagonizes ADH-associated contractile depression and stress signaling after acute ethanol exposure in murine myocytes
    Xiaochun Zhang
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    J Appl Physiol (1985) 99:2246-54. 2005
    ..These data suggest that antioxidant CAT may effectively antagonize ADH-induced enhanced cardiac depression in response to ethanol...
  92. ncbi request reprint Inhibition of PI-3 kinase/Akt/mTOR, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function
    Shi Yan Li
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming 82071, USA
    J Endocrinol 186:491-503. 2005
    ..Collectively, our data suggest that IGF-1 may provide cardiac protection against glucose in part through a PI-3 kinase/Akt/mTOR/ p70s6k-dependent and calcineurin-independent pathway...
  93. ncbi request reprint Leptin regulates cardiomyocyte contractile function through endothelin-1 receptor-NADPH oxidase pathway
    Feng Dong
    Division of Pharmaceutical Sciences, Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    Hypertension 47:222-9. 2006
    ..These results suggest that leptin suppresses cardiac contractile function in ventricular myocytes through the endothelin-1 receptor and NADPH oxidase-mediated pathway...
  94. ncbi request reprint Impact of estrogen replacement on ventricular myocyte contractile function and protein kinase B/Akt activation
    Jun Ren
    Division of Pharmaceutical Sciences, University of Wyoming College of Health Sciences, Laramie, WY 82071 3375, USA
    Am J Physiol Heart Circ Physiol 284:H1800-7. 2003
    ..Ovx reduced myocyte Ca(2+) responsiveness and lessened stimulating frequency-induced decline in PS, both ablated by E(2). These data suggest that mechanical and protein functions of ventricular myocytes are directly regulated by E(2)...
  95. ncbi request reprint Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress
    Xiaoping Yang
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming 82071 3375, USA
    FASEB J 20:1024-6. 2006
    ..Collectively, our data demonstrated that metallothionein may alleviate aging-induced cardiac contractile defects and oxidative stress, which may contribute to prolonged life span in metallothionein transgenic mice...
  96. ncbi request reprint Metallothionein antagonizes aging-induced cardiac contractile dysfunction: role of PTP1B, insulin receptor tyrosine phosphorylation and Akt
    Cindy X Fang
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, 82071, USA
    Aging Cell 5:177-85. 2006
    ..These data indicate that enhanced antioxidant defense is beneficial for aging-induced cardiac contractile dysfunction and alteration in insulin signaling...
  97. ncbi request reprint Influence of gender on intrinsic contractile properties of isolated ventricular myocytes from calmodulin-induced diabetic transgenic mice
    Xiaochun Zhang
    Division of Pharmaceutical Sciences, University of Wyoming, College of Health Sciences, Laramie, Wyoming 82071 3375, USA
    Endocr Res 29:227-36. 2003
    ..Mechanical differences existed between genders but were "cancelled off" by diabetic state. Nevertheless, a "female advantage" in ventricular function may still persist in young female diabetic subjects...