Muredach P Reilly

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Peroxisome Proliferator-Activated Receptor-α Agonism With Fenofibrate Does Not Suppress Inflammatory Responses to Evoked Endotoxemia
    Claire K Mulvey
    Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA C K M, J F F, J T M, S K, R Y S, P N P, M H U U, N N M, M P R
    J Am Heart Assoc 1:e002923. 2012
  2. pmc ABO Blood Groups and Cardiovascular Diseases
    Hanrui Zhang
    Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 5158, USA
    Int J Vasc Med 2012:641917. 2012
  3. pmc Differential associations of oral glucose tolerance test-derived measures of insulin sensitivity and pancreatic β-cell function with coronary artery calcification and microalbuminuria in type 2 diabetes
    Claire K Mulvey
    Corresponding author Muredach P Reilly
    Diabetes Care 37:124-33. 2014
  4. pmc Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes
    Luis H Eraso
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 33:408-10. 2010
  5. pmc Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies
    Muredach P Reilly
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Lancet 377:383-92. 2011
  6. pmc Genetics of coronary artery calcification among African Americans, a meta-analysis
    Mary K Wojczynski
    Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA
    BMC Med Genet 14:75. 2013
  7. pmc Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 106:1118-23. 2010
  8. pmc Experimental endotoxemia induces adipose inflammation and insulin resistance in humans
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 59:172-81. 2010
  9. ncbi request reprint Value of electrocardiographic and ankle-brachial index abnormalities for prediction of coronary atherosclerosis in asymptomatic subjects with type 2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, and Department of Medicine, Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
    Am J Cardiol 99:951-5. 2007
  10. pmc Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whites
    Seth S Martin
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 58:1887-92. 2009

Detail Information

Publications76

  1. pmc Peroxisome Proliferator-Activated Receptor-α Agonism With Fenofibrate Does Not Suppress Inflammatory Responses to Evoked Endotoxemia
    Claire K Mulvey
    Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA C K M, J F F, J T M, S K, R Y S, P N P, M H U U, N N M, M P R
    J Am Heart Assoc 1:e002923. 2012
    ....
  2. pmc ABO Blood Groups and Cardiovascular Diseases
    Hanrui Zhang
    Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 5158, USA
    Int J Vasc Med 2012:641917. 2012
    ....
  3. pmc Differential associations of oral glucose tolerance test-derived measures of insulin sensitivity and pancreatic β-cell function with coronary artery calcification and microalbuminuria in type 2 diabetes
    Claire K Mulvey
    Corresponding author Muredach P Reilly
    Diabetes Care 37:124-33. 2014
    ..Despite these pathophysiological insights, the Matsuda ISI and Insulinogenic Index are unlikely to be translated into clinical use in type 2 diabetes beyond established clinical variables, such as obesity or duration of diabetes. ..
  4. pmc Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes
    Luis H Eraso
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 33:408-10. 2010
    ..Fetuin-A is an inhibitor of vascular calcification and a mediator of insulin resistance. This study evaluated the association of plasma fetuin-A and peripheral arterial disease (PAD)...
  5. pmc Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies
    Muredach P Reilly
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Lancet 377:383-92. 2011
    ..We tested whether genetic factors distinctly contribute to either development of coronary atherosclerosis or, specifically, to myocardial infarction in existing coronary atherosclerosis...
  6. pmc Genetics of coronary artery calcification among African Americans, a meta-analysis
    Mary K Wojczynski
    Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA
    BMC Med Genet 14:75. 2013
    ..African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants...
  7. pmc Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 106:1118-23. 2010
    ..These findings suggest that FABP4 and FABP5 may represent mediators of and biomarkers for metabolic and cardiovascular disease in type 2 diabetes mellitus...
  8. pmc Experimental endotoxemia induces adipose inflammation and insulin resistance in humans
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 59:172-81. 2010
    ..This study sought to explore potential mechanisms of inflammatory-induced IR in humans with a focus on adipose tissue...
  9. ncbi request reprint Value of electrocardiographic and ankle-brachial index abnormalities for prediction of coronary atherosclerosis in asymptomatic subjects with type 2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, and Department of Medicine, Philadelphia Veterans Affairs Medical Center, Pennsylvania, USA
    Am J Cardiol 99:951-5. 2007
    ....
  10. pmc Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whites
    Seth S Martin
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 58:1887-92. 2009
    ..We investigated the hypothesis that apoB is a superior marker of CAC relative to LDL cholesterol...
  11. pmc Race and gender variation in response to evoked inflammation
    Jane F Ferguson
    Cardiovascular Institute, Perelman School of Medicine, at the University of Pennsylvania, 11 136 Smilow Center for Translational Research, Building 421, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Transl Med 11:63. 2013
    ..Our objective was to examine race and gender influence on the response to experimental endotoxemia...
  12. pmc Tissue-specific RNA-Seq in human evoked inflammation identifies blood and adipose LincRNA signatures of cardiometabolic diseases
    Yichuan Liu
    From the Departments of Biostatistics and Epidemiology and Biology, Cardiovascular Institute, Perelman School of Medicine and School of Arts and Science at the University of Pennsylvania, Philadelphia
    Arterioscler Thromb Vasc Biol 34:902-12. 2014
    ....
  13. pmc Fractalkine is a novel human adipochemokine associated with type 2 diabetes
    Rachana Shah
    Division of Pediatric Endocrinology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 60:1512-8. 2011
    ..Fractalkine (CX3CL1) and its receptor (CX3CR1) comprise a chemokine system involved in leukocyte recruitment and adhesion in atherosclerosis, but its role in adipose inflammation and type 2 diabetes is unknown...
  14. pmc Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus
    Nehal N Mehta
    Cardiovascular Institute, Philadelphia, Pennsylvania, USA
    Am J Cardiol 107:406-11. 2011
    ....
  15. pmc Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians
    Atif N Qasim
    Cardiovascular Institute, Institute for Translational Medicine and Therapeutics, and Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Clin Endocrinol (Oxf) 70:698-705. 2009
    ..We hypothesized that the -420C>G putative gain-of-function resistin variant would be associated with inflammatory markers and atherosclerosis but not with metabolic syndrome or adipokines in humans...
  16. pmc Lipoprotein(a) is strongly associated with coronary artery calcification in type-2 diabetic women
    Atif N Qasim
    Department of Medicine, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Int J Cardiol 150:17-21. 2011
    ..The purpose of this study was to investigate whether type-2 diabetic subjects, relative to non-diabetics, might benefit more from Lp(a) measurement in the prediction of CHD risk, as measured by coronary artery calcium (CAC)...
  17. doi request reprint Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines
    Subhasish Bose
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 21:E118-23. 2013
    ..The association of plasma adipokines beyond waist circumference (WC) with coronary artery calcification (CAC), a measure of subclinical atherosclerosis, is unknown...
  18. pmc Comparison of high-density lipoprotein cholesterol to apolipoprotein A-I and A-II to predict coronary calcium and the effect of insulin resistance
    Seth S Martin
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, USA
    Am J Cardiol 107:393-8. 2011
    ..In conclusion, HDL cholesterol outperformed apoA-I and apoA-II in CAC prediction, but its association with CAC was attenuated by measures of insulin resistance...
  19. pmc Adipokines, insulin resistance, and coronary artery calcification
    Atif Qasim
    Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 52:231-6. 2008
    ..In addition, we assessed which biomarkers of adiposity and insulin resistance are the strongest predictors of CAC beyond traditional risk factors, metabolic syndrome, and plasma C-reactive protein (CRP)...
  20. pmc Adipocyte modulation of high-density lipoprotein cholesterol
    Yuzhen Zhang
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Circulation 121:1347-55. 2010
    ....
  21. pmc Gene profiling of human adipose tissue during evoked inflammation in vivo
    Rachana Shah
    Division of Pediatric Endocrinology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2211-9. 2009
    ..However, few human adipose-secreted proteins are known to mediate these processes. We hypothesized that microarray mRNA profiling of human adipose during evoked inflammation could identify novel adipocytokines...
  22. pmc A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trial
    Nehal N Mehta
    Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    J Transl Med 10:124. 2012
    ....
  23. ncbi request reprint Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes
    Muredach P Reilly
    Cardiovascular Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Endocrinol Metab 89:3872-8. 2004
    ..Whether leptin signaling promotes atherosclerosis directly or represents a therapeutic target for the prevention of atherosclerotic cardiovascular disease remains to be explored...
  24. ncbi request reprint Resistin is an inflammatory marker of atherosclerosis in humans
    Muredach P Reilly
    Division of Cardiology, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 111:932-9. 2005
    ..Given the convergence of adipocyte and macrophage function, resistin may provide unique insight into links between obesity, inflammation, and atherosclerosis in humans...
  25. ncbi request reprint Measures of insulin resistance add incremental value to the clinical diagnosis of metabolic syndrome in association with coronary atherosclerosis
    Muredach P Reilly
    Cardiovascular Division and Center for Experimental Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 110:803-9. 2004
    ....
  26. pmc Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway
    Fiona C McGillicuddy
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:31936-44. 2009
    ..We demonstrate that IFNgamma attenuates insulin sensitivity and suppresses differentiation in human adipocytes, an effect most likely mediated via sustained JAK-STAT1 pathway activation...
  27. ncbi request reprint Plasma cytokines, metabolic syndrome, and atherosclerosis in humans
    Muredach P Reilly
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    J Investig Med 55:26-35. 2007
    ..We hypothesized that plasma levels of IL-6 and soluble tumor necrosis factor alpha receptor 2 (sol-TNFR2) would be related to coronary atherosclerosis beyond established risk factors and the metabolic syndrome...
  28. ncbi request reprint CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans
    Michael Lehrke
    Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 49:442-9. 2007
    ..This study was designed to determine the association of CXCL16 with inflammation, atherosclerosis, and acute coronary syndromes...
  29. pmc Adipose genes down-regulated during experimental endotoxemia are also suppressed in obesity
    Rachana Shah
    Division of Endocrinology and Diabetes at the Children s Hospital of Philadelphia, 11NW Tower, 34th and Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 97:E2152-9. 2012
    ..Adipose inflammation is a crucial link between obesity and its metabolic complications. Human experimental endotoxemia is a controlled model for the study of inflammatory cardiometabolic responses in vivo...
  30. doi request reprint Endothelial lipase is increased in vivo by inflammation in humans
    Karen O Badellino
    School of Nursing, and Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 117:678-85. 2008
    ..Furthermore, we directly tested the hypothesis that plasma EL concentrations would increase with induction of an inflammatory state by low-dose endotoxin in humans...
  31. pmc Translational studies of lipoprotein-associated phospholipase A₂ in inflammation and atherosclerosis
    Jane F Ferguson
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Am Coll Cardiol 59:764-72. 2012
    ..This study sought to examine the role of lipoprotein-associated phospholipase A₂ (Lp-PLA₂/PLA2G7) in human inflammation and coronary atherosclerosis...
  32. pmc Adipose inflammation, insulin resistance, and cardiovascular disease
    Arti Shah
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    JPEN J Parenter Enteral Nutr 32:638-44. 2008
    ..Developing therapeutic strategies that target both adipose inflammation and insulin resistance may help to prevent type 2 diabetes and cardiovascular disease in the emerging epidemic of obesity...
  33. pmc A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 20:3109-17. 2011
    ..Our findings continue to corroborate that genes influencing male germ cell development and differentiation have emerged as the major players in inherited TGCT susceptibility...
  34. pmc Type 2 diabetes does not attenuate racial differences in coronary calcification
    Alisha N Wade
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, United States
    Diabetes Res Clin Pract 91:101-7. 2011
    ..We investigated the relationship of race and CAC in a sample of patients with type 2 diabetes without clinical CVD...
  35. pmc Inflammation impairs reverse cholesterol transport in vivo
    Fiona C McGillicuddy
    Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 119:1135-45. 2009
    ..The present study presents the first integrated functional evidence that inflammation retards numerous components of RCT...
  36. pmc Inflammation modulates human HDL composition and function in vivo
    Margarita de la Llera Moya
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Atherosclerosis 222:390-4. 2012
    ..Inflammation may directly impair HDL functions, in particular reverse cholesterol transport (RCT), but limited data support this concept in humans...
  37. pmc Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trial
    Shrita M Patel
    Division of Endocrinology, Diabetes, and Metabolism, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 94:2161-6. 2010
    ..To determine whether insulin sensitizers lower androgen levels and whether androgen suppression improves insulin resistance in nondiabetic postmenopausal women...
  38. pmc Inflammation induces fibrinogen nitration in experimental human endotoxemia
    Sean P Heffron
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Free Radic Biol Med 47:1140-6. 2009
    ..Inflammation-induced fibrinogen nitration may be a risk factor for promoting CVD events...
  39. ncbi request reprint Innate immunity modulates adipokines in humans
    Paul D Anderson
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
    J Clin Endocrinol Metab 92:2272-9. 2007
    ..Chronic inflammation converges in type 2 diabetes and atherosclerosis. Modulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis...
  40. pmc Importance of evaluating cell cholesterol influx with efflux in determining the impact of human serum on cholesterol metabolism and atherosclerosis
    Ginny L Weibel
    From the Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, PA G L W, D D S, D K S, G H R, M d l L M Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia M P R and School of Public Health and School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa A N W
    Arterioscler Thromb Vasc Biol 34:17-25. 2014
    ..Cholesterol efflux relates to cardiovascular disease but cannot predict cellular cholesterol mass changes. We asked whether influx and net flux assays provide additional insights...
  41. pmc A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis
    Robert J Brown
    Department of Medicine and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
    J Lipid Res 50:1910-6. 2009
    ..Thus, this N-terminal variant results in reduced secretion of EL protein, plausibly leading to increased HDL-C levels...
  42. pmc Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol
    Andrew C Edmondson
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Circ Cardiovasc Genet 4:145-55. 2011
    ..SNP selection was based on tagging SNPs and included low-frequency nonsynonymous SNPs...
  43. doi request reprint Intercellular adhesion molecule 1 (ICAM-1) gene variant is associated with coronary artery calcification independent of soluble ICAM-1 levels
    Muredach P Reilly
    Cardiovascular Division, Department of Medicine, The Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Investig Med 52:515-22. 2004
    ....
  44. pmc The long noncoding RNA landscape in hypoxic and inflammatory renal epithelial injury
    Jennie Lin
    Renal Electrolyte and Hypertension Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
    Am J Physiol Renal Physiol 309:F901-13. 2015
    ..The lncRNA landscape characterized here provides insights into novel transcriptomic variations in the renal epithelial cell response to hypoxic and inflammatory stress. ..
  45. pmc Insulin sensitivity index in type 1 diabetes and following human islet transplantation: comparison of the minimal model to euglycemic clamp measures
    Michael R Rickels
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Am J Physiol Endocrinol Metab 306:E1217-24. 2014
    ..That the minimal model SIC is highly correlated to the clamp-derived measures indicates that the FSIGT is an appropriate methodology for the determination of insulin sensitivity in T1D and following islet transplantation. ..
  46. pmc Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation
    Thomas P Cappola
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:2456-61. 2011
    ..The variant CLCNKA risk allele, telegraphed by linked variants in the adjacent HSPB7 gene, uncovers a previously overlooked genetic mechanism affecting the cardio-renal axis...
  47. pmc PennSeq: accurate isoform-specific gene expression quantification in RNA-Seq by modeling non-uniform read distribution
    Yu Hu
    Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA and Cardiovascular Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Nucleic Acids Res 42:e20. 2014
    ..Our results indicate superior performance of PennSeq over existing methods, particularly for isoforms demonstrating severe non-uniformity. PennSeq is freely available for download at http://sourceforge.net/projects/pennseq. ..
  48. pmc Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort)
    Jane F Ferguson
    Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    J Am Coll Cardiol 62:789-98. 2013
    ..This study sought to identify loci for coronary artery calcification (CAC) in patients with chronic kidney disease (CKD)...
  49. pmc Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease
    Shrita M Patel
    Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 94:4776-84. 2009
    ..Early postmenopausal women with higher testosterone (T) levels have increased insulin resistance (IR) and cardiovascular risk factors, but whether this translates into increased cardiovascular disease later in life is unknown...
  50. ncbi request reprint C-reactive protein and coronary artery calcification: The Study of Inherited Risk of Coronary Atherosclerosis (SIRCA)
    Muredach P Reilly
    Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, USA
    Arterioscler Thromb Vasc Biol 23:1851-6. 2003
    ..In the largest study to date, we examined the association of plasma CRP with coronary artery calcification (CAC) in 914 asymptomatic subjects in the Study of Inherited Risk of Coronary Atherosclerosis (SIRCA)...
  51. ncbi request reprint Coronary artery calcification and cardiovascular risk factors: impact of the analytic approach
    Muredach P Reilly
    Cardiovascular Division, Department of Medicine, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19004 6160, USA
    Atherosclerosis 173:69-78. 2004
    ..We present analytic approaches that are likely to provide consistent results and recommend the use of at least two distinct multivariable methods...
  52. ncbi request reprint Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo
    Snehal U Naik
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 113:90-7. 2006
    ..In the present study we used this approach to test the hypothesis that administration of the synthetic LXR agonist GW3965 would increase the rate of macrophage RCT in vivo...
  53. pmc Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes
    Atif N Qasim
    The Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
    Clin Endocrinol (Oxf) 74:44-50. 2011
    ..Whether CRP has value as a CVD risk marker in type-2 diabetes (T2DM) is unclear. We examined whether CRP has gender differences in association with coronary artery calcium (CAC) in diabetic and nondiabetic samples without clinical CVD...
  54. pmc C-reactive protein modifies the association of plasma leptin with coronary calcium in asymptomatic overweight individuals
    Seth S Martin
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 20:856-61. 2012
    ....
  55. pmc An inflammatory cascade leading to hyperresistinemia in humans
    Michael Lehrke
    Division of Endocrinology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS Med 1:e45. 2004
    ..Adipocyte-derived resistin is a circulating protein implicated in insulin resistance in rodents, but the role of human resistin is uncertain because it is produced largely by macrophages...
  56. pmc Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis
    Karen O Badellino
    Institute for Translational Medicine and Therapeutics, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Med 3:e22. 2006
    ..We hypothesized that EL concentrations would be associated with decreased HDL-C and increased atherosclerosis in humans...
  57. pmc Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing
    Jennie Lin
    From the Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine J L, Department of Biostatistics and Epidemiology Y H, M L, Department of Genetics, Perelman School of Medicine B C, K M, D J R, and Cardiovascular Institute, Department of Medicine, Perelman School of Medicine M G, W L, K M, University of Pennsylvania, Philadelphia Irving Institute for Clinical and Translational Research M P R and Division of Cardiology, Department of Medicine C X, H Z, M P R, Columbia University Medical Center, New York, NY and Department of Mathematics and Statistics, Mount Holyoke College, South Hadley, MA S N, A S F
    Arterioscler Thromb Vasc Biol 36:1434-47. 2016
    ..We investigated the extent to which AS occurs in M1 activation within the cardiometabolic disease context and validated a functional genomic cell model for studying human macrophage-related AS events...
  58. pmc Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease
    Hanrui Zhang
    From the Cardiovascular Institute H Z, C X, R S, K B, C C H, W L, A R, J T M, E E P, E E M, D J R, M P R, and Department of Biostatistics and Epidemiology M L, Perelman School of Medicine, Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism A R, M C, E E P, D J R, Department of Medicine, Metabolic Tracer Resource, Institute for Diabetes, Obesity, and Metabolism J S M, Institute for Regenerative Medicine Y L, R Y, W Y, E E M, Department of Biology, Perelman School of Medicine and School of Arts and Science S J G, B D G, Bundoora 3083
    Circ Res 117:17-28. 2015
    ..An efficient and reproducible source of genotype-specific human macrophages is essential for study of human macrophage biology and related diseases...
  59. pmc Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, USA
    Atherosclerosis 224:218-21. 2012
    ..We sought to study how chronic in vivo inflammation modulates lipoprotein particle composition using nuclear magnetic resonance spectroscopy (NMR) and HDL efflux in psoriasis...
  60. ncbi request reprint Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome
    Philippe O Szapary
    Division of General Internal Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Arterioscler Thromb Vasc Biol 26:182-8. 2006
    ..The purpose of this research was to evaluate the short-term effects of pioglitazone (PIO) on high-density lipoprotein cholesterol (HDL-C) and other metabolic parameters in nondiabetic patients with metabolic syndrome (MetSyn)...
  61. pmc Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania Medical Center, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Cardiovasc Drugs Ther 23:17-24. 2009
    ..Prior studies demonstrate beneficial effects of PKC beta inhibition on microvascular parameters, but, to date, no study has examined the effect on macrovascular atherosclerotic readouts...
  62. pmc Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
    Andrew C Edmondson
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Clin Invest 119:1042-50. 2009
    ..Our results establish that loss-of-function mutations in LIPG lead to increased HDL-C levels and support the idea that inhibition of endothelial lipase may be an effective mechanism to raise HDL-C...
  63. pmc Activation of innate immunity modulates insulin sensitivity, glucose effectiveness and pancreatic β-cell function in both African ancestry and European ancestry healthy humans
    Jane F Ferguson
    Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA Electronic address
    Metabolism 64:513-20. 2015
    ....
  64. pmc Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers
    Jane F Ferguson
    Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    Mol Nutr Food Res 58:601-13. 2014
    ..However, findings in clinical studies are conflicting. We hypothesized that n-3 PUFA supplementation would dose-dependently reduce the systemic inflammatory response to experimental endotoxemia in healthy humans...
  65. pmc Comparison of matrix metalloproteinase 9 and brain natriuretic peptide as clinical biomarkers in chronic heart failure
    Esther E Vorovich
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am Heart J 155:992-7. 2008
    ..We tested MMP-9 as a biomarker of remodeling and predictor of outcomes in a systolic heart failure cohort derived from clinical practice and compared its performance to brain natriuretic peptide (BNP)...
  66. pmc Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Nat Genet 41:811-5. 2009
    ..All of the genotypes were associated with both seminoma and nonseminoma TGCT subtypes. These results demonstrate that common genetic variants affect TGCT risk and implicate KITLG and SPRY4 as genes involved in TGCT susceptibility...
  67. pmc Evaluating the impact of sequencing depth on transcriptome profiling in human adipose
    Yichuan Liu
    Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e66883. 2013
    ..Our results suggest that a much higher sequencing depth is needed to reliably identify DAS events than for DE genes. ..
  68. pmc Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease
    Seth S Martin
    Department of Medicine, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Am Coll Cardiol 52:1201-10. 2008
    ..Leptin resistance and its interactions with metabolic and inflammatory factors, therefore, represent potential novel diagnostic and therapeutic targets in obesity-related cardiovascular disease...
  69. pmc Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
    Benjamin F Voight
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA
    Lancet 380:572-80. 2012
    ....
  70. ncbi request reprint Higher order lipase gene association with plasma triglycerides
    Muredach P Reilly
    Cardiovascular Division and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Lipid Res 46:1914-22. 2005
    ....
  71. pmc The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels
    Nehal N Mehta
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Penn Tower, 6th Floor, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA
    Eur Heart J 32:963-71. 2011
    ..Therefore, we examined the relationship between these two SNPs and plasma CXCL12 levels...
  72. pmc CXCL12: a new player in coronary disease identified through human genetics
    Samira S Farouk
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Trends Cardiovasc Med 20:204-9. 2010
    ..These GWAS demonstrate that CXCL12 may emerge as a potential therapeutic target for atherosclerosis and thrombosis...
  73. ncbi request reprint Coronary artery calcification at electron beam computed tomography is increased in asymptomatic type 2 diabetics independent of traditional risk factors
    Megan L Wolfe
    Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, 815 BRB2 3, Philadelphia, PA 19104, USA
    J Cardiovasc Risk 9:369-76. 2002
    ..We hypothesized that the presence and extent of CAC would be greater in asymptomatic type 2 diabetics than in non-diabetics independent of traditional risk factors...
  74. pmc Genetic basis of atherosclerosis: insights from mice and humans
    Ioannis M Stylianou
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, 654 BRBII III Labs, 421 Curie Boulevard, Philadelphia, Pennsylvania, 19104 6160, USA
    Circ Res 110:337-55. 2012
    ..The combination of mouse and human genetics has the potential to identify and validate novel genes that influence atherosclerosis, some of which may be candidates for new therapeutic approaches...
  75. pmc Atheroprotective lipoprotein effects of a niacin-simvastatin combination compared to low- and high-dose simvastatin monotherapy
    Subha L Airan-Javia
    The Cardiovascular Institute and the Institute for Translational Medicine and Therapeutics, Philadelphia, PA, USA
    Am Heart J 157:687.e1-8. 2009
    ..Niacin has multiple lipoprotein effects that may provide cardiovascular benefit when added to statin monotherapy...
  76. pmc Strong synaptic transmission impact by copy number variations in schizophrenia
    Joseph T Glessner
    Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10584-9. 2010
    ..Our results suggest that novel variations involving the processes of synaptic transmission contribute to the genetic susceptibility of schizophrenia...