Janina Ratajczak

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Adult murine bone marrow-derived very small embryonic-like stem cells differentiate into the hematopoietic lineage after coculture over OP9 stromal cells
    Janina Ratajczak
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S Floyd Street, Louisville, KY 40202, USA
    Exp Hematol 39:225-37. 2011
  2. ncbi request reprint The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner
    Magda Kucia
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, 529 South Jackson Street, Louisville, KY 40202, USA
    Arch Immunol Ther Exp (Warsz) 54:121-35. 2006
  3. ncbi request reprint Flt3-ligand-mobilized peripheral blood, but not Flt3-ligand-expanded bone marrow, facilitating cells promote establishment of chimerism and tolerance
    Yiming Huang
    Institute for Cellular Therapeutics, University of Louisville, 570 S Preston Street, Suite 404, Louisville, Kentucky 40202 1760, USA
    Stem Cells 24:936-48. 2006
  4. doi request reprint CXCR7: a new SDF-1-binding receptor in contrast to normal CD34(+) progenitors is functional and is expressed at higher level in human malignant hematopoietic cells
    Maciej Tarnowski
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Eur J Haematol 85:472-83. 2010
  5. pmc Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction
    Magda Kucia
    Stem Cell Biology Program, University of Louisville, Louisville, Ken 40202, USA
    Circ Res 95:1191-9. 2004
  6. ncbi request reprint Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient
    Marcin Wysoczynski
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 105:40-8. 2005
  7. ncbi request reprint Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis
    Magda Kucia
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Stem Cells 23:879-94. 2005
  8. pmc Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy
    Gabriela Schneider
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S Floyd Street, Louisville, KY 40202, USA
    Mol Cancer Res 11:793-807. 2013
  9. doi request reprint Very small embryonic-like (VSEL) stem cells: purification from adult organs, characterization, and biological significance
    Mariusz Z Ratajczak
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Louisville, KY 40202, USA
    Stem Cell Rev 4:89-99. 2008
  10. doi request reprint Optimization of isolation and further characterization of umbilical-cord-blood-derived very small embryonic/ epiblast-like stem cells (VSELs)
    Ewa K Zuba-Surma
    Stem Cell Biology Institute, University of Louisville, KY 40202, USA
    Eur J Haematol 84:34-46. 2010

Collaborators

Detail Information

Publications64

  1. pmc Adult murine bone marrow-derived very small embryonic-like stem cells differentiate into the hematopoietic lineage after coculture over OP9 stromal cells
    Janina Ratajczak
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S Floyd Street, Louisville, KY 40202, USA
    Exp Hematol 39:225-37. 2011
    ..g., Oct-4 and SSEA-4) that we named "very small embryonic-like stem cells" (VSELs). In this report, we test the hypothesis that VSELs can differentiate along the hemato/lymphopoietic lineage...
  2. ncbi request reprint The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner
    Magda Kucia
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, 529 South Jackson Street, Louisville, KY 40202, USA
    Arch Immunol Ther Exp (Warsz) 54:121-35. 2006
    ..In this study we evaluated whether TCSCs respond to other motomorphogens, such as hepatocyte growth factor (HGF) and leukemia inhibitory factor (LIF)...
  3. ncbi request reprint Flt3-ligand-mobilized peripheral blood, but not Flt3-ligand-expanded bone marrow, facilitating cells promote establishment of chimerism and tolerance
    Yiming Huang
    Institute for Cellular Therapeutics, University of Louisville, 570 S Preston Street, Suite 404, Louisville, Kentucky 40202 1760, USA
    Stem Cells 24:936-48. 2006
    ..These findings may have implications in development of strategies for retaining function of ex vivo manipulated FCs and HSCs...
  4. doi request reprint CXCR7: a new SDF-1-binding receptor in contrast to normal CD34(+) progenitors is functional and is expressed at higher level in human malignant hematopoietic cells
    Maciej Tarnowski
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Eur J Haematol 85:472-83. 2010
    ....
  5. pmc Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction
    Magda Kucia
    Stem Cell Biology Program, University of Louisville, Louisville, Ken 40202, USA
    Circ Res 95:1191-9. 2004
    ..The present findings provide a novel paradigm that could reconcile current controversies and a rationale for investigating the use of BM-derived cardiac progenitors for myocardial regeneration...
  6. ncbi request reprint Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient
    Marcin Wysoczynski
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 105:40-8. 2005
    ....
  7. ncbi request reprint Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis
    Magda Kucia
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Stem Cells 23:879-94. 2005
    ....
  8. pmc Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy
    Gabriela Schneider
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S Floyd Street, Louisville, KY 40202, USA
    Mol Cancer Res 11:793-807. 2013
    ..These data indicate that bioactive lipids play a vital role in dissemination of RMS and contribute to the unwanted side effects of radio/chemotherapy by creating a prometastatic microenvironment...
  9. doi request reprint Very small embryonic-like (VSEL) stem cells: purification from adult organs, characterization, and biological significance
    Mariusz Z Ratajczak
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Louisville, KY 40202, USA
    Stem Cell Rev 4:89-99. 2008
    ..We named these primitive cells very small embryonic-like (VSEL) SCs. Our data indicate that VSELs may differentiate into cells from all three germ layers...
  10. doi request reprint Optimization of isolation and further characterization of umbilical-cord-blood-derived very small embryonic/ epiblast-like stem cells (VSELs)
    Ewa K Zuba-Surma
    Stem Cell Biology Institute, University of Louisville, KY 40202, USA
    Eur J Haematol 84:34-46. 2010
    ..The whole isolation procedure takes approximately 2-3 h per UCB unit and isolated cells are highly enriched for an Oct-4(+) and SSEA-4(+) population of small Lin(-)/CD45(-)/CD133(+) cells...
  11. doi request reprint Fetal liver very small embryonic/epiblast like stem cells follow developmental migratory pathway of hematopoietic stem cells
    Ewa K Zuba-Surma
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Ann N Y Acad Sci 1176:205-18. 2009
    ..Thus, our data support the hypothesis that VSELs are a mobile pool of primitive stem cells that respond to similar chemotactic gradients as HSCs and follow their developmental migratory route...
  12. doi request reprint Evidence that very small embryonic-like stem cells are mobilized into peripheral blood
    Magda J Kucia
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Room 107, Louisville, Kentucky 40202, USA
    Stem Cells 26:2083-92. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  13. pmc Paracrine proangiopoietic effects of human umbilical cord blood-derived purified CD133+ cells--implications for stem cell therapies in regenerative medicine
    Janina Ratajczak
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Stem Cells Dev 22:422-30. 2013
    ..This observation should be taken into consideration when evaluating clinical outcomes from purified CD133+ cell therapies in regenerative medicine...
  14. doi request reprint A multi-instrumental approach to identify and purify very small embryonic like stem cells (VSELs) from adult tissues
    Mariusz Z Ratajczak
    University of Louisville, 500 South Floyd Street, Louisville, KY 40202, USA
    Micron 40:386-93. 2009
    ..We believe that VSELs could be harnessed as a source of pluripotent stem cells for regenerative medicine...
  15. ncbi request reprint Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy
    Kacper Jankowski
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, 529 South Jackson Street, Louisville, KY 40202, USA
    Cancer Res 63:7926-35. 2003
    ..Signaling from the c-MET receptor may also contribute to the resistance of RMS cells to conventional treatment modalities...
  16. pmc Overlapping and distinct role of CXCR7-SDF-1/ITAC and CXCR4-SDF-1 axes in regulating metastatic behavior of human rhabdomyosarcomas
    Katarzyna Grymula
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Int J Cancer 127:2554-68. 2010
    ....
  17. ncbi request reprint Leukemia inhibitory factor: a newly identified metastatic factor in rhabdomyosarcomas
    Marcin Wysoczynski
    James Graham Brown Cancer Center, University of Louisville, 580 South Preston Street, Louisville, KY 40202, USA
    Cancer Res 67:2131-40. 2007
    ..Further, because we showed that the in vivo metastasis of RH30 cells is inhibited by small interfering RNA against LIF-R, molecular targeting of this axis could become a new strategy to control the metastasis of rhabdomyosarcoma...
  18. ncbi request reprint Modulation of the SDF-1-CXCR4 axis by the third complement component (C3)--implications for trafficking of CXCR4+ stem cells
    Marius Z Ratajczak
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Exp Hematol 34:986-95. 2006
    ..In this review we will focus on interactions between the SDF-1-CXCR4 axis and the C3 cleavage fragments in a model of mobilization, trafficking, and homing of hematopoietic stem/progenitor cells (HSPC)...
  19. ncbi request reprint A pivotal role of activation of complement cascade (CC) in mobilization of hematopoietic stem/progenitor cells (HSPC)
    Mariusz Z Ratajczak
    James Graham Brown Cancer Center, Stem Cell Institute, University of Louisville, Louisville, KY 40202, USA
    Adv Exp Med Biol 632:47-60. 2008
    ..Hence modulation of CC activation could allow for the development of more efficient mobilization strategies in patients who are poor mobilizers of HSPC...
  20. pmc Very small embryonic/epiblast-like stem cells (VSELs) and their potential role in aging and organ rejuvenation--an update and comparison to other primitive small stem cells isolated from adult tissues
    Mariusz Z Ratajczak
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KT, USA
    Aging (Albany NY) 4:235-46. 2012
    ..Finally, while murine BM-derived VSELs have been extensively characterized more work is needed to better characterize these small cells at the molecular level in humans...
  21. ncbi request reprint CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion
    Magda Kucia
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    J Mol Histol 35:233-45. 2004
    ..In this review, we focus on a role of the SDF-1-CXCR4 axis in regulating the metastatic behaviour of tumour cells and discuss the molecular mechanisms that are essential to this process...
  22. pmc Sphingosine-1-phosphate-mediated mobilization of hematopoietic stem/progenitor cells during intravascular hemolysis requires attenuation of SDF-1-CXCR4 retention signaling in bone marrow
    Kasia Mierzejewska
    Stem Cell Institute, James Graham Brown Cancer Center, University of Louisville, 500 S Floyd Street, Room 107, Louisville, KY 40202, USA Department of Physiology, Pomeranian Medical University, Szczecin, Poland
    Biomed Res Int 2013:814549. 2013
    ..However, to egress from BM, HSPCs first have to be released from BM niches by blocking the SDF-1-CXCR4 retention signal. ..
  23. doi request reprint Molecular characterization of isolated from murine adult tissues very small embryonic/epiblast like stem cells (VSELs)
    Dong Myung Shin
    Stem Cell Institute, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
    Mol Cells 29:533-8. 2010
    ..Mounting evidence accumulates that perturbation of expression of imprinted genes is a common phenomenon observed in developing tumors...
  24. pmc Macrophage migration inhibitory factor is secreted by rhabdomyosarcoma cells, modulates tumor metastasis by binding to CXCR4 and CXCR7 receptors and inhibits recruitment of cancer-associated fibroblasts
    Maciej Tarnowski
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Mol Cancer Res 8:1328-43. 2010
    ..Our data indicate that therapeutic inhibition of MIF in RMS may accelerate metastasis and tumor growth...
  25. ncbi request reprint Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1
    Ryan Reca
    Stem Cell Biology Program, University of Louisville, Louisville, KY 40202, USA
    Blood 101:3784-93. 2003
    ..C3a is the first positive regulator of this axis to be identified...
  26. pmc The negative effect of prolonged somatotrophic/insulin signaling on an adult bone marrow-residing population of pluripotent very small embryonic-like stem cells (VSELs)
    Magda Kucia
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S Floyd Street, Louisville, KY 40202, USA
    Age (Dordr) 35:315-30. 2013
    ..Thus, we propose that a chronic increase in IIS contributes to aging by premature depletion of pluripotent VSELs in adult tissues...
  27. ncbi request reprint A novel role of complement in mobilization: immunodeficient mice are poor granulocyte-colony stimulating factor mobilizers because they lack complement-activating immunoglobulins
    Ryan Reca
    Stem Cell Institute, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Stem Cells 25:3093-100. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  28. pmc Very small embryonic-like stem cells are present in adult murine organs: ImageStream-based morphological analysis and distribution studies
    Ewa K Zuba-Surma
    Stem Cell Biology Institute, University of Louisville, Louisville, Kentucky 40202, USA
    Cytometry A 73:1116-27. 2008
    ..Further studies are needed to determine whether these cells, after being isolated from various adult human organs similarly to their murine BM-derived counterparts, are endowed with pluripotent stem cell properties...
  29. doi request reprint The role of pluripotent embryonic-like stem cells residing in adult tissues in regeneration and longevity
    Mariusz Z Ratajczak
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Differentiation 81:153-61. 2011
    ..We provide an evidence that the quiescent state of these cells in adult tissues, which prevents teratoma formation, is the result of epigenetic changes in some of the imprinted genes...
  30. pmc Beta-glucan enhances complement-mediated hematopoietic recovery after bone marrow injury
    Daniel E Cramer
    Tumor Immunobiology Program, James Graham Brown Cancer Center, University of Louisville, 580 South Preston St, Louisville, KY 40202, USA
    Blood 107:835-40. 2006
    ..Taken together, these observations suggest a novel role for C, CR3, and beta-glucan in the restoration of hematopoiesis following injury...
  31. ncbi request reprint The third complement component as modulator of platelet production
    Marcin Wysoczynski
    James Graham Brown Cancer Center University of Louisville, Stem Cell Biology Program, Louisville, KY 40202, USA
    Adv Exp Med Biol 598:226-39. 2007
  32. ncbi request reprint Adult marrow-derived very small embryonic-like stem cells and tissue engineering
    Magda Kucia
    University of Louisville, Stem Cell Institute at James Graham Brown Cancer Center, 500 South Floyd Street, Louisville, KY 40202, USA
    Expert Opin Biol Ther 7:1499-514. 2007
    ..The authors envision that VSEL-SC are epiblast-derived pluripotent stem cells and could potentially become a less-controversial source of stem cells for regeneration...
  33. pmc Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells--implications for tissue regeneration
    Chihwa Kim
    Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Kentucky 40202, USA
    Stem Cells 31:500-10. 2013
    ....
  34. pmc RasGrf1: genomic imprinting, VSELs, and aging
    Mariusz Z Ratajczak
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Aging (Albany NY) 3:692-7. 2011
    ..All this in toto supports a concept that the sperm genome may have a detrimental effect on longevity in mammals. We will discuss a role of RasGrf1 on life span in context of genomic imprinting and VSELs...
  35. ncbi request reprint Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow
    Janina Ratajczak
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, 529 South Jackson St, KY 40202, USA
    Blood 103:2071-8. 2004
    ..The C3a-C3aR axis may prevent an uncontrolled release of HSPCs into peripheral blood. These data further suggest that the C3aR antagonist SB 290157 could be developed as a drug to mobilize HSPCs for transplantation...
  36. ncbi request reprint Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury
    Magda Kucia
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202 3270, USA
    Blood Cells Mol Dis 32:52-7. 2004
    ....
  37. pmc Hunt for pluripotent stem cell -- regenerative medicine search for almighty cell
    Mariusz Z Ratajczak
    Stem Cell Institute, James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Louisville, KY 40202, USA
    J Autoimmun 30:151-62. 2008
    ..This review will summarize current approaches and limitations to isolate PSC from adult tissues or, alternatively, to generate it by nuclear reprogramming from already differentiated somatic cells...
  38. pmc Very small embryonic-like stem cells: characterization, developmental origin, and biological significance
    Mariusz Z Ratajczak
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Exp Hematol 36:742-51. 2008
    ..Finally, we envision that in pathological situations VSELs are involved in development of some malignancies (e.g., teratomas, germinal tumors)...
  39. pmc "Small stem cells" in adult tissues: very small embryonic-like stem cells stand up!
    Ewa K Zuba-Surma
    Stem Cell Biology Institute, University of Louisville, Louisville, Kentucky 40202, USA
    Cytometry A 75:4-13. 2009
    ..We will also present different populations of very "small SCs" that have been recently described in the literature (e.g., spore-like cells and Lin(-)/ALDH(high) long-term repopulating hematopoietic SCs)...
  40. ncbi request reprint Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets
    Marcin Majka
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Exp Hematol 30:751-60. 2002
    ..We attempted to identify signal transduction pathways activated by these factors in normal human megakaryocytes...
  41. pmc The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells
    Mariusz Z Ratajczak
    University of Louisville, Stem Cell Institute, James Graham Brown Cancer Center, 500 S Floyd Street, Rm 107, Louisville, KY 40202, USA 1 502 852 1788 1 502 852 3032
    Expert Opin Ther Targets 18:95-107. 2014
    ..However, additional evidence has accumulated that, in addition to these peptide-based chemoattractants, an important role in cell migration is played by bioactive lipids...
  42. doi request reprint Erythrocyte-derived microvesicles may transfer phosphatidylserine to the surface of nucleated cells and falsely 'mark' them as apoptotic
    Rui Liu
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Eur J Haematol 83:220-9. 2009
    ..This observation should be considered whenever Ann-V binding viability assays are employed to evaluate the quality of NCs depleted from erythrocytes via hypotonic lysis...
  43. pmc Evidence for the involvement of sphingosine-1-phosphate in the homing and engraftment of hematopoietic stem cells to bone marrow
    Mateusz Adamiak
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
    Oncotarget 6:18819-28. 2015
    ..They also support the concept that, in addition to the SDF-1-CXCR4 axis, other chemotactic axes are also involved in homing and engraftment of HSPCs. ..
  44. pmc Epiblast/germ line hypothesis of cancer development revisited: lesson from the presence of Oct-4+ cells in adult tissues
    Mariusz Z Ratajczak
    Stem Cell Institute, James Graham Brown Cancer Center, University of Louisville, 500 S Floyd Street, Louisville, KY 40202, USA
    Stem Cell Rev 6:307-16. 2010
    ..However, we are aware that this working hypothesis requires further direct experimental confirmation...
  45. pmc Genome-wide analysis of murine bone marrow‑derived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells
    Katarzyna Mierzejewska
    Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
    Int J Mol Med 32:281-90. 2013
    ..Thus, restoring the responsiveness to mitogenic growth factors may be a crucial step in employing these cells in regenerative medicine...
  46. ncbi request reprint Bone marrow as a source of circulating CXCR4+ tissue-committed stem cells
    Magda Kucia
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Biol Cell 97:133-46. 2005
    ....
  47. pmc The expanding family of bone marrow homing factors for hematopoietic stem cells: stromal derived factor 1 is not the only player in the game
    Mariusz Z Ratajczak
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    ScientificWorldJournal 2012:758512. 2012
    ....
  48. doi request reprint The role of innate immunity in trafficking of hematopoietic stem cells-an emerging link between activation of complement cascade and chemotactic gradients of bioactive sphingolipids
    Mariusz Z Ratajczak
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
    Adv Exp Med Biol 946:37-54. 2012
    ..Finally, the chemotactic activity of all chemoattractants for HSPCs including SDF-1, S1P and C1P is enhanced in presence of CC cleavage fragments (e.g., C3a) and MAC that is a final product of CC activation...
  49. ncbi request reprint Quiescent CD34+ early erythroid progenitors are resistant to several erythropoietic 'inhibitory' cytokines; role of FLIP
    Janina Ratajczak
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Br J Haematol 123:160-9. 2003
    ..Thus, we hypothesize that cycling cells may become more sensitive to proapoptotic stimuli (e.g. chemotherapy, inhibitory cytokines) than quiescent ones because of the downregulation of protective FLIP...
  50. ncbi request reprint Are bone marrow stem cells plastic or heterogenous--that is the question
    Magda Kucia
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Exp Hematol 33:613-23. 2005
    ..In this review, we will discuss this alternative explanation of plasticity of HSC, providing data from others and our laboratory that supports the concept that BM-derived stem cells are heterogeneous...
  51. pmc The role of stromal-derived factor-1--CXCR7 axis in development and cancer
    Radoslaw B Maksym
    Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Eur J Pharmacol 625:31-40. 2009
    ..Augmenting evidence suggests that CXCR7 is involved in several aspects of tumorogenesis and could become an important target for new anti-metastatic and anti-cancer drugs...
  52. pmc Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes
    Teresa W M Fan
    Department of Chemistry, University of Louisville, KY, USA
    Mol Cancer 7:79. 2008
    ..These include metabolites that report on the activity of glycolysis, Krebs' cycle, pentose phosphate pathway and pyrimidine biosynthesis...
  53. pmc The proper criteria for identification and sorting of very small embryonic-like stem cells, and some nomenclature issues
    Malwina Suszynska
    1 Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky
    Stem Cells Dev 23:702-13. 2014
    ....
  54. pmc Very small embryonic-like (VSEL) stem cells in adult organs and their potential role in rejuvenation of tissues and longevity
    Mariusz Z Ratajczak
    Stem Cell Institute at James Graham Brown Cancer Center, Hoenig Endowed Chair in Cancer Biology, University of Louisville, Louisville, KY 40202, USA
    Exp Gerontol 43:1009-17. 2008
    ..Thus, these cells are potential SCs candidates for regenerative medicine and we envision that the regenerative potential of these cells could be harnessed to decelerate the aging processes...
  55. ncbi request reprint Innate immunity as orchestrator of bone marrow homing for hematopoietic stem/progenitor cells
    Mariusz Z Ratajczak
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, 500 S Floyd Street, Rm 107, Louisville, KY 40202, USA
    Adv Exp Med Biol 735:219-32. 2013
    ..We also propose modulation of CC as a novel strategy to optimize/accelerate homing of HSPCs...
  56. pmc A novel insight into aging: are there pluripotent very small embryonic-like stem cells (VSELs) in adult tissues overtime depleted in an Igf-1-dependent manner?
    Mariusz Z Ratajczak
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Aging (Albany NY) 2:875-83. 2010
    ..Our preliminary data in long-living Igf-1-signaling-deficient mice show that these animals possess a 3-4 times higher number of VSELs deposited in adult BM, lending support to this novel hypothesis...
  57. doi request reprint An emerging link in stem cell mobilization between activation of the complement cascade and the chemotactic gradient of sphingosine-1-phosphate
    Mariusz Z Ratajczak
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Prostaglandins Other Lipid Mediat 104:122-9. 2013
    ....
  58. pmc Human haematopoietic stem/progenitor cells express several functional sex hormone receptors
    Ahmed Abdelbaset-Ismail
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
    J Cell Mol Med 20:134-46. 2016
    ..Most importantly, SexH if added to suboptimal doses of haematopoietic cytokines and growth factors enhance clonogenic growth of human HSPCs as well as directly stimulate proliferation of MSCs. ..
  59. ncbi request reprint Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients
    Paula M Chilton
    Institute for Cellular Therapeutics, University of Louisville, 570 South Preston St, Suite 404, Louisville, KY 40202 1760, USA
    Blood 105:2189-97. 2005
    ..These findings may have important implications to understand the evolution of autoimmune disease and impact on potential strategies for cure...
  60. ncbi request reprint Biological significance of the different erythropoietic factors secreted by normal human early erythroid cells
    Janina Ratajczak
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leuk Lymphoma 44:767-74. 2003
    ....
  61. pmc The cell cycle- and insulin-signaling-inhibiting miRNA expression pattern of very small embryonic-like stem cells contributes to their quiescent state
    Magdalena Maj
    Stem Cell Institute, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Exp Biol Med (Maywood) 240:1107-11. 2015
    ..These observations are important for understanding the biology of these cells and for developing efficient ex vivo expansion strategies for VSELs isolated from adult tissues. ..
  62. ncbi request reprint Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV
    Tomasz Rozmyslowicz
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    AIDS 17:33-42. 2003
    ..We found that peripheral blood platelet- (PMP) and megakaryocyte-derived MP (MegaMP) that highly express CXCR4 may transfer this receptor from the surface of platelets or megakaryocytes to the surface of CXCR4-null cells...
  63. doi request reprint CD133 Expression Strongly Correlates with the Phenotype of Very Small Embryonic-/Epiblast-Like Stem Cells
    Mariusz Z Ratajczak
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S Floyd Street, 40202 Rm 107, Louisville, KY, USA
    Adv Exp Med Biol 777:125-41. 2013
    ..However, still more labor is needed to characterize better at a molecular level these rare cells...
  64. pmc Expression of the erythropoietin receptor by germline-derived cells - further support for a potential developmental link between the germline and hematopoiesis
    Malwina Suszynska
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S Floyd Street, Rm 107, Louisville, KY 40202, USA Department of Physiology, Pomeranian Medical University, Szczecin, Poland
    J Ovarian Res 7:66. 2014
    ..These two properties of VSELs support the possibility of a developmental origin of HSPCs from migrating PGCs...