R Lor Randall

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Grade 1 chondrosarcoma of bone: a diagnostic and treatment dilemma
    R Lor Randall
    Department of Orthopedics, Huntsman Cancer Institute and Primary Children s Medical Center, University of Utah, Salt Lake City, UT 84112 5550, USA
    J Natl Compr Canc Netw 3:149-56. 2005
  2. ncbi request reprint Validation of cDNA microarray analysis to distinguish tumor type ex vivo
    R Lor Randall
    Sarcoma Service, University of Utah, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res . 2003
  3. ncbi request reprint Retrieval yield of total and messenger RNA in mesenchymal tissue ex vivo
    R Lor Randall
    SARC Lab, Sarcoma Service Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res . 2003
  4. pmc Potential for modulation of the fas apoptotic pathway by epidermal growth factor in sarcomas
    David E Joyner
    Department of Orthopaedics, Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USA
    Sarcoma 2011:847409. 2011
  5. doi request reprint FAP-associated desmoid invasiveness correlates with in vitro resistance to doxorubicin
    David E Joyner
    Department of Orthopaedics, Sarcoma Services, SARC Laboratory, and Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Fam Cancer 8:569-80. 2009
  6. ncbi request reprint Potential for functional redundancy in EGF and TGFalpha signaling in desmoid cells: a cDNA microarray analysis
    Sylvia H Trang
    SARC Laboratory, Sarcoma Services, Department of Orthopaedics and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Growth Factors 28:10-23. 2010
  7. doi request reprint Preoperative versus postoperative radiotherapy in soft-tissue sarcoma: multi-institutional analysis of 821 patients
    Sagus Sampath
    Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, UT 84106, USA
    Int J Radiat Oncol Biol Phys 81:498-505. 2011
  8. ncbi request reprint G3139 antisense oligonucleotide directed against antiapoptotic Bcl-2 enhances doxorubicin cytotoxicity in the FU-SY-1 synovial sarcoma cell line
    David E Joyner
    SARC Laboratory, Sarcoma Services, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA
    J Orthop Res 24:474-80. 2006
  9. ncbi request reprint Doxorubicin induces cell senescence preferentially over apoptosis in the FU-SY-1 synovial sarcoma cell line
    David E Joyner
    SARC Laboratory, Sarcoma Services, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA
    J Orthop Res 24:1163-9. 2006
  10. doi request reprint Desmoid cell motility is induced in vitro by rhEGF
    David E Joyner
    Department of Orthopaedics, University of Utah, Salt Lake City, Utah 84112, USA
    J Orthop Res 27:1258-62. 2009

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Grade 1 chondrosarcoma of bone: a diagnostic and treatment dilemma
    R Lor Randall
    Department of Orthopedics, Huntsman Cancer Institute and Primary Children s Medical Center, University of Utah, Salt Lake City, UT 84112 5550, USA
    J Natl Compr Canc Netw 3:149-56. 2005
    ..We discuss the promise of emerging molecular technologies. Finally, we provide a review of the available literature on treatment outcomes, along with a discussion of our own particular preferences...
  2. ncbi request reprint Validation of cDNA microarray analysis to distinguish tumor type ex vivo
    R Lor Randall
    Sarcoma Service, University of Utah, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res . 2003
    ....
  3. ncbi request reprint Retrieval yield of total and messenger RNA in mesenchymal tissue ex vivo
    R Lor Randall
    SARC Lab, Sarcoma Service Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res . 2003
    ..Surgeons, pathologists, and clinical intermediaries must be aware of issues surrounding messenger ribonucleic acid retrieval from surgical specimens to optimize collection...
  4. pmc Potential for modulation of the fas apoptotic pathway by epidermal growth factor in sarcomas
    David E Joyner
    Department of Orthopaedics, Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USA
    Sarcoma 2011:847409. 2011
    ..Cells destined for elimination inhibit this prosurvival response via a presently undefined pathway. This scenario represents a novel role for EGF and CTGF as regulators of the Fas pathway in sarcomas...
  5. doi request reprint FAP-associated desmoid invasiveness correlates with in vitro resistance to doxorubicin
    David E Joyner
    Department of Orthopaedics, Sarcoma Services, SARC Laboratory, and Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Fam Cancer 8:569-80. 2009
    ..Three genes associated with apoptosis were identified by microarray, two prosurvival genes overexpressed in FAP-associated cell cultures (NTN1, TNFRSF10C) and one proapoptosis gene overexpressed in sporadic tumor cell cultures (FOXL2)...
  6. ncbi request reprint Potential for functional redundancy in EGF and TGFalpha signaling in desmoid cells: a cDNA microarray analysis
    Sylvia H Trang
    SARC Laboratory, Sarcoma Services, Department of Orthopaedics and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Growth Factors 28:10-23. 2010
    ..Approximately 150 genes costimulated by rhEGF and rhTGFalpha were identified. This study suggests that EGF and TGFalpha retain some level of functional redundancy, possibly resulting from their divergence from a common ancestral gene...
  7. doi request reprint Preoperative versus postoperative radiotherapy in soft-tissue sarcoma: multi-institutional analysis of 821 patients
    Sagus Sampath
    Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, UT 84106, USA
    Int J Radiat Oncol Biol Phys 81:498-505. 2011
    ..To assess the impact of radiotherapy (RT) sequencing with surgery on overall survival (OS), cause-specific survival (CSS), local failure, and distant failure in soft-tissue sarcoma (STS)...
  8. ncbi request reprint G3139 antisense oligonucleotide directed against antiapoptotic Bcl-2 enhances doxorubicin cytotoxicity in the FU-SY-1 synovial sarcoma cell line
    David E Joyner
    SARC Laboratory, Sarcoma Services, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA
    J Orthop Res 24:474-80. 2006
    ..G3139 anti-Bcl-2 intervention sensitized the FU-SY-1 SS to doxorubicin, due to increased apoptosis. G3139 intervention was ineffective in the two non-SS cell lines...
  9. ncbi request reprint Doxorubicin induces cell senescence preferentially over apoptosis in the FU-SY-1 synovial sarcoma cell line
    David E Joyner
    SARC Laboratory, Sarcoma Services, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA
    J Orthop Res 24:1163-9. 2006
    ..Likely, both apoptosis and cell senescence contribute to doxorubicin-induced cell death in this synovial sarcoma cell line...
  10. doi request reprint Desmoid cell motility is induced in vitro by rhEGF
    David E Joyner
    Department of Orthopaedics, University of Utah, Salt Lake City, Utah 84112, USA
    J Orthop Res 27:1258-62. 2009
    ..When EGF and TGFbeta1 receptors were inhibited simultaneously, the level of rhEGF-induced cell migration was reduced significantly beyond the level of cell migration generated by inhibition of EGFR alone...
  11. pmc Fas death pathway in sarcomas correlates with epidermal growth factor transcription
    David E Joyner
    Department of Orthopaedics, Sarcoma Services, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res 466:2092-8. 2008
    ..The results suggest ligand activity in the Fas death pathway correlates with EGF transcription in sarcomas...
  12. pmc Of mice and men: opportunities to use genetically engineered mouse models of synovial sarcoma for preclinical cancer therapeutic evaluation
    Kevin B Jones
    Department of Orthopaedic Surgery, The Center for Children s Cancer Research, at the University of Utah, Salt Lake City, Utah, USA
    Cancer Control 18:196-203. 2011
    ..The biological differences between sarcoma subtypes make inclusion of multiple types in general trials unsatisfactory as well...
  13. pmc Complications of cemented long-stem hip arthroplasty in metastatic bone disease revisited
    Shawn L Price
    Department of Orthopaedics Sarcoma Services, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Drive, Salt Lake City, UT, 84112, USA
    Clin Orthop Relat Res 471:3303-7. 2013
    ..Embolic events may precipitate cardiopulmonary complications and even death; by contrast, others have reported that the use of a cemented long-stem femoral arthroplasty in patients with metastatic bone disease is a safe procedure...
  14. pmc Complex genotype sarcomas display familial inheritance independent of known cancer predisposition syndromes
    Kevin B Jones
    Sarcoma Services, Department of Orthopaedics, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cancer Epidemiol Biomarkers Prev 20:751-7. 2011
    ..The low incidence of sarcomas in the general population makes heritable contribution to disease risk difficult to discern beyond highly penetrant Mendelian syndromes...
  15. pmc Exploiting antitumor immunity to overcome relapse and improve remission duration
    Lei L Chen
    Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
    Cancer Immunol Immunother 61:1113-24. 2012
    ....
  16. pmc Extremity sarcoma surgery in younger children: ten years of patients ten years and under
    Ryan B Israelsen
    Department of Orthopaedic Surgery, University of Utah, Salt Lake City, USA
    Iowa Orthop J 31:145-53. 2011
    ..Sarcoma surgery in the younger growing child presents challenges for the surgeon, patient, and parents, but is usually successful in the long-term...
  17. pmc Microsatellites with macro-influence in ewing sarcoma
    Michael J Monument
    Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Genes (Basel) 3:444-60. 2012
    ..This unprecedented role of GGAA microsatellite DNA in Ewing sarcoma provides a unique opportunity to expand our mechanistic understanding of how EWS/ETS fusions influence cancer susceptibility, prognosis and transcriptional regulation. ..
  18. pmc Lost in translation: ambiguity in nerve sheath tumor nomenclature and its resultant treatment effect
    Nicholas M Bernthal
    Sarcoma Services, Department of Orthopaedics, Huntsman Cancer Institute and Primary Childrens Medical Center, University of Utah, Salt Lake City, UT 84112, USA
    Cancers (Basel) 5:519-28. 2013
    ..This study reviews the diagnostic criteria used to designate atypical neurofibroma from low-grade MPNSTs and reviews existing literature the natural history of each of these tumors to see if the distinction is, in fact, of importance. ..
  19. ncbi request reprint Diagnosis and management of synovial sarcoma
    R Lor Randall
    Sarcoma Services, Suite 4260, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Curr Treat Options Oncol 6:449-59. 2005
    ..Meanwhile, carefully designed clinical trials of these agents, with translational correlates, will provide in vivo data to complement the preclinical experience...
  20. ncbi request reprint Percutaneous curettage and bone grafting for humeral simple bone cysts
    Kenneth J Hunt
    Department of Orthopedics, University of Utah, Salt Lake City, Utah, USA
    Orthopedics 32:89. 2009
    ..As expected, partial recurrence of active cysts after treatment with this method is high. This percutaneous technique is a safe and effective treatment for humeral simple bone cysts...
  21. pmc Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: a report from the Children's Oncology Group
    Daniel M Lerman
    Department of Orthopedics, University of Utah, Salt Lake City, Utah Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah
    Pediatr Blood Cancer 62:759-65. 2015
    ..We sought to evaluate these variables in patients with localized disease treated prospectively on a single Children's Oncology Group protocol...
  22. pmc Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma
    Aashi Chaturvedi
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112 Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112
    Mol Biol Cell 25:2695-709. 2014
    ..This selective advantage is paired with a tradeoff in which metastatic lung colonization is compromised. ..
  23. ncbi request reprint Discriminate gene lists derived from cDNA microarray profiles of limited samples permit distinguishing mesenchymal neoplasia ex vivo
    David E Joyner
    SAR Lab, Sarcoma Services, Department of Orthopedics, Huntsman Cancer Institute and Primary Children s Medical Center, University of Utah, Salt Lake City, UT 84112, USA
    J Cancer Res Clin Oncol 131:137-46. 2005
    ..This technique may enable an eventual molecular classification schema based on expression profiles that can complement current clinical and pathologic diagnostic procedures in mesenchymal tumors...
  24. pmc Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma
    Mona S Jahromi
    Center for Children s Cancer Research C3R, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
    Cancer Genet 205:391-404. 2012
    ..CNAs detected by microarray correlate with outcome and may be useful for risk stratification in future clinical trials...
  25. ncbi request reprint Sacral resection and reconstruction for tumors and tumor-like conditions
    R Lor Randall
    Sarcoma Services, Department of Orthopedics, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
    Orthopedics 28:307-13. 2005
    ..The complication rate was 33%. Tumor control was achieved in 73%. Postoperative complications occurred in 33%. Sacral resection remains a challenging operation...
  26. pmc miRNA signatures associate with pathogenesis and progression of osteosarcoma
    Kevin B Jones
    Department of Orthopaedics and Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
    Cancer Res 72:1865-77. 2012
    ..Thus, our findings establish a miRNA signature associated with pathogenesis of osteosarcoma as well as critical pre-treatment biomarkers of metastasis and responsiveness to therapy...
  27. ncbi request reprint Oncogene coexpression in mesenchymal neoplasia correlates with EGF transcription
    David E Joyner
    Huntsman Cancer Institute, Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res 459:14-21. 2007
    ..EGF may enhance, or may indicate the presence of, oncogene coexpression in benign mesenchymal lesions, but counters gene synchronization in sarcomas...
  28. ncbi request reprint Case reports: fibrosarcoma metastatic to the sciatic nerve
    R Lor Randall
    Sarcoma Services, Huntsman Cancer Institute and Primary Children s Medical Center, Salt Lake City, UT 84132, USA
    Clin Orthop Relat Res . 2005
    ..However, we know of no recorded case of spread to a major peripheral nerve. We report a unique occurrence of fibrosarcoma with metastatic involvement of the sciatic nerve, and a review of the literature...
  29. pmc Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes
    Yoko S Derose
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA
    Nat Med 17:1514-20. 2011
    ..This bank of tumor grafts also serves as a publicly available resource for new models in which to study the biology of breast cancer...
  30. pmc Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment
    Matthew L Goodwin
    Department of Orthopaedics, University of Utah, Salt Lake City, UT 84112, USA
    Cancer Cell 26:851-62. 2014
    ..These data demonstrate lactate's role as a driver of alveolar soft part sarcomagenesis. ..
  31. pmc What are the 5-year survivorship outcomes of compressive endoprosthetic osseointegration fixation of the femur?
    Michael J Monument
    Sarcoma Services, Department of Orthopaedic Surgery, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Room 4260, Salt Lake City, UT, 84112, USA
    Clin Orthop Relat Res 473:883-90. 2015
    ..Endoprosthetic reconstruction using compressive osseointegration fixation is a relatively new limb salvage technology designed to enhance osseointegration, prevent stress shielding, and provide fixation for short end-segments...
  32. pmc Is claviculo pro humeri of value for limb salvage of pediatric proximal humerus sarcomas?
    George T Calvert
    Sarcoma Services, Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Suite 4260, Salt Lake City, UT, 84112 5550, USA
    Clin Orthop Relat Res 473:877-82. 2015
    ..CPH represents a potential option for this complicated clinical problem in very young children, but little is known about it because the indications for its use are so uncommon...
  33. pmc Intraoperative navigation for minimally invasive resection of periarticular and pelvic tumors
    Kevin Wu
    Huntsman Cancer Institute, Utah, USA
    Orthopedics 34:372. 2011
    ..The use of paired point imaging with image fusion has made approaching tumors through an accurate and minimally invasive technique a viable option for the treatment of a subset of musculoskeletal tumors...
  34. pmc A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma
    Savita Sankar
    Department of Oncological Sciences, Huntsman Cancer Institute, School of Medicine, University of Utah
    Mol Cell Biol 33:4448-60. 2013
    ..Taken together, our data reveal previously unknown molecular functions for a cytoplasmic intermediate filament protein, KRT17, in coordinating EWS/FLI- and GLI1-mediated oncogenic transformation and cellular adhesion in Ewing sarcoma. ..
  35. doi request reprint Atypical intradermal smooth muscle neoplasms (formerly cutaneous leiomyosarcomas): case series, immunohistochemical profile and review of the literature
    Brian J Hall
    Department of Pathology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, UT 84112, USA
    Appl Immunohistochem Mol Morphol 21:132-8. 2013
    ..Although the significance of frequent PTEN loss supports a molecular mechanism of tumor genesis, the diagnostic utility of the stain remains to be determined...
  36. doi request reprint Reducing the risk of bone cement implantation syndrome during femoral arthroplasty
    David L Rothberg
    Department of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA
    Orthopedics 36:e463-7. 2013
    ..The proposed mechanism of risk reduction is through lower intramedullary pressure with no bone-cement-implant interface pullout strength reduction. Further clinical trials are needed to prove this biomechanical effect...
  37. pmc At-risk populations for osteosarcoma: the syndromes and beyond
    George T Calvert
    Department of Orthopaedics and Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USA
    Sarcoma 2012:152382. 2012
    ..This paper reviews the genetic and clinical features of the known osteosarcoma predisposition syndromes...
  38. pmc EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations
    Robert Beck
    Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
    Cancer Genet 205:304-12. 2012
    ..These data suggest that GGAA microsatellite polymorphisms in the NR0B1 gene might influence disease susceptibility and prognosis in Ewing sarcoma in unanticipated ways...
  39. doi request reprint Radiotherapy and extent of surgical resection in retroperitoneal soft-tissue sarcoma: multi-institutional analysis of 261 patients
    Sagus Sampath
    Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, Utah 84112, USA
    J Surg Oncol 101:345-50. 2010
    ..To examine the impact of adjuvant radiotherapy (RT) and surgical technique on survival in retroperitoneal soft-tissue sarcoma...
  40. pmc Synovial sarcoma: from genetics to genetic-based animal modeling
    Malay Haldar
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112 5331, USA
    Clin Orthop Relat Res 466:2156-67. 2008
    ....
  41. pmc Sarcoma immunotherapy
    Launce G Gouw
    Departments of Oncology, Huntsman Cancer Institute at the University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Cancers (Basel) 3:4139-50. 2011
    ..More sophisticated approaches will likely require multimodal techniques, both by enhancing immunity, but also geared towards overcoming innate mechanisms of immunosuppression that favor tumorigenesis. ..
  42. ncbi request reprint Malignant fibrous histiocytoma of soft tissue: an abandoned diagnosis
    R Lor Randall
    Sarcoma Services, Suite 4260, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Am J Orthop (Belle Mead NJ) 33:602-8. 2004
    ..In this article, we review the current understanding of the histologic subtype classification of tumors previously diagnosed as MFH and its relation to clinical outcomes...
  43. doi request reprint Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor correlates with the mechanism of mitotic nondisjunction and significant tumor progression
    Lei L Chen
    Department of Internal Medicine, Division of Hematology Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Mod Pathol 21:826-36. 2008
    ....
  44. ncbi request reprint Non-neurogenic sarcomas in four children and young adults with neurofibromatosis type 1
    Cheryl M Coffin
    Department of Pathology, The University of Utah School of Medicine, 100 North Medical Drive, Salt Lake City, UT 84113, USA
    Am J Med Genet A 127:40-3. 2004
    ..The purpose is to emphasize that early diagnosis of NF1 and recognition of potential manifestations of non-neurogenic sarcomas are important for clinical care of these patients and their families...
  45. doi request reprint Molecular Confirmation of Ewing Sarcoma in an 85-Year-Old Woman
    Michael J Monument
    University of Utah, Salt Lake City, UT, USA
    Int J Surg Pathol 23:500-4. 2015
    ..Ewing sarcoma is predominantly a pediatric disease and uncommon in patients older than 40 years of age. To the best of our knowledge, this is the oldest documented case of Ewing sarcoma, diagnosed using modern molecular techniques. ..
  46. pmc Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group
    Michael J Monument
    Sarcoma Services, Department of Orthopedic Surgery, University of Utah, Salt Lake City, Utah, United States of America Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 9:e104378. 2014
    ..These microsatellites are highly polymorphic in humans, and preliminary evidence suggests EWS/FLI-mediated gene expression is highly dependent on the number of GGAA motifs within the microsatellite...
  47. doi request reprint Unknown partner for USP6 and unusual SS18 rearrangement detected by fluorescence in situ hybridization in a solid aneurysmal bone cyst
    Katherine Geiersbach
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, UT, USA
    Cancer Genet 204:195-202. 2011
    ..In this case, the SS18 rearrangement by FISH resulted from a complex rearrangement of 18q11.2 with a deletion of the SS18 gene. The translocation partner for USP6 remains unknown in this case...
  48. pmc Intratendinous tophaceous gout imitating patellar tendonitis in an athletic man
    Jeremy M Gililland
    Department of Orthopedic Surgery, University of Utah, Salt Lake City, Utah, USA
    Orthopedics 34:223. 2011
    ..Without appropriate medical management, tophaceous deposition may continue to occur and treatment of the resultant mass may require surgical intervention...
  49. pmc Extra-abdominal desmoid tumors associated with familial adenomatous polyposis
    George T Calvert
    Department of Orthopaedics and Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USA
    Sarcoma 2012:726537. 2012
    ..This paper analyzes recent evidence pertaining to the epidemiology, molecular biology, histopathology, screening, and treatment of extra-abdominal desmoid tumors associated with familial adenomatous polyposis syndrome...
  50. ncbi request reprint Surgical fixation of pathologic fractures: an evaluation of evolving treatment methods
    Kenneth J Hunt
    Sarcoma Service, Department of Orthopedics, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Suite 2100, Salt Lake City, Utah 84112, USA
    Bull Hosp Jt Dis 63:77-82. 2006
    ..02). This data, in addition to several additional advantages of indirect reduction and intramedullary fixation of pathologic fractures, supports this method of fracture care over open reduction and internal fixation in appropriate cases...
  51. ncbi request reprint Complications of cemented long-stem hip arthroplasties in metastatic bone disease
    R Lor Randall
    Huntsman Cancer Institute, Department of Orthopaedics, Salt Lake City, UT 84112, USA
    Clin Orthop Relat Res 443:287-95. 2006
    ..Increased awareness of cement-related cardiopulmonary pathophysiology, and modifying conventional surgical techniques can minimize cement-associated complications...
  52. pmc Has the Level of Evidence of Podium Presentations at the Musculoskeletal Tumor Society Annual Meeting Changed Over Time?
    Daniel M Lerman
    Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA
    Clin Orthop Relat Res . 2016
    ..Improvements in LOE have been demonstrated throughout orthopaedics, prompting our evaluation of orthopaedic oncology research LOE to determine if it has changed in kind...
  53. ncbi request reprint Giant cell tumor of the sacrum
    R Lor Randall
    Sarcoma Services, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Neurosurg Focus 15:E13. 2003
    ..Embolization may also prove palliative and/or curative in cases in which the tumor is unresectable or refractory to treatment...
  54. ncbi request reprint Her-2/neu expression in osteosarcoma increases risk of lung metastasis and can be associated with gene amplification
    Holly Zhou
    Department of Pathology, University of Utah, Salt Lake City, UT, USA
    J Pediatr Hematol Oncol 25:27-32. 2003
    ..Whether Her-2/neu expression influences outcome needs to be examined further in a prospective fashion. The hope is that Her-2/neu expression will identify patients who may benefit from the addition of directed biologic therapy...
  55. doi request reprint RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis
    Kelsi Andrade
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Sci Transl Med 9:. 2017
    ..These findings uncover a new therapeutic target for pathogenic bone loss and provide a rationale for treatment of bone destruction in various diseases with RON inhibitors...
  56. doi request reprint Novel applications of osseointegration in orthopedic limb salvage surgery
    Michael J Monument
    Sarcoma Services, Department of Orthopaedic Surgery, Huntsman Cancer Institute, Primary Children s Medical Center, University of Utah, 2000 Circle of Hope, Room 4260, Salt Lake City, UT 84112, USA
    Orthop Clin North Am 46:77-87. 2015
    ..This articles reviews osseointegration and emerging novel applications of this technology in limb salvage surgery and future prosthetics for amputees. ..
  57. pmc Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis
    Ashley A Kowalewski
    Department of Oncological Sciences, University of Utah School of Medicine, 2000 Circle of Hope, Room 4242, Salt Lake City, UT 84112, USA
    Sarcoma 2011:598704. 2011
    ..This paper will summarize current published data associated with deregulation of the cell cycle in Ewing's sarcoma and highlight important questions that remain to be answered...
  58. pmc Salient features of mesenchymal stem cells-implications for Ewing sarcoma modeling
    Michael J Monument
    Sarcoma Services, Department of Orthopaedic Surgery, Huntsman Cancer Institute, University of Utah Salt Lake City, UT, USA
    Front Oncol 3:24. 2013
    ....