Jaya Rajaiya

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. pmc Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression
    Jaya Rajaiya
    Molecular Pathogenesis of Eye Infection Research Center, Dean A, McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Virol J 5:17. 2008
  2. pmc Predicting the next eye pathogen: analysis of a novel adenovirus
    Christopher M Robinson
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    MBio 4:e00595-12. 2013
  3. pmc Analysis of human adenovirus type 19 associated with epidemic keratoconjunctivitis and its reclassification as adenovirus type 64
    Xiaohong Zhou
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 53:2804-11. 2012
  4. pmc Molecular evolution of human adenoviruses
    Christopher M Robinson
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Sci Rep 3:1812. 2013
  5. pmc Viral capsid is a pathogen-associated molecular pattern in adenovirus keratitis
    Ashish V Chintakuntlawar
    University of Oklahoma Health Sciences Center, Department of Ophthalmology, Oklahoma City, Oklahoma, United States of America
    PLoS Pathog 6:e1000841. 2010
  6. doi request reprint Role of MyD88 in adenovirus keratitis
    Xiaohong Zhou
    Howe Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Immunol Cell Biol . 2016
  7. pmc The E3 CR1-gamma gene in human adenoviruses associated with epidemic keratoconjunctivitis
    Christopher M Robinson
    Howe Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Virus Res 160:120-7. 2011
  8. pmc Resident corneal c-fms(+) macrophages and dendritic cells mediate early cellular infiltration in adenovirus keratitis
    Mirja Ramke
    Howe Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA, USA
    Exp Eye Res 147:144-7. 2016
  9. pmc Selection Pressure in the Human Adenovirus Fiber Knob Drives Cell Specificity in Epidemic Keratoconjunctivitis
    Ashrafali M Ismail
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 90:9598-9607. 2016
  10. pmc Heat shock protein 27 mediated signaling in viral infection
    Jaya Rajaiya
    Howe Laboratory, Mass Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Biochemistry 51:5695-702. 2012

Collaborators

Detail Information

Publications13

  1. pmc Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression
    Jaya Rajaiya
    Molecular Pathogenesis of Eye Infection Research Center, Dean A, McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Virol J 5:17. 2008
    ....
  2. pmc Predicting the next eye pathogen: analysis of a novel adenovirus
    Christopher M Robinson
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    MBio 4:e00595-12. 2013
    ..The combination of bioinformatics and laboratory simulation may have important applications in the prediction of tissue tropism for newly discovered and emerging viruses...
  3. pmc Analysis of human adenovirus type 19 associated with epidemic keratoconjunctivitis and its reclassification as adenovirus type 64
    Xiaohong Zhou
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 53:2804-11. 2012
    ..Confusion exists regarding the origins of HAdV-D19. The prototype virus (HAdV-D19p) does not cause EKC, while a virus identified later with the identical serologic determinant is a significant ocular pathogen...
  4. pmc Molecular evolution of human adenoviruses
    Christopher M Robinson
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Sci Rep 3:1812. 2013
    ....
  5. pmc Viral capsid is a pathogen-associated molecular pattern in adenovirus keratitis
    Ashish V Chintakuntlawar
    University of Oklahoma Health Sciences Center, Department of Ophthalmology, Oklahoma City, Oklahoma, United States of America
    PLoS Pathog 6:e1000841. 2010
    ....
  6. doi request reprint Role of MyD88 in adenovirus keratitis
    Xiaohong Zhou
    Howe Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Immunol Cell Biol . 2016
    ..Immunology and Cell Biology advance online publication, 6 September 2016; doi:10.1038/icb.2016.73...
  7. pmc The E3 CR1-gamma gene in human adenoviruses associated with epidemic keratoconjunctivitis
    Christopher M Robinson
    Howe Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Virus Res 160:120-7. 2011
    ..The cytoplasmic domain contains a putative protein kinase C phosphorylation site and potential YXXϕ and dileucine (LL) motifs suggesting a potential role in modification of host proteins...
  8. pmc Resident corneal c-fms(+) macrophages and dendritic cells mediate early cellular infiltration in adenovirus keratitis
    Mirja Ramke
    Howe Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA, USA
    Exp Eye Res 147:144-7. 2016
    ..Clinical keratitis and recruitment of myeloperoxidase and CD45(+) cells were diminished in c-fms depleted, adenovirus infected mice, as compared to controls, consistent with a role for myeloid-lineage cells in adenovirus keratitis. ..
  9. pmc Selection Pressure in the Human Adenovirus Fiber Knob Drives Cell Specificity in Epidemic Keratoconjunctivitis
    Ashrafali M Ismail
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 90:9598-9607. 2016
    ..This same amino acid residue in EKC viruses shows evidence for positive selection, suggesting that evolutionary pressure enhances fitness in corneal infection, and may be a molecular determinant in EKC pathogenesis...
  10. pmc Heat shock protein 27 mediated signaling in viral infection
    Jaya Rajaiya
    Howe Laboratory, Mass Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Biochemistry 51:5695-702. 2012
    ..These studies strongly suggest that HSP27, p38, and NFκB-p65 form a signalosome in virus-infected cells and influence downstream expression of pro-inflammatory mediators...
  11. pmc Specific NFkappaB subunit activation and kinetics of cytokine induction in adenoviral keratitis
    Jaya Rajaiya
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 15:2879-89. 2009
    ..Therefore, we sought to better understand the differential regulation of chemokine expression by NFkappaB in adenoviral infection of the cornea...
  12. doi request reprint Novel model of innate immunity in corneal infection
    Jaya Rajaiya
    Howe Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA
    In Vitro Cell Dev Biol Anim 51:827-34. 2015
    ..The corneal facsimile, literally a cornea in a test tube, permits mechanistic studies on human tissue in a highly tractable system. ..
  13. pmc Computational analysis of human adenovirus type 22 provides evidence for recombination among species D human adenoviruses in the penton base gene
    Christopher M Robinson
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 83:8980-5. 2009
    ..Further study of recombination among HAdVs is needed to better predict possible recombination events among wild-type viruses and adenoviral gene therapy vectors...