Sanjay Rajagopalan

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Phase I study of direct administration of a replication deficient adenovirus vector containing the vascular endothelial growth factor cDNA (CI-1023) to patients with claudication
    Sanjay Rajagopalan
    Division of Cardiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Cardiol 90:512-6. 2002
  2. ncbi request reprint Regional Angiogenesis with Vascular Endothelial Growth Factor (VEGF) in peripheral arterial disease: Design of the RAVE trial
    Sanjay Rajagopalan
    Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiology, University of Michigan Health System, Ann Arbor 48109 0273, USA
    Am Heart J 145:1114-8. 2003
  3. ncbi request reprint Aldosterone as a target in congestive heart failure
    Sanjay Rajagopalan
    University of Michigan School of Medicine, Ann Arbor, MI, USA
    Med Clin North Am 87:441-57. 2003
  4. ncbi request reprint Increased asymmetric dimethylarginine and endothelin 1 levels in secondary Raynaud's phenomenon: implications for vascular dysfunction and progression of disease
    Sanjay Rajagopalan
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0273, USA
    Arthritis Rheum 48:1992-2000. 2003
  5. ncbi request reprint Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent cl
    Sanjay Rajagopalan
    Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, USA
    Circulation 108:1933-8. 2003
  6. ncbi request reprint Management of chronic critical limb ischemia
    Sanjay Rajagopalan
    Section of Vascular Medicine, Division of Cardiology, L3119, Women s Hospital 1500, East Medical Center Dr, Ann Arbor, MI 48109 0273, USA
    Cardiol Clin 20:535-45. 2002
  7. ncbi request reprint Magnetic resonance angiographic techniques for the diagnosis of arterial disease
    Sanjay Rajagopalan
    Division of Cardiology, Section of Vascular Medicine, University of Michigan, 1311 Women s Hospital, 1500 E Medical Center Drive, Ann Arbor, MI 48107, USA
    Cardiol Clin 20:501-12, v. 2002
  8. ncbi request reprint Effects of cilostazol in patients with Raynaud's syndrome
    Sanjay Rajagopalan
    Division of Cardiology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Am J Cardiol 92:1310-5. 2003
  9. ncbi request reprint Effect of losartan in aging-related endothelial impairment
    Sanjay Rajagopalan
    Department of Internal Medicine, Divisions of Cardiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0273, USA
    Am J Cardiol 89:562-6. 2002
  10. ncbi request reprint Aldosterone antagonists in the treatment of hypertension and target organ damage
    S Rajagopalan
    Division of Cardiology, L3119, Women s Hospital, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0273, USA
    Curr Hypertens Rep 3:240-8. 2001

Collaborators

Detail Information

Publications94

  1. ncbi request reprint Phase I study of direct administration of a replication deficient adenovirus vector containing the vascular endothelial growth factor cDNA (CI-1023) to patients with claudication
    Sanjay Rajagopalan
    Division of Cardiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Cardiol 90:512-6. 2002
    ..Conclusions on efficacy could not be made due to the small number of patients. However, there were encouraging trends in ABI at rest and peak walking time at follow-up...
  2. ncbi request reprint Regional Angiogenesis with Vascular Endothelial Growth Factor (VEGF) in peripheral arterial disease: Design of the RAVE trial
    Sanjay Rajagopalan
    Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiology, University of Michigan Health System, Ann Arbor 48109 0273, USA
    Am Heart J 145:1114-8. 2003
    ..10)) to patients with severe IC caused by infrainguinal disease...
  3. ncbi request reprint Aldosterone as a target in congestive heart failure
    Sanjay Rajagopalan
    University of Michigan School of Medicine, Ann Arbor, MI, USA
    Med Clin North Am 87:441-57. 2003
    ..0 mg/dL and serum potassium levels are < 5.0 meq/L at baseline...
  4. ncbi request reprint Increased asymmetric dimethylarginine and endothelin 1 levels in secondary Raynaud's phenomenon: implications for vascular dysfunction and progression of disease
    Sanjay Rajagopalan
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0273, USA
    Arthritis Rheum 48:1992-2000. 2003
    ..To compare microvascular and macrovascular functions in a cohort of patients with primary and secondary Raynaud's phenomenon (RP) who were matched for demographic, risk factor, and severity profiles...
  5. ncbi request reprint Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent cl
    Sanjay Rajagopalan
    Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, USA
    Circulation 108:1933-8. 2003
    ....
  6. ncbi request reprint Management of chronic critical limb ischemia
    Sanjay Rajagopalan
    Section of Vascular Medicine, Division of Cardiology, L3119, Women s Hospital 1500, East Medical Center Dr, Ann Arbor, MI 48109 0273, USA
    Cardiol Clin 20:535-45. 2002
    ..Fig. 4 details the approach at the University of Michigan's comprehensive vascular medicine program...
  7. ncbi request reprint Magnetic resonance angiographic techniques for the diagnosis of arterial disease
    Sanjay Rajagopalan
    Division of Cardiology, Section of Vascular Medicine, University of Michigan, 1311 Women s Hospital, 1500 E Medical Center Drive, Ann Arbor, MI 48107, USA
    Cardiol Clin 20:501-12, v. 2002
    ..Additionally, recognition of artifacts and learning to avoid them is important...
  8. ncbi request reprint Effects of cilostazol in patients with Raynaud's syndrome
    Sanjay Rajagopalan
    Division of Cardiology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Am J Cardiol 92:1310-5. 2003
    ..018). Cilostazol increased conduit vessel diameter in patients with primary and secondary RS, with a favorable impact on conduit vessel responsiveness to cold in patients with primary RS without affecting microvascular flow or symptoms...
  9. ncbi request reprint Effect of losartan in aging-related endothelial impairment
    Sanjay Rajagopalan
    Department of Internal Medicine, Divisions of Cardiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0273, USA
    Am J Cardiol 89:562-6. 2002
    ..47, p = 0.05). Thus, administration of losartan for a duration of 6 weeks has favorable effects on inflammatory markers in healthy older subjects, but does not alter peripheral conduit endothelial function...
  10. ncbi request reprint Aldosterone antagonists in the treatment of hypertension and target organ damage
    S Rajagopalan
    Division of Cardiology, L3119, Women s Hospital, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0273, USA
    Curr Hypertens Rep 3:240-8. 2001
    ..The evolution of selective aldosterone receptor antagonists will help us understand the role that mineralocorticoids play in the pathogenesis of hypertension, heart failure, and atherosclerosis...
  11. ncbi request reprint Adenovirus-mediated gene transfer of VEGF(121) improves lower-extremity endothelial function and flow reserve
    S Rajagopalan
    Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Circulation 104:753-5. 2001
    ..10)) would improve peripheral endothelial function. Accordingly, we investigated lower-extremity endothelial function in patients enrolled in a Phase I adenovirus-mediated gene delivery trial of VEGF(121.10)...
  12. ncbi request reprint Abnormal brachial artery flow-mediated vasodilation in young adults with major depression
    S Rajagopalan
    Department of Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Am J Cardiol 88:196-8, A7. 2001
    ..Further studies are needed to define the mechanisms that underlie these observations...
  13. pmc Predictors of heart rate variability and its prognostic significance in chronic kidney disease
    Preeti Chandra
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Nephrol Dial Transplant 27:700-9. 2012
    ..Heart rate variability (HRV), a noninvasive measure of autonomic dysfunction and a risk factor for cardiovascular disease (CVD), has not been systematically studied in nondialysis chronic kidney disease (CKD)...
  14. ncbi request reprint Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study
    Rachel L Perlman
    Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Am J Kidney Dis 45:658-66. 2005
    ..Dialysis patients have decreased QOL relative to healthy controls. Little is known about QOL in patients with chronic kidney disease (CKD) before renal replacement therapy...
  15. ncbi request reprint Adenoviral-mediated gene transfer of vascular endothelial growth factor in critical limb ischemia: safety results from a phase I trial
    Emile R Mohler
    Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiology, University of Pennsylvania Health System, Philadelphia, PA, USA
    Vasc Med 8:9-13. 2003
    ..CI-1023 appears to be well tolerated and safe for single-dose administration in patients with critical limb ischemia due to PAD. Further studies are needed to determine the efficacy of this form of therapeutic angiogenesis...
  16. doi request reprint Acute increase in blood pressure during inhalation of coarse particulate matter air pollution from an urban location
    J Brian Byrd
    Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    J Am Soc Hypertens 10:133-139.e4. 2016
    ..Brief exposure to coarse PM in an urban environment raises arterial BP. These findings add mechanistic support to the contention that coarse PM may be capable of promoting cardiovascular events. ..
  17. pmc Relationship between heart rate variability and pulse wave velocity and their association with patient outcomes in chronic kidney disease
    Preeti Chandra
    Department of Internal Medicine, University of Maryland, Baltimore, MD, University of Michigan Kidney Epidemiology and Cost Center, Ann Arbor, MI, Renal Research Institute, New York, NY, Department of Internal Medicine, University of North Carolina, Chapel Hill, NC, Hospital of St Raphael Yale University, New Haven, CT, Department of Internal Medicine, University of North Carolina, Chapel Hill, NC, Department of Cardiovascular Medicine, Ohio State University, Columbus, OH, Oakwood Healthcare System, Dearborn, MI, and Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Clin Nephrol 81:9-19. 2014
    ....
  18. pmc Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans
    Robert D Brook
    University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Hypertension 54:659-67. 2009
    ..Our findings demonstrate credible mechanisms whereby fine particulate matter could trigger acute cardiovascular events and that aspects of exposure location may be an important determinant of the health consequences...
  19. ncbi request reprint Neutral effect on markers of heart failure, inflammation, endothelial activation and function, and vagal tone after high-dose HMG-CoA reductase inhibition in non-diabetic patients with non-ischemic cardiomyopathy and average low-density lipoprotein level
    Barry E Bleske
    University of Michigan, College of Pharmacy, Ann Arbor, Michigan 48109 1065, USA
    J Am Coll Cardiol 47:338-41. 2006
    ....
  20. doi request reprint Initial feasibility of a multi-station high resolution three-dimensional dark blood angiography protocol for the assessment of peripheral arterial disease
    Georgeta Mihai
    Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA
    J Magn Reson Imaging 30:785-93. 2009
    ....
  21. ncbi request reprint Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience
    Sanjay Rajagopalan
    Section of Vascular Medicine, 473 W 12th Ave, Division of Cardiovascular Medicine, Ohio State University, Columbus, OH 43210 1252, USA
    Circulation 115:1234-43. 2007
    ....
  22. ncbi request reprint Altered cutaneous microvascular responses to reactive hyperaemia in coronary artery disease: a comparative study with conduit vessel responses
    Qurratul Aine Shamim-Uzzaman
    Department of Internal Medicine, and Section of Vascular Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109 0273, USA
    Clin Sci (Lond) 103:267-73. 2002
    ..However, a time to peak response of >10 s as measured by laser Doppler imaging offers superior specificity for the diagnosis of CAD compared with brachial FMD...
  23. pmc Air-Pollution and Cardiometabolic Diseases (AIRCMD): a prospective study investigating the impact of air pollution exposure and propensity for type II diabetes
    Zhichao Sun
    Department of Biostatistics, The University of Michigan, Ann Arbor, MI, USA
    Sci Total Environ 448:72-8. 2013
    ..We believe that AIRCMD will allow for unprecedented new investigations into the association between environmental risk factors and CM disorders...
  24. pmc Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, United States
    Sci Total Environ 448:66-71. 2013
    ..5 exposures. Our findings suggest that ambient PM2.5, even at low levels, may reduce metabolic insulin sensitivity supporting the plausibility that air pollution could potentiate the development of DM...
  25. doi request reprint Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication
    Mark A Creager
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 124:1765-73. 2011
    ....
  26. doi request reprint Dominance of traditional cardiovascular risk factors over renal function in predicting arterial stiffness in subjects with chronic kidney disease
    David Sengstock
    Geriatric Research, Education, and Clinical Center GRECC, Ann Arbor Veterans Administration Hospital, Ann Arbor, MI, USA
    Nephrol Dial Transplant 25:853-61. 2010
    ..The predictors of arterial stiffness across the spectrum of renal function are unclear. These predictors were investigated across a wide range of estimated glomerular filtration rates (eGFR)...
  27. pmc Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location
    Robert D Brook
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Environ Health Perspect 122:624-30. 2014
    ..Coarse PM substantially contributes to global air pollution, yet differs in characteristics from fine particles and is currently not regulated. However, the cardiovascular (CV) impacts of coarse PM exposure remain largely unknown...
  28. ncbi request reprint Effects of concentrated fine ambient particles on rat plasma levels of asymmetric dimethylarginine
    J Timothy Dvonch
    Department of Environmental Health Sciences, University of Michigan, Ann Arbor, 48109 2029, USA
    Inhal Toxicol 16:473-80. 2004
    ..5) at high concentrations may trigger an acute increase in circulating ADMA level. This finding has implications for the regulation of vasomotor tone by particulate pollutants and the propensity for adverse cardiovascular events...
  29. ncbi request reprint Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease
    Michael A Schmidt
    Section of Vascular Medicine, Division of Cardiology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0273, USA
    Vasc Med 8:177-83. 2003
    ....
  30. pmc The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures
    Masako Morishita
    School of Public Health, University of Michigan, Ann Arbor, Michigan, USA
    J Expo Sci Environ Epidemiol 25:153-9. 2015
    ..These findings suggest that particulate mass may be an adequate metric of exposure to predict some, but not all, hemodynamic alterations induced by coarse PM mass...
  31. ncbi request reprint Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity
    Sanjay Rajagopalan
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 0680, USA
    Blood 103:3677-83. 2004
    ..Heightened endothelial apoptosis may represent an important mechanism for development of atherothrombosis in SLE...
  32. pmc Assessment of carotid stenosis using three-dimensional T2-weighted dark blood imaging: Initial experience
    Georgeta Mihai
    Department of Internal Medicine, Division of Cardiovascular Medicine, Ohio State University, Columbus, Ohio, USA
    J Magn Reson Imaging 35:449-55. 2012
    ..To evaluate the use of a T2-weighted SPACE sequence (T2w-SPACE) to assess carotid stenosis via several methods and compare its performance with contrast-enhanced magnetic resonance angiography (ceMRA)...
  33. ncbi request reprint Sustained vascular endothelial growth factor delivery enhances angiogenesis and perfusion in ischemic hind limb
    Qinghua Sun
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Hospitals and Health System, Ann Arbor, Michigan 48109 0311, USA
    Pharm Res 22:1110-6. 2005
    ..We hypothesized that sustained delivery of vascular endothelial growth factor (VEGF) using a polymer [85:15 poly(lactide-co-glycolide) (PLG)] would enhance angiogenesis and improve perfusion of ischemic tissue...
  34. ncbi request reprint Effects of valsartan alone versus valsartan/simvastatin combination on ambulatory blood pressure, C-reactive protein, lipoproteins, and monocyte chemoattractant protein-1 in patients with hyperlipidemia and hypertension
    Sanjay Rajagopalan
    Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA
    Am J Cardiol 100:222-6. 2007
    ..In conclusion, addition of simvastatin to valsartan did not incrementally lower BP. However, V/S80 was superior to V and V/S20 in reducing high-sensitivity C-reactive protein...
  35. ncbi request reprint Design of the Del-1 for therapeutic angiogenesis trial (DELTA-1), a phase II multicenter, double-blind, placebo-controlled trial of VLTS-589 in subjects with intermittent claudication secondary to peripheral arterial disease
    Sanjay Rajagopalan
    Section of Vascular Medicine, Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, Box 1030, One Gustave Levy Place, New York, NY 10029, USA
    Hum Gene Ther 15:619-24. 2004
    ....
  36. pmc The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study
    Robert D Brook
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48106, USA
    Inhal Toxicol 25:587-92. 2013
    ..However, the impact of coarse PM on EPCs is unknown...
  37. ncbi request reprint Rapid-onset endothelial dysfunction with adriamycin: evidence for a dysfunctional nitric oxide synthase
    Damon Duquaine
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Vasc Med 8:101-7. 2003
    ..These findings may have implications for cardiovascular complications noted with ADR...
  38. doi request reprint Effect of niacin ER/lovastatin on claudication symptoms in patients with peripheral artery disease
    William R Hiatt
    Section of Vascular Medicine, Division of Geriatrics, University of Colorado Denver School of Medicine, Denver, CO 80203, USA
    Vasc Med 15:171-9. 2010
    ..6% on low niacin-statin (p = 0.096). Flushing as the most common event leading to discontinuation and treatment was associated with increases in liver enzymes, fasting blood glucose concentration and a decrease in platelet count...
  39. ncbi request reprint Air pollution: the "Heart" of the problem
    Robert D Brook
    University of Michigan, 3918 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Curr Hypertens Rep 5:32-9. 2003
    ..Many questions, however, remain unanswered and future studies will be required to clarify the relevant biologic mechanisms and to identify the specific constituents responsible for mediating the adverse health impacts...
  40. ncbi request reprint Aldosterone receptor antagonists for heart failure: current status, future indications
    Bertram Pitt
    University of Michigan School of Medicine, Ann Arbor, MI, USA
    Cleve Clin J Med 73:257-60, 264-8. 2006
    ..We review the evidence and indications...
  41. ncbi request reprint Peripheral arterial disease in patients with end-stage renal disease: observations from the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Sanjay Rajagopalan
    Division of Cardiovascular Medicine, 473 W 12th Ave, Ohio State University, Columbus, OH 43202, USA
    Circulation 114:1914-22. 2006
    ..The aims of the present study were to describe the prevalence of peripheral arterial disease (PAD) and its effects on prognosis and health-related quality of life (HRQOL) in an international cohort of patients on hemodialysis...
  42. ncbi request reprint Development of a multicenter peripheral arterial interventional database: the PVD-QI2
    Debabrata Mukherjee
    Gill Heart Institute, Division of Cardiovascular Medicine, Lexington, KY 40436 0200, USA
    Am Heart J 149:1003-8. 2005
    ..The registry aims to elucidate which comorbid conditions and procedure-related variables are associated with beneficial or adverse outcomes after vascular interventions...
  43. ncbi request reprint Chronic iron administration increases vascular oxidative stress and accelerates arterial thrombosis
    Sharlene M Day
    University of Michigan Medical School, Division of Cardiology, Ann Arbor, USA
    Circulation 107:2601-6. 2003
    ..Iron overload has been implicated in the pathogenesis of ischemic cardiovascular events. However, the effects of iron excess on vascular function and the thrombotic response to vascular injury are not well understood...
  44. ncbi request reprint Calf flow reserve with H(2)(15)O PET as a quantifiable index of lower extremity flow
    Michael A Schmidt
    Section of Vascular Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA
    J Nucl Med 44:915-9. 2003
    ..Objective measures of recruitable blood flow are of importance in angiogenesis trials. We validated a new PET-derived flow reserve (FR) measurement in healthy subjects and subjects with peripheral artery disease (PAD)...
  45. ncbi request reprint Effect of carotid atherosclerosis screening on risk stratification during primary cardiovascular disease prevention
    Robert L Bard
    Division of Cardiovascular Medicine, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Am J Cardiol 93:1030-2. 2004
    ..These tests adjust the risk strata of >/=63% of patients deemed as having intermediate risk by Framingham scores...
  46. ncbi request reprint Effect of short-term weight loss on the metabolic syndrome and conduit vascular endothelial function in overweight adults
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am J Cardiol 93:1012-6. 2004
    ..18 +/- 5.89 vs 18.87 +/- 7.11%, p = 0.13) of the brachial artery. A moderate degree of weight reduction over 3 months improved the metabolic syndrome profile but not the vascular dysfunction associated with uncomplicated obesity...
  47. doi request reprint "Environmental hypertensionology" the effects of environmental factors on blood pressure in clinical practice and research
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48188, USA
    J Clin Hypertens (Greenwich) 13:836-42. 2011
    ..The authors propose using the term environmental hypertensionology to refer to the study of the effects of environmental factors on BP in clinical and research settings...
  48. ncbi request reprint Statin therapy is associated with improved cardiovascular outcomes and levels of inflammatory markers in patients with heart failure
    Srikanth Sola
    Emory University School of Medicine, Division of Cardiology, Atlanta, Georgia 30303, USA
    J Card Fail 11:607-12. 2005
    ..We wished to determine whether the addition of statins affect cardiovascular events and markers of inflammation in patients with heart failure...
  49. ncbi request reprint Intrasubject variability of radial artery flow-mediated dilatation in healthy subjects and implications for use in prospective clinical trials
    Robert Brook
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Cardiol 96:1345-8. 2005
    ..In conclusion, these findings show that FMD-R is highly variable within subjects, even in a healthy population, after adjusting for multiple technical factors and implies biologic variation in radial artery tone...
  50. ncbi request reprint Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults
    Robert D Brook
    University of Michigan, Ann Arbor, USA
    Circulation 105:1534-6. 2002
    ..Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function...
  51. ncbi request reprint Hypertension and triglyceride catabolism: implications for the hemodynamic model of the metabolic syndrome
    Robert D Brook
    Division of Hypertension, University of Michigan, 3918 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48104, USA
    J Am Coll Nutr 22:290-5. 2003
    ..We sought to determine if hypertensive adults have a blunted triglyceride catabolic rate (TG K(2)) and if related hemodynamic and vascular alterations are determinants of TG K(2)...
  52. pmc Exploration of the composition and sources of urban fine particulate matter associated with same-day cardiovascular health effects in Dearborn, Michigan
    Masako Morishita
    Environmental Health Sciences, The University of Michigan, Ann Arbor, Michigan, USA
    J Expo Sci Environ Epidemiol 25:145-52. 2015
    ..This study indicates composition of PM2.5 and its sources may contribute to CV health effects independently of PM2.5 mass...
  53. ncbi request reprint Mineralocorticoid receptor blockade: new insights into the mechanism of action in patients with cardiovascular disease
    Bertram Pitt
    Division of Cardiology, University of Michigan, USA
    J Renin Angiotensin Aldosterone Syst 4:164-8. 2003
    ..This hypothesis will, however, require further prospective evaluation...
  54. ncbi request reprint Blood pressure and vascular effects of leptin in humans
    Robert D Brook
    Cardiovascular Medicine Division, University of Michigan, Ann Arbor, MI
    Metab Syndr Relat Disord 5:270-4. 2007
    ..These combined findings do not support a direct role for leptin in linking obesity to hypertension, however more studies are required to corroborate these observations...
  55. ncbi request reprint Variation in outcomes after percutaneous coronary intervention in the United States and predictors of periprocedural mortality
    Debabrata Mukherjee
    University of Michigan Cardiovascular Center, Ann Arbor, Mich, USA
    Cardiology 103:143-7. 2005
    ..Even in the contemporary era of adjunctive pharmacological therapies and ubiquitous use of stents, hospital volume remains a significant independent predictor of in-hospital mortality...
  56. doi request reprint T1-weighted-SPACE dark blood whole body magnetic resonance angiography (DB-WBMRA): initial experience
    Georgeta Mihai
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
    J Magn Reson Imaging 31:502-9. 2010
    ....
  57. ncbi request reprint Mineralocorticoid receptor antagonism in experimental atherosclerosis
    Sanjay Rajagopalan
    Department of Internal Medicine, University of Michigan, Ann Arbor, Mich, USA srajagop umich edu
    Circulation 105:2212-6. 2002
    ..We hypothesized that there is local expression of the mineralocorticoid receptor (MR) in the vasculature and that the use of a selective aldosterone receptor antagonist (SARA) improves endothelial function in early atherosclerosis...
  58. ncbi request reprint Valsartan Improves Insulin Sensitivity without Altering Vascular Function in Healthy Overweight Adults without the Metabolic Syndrome
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI
    Metab Syndr Relat Disord 5:255-61. 2007
    ..However, it is possible that obese patients with central adiposity may improve FMD with RAS blockade, and future investigation is warranted in this subgroup...
  59. ncbi request reprint Carotid stenosis: medical and surgical aspects
    Gorav Ailawadi
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cardiol Clin 20:599-609. 2002
    ..Higher-risk, asymptomatic patients can safely undergo CEA in high-volume centers for stenosis greater than 80% as defined by ultrasound...
  60. pmc Visceral Adipose MicroRNA 223 Is Upregulated in Human and Murine Obesity and Modulates the Inflammatory Phenotype of Macrophages
    Jeffrey A Deiuliis
    Department of Medicine, Division of Cardiovascular Medicine, University of Maryland, Baltimore, Baltimore, MD 21201, United States of America
    PLoS ONE 11:e0165962. 2016
    ..We concluded that the abundance of miR-223 in macrophages significantly modulates macrophage phenotype / activation state and response to stimuli via effects on the TLR4/FBXW7 axis...
  61. doi request reprint GLP-1 Agonists and Blood Pressure: A Review of the Evidence
    Aditya Goud
    Division of Cardiovascular Medicine, University of Maryland Baltimore, 20 Penn St, Health Science Facility II, Baltimore, MD, 21201, USA
    Curr Hypertens Rep 18:16. 2016
    ..An understanding of their effects on BP may help provide an explanation for the ability of GLP-1a to influence cardiovascular (CV) events in ongoing event-driven CV trials. ..
  62. ncbi request reprint Impaired vasoreactivity despite an increase in plasma nitrite in patients with abdominal aortic aneurysms
    Brian S Knipp
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, Department of Surgery, Division of Cardiology, University of Michigan Medical Center, Ann Arbor 48109 0329, USA
    J Vasc Surg 35:363-7. 2002
    ....
  63. ncbi request reprint Ultrasound-mediated transfection of canine myocardium by intravenous administration of cationic microbubble-linked plasmid DNA
    Mani Vannan
    Department of Internal Medicine, Division of Cardiology, University of Michigan Health System, Ann Arbor, Michigan, USA
    J Am Soc Echocardiogr 15:214-8. 2002
    ..Thus, disruption of cationic-linked, low-dose plasmid systems by diagnostic ultrasound may facilitate transfection of large animal hearts...
  64. ncbi request reprint Circadian blood pressure overswinging in a physically fit, normotensive African American woman
    Katarina T Borer
    Division of Kinesiology, University of Michigan, Ann Arbor 48109 2214, USA
    Am J Hypertens 15:827-30. 2002
    ..These results suggest beta1-adrenergic mediation of CHAT and its refractoriness to exercise training...
  65. ncbi request reprint Management of intermittent claudication
    Robert D Brook
    Division of Cardiology and Vascular Medicine Program, University of Michigan, 3918 Taubman Medical Center, Ann Arbor, MI 48109, USA
    Cardiol Clin 20:521-34. 2002
    ..In the future, the availability of newer stents and therapies to prevent re-stenosis may extend the applicability of endovascular treatment to difficult-to-treat infra-inguinal lesions...
  66. ncbi request reprint Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study
    Rajiv Saran
    Division of Nephrology, University of Michigan, Ann Arbor, MI 48103 4262, USA
    Nephrol Dial Transplant 18:2415-20. 2003
    ..bioavailability and potentially limit atherosclerosis. We hypothesized that the antioxidant alpha-tocopherol (vitamin E) reduces ADMA levels in CKD...
  67. ncbi request reprint Upper extremity arterial disease
    Lazar J Greenfield
    Department of Surgery, University of Michigan, 2101 Taubman Center Box 0346, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0346, USA
    Cardiol Clin 20:623-31. 2002
    ..Angioplasty and stent techniques also can provide an effective treatment option...
  68. ncbi request reprint The longitudinal chronic kidney disease study: a prospective cohort study of predialysis renal failure
    Rachel L Perlman
    Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Semin Dial 16:418-23. 2003
    ..This article describes the LCKD Study in the context of current knowledge of CKD...
  69. ncbi request reprint Usefulness of quinapril and irbesartan to improve the anti-inflammatory response of atorvastatin and aspirin in patients with coronary heart disease
    Wright B Lauten
    Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Am J Cardiol 91:1116-9. 2003
  70. doi request reprint Perspectives on optimizing trial design and endpoints in peripheral arterial disease: a case for imaging-based surrogates as endpoints of functional efficacy
    Sanjay Rajagopalan
    Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, 473 West 12 Avenue, Columbus, OH 43210, USA
    Cardiol Clin 29:419-31. 2011
    ..This review focuses on aspects relating to the current state of surrogate endpoints in PAD and reviews emerging endpoints using imaging approaches that may have the potential of improving study design in PAD...
  71. doi request reprint Medical management of the patient with intermittent claudication
    Deepthi Vodnala
    Michigan State University, East Lansing, MI, USA
    Cardiol Clin 29:363-79. 2011
    ..Management of IC requires a comprehensive approach toward symptomatic relief of pain with strategies that prolong life and prevent limb loss...
  72. doi request reprint Particulate matter air pollution and atherosclerosis
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Dr, PO Box 322, Ann Arbor, MI 48106, USA
    Curr Atheroscler Rep 12:291-300. 2010
    ..Due to the billions of people continually exposed to PM(2.5), the long-term pro-atherosclerotic effects of this ubiquitous air pollutant are likely to be of enormous and growing global public health importance...
  73. ncbi request reprint Particulate matter, air pollution, and blood pressure
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Am Soc Hypertens 3:332-50. 2009
    ..Due to the ubiquitous, continuous and often involuntary nature of exposure, PM(2.5) may be an important and under-appreciated worldwide environmental risk factor for increased arterial BP...
  74. pmc Radiation dose and cancer risk estimates in 16-slice computed tomography coronary angiography
    Andrew J Einstein
    Department of Medicine, Division of Cardiology, The Mount Sinai Medical Center, New York, NY, USA
    J Nucl Cardiol 15:232-40. 2008
    ..Whereas several studies have reported the effective dose, there are no data available on cancer risk for current CTCA protocols...
  75. ncbi request reprint Angiotensin receptor blockade improves vascular compliance in healthy normotensive elderly individuals: results from a randomized double-blind placebo-controlled trial
    Sanjay Rajagopalan
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai Medical Center, New York, NY, USA
    J Clin Hypertens (Greenwich) 8:783-90. 2006
    ..Mechanisms regulating compliance and endothelial function are complex and may not necessarily converge in aging...
  76. ncbi request reprint Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants
    Jeannette Vasquez-Vivar
    Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, USA
    Arterioscler Thromb Vasc Biol 22:1655-61. 2002
    ..The purpose of this study was to investigate the effects of hyperlipidemia on vascular BH4 levels and the effect of supplementation with sepiapterin in the presence and absence of N-acetylcysteine (NAC)...
  77. ncbi request reprint Ambient air particulate matter exposure and tissue factor expression in atherosclerosis
    Qinghua Sun
    Division of Environmental Health Sciences, The Ohio State University, Columbus, Ohio, USA
    Inhal Toxicol 20:127-37. 2008
    ..TF mRNA expression increased rapidly (within 1 h) in response to SRM PM. We conclude that in vivo and in vitro exposure to ambient air PM(2.5) induces TF expression...
  78. ncbi request reprint Letter by Brook et al regarding article "Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis"
    Robert D Brook
    Circulation 113:e871; author reply e872. 2006
  79. ncbi request reprint Technology insight: Clinical role of magnetic resonance angiography in the diagnosis and management of renal artery stenosis
    Santo Dellegrottaglie
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai Medical Center, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 3:329-38. 2006
    ..An overview of the clinical role of MRA, in conjunction with the other diagnostic modalities, in the identification and management of patients with renal artery stenosis, is also presented...
  80. ncbi request reprint Relative contributions of PM2.5 chemical constituents to acute arterial vasoconstriction in humans
    Bruce Urch
    Gage Occupational and Environmental Health Unit, St Michael s Hospital, and Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Inhal Toxicol 16:345-52. 2004
    ..An understanding of the PM constituents most responsible for adverse health outcomes is critical for efforts to develop pollution abatement strategies that maximize benefits to public health...
  81. pmc Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK
    Qinghua Sun
    Division of Environmental Health Sciences, Davis Heart Lung Research Institute, Colleges of Medicine and Public Health, The Ohio State University, Columbus, OH 43210 1252, USA
    Arterioscler Thromb Vasc Biol 28:1760-6. 2008
    ..Fine particulate matter <2.5 microm (PM(2.5)) has been implicated in vasoconstriction and potentiation of hypertension in humans. We investigated the effects of short-term exposure to PM(2.5) in the angiotensin II (AII) infusion model...
  82. ncbi request reprint The utility of magnetic resonance imaging in cardiac tissue regeneration trials
    Valentin Fuster
    Zena and Michael A Wiener Cardiovascular Institute and The Marie Josée and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 3:S2-7. 2006
    ..We contend that cardiac magnetic resonance imaging is ideally suited to assess response to myocardial regeneration therapy and can be exploited to yield valuable insights into the mechanism of action of myocardial regeneration therapies...
  83. ncbi request reprint Particulate pollution and endothelial function: déjà vu all over again in the air
    Sanjay Rajagopalan
    Circulation 111:2869-71. 2005
  84. ncbi request reprint Air pollution and cardiovascular events
    Robert D Brook
    N Engl J Med 356:2104-5; author reply 2105-6. 2007
  85. ncbi request reprint Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model
    Qinghua Sun
    The Zena and Michael A Wiener Cardiovascular Institute, Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    JAMA 294:3003-10. 2005
    ..Recent studies have suggested a link between inhaled particulate matter exposure in urban areas and susceptibility to cardiovascular events; however, the precise mechanisms remain to be determined...
  86. pmc Acute blood pressure responses in healthy adults during controlled air pollution exposures
    Bruce Urch
    Gage Occupational and Environmental Health Unit, St Michael s Hospital, Toronto, Ontario, Canada
    Environ Health Perspect 113:1052-5. 2005
    ..5 carbon content. Exposure to vehicular traffic may provide a common link between our observations and previous studies in which traffic exposure was identified as a potential risk factor for cardiovascular disease...
  87. ncbi request reprint ACCF/AHA 2007 clinical competence statement on vascular imaging with computed tomography and magnetic resonance. A report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Com
    Christopher M Kramer
    J Am Coll Cardiol 50:1097-114. 2007
  88. ncbi request reprint Technology Insight: magnetic resonance angiography for the evaluation of patients with peripheral artery disease
    Santo Dellegrottaglie
    Zena and Michael A Wiener Cardiovascular Institute and The Marie Josée and Henry R Kravis Center for Cardiovascular Health, Mount Sinai Medical Center, New York, NY, USA
    Nat Clin Pract Cardiovasc Med 4:677-87. 2007
    ..Continued hardware and software improvements will enable further refinements in imaging protocol for peripheral MRA, consolidating its clinical role for the evaluation of patients with PAD...
  89. doi request reprint Investigations of statins in heart failure: inflammatory biomarkers and hormones
    Bobby V Khan
    Emory University School of Medicine, Atlanta, GA, USA
    Heart Fail Clin 4:171-6. 2008
    ..This article evaluates the potential mechanisms for these effects in the management of heart failure and postulates their clinical and beneficial use...
  90. ncbi request reprint Images in vascular medicine. An unusual case of claudication
    Hale Erel
    Department of Radiology, New York Presbyterian Hospital Weil Medical College, Cornell University, NY, USA
    Vasc Med 7:55. 2002
  91. pmc ACCF/AHA 2007 Clinical Competence Statement on vascular imaging with computed tomography and magnetic resonance
    Christopher M Kramer
    Society of Cardiovascular Computed Tomography Representative
    Vasc Med 12:359-78. 2007
  92. ncbi request reprint Images in vascular medicine the Arc of Riolan: diagnosis by magnetic resonance angiography
    Andrew J Einstein
    The Zena and Michael A Wiener Cardiovascular Institute and The Marie Josee and Henry R Kravis Center for Cardiovascular Health, The Mount Sinai Medical Center, New York, NY 10029 6574, USA
    Vasc Med 10:239. 2005
  93. ncbi request reprint Eplerenone: will it have a role in the treatment of acute coronary syndromes?
    David J Meier
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Curr Cardiol Rep 6:259-63. 2004
    ..If MR blockade is found to be beneficial in patients with ACS, the potential reduction in morbidity, mortality, and health care costs are profound...
  94. ncbi request reprint Vascular calcification in patients with renal failure: culprit or innocent bystander?
    Santo Dellegrottaglie
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Cardiol Clin 23:373-84. 2005
    ..Large-scale, prospective, observational studies should be designed to identify the determinants of VC and to define the prognostic role of calcium scoring in cohorts of patients who have predialysis CKD and with ESRD...