Subbiah Pugazhenthi

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. ncbi request reprint Glucagon-Like Peptide-1-Mediated Modulation of Inflammatory Pathways in the Diabetic Brain: Relevance to Alzheimer's Disease
    Limei Qin
    Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Mail Stop 8106, 12801 E 17th Ave, Aurora, CO 80045, USA
    Curr Alzheimer Res 13:1346-1355. 2016
  2. pmc Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease
    Subbiah Pugazhenthi
    Section of Endocrinology, Veterans Affairs Medical Center, Denver, CO, USA Department of Medicine, University of Colorado Denver, Aurora, CO, USA Electronic address
    Biochim Biophys Acta . 2016
  3. doi request reprint Dipeptidyl peptidase-4 inhibition in diabetic rats leads to activation of the transcription factor CREB in β-cells
    Subbiah Pugazhenthi
    Veterans Affairs Medical Center, Denver, CO, United States Department of Medicine, University of Colorado School of Medicine, Aurora, CO, United States Electronic address
    Eur J Pharmacol 755:42-9. 2015
  4. pmc Modulation of apoptosis pathways by oxidative stress and autophagy in β cells
    Maorong Wang
    Section of Endocrinology, Veterans Affairs Medical Center, Denver, CO 80220, USA
    Exp Diabetes Res 2012:647914. 2012
  5. pmc Induction of an inflammatory loop by interleukin-1β and tumor necrosis factor-α involves NF-kB and STAT-1 in differentiated human neuroprogenitor cells
    Subbiah Pugazhenthi
    Section of Endocrinology, Veterans Affairs Medical Center, Denver, Colorado, United States of America
    PLoS ONE 8:e69585. 2013
  6. pmc Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons
    Subbiah Pugazhenthi
    Section of Endocrinology, Veterans Affairs Medical Center, Denver, CO, USA
    Mol Neurodegener 6:60. 2011
  7. doi request reprint Role for oxidative stress in the regeneration of islet beta cells?
    Kathryn Haskins
    Department of Immunology, University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Investig Med 52:45-9. 2004
  8. ncbi request reprint Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease
    Chun I Sze
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:30498-506. 2004
  9. ncbi request reprint SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway
    Dhara Vaishnav
    Division of Endocrinology, Department of Medicine, 4200 East Ninth Avenue, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Biochem Biophys Res Commun 307:855-60. 2003
  10. ncbi request reprint Transactivation of the simian varicella virus (SVV) open reading frame (ORF) 21 promoter by SVV ORF 62 is upregulated in neuronal cells but downregulated in non-neuronal cells by SVV ORF 63 protein
    Ravi Mahalingam
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Virology 345:244-50. 2006

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Glucagon-Like Peptide-1-Mediated Modulation of Inflammatory Pathways in the Diabetic Brain: Relevance to Alzheimer's Disease
    Limei Qin
    Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Mail Stop 8106, 12801 E 17th Ave, Aurora, CO 80045, USA
    Curr Alzheimer Res 13:1346-1355. 2016
    ..Dual actions of GLP-1 in the pancreatic beta cells and in the brain suggest that incretin therapies may reduce cognitive decline in the aging diabetic patients and also have the potential to be used in treating Alzheimer's patients...
  2. pmc Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease
    Subbiah Pugazhenthi
    Section of Endocrinology, Veterans Affairs Medical Center, Denver, CO, USA Department of Medicine, University of Colorado Denver, Aurora, CO, USA Electronic address
    Biochim Biophys Acta . 2016
    ..This article is part of a Special Issue entitled: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases - edited by P. Hemachandra Reddy...
  3. doi request reprint Dipeptidyl peptidase-4 inhibition in diabetic rats leads to activation of the transcription factor CREB in β-cells
    Subbiah Pugazhenthi
    Veterans Affairs Medical Center, Denver, CO, United States Department of Medicine, University of Colorado School of Medicine, Aurora, CO, United States Electronic address
    Eur J Pharmacol 755:42-9. 2015
    ..Findings from this study suggest potential activation of cytoprotective CREB by GLP-1 in pancreatic β-cells of diabetic patients undergoing incretin-based therapies...
  4. pmc Modulation of apoptosis pathways by oxidative stress and autophagy in β cells
    Maorong Wang
    Section of Endocrinology, Veterans Affairs Medical Center, Denver, CO 80220, USA
    Exp Diabetes Res 2012:647914. 2012
    ..Our findings suggest that β cell apoptosis by multiple stresses in islets isolated for transplantation is the result of orchestrated gene expression in apoptosis pathway...
  5. pmc Induction of an inflammatory loop by interleukin-1β and tumor necrosis factor-α involves NF-kB and STAT-1 in differentiated human neuroprogenitor cells
    Subbiah Pugazhenthi
    Section of Endocrinology, Veterans Affairs Medical Center, Denver, Colorado, United States of America
    PLoS ONE 8:e69585. 2013
    ....
  6. pmc Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons
    Subbiah Pugazhenthi
    Section of Endocrinology, Veterans Affairs Medical Center, Denver, CO, USA
    Mol Neurodegener 6:60. 2011
    ..Therefore, we examined the expression of CREB in the hippocampal neurons of Tg2576 mice, AD post-mortem brain and in cultured rat hippocampal neurons exposed to Aβ aggregates...
  7. doi request reprint Role for oxidative stress in the regeneration of islet beta cells?
    Kathryn Haskins
    Department of Immunology, University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Investig Med 52:45-9. 2004
    ..Lc7 mice than in NOD mice, suggesting that NOD.Lc7 islets are less susceptible to oxidative damage. We hypothesize that there may be a link between the ability of islet cells to regenerate and their resistance to oxidative stress...
  8. ncbi request reprint Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease
    Chun I Sze
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:30498-506. 2004
    ..Together WOX1 binds Tau via its short-chain alcohol dehydrogenase/reductase domain and is likely to play a critical role in regulating Tau hyperphosphorylation and NFT formation in vivo...
  9. ncbi request reprint SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway
    Dhara Vaishnav
    Division of Endocrinology, Department of Medicine, 4200 East Ninth Avenue, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Biochem Biophys Res Commun 307:855-60. 2003
    ..SB203580, an inhibitor of p38 MAPK, partially blocked SP600125-mediated activation of CREB. These observations suggest that SP600125 could be used as a small molecular weight activator of CREB...
  10. ncbi request reprint Transactivation of the simian varicella virus (SVV) open reading frame (ORF) 21 promoter by SVV ORF 62 is upregulated in neuronal cells but downregulated in non-neuronal cells by SVV ORF 63 protein
    Ravi Mahalingam
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Virology 345:244-50. 2006
    ..This is the first study in which a varicella protein (ORF 63) expressed during latency has been shown to have a differential effect on a promoter that is also active during latency, in neuronal as compared to non-neuronal cells...
  11. doi request reprint Antiapoptotic actions of exendin-4 against hypoxia and cytokines are augmented by CREB
    Kalpana Velmurugan
    Section of Endocrinology, Veterans Affairs Medical Center, Denver, Colorado 80220, USA
    Endocrinology 153:1116-28. 2012
    ..These observations have significant implications in the therapeutic potential of exendin-4 and CREB in the islet transplantation setting as well as in preserving β-cell mass of diabetic patients...
  12. ncbi request reprint Oxidative stress in type 1 diabetes
    Kathryn Haskins
    Department of Immunology, University of Colorado Health Sciences Center, and National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Ann N Y Acad Sci 1005:43-54. 2003
    ....
  13. doi request reprint Regulation of cyclic AMP response element-binding protein during neuroglial interactions
    Limei Qin
    Section of Endocrinology, Veterans Affairs Medical Center, Denver, Colorado, USA
    J Neurochem 136:918-30. 2016
    ....
  14. doi request reprint Neuroprotective actions of glucagon-like peptide-1 in differentiated human neuroprogenitor cells
    Kalpana Velmurugan
    Section of Endocrinology, Veterans Affairs Medical Center, Denver, Colorado 80045, USA
    J Neurochem 123:919-31. 2012
    ..Diabetes is a risk factor in the pathogenesis of Alzheimer's disease. Our findings suggest that GLP-1-based therapies can decrease the incidence of Alzheimer's disease among aging diabetic population...
  15. ncbi request reprint Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells
    Purevsuren Jambal
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 278:23055-65. 2003
    ..Together, these results point to CREB as a novel target for strategies aimed at improving the survival of beta-cells...
  16. pmc 2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways
    Remy Kachadourian
    Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    Free Radic Biol Med 51:1146-54. 2011
    ..These findings suggest that the 2',5'-DHC-induced increase in GSH levels results from a combination of ROS-dependent and ROS-independent pathways...