Daniel E L Promislow

Summary

Affiliation: University of Georgia
Country: USA

Publications

  1. ncbi request reprint Age-specific metabolic rates and mortality rates in the genus Drosophila
    Daniel E L Promislow
    Department of Genetics, University of Georgia, Athens, GA 30602 7223, USA
    Aging Cell 1:66-74. 2002
  2. ncbi request reprint The functional costs and benefits of dietary restriction in Drosophila
    Joep M S Burger
    Department of Genetics, University of Georgia, Life Sciences Building, Athens, GA 30602 7223, USA
    Aging Cell 6:63-71. 2007
  3. ncbi request reprint Are functional and demographic senescence genetically independent?
    Joep M S Burger
    Department of Genetics, University of Georgia, Life Sciences Building, Athens, GA 30602, USA
    Exp Gerontol 41:1108-16. 2006
  4. pmc What can genetic variation tell us about the evolution of senescence?
    Jacob A Moorad
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    Proc Biol Sci 276:2271-8. 2009
  5. pmc Female age and sperm competition: last-male precedence declines as female age increases
    Paul D Mack
    Department of Genetics, University of Georgia, Athens, GA 30602 7223, USA
    Proc Biol Sci 270:159-65. 2003
  6. pmc Testing an 'aging gene' in long-lived drosophila strains: increased longevity depends on sex and genetic background
    Christine C Spencer
    Department of Genetics, The University of Georgia, University of Georgia, Life Sciences Building, Athens, GA 30602, USA
    Aging Cell 2:123-30. 2003
  7. pmc Cross-generational fitness effects of infection in Drosophila melanogaster
    Jodell E Linder
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    Fly (Austin) 3:143-50. 2009
  8. pmc A theory of age-dependent mutation and senescence
    Jacob A Moorad
    Department of Genetics, University of Georgia, Athens, Georgia 30602 7223, USA
    Genetics 179:2061-73. 2008
  9. pmc The effects of temperature on host-pathogen interactions in D. melanogaster: who benefits?
    Jodell E Linder
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    J Insect Physiol 54:297-308. 2008
  10. ncbi request reprint Genes, culture, and aging flies--what the lab can and cannot tell us about natural genetic variation for senescence
    Christine C Spencer
    Department of Genetics at the University of Georgia, Athens, GA 30602, USA
    Sci Aging Knowledge Environ 2002:pe6. 2002

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Age-specific metabolic rates and mortality rates in the genus Drosophila
    Daniel E L Promislow
    Department of Genetics, University of Georgia, Athens, GA 30602 7223, USA
    Aging Cell 1:66-74. 2002
    ..We suggest that comparisons of specific traits that do not show signs of aging with those traits that do decline with age could provide insight into the aging process...
  2. ncbi request reprint The functional costs and benefits of dietary restriction in Drosophila
    Joep M S Burger
    Department of Genetics, University of Georgia, Life Sciences Building, Athens, GA 30602 7223, USA
    Aging Cell 6:63-71. 2007
    ..Given the age-specific effects of DR on functional state, imposing DR late in life might not provide the same functional benefits as when applied at early ages...
  3. ncbi request reprint Are functional and demographic senescence genetically independent?
    Joep M S Burger
    Department of Genetics, University of Georgia, Life Sciences Building, Athens, GA 30602, USA
    Exp Gerontol 41:1108-16. 2006
    ..Models for the genetic basis of senescence may do well to distinguish between quality and quantity of life in terms of their genetic architectures, and the way selection acts upon these two age-related factors...
  4. pmc What can genetic variation tell us about the evolution of senescence?
    Jacob A Moorad
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    Proc Biol Sci 276:2271-8. 2009
    ..We suggest that the tests that seek to identify the relative contributions of AP and MA to the evolution of ageing by partitioning genetic variance components are likely to be too conservative to be of general value...
  5. pmc Female age and sperm competition: last-male precedence declines as female age increases
    Paul D Mack
    Department of Genetics, University of Georgia, Athens, GA 30602 7223, USA
    Proc Biol Sci 270:159-65. 2003
    ..These results could lead to a greater understanding of the physiological mechanisms that regulate the outcome of sperm competition...
  6. pmc Testing an 'aging gene' in long-lived drosophila strains: increased longevity depends on sex and genetic background
    Christine C Spencer
    Department of Genetics, The University of Georgia, University of Georgia, Life Sciences Building, Athens, GA 30602, USA
    Aging Cell 2:123-30. 2003
    ..This study points to the need to identify mutants that increase longevity not only in the lab strain of origin but also in naturally long-lived genetic backgrounds...
  7. pmc Cross-generational fitness effects of infection in Drosophila melanogaster
    Jodell E Linder
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    Fly (Austin) 3:143-50. 2009
    ..While previous studies in bumblebees and beetles have demonstrated cross-generation priming, our results suggest that it may not be a general phenomenon, and more work is needed to determine how widespread it is...
  8. pmc A theory of age-dependent mutation and senescence
    Jacob A Moorad
    Department of Genetics, University of Georgia, Athens, Georgia 30602 7223, USA
    Genetics 179:2061-73. 2008
    ..Simulations show us that these age-specific mutational effects may generate patterns of senescence at mutation-selection equilibrium that are consistent with observed demographic patterns that are otherwise difficult to explain...
  9. pmc The effects of temperature on host-pathogen interactions in D. melanogaster: who benefits?
    Jodell E Linder
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    J Insect Physiol 54:297-308. 2008
    ..The approach described here allows us to determine whether this effect is due primarily to temperature-specific effects on the host or on its pathogen. These results suggest that both may be important...
  10. ncbi request reprint Genes, culture, and aging flies--what the lab can and cannot tell us about natural genetic variation for senescence
    Christine C Spencer
    Department of Genetics at the University of Georgia, Athens, GA 30602, USA
    Sci Aging Knowledge Environ 2002:pe6. 2002
    ..These results might not be fully relevant to wild populations. Experiments that reduce selection for shorter life-span or seek genes in naturally long-lived cohorts should lead to a more accurate understanding of aging...
  11. ncbi request reprint Advice to an aging scientist
    Daniel E L Promislow
    Department of Genetics, University of Georgia, Athens, GA 30602 7223, USA
    Mech Ageing Dev 123:841-50. 2002
    ..In addition, we present new results which suggest that the analysis of gene networks may lend particular insight into the genetic underpinnings of the aging process...
  12. pmc Protein networks, pleiotropy and the evolution of senescence
    Daniel E L Promislow
    Department of Genetics, University of Georgia, Athens, GA 30602 7223, USA
    Proc Biol Sci 271:1225-34. 2004
    ..These findings integrate molecular and evolutionary models of senescence, and should aid in the search for new ageing genes...
  13. ncbi request reprint Biologists finally horn in on senescence in the wild
    Christine C Spencer
    Genetics Department at the University of Georgia, Athens, GA, 30602 7223, USA
    Sci Aging Knowledge Environ 2002:pe19. 2002
    ..This small species offers huge opportunities to study senescence and age-related selection on fitness characters in the wild...
  14. pmc Evolutionary demography and quantitative genetics: age-specific survival as a threshold trait
    Jacob A Moorad
    Department of Genetics, University of Georgia, Athens, GA, USA
    Proc Biol Sci 278:144-51. 2011
    ..We also show how this model can be developed further to unify quantitative genetics and evolutionary demography into a more complete conceptual framework for understanding the evolution of ageing...
  15. pmc Geographical distribution and diversity of bacteria associated with natural populations of Drosophila melanogaster
    Vanessa Corby-Harris
    Department of Genetics, University of Georgia, Athens, GA 30602 7223, USA
    Appl Environ Microbiol 73:3470-9. 2007
    ..Overall, bacterial communities associated with adult D. melanogaster hosts are diverse and differ across host populations...
  16. pmc The Companion Dog as a Model for the Longevity Dividend
    Kate E Creevy
    Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602
    Cold Spring Harb Perspect Med 6:a026633. 2016
    ..Overall, we conclude that the companion dog offers high potential as a model system that will enable deeper research into the LD than is otherwise possible. ..
  17. pmc A longitudinal analysis of the effects of age on the blood plasma metabolome in the common marmoset, Callithrix jacchus
    Jessica M Hoffman
    Department of Genetics, University of Georgia, 120 Green Street, Athens, GA 30602, USA Electronic address
    Exp Gerontol 76:17-24. 2016
    ..Moreover, we found that many metabolic pathways associated with age were sex specific. Our work illustrates the power of longitudinal approaches, even in a short time frame, to discover novel biochemical changes that occur with age. ..
  18. pmc Reproductive capability is associated with lifespan and cause of death in companion dogs
    Jessica M Hoffman
    Department of Genetics, University of Georgia, Athens, Georgia, United States of America
    PLoS ONE 8:e61082. 2013
    ..Such an approach may also clarify the effects of reproduction on lifespan in people...
  19. doi request reprint Evolution: aging up a tree?
    Jacob A Moorad
    Department of Genetics, University of Georgia, Athens, GA 30602 7223, USA
    Curr Biol 20:R406-8. 2010
    ..A new study comparing lifespan in arboreal and terrestrial mammals provides further support for this prediction. But is the prediction valid?..
  20. ncbi request reprint Phylogenetic perspectives in the evolution of parental care in ray-finned fishes
    Judith E Mank
    Department of Genetics, University of Georgia, Athens, Georgia 30602, USA
    Evolution 59:1570-8. 2005
    ..Results are discussed in the context of prior thought about the evolution of alternative parental care modes in vertebrates...
  21. ncbi request reprint Sex-specific effects of interventions that extend fly life span
    Joep M S Burger
    Department of Genetics, University of Georgia, Athens, GA 30602 7223, USA
    Sci Aging Knowledge Environ 2004:pe30. 2004
    ..We argue that understanding sex differences in the response to life span-extending manipulations should lead to new insights about the basic mechanisms that underlie the biology of aging in both sexes...
  22. pmc Host ecology shapes geographical variation for resistance to bacterial infection in Drosophila melanogaster
    Vanessa Corby-Harris
    Department of Genetics, University of Georgia, Tucson, AZ 85721, USA
    J Anim Ecol 77:768-76. 2008
    ..We discuss our results in the context of what is known about the evolutionary ecology of resistance in invertebrate systems...
  23. pmc The unavoidable costs and unexpected benefits of parasitism: population and metapopulation models of parasite-mediated competition
    Chih Horng Kuo
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    J Theor Biol 250:244-56. 2008
    ..Furthermore, this work highlights the possibility that the 'introduction of enemies' process may facilitate species invasion...
  24. pmc Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster
    Jessica M Hoffman
    Department of Genetics, University of Georgia, Athens, GA, 30602, USA
    Aging Cell 13:596-604. 2014
    ....
  25. pmc A comparative assessment of univariate longevity measures using zoological animal records
    Jacob A Moorad
    Department of Biology, Duke University, Durham, NC 27708, USA
    Aging Cell 11:940-8. 2012
    ..These measures should take the place of MRLS in comparative studies of lifespan...
  26. ncbi request reprint The role of parental age effects on the evolution of aging
    Nicholas K Priest
    Department of Genetics, University of Georgia, Athens 30602 7223, USA
    Evolution 56:927-35. 2002
    ..These results suggest that maternal age effects on progeny aging may influence the evolution of aging...
  27. ncbi request reprint Sperm competitive ability and genetic relatedness in Drosophila melanogaster: similarity breeds contempt
    Paul D Mack
    Department of Genetics, University of Georgia, Athens 30602 7223, USA
    Evolution 56:1789-95. 2002
    ..We provide the strongest evidence to date that sperm competitive ability is negatively correlated with relatedness, even after controlling for inbreeding depression...
  28. pmc First evidence for heritable variation in cooperative breeding behaviour
    Anne Charmantier
    Edward Grey Institute, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Proc Biol Sci 274:1757-61. 2007
    ..These findings provide useful insights into the possible mechanisms which have led to the evolution of cooperative breeding and other social systems...
  29. ncbi request reprint Physiology. Still pondering an age-old question
    Thomas Flatt
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Science 318:1255-6. 2007
  30. ncbi request reprint Functional and evolutionary inference in gene networks: does topology matter?
    Mark L Siegal
    Department of Biology, New York University, New York, NY 10003, USA
    Genetica 129:83-103. 2007
    ..This latter pattern is generally taken as a signature of positive selection, but in our simulations its cause is often neutral coevolution of regulatory inputs to the same gene...
  31. pmc Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
    Erica D Smith
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genome Res 18:564-70. 2008
    ..Together, these findings indicate that the genetic component of life span determination is significantly conserved between divergent eukaryotic species, and suggest pathways that are likely to play a similar role in mammalian aging...
  32. pmc Evolution of female preference for younger males
    Christopher W Beck
    Department of Biology, Emory University, Atlanta, Georgia, USA
    PLoS ONE 2:e939. 2007
    ..These results suggest that germ-line quality, rather than somatic quality, should be the focus of female preference in good genes models...