M A Prendergast

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Microtubule-associated targets in chlorpyrifos oxon hippocampal neurotoxicity
    M A Prendergast
    Department of Psychology, Spinal Cord and Brain Injury Research Center, B363 BBSRB, 741 South Limestone, University of Kentucky, Lexington, KY 40536 0509, USA
    Neuroscience 146:330-9. 2007
  2. ncbi request reprint Ethanol and nicotine: a pharmacologic balancing act?
    Mark A Prendergast
    Department of Psychology, University of Kentucky, Lexington 40506 0044, USA
    Alcohol Clin Exp Res 26:1917-8. 2002
  3. ncbi request reprint Hippocampal CA1 region neurodegeneration produced by ethanol withdrawal requires activation of intrinsic polysynaptic hippocampal pathways and function of N-methyl-D-aspartate receptors
    M A Prendergast
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Neuroscience 124:869-77. 2004
  4. ncbi request reprint Chronic nicotine exposure reduces N-methyl-D-aspartate receptor-mediated damage in the hippocampus without altering calcium accumulation or extrusion: evidence of calbindin-D28K overexpression
    M A Prendergast
    Department of Psychology, University of Kentucky, Lexington 40506 0044, USA
    Neuroscience 102:75-85. 2001
  5. pmc Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors
    T R Butler
    Department of Psychology, University of Kentucky, Lexington, KY 40536 0509, USA
    Neuroscience 165:525-34. 2010
  6. ncbi request reprint The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site
    Rachel L Self
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Brain Res 995:39-45. 2004
  7. pmc Intra-cornu ammonis 1 administration of the human immunodeficiency virus-1 protein trans-activator of transcription exacerbates the ethanol withdrawal syndrome in rodents and activates N-methyl-D-aspartate glutamate receptors to produce persisting spatial
    R L Self
    Department of Psychology, University of Kentucky, B449 Biomedical and Biological Sciences Research Building, 741 South Limestone Street, Lexington, KY 40536 0509, USA
    Neuroscience 163:868-76. 2009
  8. ncbi request reprint Chronic, but not acute, nicotine exposure attenuates ethanol withdrawal-induced hippocampal damage in vitro
    M A Prendergast
    Department of Psychology, University of Kentucky, Lexington 40506 0044, USA
    Alcohol Clin Exp Res 24:1583-92. 2000
  9. pmc Temporal dependence of cysteine protease activation following excitotoxic hippocampal injury
    J N Berry
    Department of Psychology, Spinal Cord and Brain Injury Research Center, B449 Biomedical and Biological Sciences Research Building, 741 South Limestone Street, Lexington, KY 40536 0509, United States
    Neuroscience 222:147-58. 2012
  10. ncbi request reprint In vitro effects of ethanol withdrawal and spermidine on viability of hippocampus from male and female rat
    M A Prendergast
    Department of Psychology, University of Kentucky, Lexington 40506 0044, USA
    Alcohol Clin Exp Res 24:1855-61. 2000

Collaborators

Detail Information

Publications41

  1. pmc Microtubule-associated targets in chlorpyrifos oxon hippocampal neurotoxicity
    M A Prendergast
    Department of Psychology, Spinal Cord and Brain Injury Research Center, B363 BBSRB, 741 South Limestone, University of Kentucky, Lexington, KY 40536 0509, USA
    Neuroscience 146:330-9. 2007
    ..These data suggest that exposure to CPO produces a progressive decrease in neuronal viability that may be associated with impaired microtubule synthesis and/or function...
  2. ncbi request reprint Ethanol and nicotine: a pharmacologic balancing act?
    Mark A Prendergast
    Department of Psychology, University of Kentucky, Lexington 40506 0044, USA
    Alcohol Clin Exp Res 26:1917-8. 2002
  3. ncbi request reprint Hippocampal CA1 region neurodegeneration produced by ethanol withdrawal requires activation of intrinsic polysynaptic hippocampal pathways and function of N-methyl-D-aspartate receptors
    M A Prendergast
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Neuroscience 124:869-77. 2004
    ..These data suggest that neurodegeneration observed during ethanol withdrawal is dependent upon polysynaptic propagation of action potentials ("network excitation") and whole-hippocampal excitation of glutamatergic systems...
  4. ncbi request reprint Chronic nicotine exposure reduces N-methyl-D-aspartate receptor-mediated damage in the hippocampus without altering calcium accumulation or extrusion: evidence of calbindin-D28K overexpression
    M A Prendergast
    Department of Psychology, University of Kentucky, Lexington 40506 0044, USA
    Neuroscience 102:75-85. 2001
    ....
  5. pmc Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors
    T R Butler
    Department of Psychology, University of Kentucky, Lexington, KY 40536 0509, USA
    Neuroscience 165:525-34. 2010
    ..These data suggest that selective sensitivity of the CA1 region to excitotoxic stimuli may be attributable to the density of mature neurons expressing polyamine-sensitive NR2B polypeptide subunits...
  6. ncbi request reprint The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site
    Rachel L Self
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Brain Res 995:39-45. 2004
    ..Polyamine-sensitive portions of this receptor may then represent novel therapeutic targets in the pharmacologic treatment of HAD-related neurotoxicity...
  7. pmc Intra-cornu ammonis 1 administration of the human immunodeficiency virus-1 protein trans-activator of transcription exacerbates the ethanol withdrawal syndrome in rodents and activates N-methyl-D-aspartate glutamate receptors to produce persisting spatial
    R L Self
    Department of Psychology, University of Kentucky, B449 Biomedical and Biological Sciences Research Building, 741 South Limestone Street, Lexington, KY 40536 0509, USA
    Neuroscience 163:868-76. 2009
    ..These findings suggest that EtOH abuse and/or dependence in HIV-positive individuals may promote HIV-1-associated cognitive deficits by altering NMDA receptor function in the absence of microglial activation or neuroinflammation...
  8. ncbi request reprint Chronic, but not acute, nicotine exposure attenuates ethanol withdrawal-induced hippocampal damage in vitro
    M A Prendergast
    Department of Psychology, University of Kentucky, Lexington 40506 0044, USA
    Alcohol Clin Exp Res 24:1583-92. 2000
    ..Thus, the present study was designed to use an organotypic hippocampal slice culture model to examine the ability of chronic and acute nicotine exposure to reduce neurotoxicity associated with withdrawal from long-term ethanol exposure...
  9. pmc Temporal dependence of cysteine protease activation following excitotoxic hippocampal injury
    J N Berry
    Department of Psychology, Spinal Cord and Brain Injury Research Center, B449 Biomedical and Biological Sciences Research Building, 741 South Limestone Street, Lexington, KY 40536 0509, United States
    Neuroscience 222:147-58. 2012
    ..Further, these data suggest that synaptophysin may be a substrate for calpains and related proteases...
  10. ncbi request reprint In vitro effects of ethanol withdrawal and spermidine on viability of hippocampus from male and female rat
    M A Prendergast
    Department of Psychology, University of Kentucky, Lexington 40506 0044, USA
    Alcohol Clin Exp Res 24:1855-61. 2000
    ..Thus, we designed this study to examine effects of the polyamine spermidine on neurotoxicity associated with withdrawal from long-term ethanol exposure by using organotypic hippocampal slice cultures derived from male and female rats...
  11. ncbi request reprint Corticosterone and dexamethasone potentiate cytotoxicity associated with oxygen-glucose deprivation in organotypic cerebellar slice cultures
    P J Mulholland
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Neuroscience 136:259-67. 2005
    ..In conclusion, these data demonstrated that glucocorticoid exposure modulated oxygen-glucose deprivation-mediated propidium iodide uptake, which likely involved glucocorticoid receptor activation and pro-oxidant effects...
  12. ncbi request reprint Nicotine exposure reduces N-methyl-D-aspartate toxicity in the hippocampus: relation to distribution of the alpha7 nicotinic acetylcholine receptor subunit
    M A Prendergast
    Department of Psychology, University of Kentucky, Lexington, Kentucky 40506-0044, USA
    Med Sci Monit 7:1153-60. 2001
    ..CONCLUSIONS: The neuroprotective effect of nicotine against excitotoxicity, then, is not directly related to alpha7 subunit localization in the hippocampus...
  13. pmc Methamphetamine exposure antagonizes N-methyl-D-aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures
    Katherine J Smith
    University of Kentucky, Department of Psychology, B363 Biomedical and Biological Sciences Building, Lexington, KY 40536 0509, USA
    Brain Res 1157:74-80. 2007
    ..These findings indicate that the pharmacological effects of short-term METH exposure involve inhibition of NMDA receptor-mediated neuronal signaling, not reflective of direct channel inhibition at an MK-801-sensitive site...
  14. ncbi request reprint Thiamine deficiency in the pathogenesis of chronic ethanol-associated cerebellar damage in vitro
    P J Mulholland
    Department of Psychology, 012 I Kastle Hall, University of Kentucky, Lexington, KY 40506 0044, USA
    Neuroscience 135:1129-39. 2005
    ..Findings from this report suggest that the cerebellum may be more sensitive to the toxic effects of thiamine deficiency, as compared with alcohol withdrawal, associated with alcohol dependence...
  15. ncbi request reprint Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus
    Sveta Mayer
    Department of Molecular and Biomedial Pharmacology, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40546 0236, USA
    Alcohol Clin Exp Res 26:1468-78. 2002
    ....
  16. ncbi request reprint (-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity
    P J Mulholland
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Neuroscience 125:671-82. 2004
    ..Thus, it is possible that one consequence of heavy smoking in those suffering from hypercortisolemia may be a reduction of neuronal injury and sparing of cellular function...
  17. ncbi request reprint Potential value of changes in cell markers in organotypic hippocampal cultures associated with chronic EtOH exposure and withdrawal: comparison with NMDA-induced changes
    Lincoln H Wilkins
    Department of Behavioral Sciences, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Alcohol Clin Exp Res 30:1768-80. 2006
    ....
  18. ncbi request reprint A 24 h corticosterone exposure exacerbates excitotoxic insult in rat hippocampal slice cultures independently of glucocorticoid receptor activation or protein synthesis
    Patrick J Mulholland
    Department of Psychology, 012 I Kastle Hall, University of Kentucky, Lexington, 40506 0044, USA
    Brain Res 1082:165-72. 2006
    ..These data suggest that relatively brief elevations in CORT levels may sensitize the hippocampus to injury independently of GC receptor activity and protein synthesis...
  19. pmc Potentiation of N-methyl-D-aspartate receptor-mediated neuronal injury during methamphetamine withdrawal in vitro requires co-activation of IP3 receptors
    Katherine J Smith
    University of Kentucky, Department of Psychology, B449 Biomedical and Biological Sciences Research Building, 741 South Limestone St, Lexington, KY 40536 0509, USA
    Brain Res 1187:67-73. 2008
    ..The results of the present studies suggest that long-term METH withdrawal functionally sensitizes the NMDA receptor to agonist exposure and requires the co-activation of NMDA and IP(3) receptors...
  20. ncbi request reprint Corticosterone increases damage and cytosolic calcium accumulation associated with ethanol withdrawal in rat hippocampal slice cultures
    Patrick J Mulholland
    Department of Psychology, University of Kentucky, Lexington, Kentucky 40506 0044, USA
    Alcohol Clin Exp Res 29:871-81. 2005
    ..The goal of the current studies was to examine the hypothesis that increased glucocorticoid levels in conjunction with ethanol exposure and withdrawal may cause hippocampal damage...
  21. ncbi request reprint Ethanol exposure and withdrawal sensitizes the rat hippocampal CA1 pyramidal cell region to beta-amyloid (25-35)-induced cytotoxicity: NMDA receptor involvement
    Rachel L Self
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Alcohol Clin Exp Res 29:2063-9. 2005
    ..Therefore, the current studies aimed to investigate the effects of exposure to 50 or 100 mM ethanol (EtOH) and withdrawal on hippocampal injury induced by Abeta peptide treatment...
  22. ncbi request reprint Transection of intrinsic polysynaptic pathways reduces N-methyl-D-aspartate neurotoxicity in hippocampal slice cultures
    Patrick J Mulholland
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Neurosci Res 46:369-76. 2003
    ..These data indicate that CA1 neurotoxicity caused by excitotoxic insult depends, in part, on 'network activation' of intrinsic polysynaptic pathways...
  23. ncbi request reprint Polyamines contribute to ethanol withdrawal-induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptor
    D Alex Gibson
    Department of Pharmacology, University of Kentucky, Tobacco and Health Research Institute, Lexington 40546 0236, USA
    Alcohol Clin Exp Res 27:1099-106. 2003
    ..Therefore, the goal of this investigation was to examine what role, if any, spermidine and spermine have in the generation of ethanol withdrawal-induced neurotoxicity...
  24. doi request reprint Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures
    Susan Barron
    Psychology Department, University of Kentucky, Lexington, Kentucky 40506 0044, USA
    Alcohol Clin Exp Res 32:929-36. 2008
    ..Due to changes in NMDAR subtypes and response to polyamines, we predicted that slices taken from PND 2 pups would be more sensitive to EWD and polyamine challenge...
  25. ncbi request reprint Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor
    Mark A Prendergast
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Brain Res 954:300-7. 2002
    ..These data suggest that the neurotoxic effects of HIV-1 Tat are mediated, in part, by direct interactions with a polyamine-sensitive site on the NMDAr that positively modulates the function of this receptor...
  26. pmc Sex differences in caffeine neurotoxicity following chronic ethanol exposure and withdrawal
    Tracy R Butler
    Department of Psychology, University of Kentucky, Lexington, KY 40536 0509, USA
    Alcohol Alcohol 44:567-74. 2009
    ..The current studies were designed to examine the effect of non-specific adenosine receptor antagonism with caffeine during ethanol withdrawal on hippocampal toxicity in cultures derived from male and female rats...
  27. ncbi request reprint Acamprosate has no effect on NMDA-induced toxicity but reduces toxicity induced by spermidine or by changing the medium in organotypic hippocampal slice cultures from rat
    Sveta Mayer
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Chandler Medical Center, Lexington, USA
    Alcohol Clin Exp Res 26:655-62. 2002
    ..These effects on NMDA receptors imply that the drug may have neurotoxic or neuroprotective actions under different conditions, and these studies were undertaken to evaluate this possibility in hippocampal neuronal cultures...
  28. ncbi request reprint Clinical neuropharmacology of drugs of abuse: a comparison of drug-discrimination and subject-report measures
    Thomas H Kelly
    Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington 40536 0086, USA
    Behav Cogn Neurosci Rev 2:227-60. 2003
    ....
  29. pmc Sex differences in the neurotoxic effects of adenosine A1 receptor antagonism during ethanol withdrawal: reversal with an A1 receptor agonist or an NMDA receptor antagonist
    Tracy R Butler
    Department of Psychology, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    Alcohol Clin Exp Res 32:1260-70. 2008
    ..The adenosine receptor system warrants further examination in this regard, as recent evidence has implicated adenosine receptor involvement in the behavioral effects of both EtOH exposure and withdrawal...
  30. pmc Inhibition of sigma-1 receptor reduces N-methyl-D-aspartate induced neuronal injury in methamphetamine-exposed and -naive hippocampi
    Katherine J Smith
    Department of Psychology, Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536 0356, USA
    Neurosci Lett 481:144-8. 2010
    ....
  31. ncbi request reprint Cytotoxic effects of exposure to the human immunodeficiency virus type 1 protein Tat in the hippocampus are enhanced by prior ethanol treatment
    Rachel L Self
    University of Kentucky, Department of Psychology, 115 Kastle Hall, Lexington, KY 40505 0044, USA
    Alcohol Clin Exp Res 28:1916-24. 2004
    ..Thus, these studies examined the hypothesis that long-term ethanol pre-exposure would sensitize the hippocampus to Tat-induced cytotoxicity in an NMDA receptor-dependent manner...
  32. ncbi request reprint Opposing effects of ethanol and nicotine on hippocampal calbindin-D28k expression
    Patrick J Mulholland
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Alcohol 31:1-10. 2003
    ..Further, long-term exposure to (-)-nicotine enhances calbindin-D(28k) expression in an alpha(7)* nAChR-dependent manner and antagonizes the effects of ethanol on calbindin-D(28k) expression...
  33. ncbi request reprint Choline exposure reduces potentiation of N-methyl-D-aspartate toxicity by corticosterone in the developing hippocampus
    Patrick J Mulholland
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Brain Res Dev Brain Res 153:203-11. 2004
    ....
  34. ncbi request reprint Adolescence, glucocorticoids and alcohol
    Mark A Prendergast
    Department of Psychology, University of Kentucky, B363 BBSRB, 741 S Limestone, University of Kentucky, Lexington, KY 40536 0509, USA
    Pharmacol Biochem Behav 86:234-45. 2007
    ..In conclusion, more information concerning the effects of glucocorticoids on plasticity and alcohol neurotoxicity during the adolescent period is needed...
  35. ncbi request reprint Post-insult exposure to (+/-) kavain potentiates N-methyl-D-aspartate toxicity in the developing hippocampus
    Patrick J Mulholland
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Brain Res 945:106-13. 2002
    ..In conclusion, while the kavapyrone (+/-) kavain is neurotoxic only at high concentrations when exposed alone to the developing hippocampus, it appears to adversely affect neuronal recovery following excitotoxic insults...
  36. ncbi request reprint Do women possess a unique susceptibility to the neurotoxic effects of alcohol?
    Mark A Prendergast
    Department of Psychology, University of Kentucky, Lexington, USA
    J Am Med Womens Assoc 59:225-7. 2004
    ..As a whole, these findings clearly indicate the need for a significant expansion of both clinical and basic science research of this topic...
  37. ncbi request reprint The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors
    Barton R Harris
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Chandler Medical Center, Lexington 40546, USA
    Alcohol Clin Exp Res 27:1724-35. 2003
    ..The following studies use organotypic hippocampal slice cultures at a mature age to investigate the potential for this interplay in the neurotoxicity associated with withdrawal from long-term ethanol exposure...
  38. ncbi request reprint Chlorpyrifos, chlorpyrifos-oxon, and diisopropylfluorophosphate inhibit kinesin-dependent microtubule motility
    Debra A Gearhart
    Department of Pharmacology and Toxicology, 1120 Fifteenth Street, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Toxicol Appl Pharmacol 218:20-9. 2007
    ..We postulate that disruption of kinesin-dependent intracellular transport could account for some of the long-term effects of organophosphates on the peripheral and central nervous system...
  39. ncbi request reprint Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing
    Alvin V Terry
    Department of Pharmacology and Toxicology, University of Georgia College of Pharmacy, Augusta, Georgia 30912 2300, USA
    J Pharmacol Exp Ther 322:1117-28. 2007
    ..Such neurochemical changes may lead to deficits in information processing and cognitive function...
  40. ncbi request reprint Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors
    Barton R Harris
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Chandler Medical Center, Lexington 40546 0236, USA
    Alcohol Clin Exp Res 26:1779-93. 2002
    ....
  41. ncbi request reprint Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential
    John N Bain
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Psychopharmacology (Berl) 169:150-60. 2003
    ..Dopaminergic pathways in the frontal and limbic cortex also may be targets for these agents, where pharmacological effects could result in heightened attention and/or support self-administration behavior...