Richard Thomas Porter

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc Diagnostic Ultrasound High Mechanical Index Impulses Restore Microvascular Flow in Peripheral Arterial Thromboembolism
    Thomas R Porter
    University of Nebraska Medical Center, Omaha, Nebraska, USA Electronic address
    Ultrasound Med Biol 42:1531-40. 2016
  2. pmc Targeted Transthoracic Acoustic Activation of Systemically Administered Nanodroplets to Detect Myocardial Perfusion Abnormalities
    Thomas R Porter
    From the Department of Internal Medicine, University of Nebraska Medical Center, Omaha T R P, S S, J L, R R H, F X Department of Engineering, Elon University, NC C A and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University P A D
    Circ Cardiovasc Imaging 9:. 2016
  3. doi request reprint Contrast echocardiography: latest developments and clinical utility
    Thomas R Porter
    Division of Cardiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA
    Curr Cardiol Rep 17:569. 2015
  4. pmc Prevention of arteriovenous shunt occlusion using microbubble and ultrasound mediated thromboprophylaxis
    Shelby Kutty
    Division of Pediatric Cardiology, University of Nebraska College of Medicine Children s Hospital and Medical Center, Omaha, NE
    J Am Heart Assoc 3:e000689. 2014
  5. pmc Diagnostic ultrasound induced inertial cavitation to non-invasively restore coronary and microvascular flow in acute myocardial infarction
    Feng Xie
    University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 8:e69780. 2013
  6. pmc Microbubble mediated thrombus dissolution with diagnostic ultrasound for the treatment of chronic venous thrombi
    Shelby Kutty
    Joint Division of Pediatric Cardiology, University of Nebraska College of Medicine Creighton University, Children s Hospital and Medical Center, Omaha, Nebraska, USA
    PLoS ONE 7:e51453. 2012
  7. doi request reprint Patient outcome following 2 different stress imaging approaches: a prospective randomized comparison
    Thomas R Porter
    Department of Cardiology, Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Am Coll Cardiol 61:2446-55. 2013
  8. doi request reprint Emerging cardiovascular imaging techniques to non-invasively detect coronary artery disease
    Thomas R Porter
    University of Nebraska Medical Center, Department of Internal Medicine, Section of Cardiology, 982265 Nebraska, Omaha, NE 68198 2265, USA 1 402 559 8150
    Expert Opin Med Diagn 1:203-11. 2007
  9. ncbi request reprint Effect of significant two-vessel versus one-vessel coronary artery stenosis on myocardial contrast defects observed with intermittent harmonic imaging after intravenous contrast injection during dobutamine stress echocardiography
    T R Porter
    University of Nebraska Medical Center, Omaha 68198 2265, USA
    J Am Coll Cardiol 30:1399-406. 1997
  10. doi request reprint Rapid detection of coronary artery stenoses with real-time perfusion echocardiography during regadenoson stress
    Thomas R Porter
    University of Nebraska Medical Center, Omaha, NE 68198 8865, USA
    Circ Cardiovasc Imaging 4:628-35. 2011

Collaborators

Detail Information

Publications77

  1. pmc Diagnostic Ultrasound High Mechanical Index Impulses Restore Microvascular Flow in Peripheral Arterial Thromboembolism
    Thomas R Porter
    University of Nebraska Medical Center, Omaha, Nebraska, USA Electronic address
    Ultrasound Med Biol 42:1531-40. 2016
    ..IC inducing pulses from a diagnostic transducer can reverse microvascular obstruction after acute arterial thromboembolism. Nitric oxide may prevent unwanted bio-effects of these IC pulses. ..
  2. pmc Targeted Transthoracic Acoustic Activation of Systemically Administered Nanodroplets to Detect Myocardial Perfusion Abnormalities
    Thomas R Porter
    From the Department of Internal Medicine, University of Nebraska Medical Center, Omaha T R P, S S, J L, R R H, F X Department of Engineering, Elon University, NC C A and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University P A D
    Circ Cardiovasc Imaging 9:. 2016
    ..The potential for targeted activation and imaging of these agents was tested with droplets formulated from liquid octafluoropropane (C3) and 1:1 mixtures of C3 with liquid decafluorobutane (C3C4)...
  3. doi request reprint Contrast echocardiography: latest developments and clinical utility
    Thomas R Porter
    Division of Cardiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA
    Curr Cardiol Rep 17:569. 2015
    ..Newer applications are emerging in the detection of left atrial appendage thrombi and quantification of myocardial blood flow and volume in transplant patients. ..
  4. pmc Prevention of arteriovenous shunt occlusion using microbubble and ultrasound mediated thromboprophylaxis
    Shelby Kutty
    Division of Pediatric Cardiology, University of Nebraska College of Medicine Children s Hospital and Medical Center, Omaha, NE
    J Am Heart Assoc 3:e000689. 2014
    ....
  5. pmc Diagnostic ultrasound induced inertial cavitation to non-invasively restore coronary and microvascular flow in acute myocardial infarction
    Feng Xie
    University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 8:e69780. 2013
    ....
  6. pmc Microbubble mediated thrombus dissolution with diagnostic ultrasound for the treatment of chronic venous thrombi
    Shelby Kutty
    Joint Division of Pediatric Cardiology, University of Nebraska College of Medicine Creighton University, Children s Hospital and Medical Center, Omaha, Nebraska, USA
    PLoS ONE 7:e51453. 2012
    ..We sought to investigate the therapeutic efficacy of microbubble (MB) enhanced sonothrombolysis for aged CVC associated thrombi in vivo...
  7. doi request reprint Patient outcome following 2 different stress imaging approaches: a prospective randomized comparison
    Thomas R Porter
    Department of Cardiology, Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Am Coll Cardiol 61:2446-55. 2013
    ..The study sought to prospectively compare patient outcome after stress real-time myocardial contrast echocardiography (RTMCE) versus conventional stress echo (CSE), where contrast is used to optimize wall motion (WM) analysis...
  8. doi request reprint Emerging cardiovascular imaging techniques to non-invasively detect coronary artery disease
    Thomas R Porter
    University of Nebraska Medical Center, Department of Internal Medicine, Section of Cardiology, 982265 Nebraska, Omaha, NE 68198 2265, USA 1 402 559 8150
    Expert Opin Med Diagn 1:203-11. 2007
    ..This paper will present the advantages and disadvantages of stress techniques, and new developments that will further improve the accuracy of these tests...
  9. ncbi request reprint Effect of significant two-vessel versus one-vessel coronary artery stenosis on myocardial contrast defects observed with intermittent harmonic imaging after intravenous contrast injection during dobutamine stress echocardiography
    T R Porter
    University of Nebraska Medical Center, Omaha 68198 2265, USA
    J Am Coll Cardiol 30:1399-406. 1997
    ....
  10. doi request reprint Rapid detection of coronary artery stenoses with real-time perfusion echocardiography during regadenoson stress
    Thomas R Porter
    University of Nebraska Medical Center, Omaha, NE 68198 8865, USA
    Circ Cardiovasc Imaging 4:628-35. 2011
    ..We hypothesized that this technique could be used after a bolus injection of the selective A2A receptor agonist regadenoson to rapidly and safely detect coronary artery stenoses...
  11. doi request reprint Myocardial perfusion imaging with contrast ultrasound
    Thomas R Porter
    University of Nebraska Medical Center, Cardiology, 981165 Nebraska Medical Center, Omaha, Nebraska 68198 1165, USA
    JACC Cardiovasc Imaging 3:176-87. 2010
    ..A review of the clinical studies that have examined the clinical utility of myocardial perfusion imaging with MCE during rest and stress echocardiography is then presented. The limitations of MCE are also discussed...
  12. doi request reprint The utilization of ultrasound and microbubbles for therapy in acute coronary syndromes
    Thomas R Porter
    University of Nebraska Medical Center, 982265 Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Cardiovasc Res 83:636-42. 2009
    ..In addition, the pre-clinical studies utilizing transthoracic ultrasound as a therapeutic entity in acute STEMI will be reviewed. Clinical studies, completed and ongoing, will also be presented...
  13. pmc Mitral valve endocarditis presenting as complete heart block
    Thomas R Porter
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 1165, USA
    Tex Heart Inst J 33:100-1. 2006
  14. ncbi request reprint Microbubble responses to a similar mechanical index with different real-time perfusion imaging techniques
    Thomas R Porter
    Section of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha NE 68198 1165, USA
    Ultrasound Med Biol 29:1187-92. 2003
    ..1. Contrast intensity seen with PID was less than with PM. Therefore, differences in contrast enhancement and microbubble destruction rates occur at a similar MI setting when using different real-time pulse sequence schemes...
  15. ncbi request reprint A method of detecting and quantifying severity of myocardial perfusion defects with intravenous ultrasound contrast and breath holding during stress echocardiography
    Thomas R Porter
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Echocardiography 20:411-22. 2003
    ..Coronary artery territory agreement between perfusion assessed during BH(ini) and BH(reinsp) and quantitative coronary angiography was 76% and 81%, respectively...
  16. ncbi request reprint The clinical implications of no reflow demonstrated with intravenous perfluorocarbon containing microbubbles following restoration of Thrombolysis In Myocardial Infarction (TIMI) 3 flow in patients with acute myocardial infarction
    T R Porter
    University of Nebraska Medical Center, Omaha 68198 2265, USA
    Am J Cardiol 82:1173-7. 1998
    ....
  17. ncbi request reprint Real-time perfusion imaging with low mechanical index pulse inversion Doppler imaging
    T R Porter
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198 1165, USA
    J Am Coll Cardiol 37:748-53. 2001
    ..We sought to determine how successful pulse inversion Doppler (PID) imaging would be in detecting myocardial perfusion defects during dobutamine stress echocardiography...
  18. ncbi request reprint Therapeutic ultrasound for gene delivery
    T R Porter
    University of Nebraska Medical Center, 981165 Nebraska Medical Center, Omaha, Nebraska 68198 1165, USA
    Echocardiography 18:349-53. 2001
    ..Early in vivo studies confirm that ultrasound in combination with microbubbles can be used to facilitate gene deposition. However, the role of ultrasound targeting gene delivery remains to be determined...
  19. ncbi request reprint Inhibition of carotid artery neointimal formation with intravenous microbubbles
    T R Porter
    Internal Medicine Department, Section of Cardiology, University of Nebraska Medical Center, 981165 Nebraska Medical Center, Omaha, NE 68198 1165, USA
    Ultrasound Med Biol 27:259-65. 2001
    ..01). IV PESDA may be a method of noninvasively targeting the delivery of therapeutic genes...
  20. ncbi request reprint Real-time visualization of myocardial perfusion and wall thickening in human beings with intravenous ultrasonographic contrast and accelerated intermittent harmonic imaging
    T R Porter
    University of Nebraska Medical Center, Omaha, Nebraska 68198 1165
    J Am Soc Echocardiogr 12:266-71. 1999
    ..Interobserver agreement on regional contrast enhancement ranged from 88% to 90%. We conclude that accelerated intermittent imaging permits real-time visualization of myocardial blood flow and wall thickening...
  21. ncbi request reprint Myocardial cavitational activity during continuous infusion and bolus intravenous injections of perfluorocarbon-containing microbubbles
    T R Porter
    Section of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, 68198-1165, USA
    J Am Soc Echocardiogr 14:618-25. 2001
    ..These results confirm that intramyocardial cavitational activity is present during ultrasound imaging of microbubbles; imaging techniques that reduce cavitational activity increase the magnitude of myocardial contrast...
  22. ncbi request reprint Effectiveness of transcranial and transthoracic ultrasound and microbubbles in dissolving intravascular thrombi
    T R Porter
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha 69198-1165, USA
    J Ultrasound Med 20:1313-25; quiz 1326. 2001
    ..CONCLUSIONS: Transcranial and transthoracic ultrasound in the presence of intravenous microbubbles can improve flow to ischemic regions and should be considered as a supplement to current pharmacologic therapy...
  23. ncbi request reprint Comparison of dobutamine stress echocardiography with and without real-time perfusion imaging for detection of coronary artery disease
    Feng Xie
    University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Cardiol 96:506-11. 2005
    ..The addition of real-time perfusion imaging after intravenous contrast during dobutamine stress echocardiography has the potential to improve detection of coronary artery disease...
  24. ncbi request reprint Detection of myocardial perfusion in multiple echocardiographic windows with one intravenous injection of microbubbles using transient response second harmonic imaging
    T R Porter
    University of Nebraska Medical Center, Omaha 68198 2265, USA
    J Am Coll Cardiol 29:791-9. 1997
    ..The purpose of this study was to prove that transient response harmonic imaging could detect normal and abnormal myocardial perfusion in multiple echocardiographic windows with one intravenous injection of microbubbles in humans...
  25. doi request reprint Detection of subendocardial ischemia in the left anterior descending coronary artery territory with real-time myocardial contrast echocardiography during dobutamine stress echocardiography
    Feng Xie
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    JACC Cardiovasc Imaging 1:271-8. 2008
    ....
  26. ncbi request reprint Microbubble potentiated ultrasound as a method of declotting thrombosed dialysis grafts: experimental study in dogs
    W C Culp
    University of Nebraska Medical Center, Omaha 68198-1045, USA
    Cardiovasc Intervent Radiol 24:407-12. 2001
    ..01. Intravenous PESDA succeeded in 4 of 10 procedures, p = <0.04 vs saline. Direct injection of PESDA with transcutaneous LFUS succeeds in lysing moderate-size clots and recanalizing thrombosed fistulas...
  27. ncbi request reprint Real-time assessment of myocardial perfusion and wall motion during bicycle and treadmill exercise echocardiography: comparison with single photon emission computed tomography
    S Shimoni
    Section of Cardiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Coll Cardiol 37:741-7. 2001
    ..The combination of WM and MCE correlates well with SPECT and is a promising important addition to conventional stress echocardiography...
  28. ncbi request reprint Detection of coronary artery disease with a continuous infusion of definity ultrasound contrast during adenosine stress real time perfusion echocardiography
    Feng Xie
    University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198 2265, USA
    Echocardiography 24:1044-50. 2007
    ..Myocardial perfusion imaging during adenosine stress is an accurate method of detecting physiologically relevant coronary artery disease...
  29. ncbi request reprint Ultrasound, microbubbles, and thrombolysis
    T R Porter
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198-1165, USA
    Prog Cardiovasc Dis 44:101-10. 2001
    ..In vitro and in vivo studies using ultrasound alone and ultrasound in combination with microbubbles to cause thrombolysis are reviewed. Potential clinical implications of more recent findings are explored...
  30. ncbi request reprint Safety of dobutamine stress real-time myocardial contrast echocardiography
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 1165, USA
    J Am Coll Cardiol 45:1235-42. 2005
    ....
  31. ncbi request reprint Differences in definity and optison microbubble destruction rates at a similar mechanical index with different real-time perfusion systems
    Carolin Sonne
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Am Soc Echocardiogr 16:1178-85. 2003
    ..1- and 0.2-MI settings. These differences indicate that the same MI setting on different real-time perfusion imaging techniques will produce different microbubble responses...
  32. ncbi request reprint Comparative accuracy of real-time myocardial contrast perfusion imaging and wall motion analysis during dobutamine stress echocardiography for the diagnosis of coronary artery disease
    Abdou Elhendy
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Am Coll Cardiol 44:2185-91. 2004
    ..This study sought to compare the accuracy of myocardial contrast echocardiography (MCE) and wall motion analysis (WMA) during submaximal and peak dobutamine stress echocardiography (DSE) for the diagnosis of coronary artery disease (CAD)...
  33. ncbi request reprint Prognostic value of dobutamine stress myocardial contrast perfusion echocardiography
    Jeane M Tsutsui
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 1165, USA
    Circulation 112:1444-50. 2005
    ..Its prognostic value is unknown. We sought to determine the value of MP and wall motion (WM) analysis during dobutamine stress echocardiography in predicting the outcome of patients with known or suspected coronary artery disease...
  34. ncbi request reprint Clinical experience in the detection of coronary artery disease with myocardial contrast echocardiography
    Thomas R Porter
    University of Nebraska Medical Center, Omaha 68198 1165, USA
    Echocardiography 19:399-407. 2002
    ..They also have been shown to detect zones of no reflow following coronary revascularization in patients with acute myocardial infarction. These preliminary data will require validation in larger multicenter clinical studies...
  35. ncbi request reprint Incidence of cardiac arrhythmias with therapeutic versus diagnostic ultrasound and intravenous microbubbles
    Scott Chapman
    University of Nebraska Medical Center, Omaha, 68198 1165, USA
    J Ultrasound Med 24:1099-107. 2005
    ..The purpose of this study was to determine the type of arrhythmias induced with therapeutic versus diagnostic transthoracic low-frequency ultrasound (TLFUS) transducers in the presence of intravenous microbubbles...
  36. doi request reprint Real-time perfusion echocardiography during treadmill exercise and dobutamine stress testing
    S Dodla
    University of Nebraska Medical Center, 982265 Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Heart 96:220-5. 2010
    ..A continuous infusion of 3% Definity (Lantheus Medical Imaging) was used for all studies, and contrast replenishment (MCR), plateau intensity (PMCE) and wall motion (WM) were examined for the detection of CAD...
  37. doi request reprint Treatment of acute intravascular thrombi with diagnostic ultrasound and intravenous microbubbles
    Feng Xie
    Department of Internal Medicine Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    JACC Cardiovasc Imaging 2:511-8. 2009
    ..05). We conclude that a commercially available DUS transducer can successfully recanalize acute intravascular thrombi during a continuous microbubble infusion...
  38. ncbi request reprint Interaction of transthoracic ultrasound and intravenous microbubbles with cardiac mechanoreceptors
    Feng Xie
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Ultrasound Med Biol 33:136-44. 2007
    ..The changes in RSNA induced by TTU and MB in all rabbits were abolished by vagotomy. TTU, in the presence of MB, stimulates mechanoreceptors in the heart reflexively to reduce RSNA...
  39. pmc The use of microbubbles to target drug delivery
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Cardiovasc Ultrasound 2:23. 2004
    ..In addition, current studies involving this novel therapeutical application of microbubbles will be discussed...
  40. ncbi request reprint Treatment of deeply located acute intravascular thrombi with therapeutic ultrasound guided by diagnostic ultrasound and intravenous microbubbles
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, 981165 Nebraska Medical Center, Omaha, 68198 1165 USA
    J Ultrasound Med 25:1161-8. 2006
    ..We sought to determine the added value of simultaneous imaging of intravenously infused microbubbles that are being used to dissolve an intravascular thrombus with therapeutic ultrasound (TUS)...
  41. ncbi request reprint Value of dobutamine stress myocardial contrast perfusion echocardiography in patients with advanced liver disease
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 1165, USA
    Liver Transpl 12:592-9. 2006
    ..003). In conclusion, MPI obtained by RTMCE appears to be a useful tool in predicting mortality in patients with ALD. Further studies are required to verify its independent value...
  42. ncbi request reprint Assessment of myocardial perfusion with real-time myocardial contrast echocardiography: methodology and clinical applications
    Abdou Elhendy
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, 982265 Nebraska Medical Center, Omaha, NE 68198 2265, USA
    J Nucl Cardiol 12:582-90. 2005
    ..This review will discuss the physiologic basis, methodology, clinical utility, and limitations of RTMCI in the assessment of patients with known or suspected coronary artery disease...
  43. ncbi request reprint Noninvasive diagnosis of coronary artery bypass graft disease by dobutamine stress real-time myocardial contrast perfusion imaging
    Abdou Elhendy
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    J Am Soc Echocardiogr 19:1482-7. 2006
    ..The aim of this study was to assess the accuracy of real-time myocardial contrast perfusion imaging (MCPI) during dobutamine stress echocardiography, for the diagnosis of coronary artery bypass graft disease...
  44. pmc Effects of attenuation and thrombus age on the success of ultrasound and microbubble-mediated thrombus dissolution
    Feng Xie
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Ultrasound Med Biol 37:280-8. 2011
    ..This treatment modality is less effective, however, for older aged thrombi...
  45. pmc Diagnostic ultrasound combined with glycoprotein IIb/IIIa-targeted microbubbles improves microvascular recovery after acute coronary thrombotic occlusions
    Feng Xie
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Circulation 119:1378-85. 2009
    ..The high mechanical index (MI) impulses from a diagnostic ultrasound transducer may be a method of recanalizing acutely thrombosed vessels if the impulses are applied only when microbubbles are channeling through the thrombus...
  46. pmc Albumin-based microbubbles bind up-regulated scavenger receptors following vascular injury
    Daniel R Anderson
    Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 6350, USA
    J Biol Chem 285:40645-53. 2010
    ....
  47. ncbi request reprint Peak atrial systolic mitral annular velocity by Doppler tissue reliably predicts left atrial systolic function
    Banthit Khankirawatana
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198 1165, USA
    J Am Soc Echocardiogr 17:353-60. 2004
    ..A' correlates well with quantitative methods of LA function, and could be readily applied for quantifying LA contribution to diastolic performance in clinical practice...
  48. ncbi request reprint Assessment of papillary muscle function using myocardial velocity gradient derived from tissue Doppler echocardiography
    Banthit Khankirawatana
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, 68198 1165, USA
    Am J Cardiol 94:45-9. 2004
    ..PM dysfunction, indicated by lower MVG-PM, decreased mitral leaflet tethering, thus paradoxically decreasing mitral regurgitation severity. MVG is a useful tool in determining the role of PM in functional mitral regurgitation...
  49. ncbi request reprint Detection of retained microbubbles in carotid arteries with real-time low mechanical index imaging in the setting of endothelial dysfunction
    Jeane M Tsutsui
    Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 1165, USA
    J Am Coll Cardiol 44:1036-46. 2004
    ....
  50. ncbi request reprint Acute myocardial infarction after a negative dobutamine stress echocardiogram
    Abdou Elhendy
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Eur J Echocardiogr 5:469-71. 2004
    ..High shear stress may result in destabilization of a complex plaque with subsequent thrombotic occlusion, despite the absence of a flow-limiting lesion at the time of DSE...
  51. ncbi request reprint Comparison of low-mechanical index pulse sequence schemes for detecting myocardial perfusion abnormalities during vasodilator stress echocardiography
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Am J Cardiol 95:565-70. 2005
    ..These data indicate that the different low-mechanical index imaging schemes are equivalent to radionuclide SPECT in accurately detecting diseased coronary artery territories during vasodilator stress...
  52. ncbi request reprint Effectiveness of lipid microbubbles and ultrasound in declotting thrombosis
    Feng Xie
    Internal Medicine Cardiology Department, University of Nebraska Medical Center, Omaha, NE 68196 1165, USA
    Ultrasound Med Biol 31:979-85. 2005
    ..US and microbubbles are capable of recanalizing acute arteriovenous graft thromboses. Higher intensities may be needed in the presence of tissue attenuation...
  53. ncbi request reprint Noninvasive diagnosis of coronary artery disease in patients with diabetes by dobutamine stress real-time myocardial contrast perfusion imaging
    Abdou Elhendy
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Diabetes Care 28:1662-7. 2005
    ..Myocardial contrast echocardiography is a new technique that allows evaluation of myocardial perfusion. Its utility in diabetic patients has not been defined...
  54. ncbi request reprint Intravenous myocardial contrast echocardiography for the diagnosis of coronary artery disease
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 1165, USA
    Curr Opin Cardiol 20:381-5. 2005
    ..The analysis of microbubble kinetics using quantitative myocardial contrast echocardiography permits the evaluation of myocardial blood flow both at rest and during pharmacological stress...
  55. ncbi request reprint Safety and feasibility of dobutamine stress echocardiography in patients with implantable cardioverter defibrillators
    Abdou Elhendy
    Department of Cardiology and Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 2265, USA
    Am J Cardiol 92:475-7. 2003
    ..The ICD was inactivated before the stress test and reactivated after the study; no serious complications occurred. DSE is a safe and feasible method for evaluating myocardial ischemia in patients with an ICD...
  56. ncbi request reprint Association of myocardial ischemia with mortality and implantable cardioverter-defibrillator therapy in patients with coronary artery disease at risk of arrhythmic death
    Abdou Elhendy
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 2265, USA
    J Am Coll Cardiol 46:1721-6. 2005
    ..We sought to assess the relation between myocardial ischemia during stress echocardiography and major events in patients with implantable cardioverter-defibrillator (ICD)...
  57. ncbi request reprint Left atrial volume determination by three-dimensional echocardiography reconstruction: validation and application of a simplified technique
    Banthit Khankirawatana
    University of Nebraska Medical Center, Omaha, 68198 1165, USA
    J Am Soc Echocardiogr 15:1051-6. 2002
    ..65x + 2.6, r = 0.76, SEE = 8.2). Without the need for a 3D-imaging acquisition tool, simplified 3D reconstruction can be applied in the clinical setting for LA size quantitation with significant time saved...
  58. ncbi request reprint Diagnostic accuracy and prognostic value of dobutamine stress myocardial contrast echocardiography in patients with suspected acute coronary syndromes
    Jeane M Tsutsui
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 1165, USA
    Echocardiography 22:487-95. 2005
    ....
  59. pmc Evaluation of restenosis and extent of coronary artery disease in patients with previous percutaneous coronary interventions by dobutamine stress real-time myocardial contrast perfusion imaging
    A Elhendy
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Heart 92:1480-3. 2006
    ..To assess the accuracy of real-time myocardial contrast perfusion imaging (MCPI) for the diagnosis of restenosis and extent of coronary artery disease (CAD) in patients with previous percutaneous coronary intervention (PCI)...
  60. ncbi request reprint Real-time dobutamine stress myocardial perfusion echocardiography predicts outcome in the elderly
    Jeane M Tsutsui
    Section of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, 982265 Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Eur Heart J 29:377-85. 2008
    ....
  61. doi request reprint Effects of transcranial ultrasound and intravenous microbubbles on blood brain barrier permeability in a large animal model
    Feng Xie
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 2265, USA
    Ultrasound Med Biol 34:2028-34. 2008
    ..This induced opening of BBB is reversible and may be a safe noninvasive method of achieving drug or gene delivery across the BBB...
  62. ncbi request reprint Drug and gene delivery and enhancement of thrombolysis using ultrasound and microbubbles
    Jeane Mike Tsutsui
    Section of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, NE 68198, USA
    Cardiol Clin 22:299-312, vii. 2004
    ..Potential applications, such as induction of angiogenesis, inhibition of neointimal hyperplasia, and in the setting of acute myocardial infarction and ischemic stroke,are discussed briefly...
  63. ncbi request reprint Targeted vascular delivery of antisense molecules using intravenous microbubbles
    Thomas R Porter
    Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198 1165, USA
    Cardiovasc Revasc Med 7:25-33. 2006
    ..The microbubbles also adhere to sites of damaged vascular endothelium and thus may be a method of systemically targeting delivery of anti-c-myc...
  64. ncbi request reprint The role of complement in the adherence of microbubbles to dysfunctional arterial endothelium and atherosclerotic plaque
    Daniel R Anderson
    Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 2265, USA
    Cardiovasc Res 73:597-606. 2007
    ..To determine whether serum complement C3 mediates adherence of albumin-encapsulated microbubbles to vascular endothelium in the development of atherosclerotic plaques...
  65. ncbi request reprint Carcinoid crisis and reversible right ventricular dysfunction after embolization in untreated carcinoid syndrome
    Farhan Majeed
    University of Nebraska Medical Center, Department of Internal Medicine, 982055 Nebraska Medical Center, Omaha, NE 68198 2055, USA
    Eur J Echocardiogr 8:386-9. 2007
    ..These findings suggest that the acute right ventricular dysfunction was secondary to acute carcinoid crisis and resolution resulted in a significant improvement of both right ventricular systolic function and clinical condition...
  66. ncbi request reprint Myocardial contrast quantitation during stress echocardiography
    Abdou Elhendy
    Eur J Echocardiogr 7:185-6. 2006
  67. ncbi request reprint Correlation between myocardial perfusion abnormalities detected with intermittent imaging using intravenous perfluorocarbon microbubbles and radioisotope imaging during high-dose dipyridamole stress echo
    Ricardo E Ronderos
    Instituto de Cardiologia La Plata, Buenos Aires, Argentina
    Clin Cardiol 25:103-11. 2002
    ..The clinical accuracy of myocardial contrast echocardiography (MCE) using intermittent harmonic imaging and intravenous perfluorocarbon containing microbubbles during dipyridamole stress has not been evaluated in a multicenter setting...
  68. ncbi request reprint Cardiovascular imaging of remote myocardial ischemia: detecting a molecular trace of evidence left behind
    Thomas R Porter
    Circulation 115:292-3. 2007
  69. ncbi request reprint Myocardial contrast echocardiography evolving as a clinically feasible technique for accurate, rapid, and safe assessment of myocardial perfusion: the evidence so far
    Pieter A Dijkmans
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 48:2168-77. 2006
    ..Although MCE has been primarily performed for medical research, its implementation in routine clinical care is evolving. This article is intended to give an overview of the current status of MCE...
  70. ncbi request reprint Endocardial border delineation during dobutamine infusion using contrast echocardiography
    Wilson Mathias
    Paulista School of Medicine, Exata Diagnostics, Sao Paulo, Brazil
    Echocardiography 19:109-14. 2002
    ..Intravenous continuous infusion of myocardial ultrasound contrast may enhance endocardial border delineation during dobutamine-atropine stress echocardiography (DASE), improving wall-motion analysis...
  71. ncbi request reprint Microbubble-augmented ultrasound declotting of thrombosed arteriovenous dialysis grafts in dogs
    William C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 556, Little Rock, Arkansas 72205 7199, USA
    J Vasc Interv Radiol 14:343-7. 2003
    ....
  72. ncbi request reprint Carbon dioxide in the aortic arch: coronary effects and implications in a swine study
    William C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Slot 556, Little Rock, AR 72205 7199, USA
    Cardiovasc Intervent Radiol 26:128-35. 2003
    ..CO2 angiography is considered dangerous in the aortic arch where bubbles may cause critical cerebral and cardiac ischemia. We investigated CO2 distribution, physiologic effects in the heart, methods of detection and treatments...
  73. ncbi request reprint Novel site-specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in a porcine coronary restenosis model
    Nicholas N Kipshidze
    Department of Interventional Cardiac and Vascular Services, Lenox Hill Hospital, New York, NY 10021, USA
    Catheter Cardiovasc Interv 64:389-94. 2005
    ..001). In the porcine coronary model, site-specific systemic delivery of Rapamycin utilizing PGMC resulted in overexpression of p27 and a significant reduction of neointimal formation within the stented segments...
  74. ncbi request reprint Serial changes in right ventricular apical pacing lead impedance predict changes in left ventricular ejection fraction and functional class in heart failure patients
    Bruce S Stambler
    University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Pacing Clin Electrophysiol 28:S50-3. 2005
    ..A decrease in bipolar pacing impedance at the RVA was associated with worsening LVEF and the NYHA class. The use of pacing impedance to monitor the clinical status in CHF is dependent on the RV pacing site...
  75. ncbi request reprint Intracranial clot lysis with intravenous microbubbles and transcranial ultrasound in swine
    William C Culp
    Department of Radiology, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 556, Little Rock, AR 72205 7199, USA
    Stroke 35:2407-11. 2004
    ..We hypothesized that intravenous platelet-targeted microbubbles with LFUS may be a rapid noninvasive technique to recanalize thrombosed intracerebral vessels...
  76. ncbi request reprint Systemic targeted delivery of antisense with perflourobutane gas microbubble carrier reduced neointimal formation in the porcine coronary restenosis model
    Nicholas N Kipshidze
    Lenox Hill Heart and Vascular Institute and Cardiovascular Research Foundation, 130 East 77th Street, Black Hall, 9th Floor, New York, NY 10021, USA
    Cardiovasc Radiat Med 4:152-9. 2003
    ..The purpose of this study was to investigate the effects of perfluorocarbon gas microbubble carrier (PGMC)-based systemic delivery of AVI-4126 on expression of the c-myc in vascular tissue and restenosis after stent implantation...
  77. ncbi request reprint Right ventricular outflow versus apical pacing in pacemaker patients with congestive heart failure and atrial fibrillation
    Bruce S Stambler
    University Hospitals of Cleveland, Case Western Reserve University, 22200 Euclid Avenue, Cleveland, Ohio 44106, USA
    J Cardiovasc Electrophysiol 14:1180-6. 2003
    ..Whether the right ventricular outflow tract (RVOT) is a more optimal site for permanent pacing in patients with congestive heart failure (CHF) has not been established...