Stephen R Plymate

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint An antibody targeting the type I insulin-like growth factor receptor enhances the castration-induced response in androgen-dependent prostate cancer
    Stephen R Plymate
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    Clin Cancer Res 13:6429-39. 2007
  2. ncbi request reprint In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors
    Jennifer D Wu
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    Clin Cancer Res 11:3065-74. 2005
  3. pmc Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease
    Laura D Baker
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
    J Alzheimers Dis 22:569-79. 2010
  4. ncbi request reprint Androgen receptor (AR) expression in AR-negative prostate cancer cells results in differential effects of DHT and IGF-I on proliferation and AR activity between localized and metastatic tumors
    Stephen R Plymate
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Prostate 61:276-90. 2004
  5. ncbi request reprint Combined in vivo effect of A12, a type 1 insulin-like growth factor receptor antibody, and docetaxel against prostate cancer tumors
    Jennifer D Wu
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Clin Cancer Res 12:6153-60. 2006
  6. pmc Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease
    Amy Claxton
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    J Alzheimers Dis 35:789-97. 2013
  7. ncbi request reprint Suppression of growth and tumorigenicity in the prostate tumor cell line M12 by overexpression of the transcription factor SOX9
    Rolf Drivdahl
    Veterans Affairs Puget Sound Health Care System, Seattle, WA 98105, USA
    Oncogene 23:4584-93. 2004
  8. pmc Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants
    Elahe A Mostaghel
    Division of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center Department of Medicine, University of Washington, Seattle, Washington, USA
    Clin Cancer Res 17:5913-25. 2011
  9. pmc Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
    Shihua Sun
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Clin Invest 120:2715-30. 2010
  10. pmc Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults
    Mark A Reger
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:323-31. 2008

Detail Information

Publications53

  1. ncbi request reprint An antibody targeting the type I insulin-like growth factor receptor enhances the castration-induced response in androgen-dependent prostate cancer
    Stephen R Plymate
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    Clin Cancer Res 13:6429-39. 2007
    ....
  2. ncbi request reprint In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors
    Jennifer D Wu
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    Clin Cancer Res 11:3065-74. 2005
    ..In this study, we tested the in vivo effects of A12 on androgen-dependent and androgen-independent prostate tumor growth...
  3. pmc Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease
    Laura D Baker
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
    J Alzheimers Dis 22:569-79. 2010
    ..Although replication in a larger sample is needed, our findings potentially have important therapeutic implications for a growing number of adults at increased risk of cognitive decline...
  4. ncbi request reprint Androgen receptor (AR) expression in AR-negative prostate cancer cells results in differential effects of DHT and IGF-I on proliferation and AR activity between localized and metastatic tumors
    Stephen R Plymate
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Prostate 61:276-90. 2004
    ..The purpose of this study was to determine the effect of changes in IGF-IR expression on AR activity...
  5. ncbi request reprint Combined in vivo effect of A12, a type 1 insulin-like growth factor receptor antibody, and docetaxel against prostate cancer tumors
    Jennifer D Wu
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Clin Cancer Res 12:6153-60. 2006
    ..Based on these data, we investigated the combined in vivo effect of A12 and docetaxel on human androgen-independent and osseous prostate tumor growth...
  6. pmc Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease
    Amy Claxton
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    J Alzheimers Dis 35:789-97. 2013
    ..Unlike previous studies with young adults, neither men nor women taking intranasal insulin exhibited a significant change in weight over 4 months of treatment...
  7. ncbi request reprint Suppression of growth and tumorigenicity in the prostate tumor cell line M12 by overexpression of the transcription factor SOX9
    Rolf Drivdahl
    Veterans Affairs Puget Sound Health Care System, Seattle, WA 98105, USA
    Oncogene 23:4584-93. 2004
    ..These data indicate that SOX9 contributes to growth regulation by mac25 via inhibition of cell growth and promotion of differentiation...
  8. pmc Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants
    Elahe A Mostaghel
    Division of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center Department of Medicine, University of Washington, Seattle, Washington, USA
    Clin Cancer Res 17:5913-25. 2011
    ..The effectiveness of abiraterone in reducing tumor androgens is not known, nor have mechanisms contributing to abiraterone resistance been established...
  9. pmc Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
    Shihua Sun
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Clin Invest 120:2715-30. 2010
    ....
  10. pmc Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults
    Mark A Reger
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:323-31. 2008
    ..These findings suggest that groups with different genetic risks for AD may show differential dose-response curves following intranasal insulin administration...
  11. pmc Response of the insulin-like growth factor (IGF) system to IGF-IR inhibition and androgen deprivation in a neoadjuvant prostate cancer trial: effects of obesity and androgen deprivation
    James P Dean
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Clin Endocrinol Metab 98:E820-8. 2013
    ....
  12. pmc Cognitive response to estradiol in postmenopausal women is modified by high cortisol
    Laura D Baker
    Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, Seattle, WA, USA
    Neurobiol Aging 33:829.e9-20. 2012
    ..Our findings indicate that cognitive and physiological responses to estradiol are adversely affected by elevated stress hormone levels of cortisol in healthy postmenopausal women...
  13. pmc Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, S 182, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 69:29-38. 2012
    ..To examine the effects of intranasal insulin administration on cognition, function, cerebral glucose metabolism, and cerebrospinal fluid biomarkers in adults with amnestic mild cognitive impairment or Alzheimer disease (AD)...
  14. ncbi request reprint Regulation of global gene expression in the bone marrow microenvironment by androgen: androgen ablation increases insulin-like growth factor binding protein-5 expression
    Chang Xu
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Prostate 67:1621-9. 2007
    ..In particular we questioned whether the androgen therapy could adversely facilitate prostate cancer progression through an increase growth factor secretion by the bone microenvironment...
  15. ncbi request reprint Insulin effects on CSF norepinephrine and cognition in Alzheimer's disease
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center GRECC, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108 1532, USA
    Neurobiol Aging 27:38-41. 2006
    ..These findings demonstrate that raising peripheral insulin levels can modulate CNS NE levels and suggest that insulin-stimulated increases in NE may modulate cognitive functions...
  16. ncbi request reprint Muscle-specific overexpression of the type 1 IGF receptor results in myoblast-independent muscle hypertrophy via PI3K, and not calcineurin, signaling
    LeBris S Quinn
    Department of Gerontology, University of Washington, Seattle, WA 98493, USA
    Am J Physiol Endocrinol Metab 293:E1538-51. 2007
    ....
  17. ncbi request reprint Interaction of IGF signaling and the androgen receptor in prostate cancer progression
    Jennifer D Wu
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Cell Biochem 99:392-401. 2006
    ..Since fully humanized antibodies targeting the IGF-IR are now in clinical trials, the current review is intended to reveal the mechanisms of potential therapeutic effects of these antibodies on AI prostate cancers...
  18. pmc Androgen receptor variants occur frequently in castration resistant prostate cancer metastases
    Xiaotun Zhang
    Department of Urology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e27970. 2011
    ..Since specific antibodies detecting all C-terminal truncated AR variants are not available, our aim was to develop an approach to assess the prevalence and function of AR variants in prostate cancer (PCa)...
  19. ncbi request reprint Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center, Research and Development Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Am J Geriatr Psychiatry 13:950-8. 2005
    ..Authors evaluated the effects of the PPAR-gamma agonist rosiglitazone on cognition and plasma levels of the APP derivative beta-amyloid (Abeta) in humans...
  20. pmc Statin users without an APOE-epsilon4 allele have increased insulin resistance
    Brian T Vanfossen
    GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 19:1149-53. 2010
    ..0169), and with non-users who were epsilon4- (p=0.0003) or epsilon4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE epsilon4 allele...
  21. pmc Androgen receptor splice variants determine taxane sensitivity in prostate cancer
    Maria Thadani-Mulero
    Authors Affiliations Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College Weill Cornell Cancer Center, New York, New York Department of Urology, University of Washington Research Service, Puget Sound VA Health Care System Department of Medicine, University of Washington and GRECC Seattle VAMC, Seattle, Washington
    Cancer Res 74:2270-82. 2014
    ....
  22. pmc Obstructing shedding of the immunostimulatory MHC class I chain-related gene B prevents tumor formation
    Jennifer D Wu
    Department of Medicine, University of Washington, 325 9th Avenue, Box 359625, Seattle, WA 98104, USA
    Clin Cancer Res 15:632-40. 2009
    ..However, this hypothesis has never been proven. In this study, we tested this hypothesis using a prostate tumor model and investigated the effect of shedding of MIC on tumor development...
  23. pmc Effects of aerobic exercise on mild cognitive impairment: a controlled trial
    Laura D Baker
    Departments of Psychiatry and BehavioralScience, University of Washington School of Medicine, Seattle, Washington, USA
    Arch Neurol 67:71-9. 2010
    ..To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response...
  24. pmc Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment
    Jennifer L Bayer-Carter
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 68:743-52. 2011
    ....
  25. pmc Senescence-induced alterations of laminin chain expression modulate tumorigenicity of prostate cancer cells
    Cynthia C T Sprenger
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA
    Neoplasia 10:1350-61. 2008
    ..This study demonstrates that senescent prostate epithelial cells can alter the microenvironment and that these changes modulate progression of prostate cancer...
  26. pmc The effects of aging on the molecular and cellular composition of the prostate microenvironment
    Daniella Bianchi-Frias
    Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 5:. 2010
    ..In this study we sought to identify aging-associated alterations in the mouse prostate microenvironment that could influence pathology...
  27. ncbi request reprint Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-gamma expression, and NK cells: a physiological role for testosterone and/or its metabolites
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Physiol Endocrinol Metab 290:E856-63. 2006
    ..In addition, sex steroids suppress NK cell proliferation. This study supports a complex physiological role for T and/or its metabolites in immune regulation...
  28. pmc Insulin-like growth factor-I receptor blockade improves outcome in mouse model of lung injury
    Jung Eun Choi
    Divison of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, Washington, USA
    Am J Respir Crit Care Med 179:212-9. 2009
    ..Furthermore, immunodepletion of IGF from acute respiratory distress syndrome bronchoalveolar lavage increased fibroblast apoptosis...
  29. pmc Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer
    Rong Hu
    Department of Urology, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Res 72:3457-62. 2012
    ..Together, our findings support an adaptive shift toward AR-V-mediated signaling in a subset of CRPC tumors as the AR-LBD is rendered inactive, suggesting an important mechanism contributing to drug resistance to CRPC therapy...
  30. pmc Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer
    Jennifer D Wu
    Department of Medicine, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA
    J Clin Invest 114:560-8. 2004
    ....
  31. pmc Oxidative DNA damage in the prostate may predispose men to a higher risk of prostate cancer
    Jennifer D Wu
    Department of Medicine, University of Washington, Seattle, WA, USA
    Transl Oncol 2:39-45. 2009
    ....
  32. ncbi request reprint Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1/mac 25) is reduced in human prostate cancer and is inversely related to tumor volume and proliferation index in Lucap 23.12 xenografts
    Marie K Tennant
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Prostate 56:115-22. 2003
    ..Likewise, mice injected with prostate cells over-expressing IGFBP-rP1/mac 25 showed decreased tumor formation and tumor volume...
  33. pmc Aging-related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression
    Cynthia C Sprenger
    Department of Medicine, Division of Gerontology, University of Washington, Seattle, WA 98104, USA
    Int J Cancer 127:2739-48. 2010
    ..Because of the tight correlation between advanced age and the prevalence of prostate cancer, we will use prostate cancer as the model throughout this minireview...
  34. pmc Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening
    Kevin J Coe
    Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA
    Chem Res Toxicol 20:1277-90. 2007
    ..Thus, as compared to CYA, the nitroaromatic group of FLU enhances cytotoxicity to hepatocytes, likely through mechanisms involving mitochondrial dysfunction and ATP depletion that include complex I inhibition...
  35. doi request reprint Differential Effects of Meal Challenges on Cognition, Metabolism, and Biomarkers for Apolipoprotein E ɛ4 Carriers and Adults with Mild Cognitive Impairment
    Angela J Hanson
    Department of Medicine, University of Washington Medical Center, Seattle, WA, USA
    J Alzheimers Dis 48:205-18. 2015
    ..High intake of saturated fat (SF) and glycemic index (GI) foods is a risk factor for sporadic Alzheimer's disease. Meal challenges may elucidate mechanisms that contribute to this risk, enabling development of targeted interventions...
  36. pmc Capillary force seeding of sphere-templated hydrogels for tissue-engineered prostate cancer xenografts
    Thomas J Long
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    Tissue Eng Part C Methods 19:738-44. 2013
    ..These studies demonstrate that sphere-templated polymeric scaffolds have the potential to serve as an adaptable cell culture substrate for engineering a three-dimensional prostate cancer model. ..
  37. pmc Prostate cancer xenografts engineered from 3D precision-porous poly(2-hydroxyethyl methacrylate) hydrogels as models for tumorigenesis and dormancy escape
    Thomas J Long
    Department of Bioengineering, University of Washington, Seattle, WA, USA
    Biomaterials 35:8164-74. 2014
    ..These findings show the potential for this biomaterials-based model system to be used in the study of prostate cancer tumorigenesis and dormancy escape. ..
  38. ncbi request reprint Prostate carcinoma incidence in relation to prediagnostic circulating levels of insulin-like growth factor I, insulin-like growth factor binding protein 3, and insulin
    Chu Chen
    Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer 103:76-84. 2005
    ..To examine this issue further, the authors conducted a nested case-control study within the Cardiovascular Health Study cohort...
  39. pmc An six-amino acid motif in the alpha3 domain of MICA is the cancer therapeutic target to inhibit shedding
    Xuanjun Wang
    Department of Medicine, University of Washington, 325 9th Ave, Seattle, WA 98104, USA
    Biochem Biophys Res Commun 387:476-81. 2009
    ..Mutations in this motif prevented MIC shedding but did not interfere with NKG2D-mediated recognition of MIC. Our study suggests that the 6-aa motif is a feasible target to inhibit MIC shedding for cancer therapy...
  40. ncbi request reprint Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy
    Patrick S Thomas
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, 98195 7110, USA
    Hum Mol Genet 15:2225-38. 2006
    ..Our studies indicate that SBMA disease pathogenesis, both in the nervous system and the periphery, involves two simultaneous pathways: gain-of-function misfolded protein toxicity and loss of normal protein function...
  41. pmc Hyaluronan in aged collagen matrix increases prostate epithelial cell proliferation
    Mamatha Damodarasamy
    Department of Medicine, University of Washington, Harborview Medical Center, 325 9th Avenue, Box 359625, Seattle, WA, 98104, USA
    In Vitro Cell Dev Biol Anim 51:50-8. 2015
    ..Collectively, these results suggest that changes in ECM involving increased levels of HA contribute to the growth of prostatic epithelium with aging. ..
  42. ncbi request reprint Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1
    Stephen R Plymate
    Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA 98105, USA
    Oncogene 22:1024-34. 2003
    ..These results suggest that one of the downstream mediators of the senescence-associated tumor suppression effect of mac25/IGFBP-rP1 is SOD-2...
  43. pmc The link between androgen receptor splice variants and castration-resistant prostate cancer
    Cynthia C T Sprenger
    Department of Medicine, University of Washington, Seattle, WA, 98104, USA
    Horm Cancer 5:207-17. 2014
    ..In this review, we will examine androgen receptor splice variants as an alternative mechanism by which prostate cancer becomes resistant to androgen receptor-directed therapy...
  44. doi request reprint T-helper I immunity, specific for the breast cancer antigen insulin-like growth factor-I receptor (IGF-IR), is associated with increased adiposity
    Denise L Cecil
    Tumor Vaccine Group, Center for Translational Medicine in Women s Health, University of Washington, 850 Republican Street, Seattle, WA 98109, USA
    Breast Cancer Res Treat 139:657-65. 2013
    ..174, p = 0.966, respectively) or body mass index (p = 0.137, p = 0.174, respectively). Our data demonstrate that IGF-IR is a tumor antigen and IGF-IR-specific Th1 immunity may be associated with obesity rather than malignancy...
  45. pmc Molecular pathways: targeting resistance in the androgen receptor for therapeutic benefit
    Elahe A Mostaghel
    Authors Affiliations Division of Clinical Research, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, Washington
    Clin Cancer Res 20:791-8. 2014
    ....
  46. ncbi request reprint Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults
    Mark A Fishel
    Department of Neurology, University of Washington, Seattle, WA 98108, USA
    Arch Neurol 62:1539-44. 2005
    ..Hyperinsulinemia induces inflammation and is a risk factor for Alzheimer disease. Thus, insulin abnormalities may contribute to Alzheimer disease pathophysiology through effects on the inflammatory network...
  47. doi request reprint Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner
    Itay Bentov
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Endocrinology 149:1890-7. 2008
    ..Stimulation of KLF6 expression by IGF-I in a p53-dependent manner may constitute a novel mechanism of action of IGF-I, with implications in normal cell cycle progression and cancer biology...
  48. ncbi request reprint Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis
    Cynthia C Sprenger
    Geriatric Research Education and Clinical Center, VAPSHCS, Seattle Tacoma, Washington, WA 98493, USA
    Oncogene 21:140-7. 2002
    ..In addition, the appearance of cyclin A in the sub-G0/G1 phase of the cell cycle and the increased kinase activity of cyclin A/cdk-2 in the IGFBP-rP1/mac25 clones suggests that cyclin A is associated with the apoptotic cells...
  49. ncbi request reprint Proteomic identification of 14-3-3 sigma as a common component of the androgen receptor and the epidermal growth factor receptor signaling pathways of the human prostate epithelial cell line M12
    Dan Huang
    Department of Pathology, Medical Center of Virginia Commonwealth University, Richmond, VA 23298 5008, USA
    Oncogene 23:6881-9. 2004
    ..These findings implicate 14-3-3 sigma in the development of human prostate cancer cells and could provide a new target for intervention in prostate cancer...
  50. ncbi request reprint Prostate cancer risk in relation to selected genetic polymorphisms in insulin-like growth factor-I, insulin-like growth factor binding protein-3, and insulin-like growth factor-I receptor
    Chu Chen
    Program in Epidemiology, Fred Hutchinson Cancer Research Center, WA, USA
    Cancer Epidemiol Biomarkers Prev 15:2461-6. 2006
    ..Our observation that men who do not carry two copies of the IGF-IR (AGG)7 allele are at increased risk of prostate cancer merits further investigation...
  51. ncbi request reprint cDNA microarray analysis identifies genes induced in common by peptide growth factors and androgen in human prostate epithelial cells
    Timothy P York
    Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Mol Carcinog 44:242-51. 2005
    ..These results provide comprehensive and unique insights into potential mechanisms by which peptide growth factors provide alternate pathways to control prostate epithelial cell proliferation in malignant states...
  52. ncbi request reprint Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo
    Gayathri R Devi
    Department of Pediatrics, School of Medicine, Oregon Health Sciences University, Portland, Oregon, USA
    Prostate 51:141-52. 2002
    ..Insulin-like growth factor binding protein (IGFBP-3) levels are significantly reduced in malignant prostate epithelial cells. In this study, we evaluated the role of endogenous IGFBP-3 on prostate cancer cell growth and tumorigenesis...
  53. ncbi request reprint Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53
    Moran Rubinstein
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Endocrinology 145:3769-77. 2004
    ..The regulation of IGF-IR gene expression by KLF6 may have significant implications in terms of cancer initiation and/or progression...